Article ; Online: Lin
2023 Volume 56, Issue 11, Page(s) e13490
Abstract: ... myeloid repopulating activity are specifically enriched in a Lin ...
Abstract | Despite extensive characterization of the state and function of haematopoietic stem cells (HSCs), the use of transcription factors to define the HSC population is still limited. We show here that the HSC population in mouse bone marrow can be defined by the distinct expression levels of Spi1 and Gata1. By using a double fluorescence knock-in mouse model, PGdKI, in which the expression levels of PU.1 and GATA-1 are indicated by the expression of GFP and mCherry, respectively, we uncover that the HSCs with lymphoid and myeloid repopulating activity are specifically enriched in a Lin |
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MeSH term(s) | Mice ; Animals ; Cell Lineage ; Hematopoietic Stem Cells/metabolism ; Receptor Protein-Tyrosine Kinases ; Proto-Oncogene Proteins c-kit/metabolism ; Bone Marrow Cells/metabolism ; Mice, Inbred C57BL |
Chemical Substances | Receptor Protein-Tyrosine Kinases (EC 2.7.10.1) ; Proto-Oncogene Proteins c-kit (EC 2.7.10.1) |
Language | English |
Publishing date | 2023-05-05 |
Publishing country | England |
Document type | Journal Article |
ZDB-ID | 1064202-x |
ISSN | 1365-2184 ; 0008-8730 ; 0960-7722 |
ISSN (online) | 1365-2184 |
ISSN | 0008-8730 ; 0960-7722 |
DOI | 10.1111/cpr.13490 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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