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Article ; Online: Correction: Zheng et al. Geniposide Ameliorated Dexamethasone-Induced Cholesterol Accumulation in Osteoblasts by Mediating the GLP-1R/ABCA1 Axis.

Zheng, Yizhou / Xiao, Yaosheng / Zhang, Di / Zhang, Shanshan / Ouyang, Jing / Li, Linfu / Shi, Weimei / Zhang, Rui / Liu, Hai / Jin, Qi / Chen, Zhixi / Xu, Daohua / Wu, Longhuo

Cells

2022 Volume 11, Issue 23

Abstract: The authors wish to make the following changes to their paper [ ... ]. ...

Abstract	The authors wish to make the following changes to their paper [...].
Language	English
Publishing date	2022-11-30
Publishing country	Switzerland
Document type	Published Erratum
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells11233838
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Qian-Zheng-San

Wang, Zhi-Yong / Qin, Li-Hua / Zhang, Wei-Guang / Zhang, Pei-Xun / Jiang, Bao-Guo

Neural regeneration research

2019 Volume 14, Issue 4, Page(s) 683–691

Abstract: Qian-Zheng-San, a traditional Chinese prescription consisting of Typhonii Rhizoma, Bombyx ... However, it is unclear whether Qian-Zheng-San has therapeutic value for peripheral nerve injury ... Zheng-San (1.75 g/mL) daily as systemic therapy for 1, 2, 4, or 8 weeks. Rats in the control group were ...

Abstract	Qian-Zheng-San, a traditional Chinese prescription consisting of Typhonii Rhizoma, Bombyx Batryticatus, Scorpio, has been found to play an active therapeutic role in central nervous system diseases. However, it is unclear whether Qian-Zheng-San has therapeutic value for peripheral nerve injury. Therefore, we used Sprague-Dawley rats to investigate this. A sciatic nerve crush injury model was induced by clamping the right sciatic nerve. Subsequently, rats in the treatment group were administered 2 mL Qian-Zheng-San (1.75 g/mL) daily as systemic therapy for 1, 2, 4, or 8 weeks. Rats in the control group were not administered Qian-Zheng-San. Rats in sham group did not undergo surgery and systemic therapy. Footprint analysis was used to assess nerve motor function. Electrophysiological experiments were used to detect nerve conduction function. Immunofluorescence staining was used to assess axon counts and morphological analysis. Immunohistochemical staining was used to observe myelin regeneration of the sciatic nerve and the number of motoneurons in the anterior horn of the spinal cord. At 2 and 4 weeks postoperatively, the sciatic nerve function index, nerve conduction velocity, the number of distant regenerated axons and the axon diameter of the sciatic nerve increased in the Qian-Zheng-San treatment group compared with the control group. At 2 weeks postoperatively, nerve fiber diameter, myelin thickness, and the number of motor neurons in the lumbar spinal cord anterior horn increased in the Qian-Zheng-San treatment group compared with the control group. These results indicate that Qian-Zheng-San has a positive effect on peripheral nerve regeneration.
Language	English
Publishing date	2019-01-15
Publishing country	India
Document type	Journal Article
ZDB-ID	2388460-5
ISSN	1876-7958 ; 1673-5374
ISSN (online)	1876-7958
ISSN	1673-5374
DOI	10.4103/1673-5374.247472
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Article ; Online: K. ZHENG ET AL.Gold-nanoparticle-based multistage drug delivery system for antitumor therapy.

Zheng, Kaikai / Zhou, Dong / Wu, Lili / Li, Jian / Zhao, Bing / Zhang, Shihao / He, Ruiying / Xiao, Lan / Zoya, Iqbal / Yu, Li / Zhang, Yuhong / Li, Yulin / Gao, Jie / Li, Kaichun

Drug delivery

2022 Volume 29, Issue 1, Page(s) 3186–3196

Abstract: Nanoparticles can promote the accumulation of drugs in tumors. However, they find limited clinical applications because they cannot easily penetrate the stroma of cancer tissues, and it is difficult to control drug release. We developed a multiresponse ... ...

