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Article: Global Trends and Research Progress of Photodynamic Therapy in Skin Cancer: A Bibliometric Analysis and Literature Review.

Sun, Jiachen / Zhao, Hongqing / Fu, Lin / Cui, Jing / Yang, Yuguang

Clinical, cosmetic and investigational dermatology

2023 Volume 16, Page(s) 479–498

Abstract: Background: Based on photochemical reactions through the combined use of light and photosensitizers, photodynamic therapy (PDT) is gaining popularity for the treatment of skin cancer. Various photosensitizers and treatment regimens are continuously ... ...

Abstract	Background: Based on photochemical reactions through the combined use of light and photosensitizers, photodynamic therapy (PDT) is gaining popularity for the treatment of skin cancer. Various photosensitizers and treatment regimens are continuously being developed for enhancing the efficacy of PDT on skin cancer. Reviewing the development history of PDT on skin cancer, and summarizing its development direction and research status, is conducive to the further research. Methods: To evaluate the research trends and map knowledge structure, all publications covering PDT on skin cancer were retrieved and extracted from Web of Science database. We applied VOSviewer and CiteSpace softwares to evaluate and visualize the countries, institutes, authors, keywords and research trends. Literature review was performed for the analysis of the research status of PDT on skin cancer. Results: A total of 2662 publications were identified. The elements, mechanism, pros and cons, representative molecular photosensitizers, current challenges and research progress of PDT on skin cancer were reviewed and summarized. Conclusion: This study provides a comprehensive display of the field of PDT on skin cancer, which will help researchers further explore the mechanism and application of PDT more effectively and intuitively.
Language	English
Publishing date	2023-02-21
Publishing country	New Zealand
Document type	Journal Article ; Review
ZDB-ID	2494852-4
ISSN	1178-7015
ISSN	1178-7015
DOI	10.2147/CCID.S401206
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Preparation and Properties of GO/ZnO/nHAp Composite Microsphere Bone Regeneration Material.

Wu, Jiang / Wang, Chunmei / Zhang, Shuangsheng / Zhang, Ling / Hao, Jingshun / Jia, Zijian / Zheng, Xiaomei / Lv, Yuguang / Fu, Shuang / Zhang, Guoliang

Micromachines

2024 Volume 15, Issue 1

Abstract: The purpose of this study is to explore the possibility of using graphene-zinc oxide-hydroxyapatite (GO/ZnO/nHAp) composite microspheres as bone regeneration materials by making use of the complementary advantages of nanocomposites, so as to provide ... ...

Abstract	The purpose of this study is to explore the possibility of using graphene-zinc oxide-hydroxyapatite (GO/ZnO/nHAp) composite microspheres as bone regeneration materials by making use of the complementary advantages of nanocomposites, so as to provide reference for the clinical application of preventing and solving bacterial infection after implantation of synthetic materials. Firstly, GO/ZnO composites and hydroxyapatite nanoparticles were synthesized using the hydrothermal method, and then GO/ZnO/nHAp composite microspheres were prepared via high-temperature sintering. The graphene-zinc oxide-calcium phosphate composite microspheres were characterized by X-ray diffraction (XRD), field emission scanning electron microscopy (FE-SEM), X-ray photoelectron spectroscopy (XPS), energy dispersion spectroscopy (EDS), water contact angle measurement, degradation and pH determination, and differential thermal analysis (DiamondTG/DTA). The biocompatibility, osteogenic activity, and antibacterial activity of GO/ZnO/nHAp composite microspheres were further studied. The results of the cell experiment and antibacterial experiment showed that 0.5% and 1% GO-ZnO-nHAp composite microspheres not only had good biocompatibility and osteogenic ability but also inhibited
Language	English
Publishing date	2024-01-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2620864-7
ISSN	2072-666X
ISSN	2072-666X
DOI	10.3390/mi15010122
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Article ; Online: Hypoxia inducible factor-1α facilitates transmissible gastroenteritis virus replication by inhibiting type I and type III interferon production.

