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  1. Article: Vaccine Development: Steps to Approval of an Investigational Vaccine.

    Walter, Emmanuel B / Moody, M Anthony

    North Carolina medical journal

    2021  Volume 82, Issue 2, Page(s) 141–144

    MeSH term(s) Drug Approval ; Humans ; Vaccination ; Vaccines
    Chemical Substances Vaccines
    Language English
    Publishing date 2021-03-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 422795-5
    ISSN 0029-2559
    ISSN 0029-2559
    DOI 10.18043/ncm.82.2.141
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Strength through Organization: Classifying Antibody Activity against EBOV.

    Moody, M Anthony

    Cell host & microbe

    2018  Volume 24, Issue 2, Page(s) 185–186

    Abstract: In this issue of Cell Host & Microbe and in a related Cell paper, works by Gunn et al. (2018) and Saphire et al. (2018) describe a large number of monoclonal antibodies against Ebola virus (EBOV) and correlate their activity with in vivo protection. ...

    Abstract In this issue of Cell Host & Microbe and in a related Cell paper, works by Gunn et al. (2018) and Saphire et al. (2018) describe a large number of monoclonal antibodies against Ebola virus (EBOV) and correlate their activity with in vivo protection.
    MeSH term(s) Antibodies, Monoclonal/immunology ; Antibodies, Viral/immunology ; Ebolavirus/immunology ; Hemorrhagic Fever, Ebola/immunology ; Humans
    Chemical Substances Antibodies, Monoclonal ; Antibodies, Viral
    Language English
    Publishing date 2018-08-09
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2278004-X
    ISSN 1934-6069 ; 1931-3128
    ISSN (online) 1934-6069
    ISSN 1931-3128
    DOI 10.1016/j.chom.2018.07.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Anti-N-methyl-D-aspartate receptor-associated encephalitis: A review of clinicopathologic hallmarks and multimodal imaging manifestations.

    Beutler, Bryce David / Moody, Alastair E / Thomas, Jerry Mathew / Sugar, Benjamin Phillip / Ulanja, Mark B / Antwi-Amoabeng, Daniel / Tsikitas, Lucas Anthony

    World journal of radiology

    2024  Volume 16, Issue 1, Page(s) 1–8

    Abstract: Anti-N-methyl-D-aspartate receptor-associated encephalitis (NMDARE) is a rare immune-mediated neuroinflammatory condition characterized by the rapid onset of neuropsychiatric symptoms and autonomic dysfunction. The mechanism of pathogenesis remains ... ...

    Abstract Anti-N-methyl-D-aspartate receptor-associated encephalitis (NMDARE) is a rare immune-mediated neuroinflammatory condition characterized by the rapid onset of neuropsychiatric symptoms and autonomic dysfunction. The mechanism of pathogenesis remains incompletely understood, but is thought to be related to antibodies targeting the GluN1 subunit of the NMDA receptor with resultant downstream dysregulation of dopaminergic pathways. Young adults are most frequently affected; the median age at diagnosis is 21 years. There is a strong female predilection with a female sex predominance of 4:1. NMDARE often develops as a paraneoplastic process and is most commonly associated with ovarian teratoma. However, NMDARE has also been described in patients with small cell lung cancer, clear cell renal carcinoma, and other benign and malignant neoplasms. Diagnosis is based on correlation of the clinical presentation, electroencephalography, laboratory studies, and imaging. Computed tomography, positron emission tomography, and magnetic resonance imaging are essential to identify an underlying tumor, exclude clinicopathologic mimics, and predict the likelihood of long-term functional impairment. Nuclear imaging may be of value for prognostication and to assess the response to therapy. Treatment may involve high-dose corticosteroids, intravenous immunoglobulin, and plasma exchange. Herein, we review the hallmark clinicopathologic features and imaging findings of this rare but potentially devastating condition and summarize diagnostic criteria, treatment regimens, and proposed pathogenetic mechanisms.
    Language English
    Publishing date 2024-01-19
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2573705-3
    ISSN 1949-8470
    ISSN 1949-8470
    DOI 10.4329/wjr.v16.i1.1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Can ChatGPT/GPT-4 assist surgeons in confronting patients with Mpox and handling future epidemics?

    He, Yongbin / Wu, Haiyang / Chen, Yan / Wang, Dewei / Tang, Weiming / Moody, M Anthony / Ni, Guoxin / Gu, Shuqin

    International journal of surgery (London, England)

    2023  Volume 109, Issue 8, Page(s) 2544–2548

    MeSH term(s) Humans ; Mpox (monkeypox) ; Surgeons
    Language English
    Publishing date 2023-08-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2212038-5
    ISSN 1743-9159 ; 1743-9191
    ISSN (online) 1743-9159
    ISSN 1743-9191
    DOI 10.1097/JS9.0000000000000453
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Natural Compounds with Potential to Modulate Cancer Therapies and Self-Reactive Immune Cells.