Abstract	Nanoparticles can promote the accumulation of drugs in tumors. However, they find limited clinical applications because they cannot easily penetrate the stroma of cancer tissues, and it is difficult to control drug release. We developed a multiresponse multistage drug-delivery nanogel with improved tumor permeability and responsiveness to the tumor microenvironment for the controlled delivery of anticancer agents. For this purpose, ∼100 nm multistage drug delivery nanogels with pH, redox, near-infrared stimulation, and enzyme responsiveness were grown in situ using 20 nm gold nanoparticles (AuNPs) via an emulsion-aiding crosslinking technique with cysteine crosslinker. An alginate cysteine AuNP (ACA) nanocarrier can efficiently load the cationic drug doxorubicin (DOX) to produce a multistage drug delivery nanocarrier (DOX@ACA). DOX@ACA can maintain the slow release of DOX and reduce its toxicity. In cancer tissues, the high pH and reductase microenvironment combined with the in vitro delivery of alginate and near-infrared light drove drug release. The developed nanoparticles effectively inhibited cancer cells, and in vivo evaluations showed that they effectively enhanced antitumor activity while having negligible in vivo toxicity to major organs.
MeSH term(s)	Alginates ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Cysteine ; Doxorubicin ; Drug Carriers ; Drug Delivery Systems ; Drug Liberation ; Emulsions ; Gold ; Hydrogen-Ion Concentration ; Metal Nanoparticles ; Nanogels ; Nanoparticle Drug Delivery System ; Nanoparticles ; Oxidoreductases
Chemical Substances	Alginates ; Antineoplastic Agents ; Drug Carriers ; Emulsions ; Nanogels ; Nanoparticle Drug Delivery System ; Gold (7440-57-5) ; Doxorubicin (80168379AG) ; Oxidoreductases (EC 1.-) ; Cysteine (K848JZ4886)
Language	English
Publishing date	2022-10-19
Publishing country	England
Document type	Journal Article
ZDB-ID	1213261-5
ISSN	1521-0464 ; 1071-7544
ISSN (online)	1521-0464
ISSN	1071-7544
DOI	10.1080/10717544.2022.2128469
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Zs.A 4252: Show issues

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Article ; Online: Correction: Zheng, L., et al. PBN11-8, a Cytotoxic Polypeptide Purified from Marine

Zheng, Lanhong / Zhu, Xiangjie / Yang, Kangli / Zhu, Meihong / Farooqi, Ammad Ahmad / Kang, Daole / Sun, Mi / Xu, Yixin / Lin, Xiukun / Feng, Yingang / Liang, Fangfang / Zhang, Fuming / Linhardt, Robert J

Polymers

2021 Volume 13, Issue 1

Abstract: The authors wish to make a change to the published paper [ ... ]. ...

Abstract	The authors wish to make a change to the published paper [...].
Language	English
Publishing date	2021-01-05
Publishing country	Switzerland
Document type	Published Erratum
ZDB-ID	2527146-5
ISSN	2073-4360 ; 2073-4360
ISSN (online)	2073-4360
ISSN	2073-4360
DOI	10.3390/polym13010166
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Article ; Online: A morphological study of the ovipositor of the genus Capillogryllus Xie, Zheng & Liang, 2003 with a new species of the genus from China (Orthoptera: Gryllidae; Gryllinae).

Wu, Qian / Zhang, Tao / Ma, Li-Bin

Zootaxa

2023 Volume 5383, Issue 3, Page(s) 391–397

Abstract: The genus Capillogryllus includes three species, Capillogryllus dolabripalpis Xie & Zheng, 2003 ... Capillogryllus exilipalpis Xie & Zheng, 2003, Capillogryllus spinae Wu & Ma, 2023. Recently, we found ...

