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  1. Article ; Online: Extracorporeal Life Support in Respiratory Failure.

    Short, Briana / Burkart, Kristin M

    Clinics in chest medicine

    2022  Volume 43, Issue 3, Page(s) 519–528

    Abstract: Extracorporeal life support (ECLS) has a role in different types of respiratory failure including acute respiratory distress syndrome (ARDS), decompensated pulmonary hypertension, bridge to lung transplantation, and primary graft dysfunction after lung ... ...

    Abstract Extracorporeal life support (ECLS) has a role in different types of respiratory failure including acute respiratory distress syndrome (ARDS), decompensated pulmonary hypertension, bridge to lung transplantation, and primary graft dysfunction after lung transplantation. ECLS in ARDS allows for lung-protective ventilation with the goal to reduce the risk of ventilator-induced lung injury. ECLS use in severe ARDS should be considered when conventional management strategies are not sufficient to safely support gas exchange. More research is needed to identify optimal mechanical ventilation during ECLS, weaning ECLS support, strategies for mobilization, sedation and anticoagulation, and long-term outcomes post-ECLS.
    MeSH term(s) Anticoagulants ; Extracorporeal Membrane Oxygenation ; Humans ; Respiration, Artificial/adverse effects ; Respiratory Distress Syndrome/therapy ; Respiratory Insufficiency/etiology ; Respiratory Insufficiency/therapy
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2022-04-20
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 447455-7
    ISSN 1557-8216 ; 0272-5231
    ISSN (online) 1557-8216
    ISSN 0272-5231
    DOI 10.1016/j.ccm.2022.05.006
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  2. Article ; Online: Extracorporeal membrane oxygenation for coronavirus disease 2019-related acute respiratory distress syndrome.

    Short, Briana / Abrams, Darryl / Brodie, Daniel

    Current opinion in critical care

    2021  Volume 28, Issue 1, Page(s) 90–97

    Abstract: Purpose of review: To understand the potential role of extracorporeal membrane oxygenation (ECMO) in coronavirus disease 2019 (COVID-19)-related acute respiratory distress syndrome (ARDS), highlighting evolving practices and outcomes.: Recent findings! ...

    Abstract Purpose of review: To understand the potential role of extracorporeal membrane oxygenation (ECMO) in coronavirus disease 2019 (COVID-19)-related acute respiratory distress syndrome (ARDS), highlighting evolving practices and outcomes.
    Recent findings: The role for ECMO in COVID-19-related ARDS has evolved throughout the pandemic. Early reports of high mortality led to some to advocate for withholding ECMO in this setting. Subsequent data suggested mortality rates were on par with those from studies conducted prior to the pandemic. However, outcomes are evolving and mortality in these patients may be worsening with time.
    Summary: ECMO has an established role in the treatment of severe forms of ARDS. Current data suggest adherence to the currently accepted algorithm for management of ARDS, including the use of ECMO. However, planning related to resource utilization and strain on healthcare systems are necessary to determine the feasibility of ECMO in specific regions at any given time. Utilization of national and local networks, pooling of resources and ECMO mobilization units are important to optimize access to ECMO as appropriate. Reported complications of ECMO in the setting of COVID-19-related ARDS have been predominantly similar to those reported in studies of non-COVID-19-related ARDS. Further high-quality research is needed.
    MeSH term(s) COVID-19 ; Extracorporeal Membrane Oxygenation ; Humans ; Respiratory Distress Syndrome/therapy ; SARS-CoV-2
    Language English
    Publishing date 2021-10-26
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1235629-3
    ISSN 1531-7072 ; 1070-5295
    ISSN (online) 1531-7072
    ISSN 1070-5295
    DOI 10.1097/MCC.0000000000000901
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  3. Article ; Online: Preparing for Fellowship in Internal Medicine With a Focus on Pulmonary or Critical Care Medicine: Major Principles and New Realities.

    Miles, Matthew C / Lenz, Peter / McCallister, Jennifer / Burkart, Kristin M / Huebert, Candace / Moore, Jason / Hinkle, Laura / Short, Briana / Bagley, Brent / Bosslet, Gabriel

    Chest

    2024  

    Abstract: In this article, the authors provide guidance for applicants to any subspecialty in the medical specialties matching program, with a particular focus on those seeking a match into a pulmonary or critical care medicine training program, or both. The ... ...