    Moody, Rhiane / Wilson, Kirsty / Jaworowski, Anthony / Plebanski, Magdalena

    Cancers

    2020  Volume 12, Issue 3

    Abstract: Cancer-related deaths are approaching 10 million each year. Survival statistics for some cancers, such as ovarian cancer, have remained unchanged for decades, with women diagnosed at stage III or IV having over 80% chance of a lethal cancer recurrence ... ...

    Abstract Cancer-related deaths are approaching 10 million each year. Survival statistics for some cancers, such as ovarian cancer, have remained unchanged for decades, with women diagnosed at stage III or IV having over 80% chance of a lethal cancer recurrence after standard first-line treatment (reductive surgery and chemotherapy). New treatments and adjunct therapies are needed. In ovarian cancer, as in other cancers, the immune response, particularly cytotoxic (CD8
    Language English
    Publishing date 2020-03-13
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers12030673
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Modulation of HIV-1 immunity by adjuvants.

    Moody, M Anthony

    Current opinion in HIV and AIDS

    2014  Volume 9, Issue 3, Page(s) 242–249

    Abstract: Purpose of review: To summarize the role of adjuvants in eliciting desirable antibody responses against HIV-1 with particular emphasis on both historical context and recent developments.: Recent findings: Increased understanding of the role of ... ...

    Abstract Purpose of review: To summarize the role of adjuvants in eliciting desirable antibody responses against HIV-1 with particular emphasis on both historical context and recent developments.
    Recent findings: Increased understanding of the role of pattern recognition receptors such as Toll-like receptors in recruiting and directing the immune system has increased the variety of adjuvant formulations being tested in animal models and humans. Across all vaccine platforms, adjuvant formulations have been shown to enhance desirable immune responses such as higher antibody titers and increased functional activity. Although no vaccine formulation has yet succeeded in eliciting broad neutralizing antibodies against HIV-1, the ability of adjuvants to direct the immune response to immunogens suggests they will be critically important in any successful HIV-1 vaccine.
    Summary: The parallel development of adjuvants along with better HIV-1 immunogens will be needed for a successful AIDS vaccine. Additional comparative testing will be required to determine the optimal adjuvant and immunogen regimen that can elicit antibody responses capable of blocking HIV-1 transmission.
    MeSH term(s) AIDS Vaccines/immunology ; AIDS Vaccines/pharmacology ; Adjuvants, Immunologic/pharmacology ; Animals ; Antibodies, Neutralizing/immunology ; Disease Models, Animal ; HIV Antibodies/immunology ; HIV Infections/immunology ; HIV Infections/prevention & control ; HIV-1/immunology ; Humans
    Chemical Substances AIDS Vaccines ; Adjuvants, Immunologic ; Antibodies, Neutralizing ; HIV Antibodies
    Keywords covid19
    Language English
    Publishing date 2014-03-27
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2502511-9
    ISSN 1746-6318 ; 1746-630X
    ISSN (online) 1746-6318
    ISSN 1746-630X
    DOI 10.1097/COH.0000000000000052
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6812: Show issues Location:
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  7. Article ; Online: Innovations in HIV-1 Vaccine Design.

    Jones, Letitia D / Moody, M Anthony / Thompson, Amelia B

    Clinical therapeutics

    2020  Volume 42, Issue 3, Page(s) 499–514

    Abstract: Purpose: The field of HIV-1 vaccinology has evolved during the last 30 years from the first viral vector HIV gene insert constructs to vaccination regimens using a myriad of strategies. These strategies now include germline-targeting, lineage-based, and ...

    Abstract Purpose: The field of HIV-1 vaccinology has evolved during the last 30 years from the first viral vector HIV gene insert constructs to vaccination regimens using a myriad of strategies. These strategies now include germline-targeting, lineage-based, and structure-guided immunogen design. This narrative review outlines the historical context of HIV vaccinology and subsequently highlights the scientific discoveries during the last 6 years that promise to propel the field forward.
    Methods: We conducted a search of 2 electronic databases, PubMed and EMBASE, for experimental studies that involved new HIV immunogen designs between 2013 and 2019. During the title and abstract reviews, publications were excluded if they were written in language other than English and/or were a letter to the editor, a commentary, or a conference-only presentation. We then used ClinicalTrials.gov to identify completed and ongoing clinical trials using these strategies.
    Findings: The HIV vaccinology field has undergone periods of significant growth during the last 3 decades. Findings elucidated in preclinical studies have revealed the importance of the interaction between the cellular and humoral immune system. As a result, several new rationally designed vaccine strategies have been developed and explored in the last 6 years, including native-like envelope trimers, nanoparticle, and mRNA vaccine design strategies among others. Several of these strategies have shown enough promise in animal models to progress toward first-in-human Phase I clinical trials.
    Implications: Rapid developments in preclinical and early-phase clinical studies suggest that a tolerable and effective HIV vaccine may be on the horizon.
    MeSH term(s) AIDS Vaccines ; Animals ; Clinical Trials as Topic ; HIV Infections/immunology ; HIV Infections/prevention & control ; HIV Infections/virology ; Humans
    Chemical Substances AIDS Vaccines
    Keywords covid19
    Language English
    Publishing date 2020-02-05
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 603113-4
    ISSN 1879-114X ; 0149-2918
    ISSN (online) 1879-114X
    ISSN 0149-2918
    DOI 10.1016/j.clinthera.2020.01.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1435: Show issues Location:
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  8. Article ; Online: Immunologic characteristics of HIV-infected individuals who make broadly neutralizing antibodies.