Abstract	The genus Capillogryllus includes three species, Capillogryllus dolabripalpis Xie & Zheng, 2003, Capillogryllus exilipalpis Xie & Zheng, 2003, Capillogryllus spinae Wu & Ma, 2023. Recently, we found a new species of this genus in Yadong County, Xizang Autonomous Region, and described it here. In addition, we found that the ovipositor varies greatly within this taxon, so we compare and characterize their ovipositor and discuss the feasibility of using the ovipositor alone to identify them. We also provide two keys based on the genitalia of males and females.
MeSH term(s)	Male ; Female ; Animals ; Gryllidae ; Orthoptera ; Animal Distribution ; Organ Size ; Animal Structures ; Body Size ; China
Language	English
Publishing date	2023-12-12
Publishing country	New Zealand
Document type	Journal Article
ISSN	1175-5334
ISSN (online)	1175-5334
DOI	10.11646/zootaxa.5383.3.8
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Article: Bu-Yin-Qian-Zheng Formula Ameliorates MPP

Ma, Hao-Jie / Gai, Cong / Chai, Yuan / Feng, Wan-Di / Cheng, Cui-Cui / Zhang, Jin-Kun / Zhang, Yu-Xin / Yang, Lu-Ping / Guo, Zhen-Yu / Gao, Yu-Shan / Sun, Hong-Mei

Frontiers in pharmacology

2020 Volume 11, Page(s) 577017

Abstract: As a typical traditional Chinese medicine, Bu-Yin-Qian-Zheng Formula (BYQZF) has been shown to have ...

Abstract	As a typical traditional Chinese medicine, Bu-Yin-Qian-Zheng Formula (BYQZF) has been shown to have neuroprotective effects in patients with Parkinson's disease (PD), particularly by ameliorating mitochondrial dysfunction and regulating expression of the parkin protein. However, the underlying mechanisms by which BYQZF affects mitochondrial function through parkin are unclear. Accordingly, in this study, we evaluated the mechanisms by which BYQZF ameliorates mitochondrial dysfunction through parkin in PD. We constructed a parkin-knockdown cell model and performed fluorescence microscopy to observe transfected SH-SY5Y cells. Quantitative real-time reverse transcription polymerase chain reaction and western blotting were conducted to detect the mRNA and protein expression levels of parkin. Additionally, we evaluated the cell survival rates, ATP levels, mitochondrial membrane potential (ΔΨm), mitochondrial morphology, parkin protein expression, PINK1 protein expression, and mitochondrial fusion and fission protein expression after treatment with MPP
Language	English
Publishing date	2020-12-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2020.577017
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Article: ZHENG-Omics Application in ZHENG Classification and Treatment: Chinese Personalized Medicine.

Dai, Jianye / Fang, Junwei / Sun, Shujun / Chen, Qiwen / Cao, Huijuan / Zheng, Ningning / Zhang, Yongyu / Lu, Aiping

Evidence-based complementary and alternative medicine : eCAM

2013 Volume 2013, Page(s) 235969

Abstract: ... treatment based on ZHENG (TCM syndrome) classification, which could be identified clinical special ... controversy because ZHENG classification only depends on observation, knowledge, and clinical experience ... microconcept of ZHENG-omics, with the prospect of bright future in providing an objective and repeatable ...

Abstract	With the hope to provide an effective approach for personalized diagnosis and treatment clinically, traditional chinese medicine (TCM) is being paid increasing attention as a complementary and alternative medicine. It performs treatment based on ZHENG (TCM syndrome) classification, which could be identified clinical special phenotypes by symptoms and signs of patients even if they have a different disease. However, it caused controversy because ZHENG classification only depends on observation, knowledge, and clinical experience of TCM practitioners, which lacks objectivity and repeatability. Although researchers and scientists of TCM have done some work with a lot of beneficial methods, the results could not reach satisfactory with the shortcomings of generalizing the entire state of the body or ignoring the patients' feelings. By total summary, mining, and integration of existing researches, the present paper attempts to introduce a novel macro-microconcept of ZHENG-omics, with the prospect of bright future in providing an objective and repeatable approach for Chinese personalized medicine in an effective way. In this paper, we give the brief introduction and preliminary validation, and discuss strategies and system-oriented technologies for achieving this goal.
Language	English
Publishing date	2013-04-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2013/235969
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Zs.A 5995: Show issues

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ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Fu-Zheng-Xuan-Fei formula promotes macrophage polarization and Th17/Treg cell homeostasis against the influenza B virus (Victoria strain) infection.