Zhang, Yunhang / Rui, Xue / Li, Yang / Zhang, Yue / Cai, Yifei / Tan, Chen / Yang, Ning / Liu, Yuanyuan / Fu, Yuguang / Liu, Guangliang

Veterinary microbiology

2024 Volume 292, Page(s) 110055

Abstract: Transmissible gastroenteritis virus (TGEV) is characterized by watery diarrhea, vomiting, and dehydration and is associated with high mortality especially in newborn piglets, causing significant economic losses to the global pig industry. Hypoxia ... ...

Abstract	Transmissible gastroenteritis virus (TGEV) is characterized by watery diarrhea, vomiting, and dehydration and is associated with high mortality especially in newborn piglets, causing significant economic losses to the global pig industry. Hypoxia inducible factor-1α (HIF-1α) has been identified as a key regulator of TGEV-induced inflammation, but understanding of the effect of HIF-1α on TGEV infection remains limited. This study found that TGEV infection was associated with a marked increase in HIF-1α expression in ST cells and an intestinal organoid epithelial monolayer. Furthermore, HIF-1α was shown to facilitate TGEV infection by targeting viral replication, which was achieved by restraining type I and type III interferon (IFN) production. In vivo experiments in piglets demonstrated that the HIF-1α inhibitor BAY87-2243 significantly reduced HIF-1α expression and inhibited TGEV replication and pathogenesis by activating IFN production. In summary, we unveiled that HIF-1α facilitates TGEV replication by restraining type I and type III IFN production in vitro, ex vivo, and in vivo. The findings from this study suggest that HIF-1α could be a novel antiviral target and candidate drug against TGEV infection.
MeSH term(s)	Animals ; Swine ; Transmissible gastroenteritis virus ; Gastroenteritis, Transmissible, of Swine ; Interferon Lambda ; Intestines ; Virus Replication ; Hypoxia/veterinary ; Swine Diseases
Chemical Substances	Interferon Lambda
Language	English
Publishing date	2024-03-16
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	753154-0
ISSN	1873-2542 ; 0378-1135
ISSN (online)	1873-2542
ISSN	0378-1135
DOI	10.1016/j.vetmic.2024.110055
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Article ; Online: Damage Detection and Localization of Bridge Deck Pavement Based on Deep Learning.

Ni, Youhao / Mao, Jianxiao / Fu, Yuguang / Wang, Hao / Zong, Hai / Luo, Kun

Sensors (Basel, Switzerland)

2023 Volume 23, Issue 11

Abstract: Bridge deck pavement damage has a significant effect on the driving safety and long-term durability of bridges. To achieve the damage detection and localization of bridge deck pavement, a three-stage detection method based on the you-only-look-once ... ...

Abstract	Bridge deck pavement damage has a significant effect on the driving safety and long-term durability of bridges. To achieve the damage detection and localization of bridge deck pavement, a three-stage detection method based on the you-only-look-once version 7 (YOLOv7) network and the revised LaneNet was proposed in this study. In stage 1, the Road Damage Dataset 202 (RDD2022) is preprocessed and adopted to train the YOLOv7 model, and five classes of damage were obtained. In stage 2, the LaneNet network was pruned to retain the semantic segmentation part, with the VGG16 network as an encoder to generate lane line binary images. In stage 3, the lane line binary images were post-processed by a proposed image processing algorithm to obtain the lane area. Based on the damage coordinates from stage 1, the final pavement damage classes and lane localization were obtained. The proposed method was compared and analyzed in the RDD2022 dataset, and was applied on the Fourth Nanjing Yangtze River Bridge in China. The results shows that the mean average precision (mAP) of YOLOv7 on the preprocessed RDD2022 dataset reaches 0.663, higher than that of other models in the YOLO series. The accuracy of the lane localization of the revised LaneNet is 0.933, higher than that of instance segmentation, 0.856. Meanwhile, the inference speed of the revised LaneNet is 12.3 frames per second (FPS) on NVIDIA GeForce RTX 3090, higher than that of instance segmentation 6.53 FPS. The proposed method can provide a reference for the maintenance of bridge deck pavement.
MeSH term(s)	Deep Learning ; Algorithms ; China ; Image Processing, Computer-Assisted ; Rivers
Language	English
Publishing date	2023-05-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s23115138
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Article ; Online: Two-dimensional lead halide perovskite lateral homojunctions enabled by phase pinning.