    Borrow, Persephone / Moody, M Anthony

    Immunological reviews

    2017  Volume 275, Issue 1, Page(s) 62–78

    Abstract: Induction of broadly neutralizing antibodies (bnAbs) capable of inhibiting infection with diverse variants of human immunodeficiency virus type 1 (HIV-1) is a key, as-yet-unachieved goal of prophylactic HIV-1 vaccine strategies. However, some HIV- ... ...

    Abstract Induction of broadly neutralizing antibodies (bnAbs) capable of inhibiting infection with diverse variants of human immunodeficiency virus type 1 (HIV-1) is a key, as-yet-unachieved goal of prophylactic HIV-1 vaccine strategies. However, some HIV-infected individuals develop bnAbs after approximately 2-4 years of infection, enabling analysis of features of these antibodies and the immunological environment that enables their induction. Distinct subsets of CD4
    MeSH term(s) AIDS Vaccines/immunology ; Animals ; Antibodies, Neutralizing/metabolism ; B-Lymphocytes/immunology ; B-Lymphocytes/virology ; Germinal Center/immunology ; HIV Antibodies/metabolism ; HIV Infections/immunology ; HIV-1/immunology ; Humans ; Immunity, Humoral ; Immunologic Memory ; T-Lymphocyte Subsets/immunology ; T-Lymphocyte Subsets/virology
    Chemical Substances AIDS Vaccines ; Antibodies, Neutralizing ; HIV Antibodies
    Language English
    Publishing date 2017-01-30
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 391796-4
    ISSN 1600-065X ; 0105-2896
    ISSN (online) 1600-065X
    ISSN 0105-2896
    DOI 10.1111/imr.12504
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Influenza and Antibody-Dependent Cellular Cytotoxicity.

    Von Holle, Tarra A / Moody, M Anthony

    Frontiers in immunology

    2019  Volume 10, Page(s) 1457

    Abstract: Despite the availability of yearly vaccinations, influenza continues to cause seasonal, and pandemic rises in illness and death. An error prone replication mechanism results in antigenic drift and viral escape from immune pressure, and recombination ... ...

    Abstract Despite the availability of yearly vaccinations, influenza continues to cause seasonal, and pandemic rises in illness and death. An error prone replication mechanism results in antigenic drift and viral escape from immune pressure, and recombination results in antigenic shift that can rapidly move through populations that lack immunity to newly emergent strains. The development of a "universal" vaccine is a high priority and many strategies have been proposed, but our current understanding of influenza immunity is incomplete making the development of better influenza vaccines challenging. Influenza immunity has traditionally been measured by neutralization of virions and hemagglutination inhibition, but in recent years there has been a growing appreciation of other responses that can contribute to protection such as antibody-dependent cellular cytotoxicity (ADCC) that can kill influenza-infected cells. ADCC has been shown to provide cross-strain protection and to assist in viral clearance, making it an attractive target for "universal" vaccine designs. Here we provide a brief overview of the current state of influenza research that leverages "the other end of the antibody."
    MeSH term(s) Animals ; Antibodies, Viral/immunology ; Antibody-Dependent Cell Cytotoxicity/immunology ; Cross Protection/immunology ; Humans ; Influenza A virus/drug effects ; Influenza A virus/immunology ; Influenza A virus/physiology ; Influenza Vaccines/administration & dosage ; Influenza Vaccines/immunology ; Influenza, Human/immunology ; Influenza, Human/prevention & control ; Influenza, Human/virology ; Orthomyxoviridae Infections/immunology ; Orthomyxoviridae Infections/prevention & control ; Orthomyxoviridae Infections/virology ; Vaccination/methods
    Chemical Substances Antibodies, Viral ; Influenza Vaccines
    Language English
    Publishing date 2019-06-25
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2019.01457
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Reply to Diekema et al. "Are contact precautions "essential" for the prevention of healthcare-associated methicillin-resistant Staphylococcus aureus?"

    Popovich, Kyle J / Aureden, Kathy / Ham, D Cal / Harris, Anthony D / Hessels, Amanda J / Huang, Susan S / Maragakis, Lisa L / Milstone, Aaron M / Moody, Julia / Yokoe, Deborah / Calfee, David P

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2023  

    Language English
    Publishing date 2023-12-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciad777
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