    Abstract In this article, the authors provide guidance for applicants to any subspecialty in the medical specialties matching program, with a particular focus on those seeking a match into a pulmonary or critical care medicine training program, or both. The preparation, application, interview, ranking, and match steps are used to discuss available literature that informs this process. Preparing a fellowship application is discussed in terms of personal career goals, and specific strategies are suggested that can help a candidate to assess a program's fit with those goals. In addition to review of recent data on virtual interviewing and interview questioning, the authors provide practical recommendations for candidates seeking to maximize their success in the current interview environment. Finally, key points about generating a rank order list are summarized. This resource will prove useful to any candidate pursuing medical subspecialty training in the current era.
    Language English
    Publishing date 2024-03-06
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2024.02.051
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  4. Article ; Online: Approach to the Physiologically Challenging Endotracheal Intubation in the Intensive Care Unit.

    Hickey, Andrew J / Cummings, Matthew J / Short, Briana / Brodie, Daniel / Panzer, Oliver / Madahar, Purnema / O'Donnell, Max R

    Respiratory care

    2023  Volume 68, Issue 10, Page(s) 1438–1448

    Abstract: Endotracheal intubation for airway management is a common procedure in the ICU. Intubation may be difficult due to anatomic airway abnormalities but also due to physiologic derangements that predispose patients to cardiovascular collapse during the ... ...

    Abstract Endotracheal intubation for airway management is a common procedure in the ICU. Intubation may be difficult due to anatomic airway abnormalities but also due to physiologic derangements that predispose patients to cardiovascular collapse during the procedure. Results of studies demonstrate a high incidence of morbidity and mortality associated with airway management in the ICU. To reduce the likelihood of complications, medical teams must be well versed in the general principles of intubation and be prepared to manage physiologic derangements while securing the airway. In this review, we present relevant literature on the approach to endotracheal intubation in the ICU and provide pragmatic recommendations relevant to medical teams performing intubations in patients who are physiologically unstable.
    MeSH term(s) Humans ; Intubation, Intratracheal/methods ; Intensive Care Units ; Airway Management ; Incidence ; Shock
    Language English
    Publishing date 2023-05-23
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 603252-7
    ISSN 1943-3654 ; 0098-9142 ; 0020-1324
    ISSN (online) 1943-3654
    ISSN 0098-9142 ; 0020-1324
    DOI 10.4187/respcare.10821
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  5. Article: Management of Peritonsillar Abscess Within a Local Emergency Department: A Quality Analysis Study.

    Ortega, Briana K / Short, Spencer / Kane, Bryan G / Dedio, Robert

    Cureus

    2021  Volume 13, Issue 8, Page(s) e17545

    Abstract: Objective: Peritonsillar abscess (PTA) is the most common deep space infection of the head and neck, affecting thousands of people annually with high treatment costs. The purpose of this project was to determine how in-network emergency departments (EDs) ...

    Abstract Objective: Peritonsillar abscess (PTA) is the most common deep space infection of the head and neck, affecting thousands of people annually with high treatment costs. The purpose of this project was to determine how in-network emergency departments (EDs) adhere to generally accepted guidelines regarding diagnosis and management of potential PTAs.
    Methods: The authors performed a retrospective chart review to identify patients with PTA in five EDs in one year. Information pertaining to diagnostic tests, treatment, and airway status was also collected. Descriptive analysis was used to assess if EDs were consistent with generally accepted guidelines.
    Results: Six hundred twenty-one patient records were identified and 140 were included in final analysis. Out of 140 patients, 71 were admitted for inpatient management and 23 were admitted for observation. Of the 46 patients diagnosed and discharged from the ED, 61% received a computerized tomography (CT) scan and only 39% had PTA drainage performed. Four (3%) patients received a point of care ultrasound and a CT scan and no patient received only an ultrasound. Out of all patients, 116/140 received a CT scan and 22 received drainage in the ED. The remainder of these patients either had drainage performed by an otolaryngologist or had no drainage performed. Of the 94 patients admitted for inpatient or observation, 84 received a CT scan and six received drainage by an ED physician. Only 62% of patients were given a penicillin derivative and 29% were given clindamycin, which has no Gram-negative coverage.
    Conclusion: One-third of PTA patients were managed within the ED, far less than similar studies. Of these, over 50% received a CT scan and less than 50% had PTA drainage. PTA drainage can improve patients' symptoms and antibiotic effectiveness. The majority of patients were prescribed a penicillin derivative with or without another antibiotic.
    Language English
    Publishing date 2021-08-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.17545
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  6. Article ; Online: Implementation of lung protective ventilation order to improve adherence to low tidal volume ventilation: A RE-AIM evaluation.