Hong, Huilong / Guo, Songhao / Jin, Leyang / Mao, Yuhong / Chen, Yuguang / Gu, Jiazhen / Chen, Shaochuang / Huang, Xu / Guan, Yan / Li, Xiaotong / Li, Yan / Lü, Xujie / Fu, Yongping

Nature communications

2024 Volume 15, Issue 1, Page(s) 3164

Abstract: Two-dimensional organic-inorganic hybrid halide perovskites possess diverse structural polymorphs with versatile physical properties, which can be controlled by order-disorder transition of the spacer cation, making them attractive for constructing ... ...

Abstract	Two-dimensional organic-inorganic hybrid halide perovskites possess diverse structural polymorphs with versatile physical properties, which can be controlled by order-disorder transition of the spacer cation, making them attractive for constructing semiconductor homojunctions. Here, we demonstrate a space-cation-dopant-induced phase stabilization approach to creating a lateral homojunction composed of ordered and disordered phases within a two-dimensional perovskite. By doping a small quantity of pentylammonium into (butylammonium)
Language	English
Publishing date	2024-04-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-024-47406-1
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Article ; Online: Genetically light-enhanced immunotherapy mediated by a fluorinated reduction-sensitive delivery system.

Su, Mengrui / Wang, Junkai / Zhao, Nana / Yu, Bingran / Wang, Yuguang / Xu, Fu-Jian

Biomaterials

2023 Volume 305, Page(s) 122433

Abstract: The lack of safe and efficient therapeutic agent delivery platforms restricts combined therapy's effect, and combined cancer therapy's multi-component delivery effect needs improvement. The novel gene delivery system SS-HPT-F/pMIP-3β-KR was proposed to ... ...

Abstract	The lack of safe and efficient therapeutic agent delivery platforms restricts combined therapy's effect, and combined cancer therapy's multi-component delivery effect needs improvement. The novel gene delivery system SS-HPT-F/pMIP-3β-KR was proposed to construct fluorine-containing degradable cationic polymers SS-HPT-F by a mild and simple amino-epoxy ring-opening reaction. By modifying the fluorinated alkyl chain, the delivery efficiency of the plasmid was greatly improved, and the cytoplasmic transport of biomolecules was completed. At the same time, a combination plasmid (MIP-3β-KillerRed) was innovatively designed for the independent expression of immune and photodynamic proteins. Which was efficiently transported to the tumor site by SS-HPT-F. The MIP-3β is expressed as an immune chemokine realize the immune mobilization behavior. The photosensitive protein KillerRed expressed in the tumor killed cancer cells under irradiation and released the exocrine immune factor MIP-3β. The immunogenic cell death (ICD) produced by photodynamic therapy (PDT) also induced the immune response of the organism. The synergistic effect of PDT and MIP-3β mobilized the immune properties of the organism, providing light-enhanced immune combination therapy against malignant tumors. Therefore, in subcutaneous tumor-bearing and metastatic animal models, the carrier tumor growth and mobilize organism produce an immune response without systemic toxicity. This work reports the first efficient gene delivery system that achieves light-enhanced immunotherapy.
MeSH term(s)	Animals ; Photochemotherapy ; Chemokine CCL19 ; Cell Line, Tumor ; Immunotherapy ; Combined Modality Therapy ; Photosensitizing Agents/pharmacology
Chemical Substances	Chemokine CCL19 ; Photosensitizing Agents
Language	English
Publishing date	2023-12-21
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	603079-8
ISSN	1878-5905 ; 0142-9612
ISSN (online)	1878-5905
ISSN	0142-9612
DOI	10.1016/j.biomaterials.2023.122433
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Zs.B 2371: Show issues

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Article ; Online: Group Replacement-Rearrangement-Triggered Linear-Assembly Nonaqueous Precipitation Synthesis of Hydroxyapatite Fibers.