Xiao, Yan / Zhang, Jinxin / Zhu, Xiangyu / Zhao, Wenxin / Li, Yiquan / Jin, Ningyi / Lu, Huijun / Han, Jicheng

Journal of ethnopharmacology

2023 Volume 312, Page(s) 116485

Abstract: Ethnopharmacological relevance: Fu-Zheng-Xuan-Fei formula (FF) is a prescription that has been ...

Abstract	Ethnopharmacological relevance: Fu-Zheng-Xuan-Fei formula (FF) is a prescription that has been clinically used through the basic theory of traditional Chinese medicine (TCM) for treating viral pneumonia. Although FF possesses a prominent clinical therapeutic effect, seldom pharmacological studies have been reported on its anti-influenza B virus (IBV) activity. Aim of the study: Influenza is an acute infectious respiratory disease caused by the influenza virus, which has high annual morbidity and mortality worldwide. With a global decline in the COVID-19 control, the infection rate of influenza virus is gradually increasing. Therefore, it is of great importance to develop novel drugs for the effective treatment of influenza virus. Apart from conventional antiviral drugs, TCM has been widely used in the clinical treatment of influenza in China. Therefore, studying the antiviral mechanism of TCM can facilitate the scientific development of TCM. Materials and methods: Madin-Darby canine kidney cells (MDCK) and BALB/c mice were infected with IBV, and FF was added to evaluate the anti-IBV effects of FF both in vitro and in vivo by Western blotting, immunofluorescence, flow cytometry, and pathological assessment. Results: It was found that FF exhibited anti-viral activity against IBV infection both in vivo and in vitro, while inducing macrophage activation and promoting M1 macrophage polarization. In addition, FF effectively regulated the signal transducer and activator of transcription (STAT) signaling pathway-mediated Th17/Treg balance to improve the lung tissue damage caused by IBV infection-induced inflammation. The findings provided the scientific basis for the antiviral mechanism of FF against IBV infection. Conclusions: This study shows that FF is a potentially effective antiviral drug against IBV infection.
MeSH term(s)	Mice ; Animals ; Dogs ; Humans ; Influenza B virus ; T-Lymphocytes, Regulatory ; Herpesvirus 1, Cercopithecine ; Macrophage Activation ; COVID-19 ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Influenza, Human/drug therapy ; Orthomyxoviridae Infections ; Madin Darby Canine Kidney Cells
Chemical Substances	Antiviral Agents
Language	English
Publishing date	2023-04-10
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2023.116485
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Zs.A 1494: Show issues

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Article ; Online: Applying latent tree analysis to classify Traditional Chinese Medicine syndromes (Zheng) in patients with psoriasis vulgari.

Xu, Wen-Jie / Zhang, Nevin-L / Li, Ping / Wang, Tian-Fang / Chen, Wei-Wen / Liu, April-H / Mohler-Kuo, Meichun

Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan

2022 Volume 42, Issue 1, Page(s) 132–139

Abstract: ... must stratify patients into subtypes (known as TCM syndromes or Zheng) and apply appropriate TCM treatments ... to different subtypes. However, no unified symptom-based classification scheme of subtypes (Zheng) exists ... of the analysis divided patients into three subtype groups with clear TCM Zheng connotations: 'blood deficiency ...