Feng, Guo / Zheng, Entao / Jiang, Feng / Hu, Zi / Fu, Huiqun / Li, Yuguang / Wu, Qian / Liu, Jianmin / Yang, Qing / Liang, Jian

ACS biomaterials science & engineering

2023 Volume 9, Issue 8, Page(s) 4597–4606

Abstract: A novel method for hydroxyapatite fiber preparation with highly large-scale production prospects is of paramount importance but remains particularly difficult. Here, group replacement-rearrangement-triggered linear-assembly nonaqueous precipitation ... ...

Abstract	A novel method for hydroxyapatite fiber preparation with highly large-scale production prospects is of paramount importance but remains particularly difficult. Here, group replacement-rearrangement-triggered linear-assembly nonaqueous precipitation synthesis has been proposed for hydroxyapatite fibers under mild conditions. Pure hydroxyapatite fibers can be fabricated taking disodium hydrogen phosphate, calcium acetate, and glycerol as the phosphorus source, calcium source, and solvent, respectively. Single hexagonal crystal structures of hydroxyapatite fibers growing along the
Language	English
Publishing date	2023-07-06
Publishing country	United States
Document type	Journal Article
ISSN	2373-9878
ISSN (online)	2373-9878
DOI	10.1021/acsbiomaterials.3c00286
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Therapeutic effects of mesenchymal stem cells and their derivatives in common skin inflammatory diseases: Atopic dermatitis and psoriasis.

Yang, Jie / Xiao, Minglu / Ma, Kui / Li, Hongyu / Ran, Mingzi / Yang, Shuxu / Yang, Yuguang / Fu, Xiaobing / Yang, Siming

Frontiers in immunology

2023 Volume 14, Page(s) 1092668

Abstract: Chronic skin inflammatory diseases including atopic dermatitis (AD) and psoriasis have been considered uncontrolled inflammatory responses, which have usually troubled patients around the world. Moreover, the recent method to treat AD and psoriasis has ... ...

Abstract	Chronic skin inflammatory diseases including atopic dermatitis (AD) and psoriasis have been considered uncontrolled inflammatory responses, which have usually troubled patients around the world. Moreover, the recent method to treat AD and psoriasis has been based on the inhibition, not regulation, of the abnormal inflammatory response, which can induce a number of side effects and drug resistance in long-term treatment. Mesenchymal stem/stromal cells (MSCs) and their derivatives have been widely used in immune diseases based on their regeneration, differentiation, and immunomodulation with few adverse effects, which makes MSCs a promising treatment for chronic skin inflammatory diseases. As a result, in this review, we aim to systematically discuss the therapeutic effects of various resources of MSCs, the application of preconditioning MSCs and engineering extracellular vesicles (EVs) in AD and psoriasis, and the clinical evaluation of the administration of MSCs and their derivatives, which can provide a comprehensive vision for the application of MSCs and their derivatives in future research and clinical treatment.
MeSH term(s)	Humans ; Dermatitis, Atopic/therapy ; Skin ; Psoriasis/therapy ; Skin Diseases ; Mesenchymal Stem Cells
Language	English
Publishing date	2023-02-20
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1092668
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Thermophoretic glycan profiling of extracellular vesicles for triple-negative breast cancer management.

Li, Yike / Zhang, Shaohua / Liu, Chao / Deng, Jinqi / Tian, Fei / Feng, Qiang / Qin, Lili / Bai, Lixiao / Fu, Ting / Zhang, Liqin / Wang, Yuguang / Sun, Jiashu

Nature communications

2024 Volume 15, Issue 1, Page(s) 2292

Abstract: Triple-negative breast cancer (TNBC) is a highly metastatic and heterogeneous type of breast cancer with poor outcomes. Precise, non-invasive methods for diagnosis, monitoring and prognosis of TNBC are particularly challenging due to a paucity of TNBC ... ...