Abstract	Objective: To treat patients with psoriasis vulgaris using Traditional Chinese Medicine (TCM), one must stratify patients into subtypes (known as TCM syndromes or Zheng) and apply appropriate TCM treatments to different subtypes. However, no unified symptom-based classification scheme of subtypes (Zheng) exists for psoriasis vulgaris. The present paper aims to classify patients with psoriasis vulgaris into different subtypes via the analysis of clinical TCM symptom and sign data. Methods: A cross-sectional survey was carried out in Beijing from 2005-2008, collecting clinical TCM symptom and sign data from 2764 patients with psoriasis vulgaris. Roughly 108 symptoms and signs were initially analyzed using latent tree analysis, with a selection of the resulting latent variables then used as features to cluster patients into subtypes. Results: The initial latent tree analysis yielded a model with 43 latent variables. The second phase of the analysis divided patients into three subtype groups with clear TCM Zheng connotations: 'blood deficiency and wind dryness'; 'blood heat'; and 'blood stasis'. Conclusions: Via two-phase analysis of clinic symptom and sign data, three different Zheng subtypes were identified for psoriasis vulgaris. Statistical characteristics of the three subtypes are presented. This constitutes an evidence-based solution to the syndromedifferentiation problem that exists with psoriasis vulgaris.
MeSH term(s)	Cross-Sectional Studies ; Hot Temperature ; Humans ; Medicine, Chinese Traditional/methods ; Psoriasis/diagnosis ; Psoriasis/therapy ; Syndrome
Language	English
Publishing date	2022-03-19
Publishing country	China
Document type	Journal Article
ZDB-ID	603186-9
ISSN	2589-451X ; 0254-6272 ; 0255-2922
ISSN (online)	2589-451X ; 0254-6272
ISSN	0255-2922
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Zs.B 2564: Show issues

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Article ; Online: Evidence-Based Dampness-Heat ZHENG (Syndrome) in Cancer: Current Progress toward Establishing Relevant Animal Model with Pancreatic Tumor.

Jiao, Ju-Ying / Cheng, Chien-Shan / Cao, Zhang-Qi / Chen, Lian-Yu / Chen, Zhen

Chinese journal of integrative medicine

2022 Volume 30, Issue 1, Page(s) 85–95

Abstract: ... complementary and alternative medicine. It emphasizes symptoms and ZHENG (syndrome)-based treatment combined ... advantage encourages an exploration of the essence of dampness-heat ZHENG (DHZ) in cancer and investigation ... that can be used for the establishment of a future standardized ZHENG-based cancer animal model. ...

Abstract	Cancer is one of the deadliest diseases affecting the health of human beings. With limited therapeutic options available, complementary and alternative medicine has been widely adopted in cancer management and is increasingly becoming accepted by both patients and healthcare workers alike. Chinese medicine characterized by its unique diagnostic and treatment system is the most widely applied complementary and alternative medicine. It emphasizes symptoms and ZHENG (syndrome)-based treatment combined with contemporary disease diagnosis and further stratifies patients into individualized medicine subgroups. As a representative cancer with the highest degree of malignancy, pancreatic cancer is traditionally classified into the "amassment and accumulation". Emerging perspectives define the core pathogenesis of pancreatic cancer as "dampness-heat" and the respective treatment "clearing heat and resolving dampness" has been demonstrated to prolong survival in pancreatic cancer patients, as has been observed in many other cancers. This clinical advantage encourages an exploration of the essence of dampness-heat ZHENG (DHZ) in cancer and investigation into underlying mechanisms of action of herbal formulations against dampness-heat. However, at present, there is a lack of understanding of the molecular characteristics of DHZ in cancer and no standardized and widely accepted animal model to study this core syndrome in vivo. The shortage of animal models limits the ability to uncover the antitumor mechanisms of herbal medicines and to assess the safety profile of the natural products derived from them. This review summarizes the current research on DHZ in cancer in terms of the clinical aspects, molecular landscape, and animal models. This study aims to provide comprehensive insight that can be used for the establishment of a future standardized ZHENG-based cancer animal model.
MeSH term(s)	Animals ; Humans ; Medicine, Chinese Traditional ; Hot Temperature ; Pancreatic Neoplasms/therapy ; Models, Animal ; Syndrome
Language	English
Publishing date	2022-06-20
Publishing country	China
Document type	Journal Article ; Review
ZDB-ID	2171254-2
ISSN	1993-0402 ; 1672-0415
ISSN (online)	1993-0402
ISSN	1672-0415
DOI	10.1007/s11655-022-3675-8
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