Abstract	Triple-negative breast cancer (TNBC) is a highly metastatic and heterogeneous type of breast cancer with poor outcomes. Precise, non-invasive methods for diagnosis, monitoring and prognosis of TNBC are particularly challenging due to a paucity of TNBC biomarkers. Glycans on extracellular vesicles (EVs) hold the promise as valuable biomarkers, but conventional methods for glycan analysis are not feasible in clinical practice. Here, we report that a lectin-based thermophoretic assay (EVLET) streamlines vibrating membrane filtration (VMF) and thermophoretic amplification, allowing for rapid, sensitive, selective and cost-effective EV glycan profiling in TNBC plasma. A pilot cohort study shows that the EV glycan signature reaches 91% accuracy for TNBC detection and 96% accuracy for longitudinal monitoring of TNBC therapeutic response. Moreover, we demonstrate the potential of EV glycan signature for predicting TNBC progression. Our EVLET system lays the foundation for non-invasive cancer management by EV glycans.
MeSH term(s)	Humans ; Triple Negative Breast Neoplasms/therapy ; Triple Negative Breast Neoplasms/drug therapy ; Biomarkers, Tumor ; Pilot Projects ; Extracellular Vesicles/pathology ; Polysaccharides
Chemical Substances	Biomarkers, Tumor ; Polysaccharides
Language	English
Publishing date	2024-03-14
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-024-46557-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Transplantation of Umbilical Cord-Derived Mesenchymal Stem Cells Attenuates Surgical Wound-Induced Blood-Brain Barrier Dysfunction in Mice.

Yang, Jie / Li, Hongyu / Ran, Mingzi / Yang, Shuxu / Ma, Kui / Zhang, Cuiping / Xiao, Minglu / Yang, Yuguang / Fu, Xiaobing / Yang, Siming

Stem cells international

2023 Volume 2023, Page(s) 8667045

Abstract: Blood-brain barrier (BBB) is the most important component of central nervous system (CNS) to keep toxins and pathogens from CNS. Although our studies demonstrated that using interleukin-6 antibodies (IL-6-AB) reversed the increased permeability of BBB, ... ...

Abstract	Blood-brain barrier (BBB) is the most important component of central nervous system (CNS) to keep toxins and pathogens from CNS. Although our studies demonstrated that using interleukin-6 antibodies (IL-6-AB) reversed the increased permeability of BBB, IL-6-AB is limited in their application that only could be used a few hours before surgery and seemed delayed the surgical wounds healing process, which urges us to find another more effective method. In this study, we employed the C57BL/6J female mice to investigate the potential effects of umbilical cord-derived mesenchymal stem cells (UC-MSCs) transplantation on BBB dysfunction induced by surgical wound. Compared to IL-6-AB, the transplantation of UC-MSCs more effectively decreased the BBB permeability after surgical wound evaluated by dextran tracer (immunofluorescence imaging and luorescence quantification). In addition, UC-MSCs can largely decrease the ratio of proinflammatory cytokine IL-6 to the anti-inflammatory cytokine IL-10 in both serum and brain tissue after surgical wound. Moreover, UC-MSCs successfully increased the levels of tight junction proteins (TJs) in BBB such as ZO-1, Occludin, and Claudin-5 and extremely decreased the level of matrix metalloproteinase-9 (MMP-9). Interestingly, UC-MSCs treatment also had positive effects on wound healing while protecting the BBB dysfunction induced by surgical wound compared to IL-6-AB treatment. These findings suggest that UC-MSCs transplantation is a highly efficient and promising approach on protecting the integrity of BBB which caused by peripheral traumatic injuries.
Language	English
Publishing date	2023-02-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	2573856-2
ISSN	1687-9678 ; 1687-966X
ISSN (online)	1687-9678
ISSN	1687-966X
DOI	10.1155/2023/8667045
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