    Short, Briana / Serra, Alexis / Tariq, Abdul / Moitra, Vivek / Brodie, Daniel / Patel, Sapana / Baldwin, Matthew R / Yip, Natalie H

    Journal of critical care

    2020  Volume 63, Page(s) 167–174

    Abstract: Purpose: Lung protective ventilation (LPV), defined as a tidal volume (Vt) ≤8 cc/kg of predicted body weight, reduces ventilator-induced lung injury but is applied inconsistently.: Materials and methods: We conducted a prospective, quasi-experimental, ...

    Abstract Purpose: Lung protective ventilation (LPV), defined as a tidal volume (Vt) ≤8 cc/kg of predicted body weight, reduces ventilator-induced lung injury but is applied inconsistently.
    Materials and methods: We conducted a prospective, quasi-experimental, cohort study of adults mechanically ventilated admitted to intensive care units (ICU) in the year before, year after, and second year after implementation of an electronic medical record based LPV order, and a cross-sectional qualitative study of ICU providers regarding their perceptions of the order. We applied the Reach, Efficacy, Adoption, Implementation, and Maintenance (RE-AIM) framework to evaluate the implementation.
    Results: There were 1405, 1424, and 1342 in the control, adoption, and maintenance cohorts, representing 95% of mechanically ventilated adult ICU patients. The overall prevalence of LPV increased from 65% to 73% (p < 0.001, adjusted-OR for LPV adherence: 1.9, 95% CI 1.5-2.3), but LPV adherence in women was approximately 30% worse than in men (women: 44% to 56% [p < 0.001],men: 79% to 86% [p < 0.001]). ICU providers noted difficulty obtaining an accurate height measurement and mistrust of the Vt calculation as barriers to implementation. LPV adherence increased further in the second year post implementation.
    Conclusion: We designed and implemented an LPV order that sustainably improved LPV adherence across diverse ICUs.
    MeSH term(s) Adult ; Cohort Studies ; Cross-Sectional Studies ; Female ; Humans ; Lung ; Male ; Prospective Studies ; Respiration, Artificial ; Retrospective Studies ; Tidal Volume
    Keywords covid19
    Language English
    Publishing date 2020-09-20
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 632818-0
    ISSN 1557-8615 ; 0883-9441
    ISSN (online) 1557-8615
    ISSN 0883-9441
    DOI 10.1016/j.jcrc.2020.09.013
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    Zs.A 2152: Show issues Location:
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  7. Article ; Online: Fibrotic-Like Pulmonary Radiographic Patterns Are Not Associated With Adverse Outcomes in COVID-19 Chronic Critical Illness.

    Madahar, Purnema / Capaccione, Kathleen M / Salvatore, Mary M / Short, Briana / Wahab, Romina / Abrams, Darryl / Parekh, Madhavi / Geleris, Joshua D / Furfaro, David / Anderson, Michaela R / Zucker, Jason / Brodie, Daniel / Cummings, Matthew J / O'Donnell, Max / McGroder, Claire F / Wei, Ying / Garcia, Christine K / Baldwin, Matthew R

    Critical care medicine

    2023  Volume 51, Issue 11, Page(s) e209–e220

    Abstract: Objectives: Pulmonary fibrosis is a feared complication of COVID-19. To characterize the risks and outcomes associated with fibrotic-like radiographic abnormalities in patients with COVID-19-related acute respiratory distress syndrome (ARDS) and chronic ...

    Abstract Objectives: Pulmonary fibrosis is a feared complication of COVID-19. To characterize the risks and outcomes associated with fibrotic-like radiographic abnormalities in patients with COVID-19-related acute respiratory distress syndrome (ARDS) and chronic critical illness.
    Design: Single-center prospective cohort study.
    Setting: We examined chest CT scans performed between ICU discharge and 30 days after hospital discharge using established methods to quantify nonfibrotic and fibrotic-like patterns.
    Patients: Adults hospitalized with COVID-19-related ARDS and chronic critical illness (> 21 d of mechanical ventilation, tracheostomy, and survival to ICU discharge) between March 2020 and May 2020.
    Interventions: None.
    Measurements and main results: We tested associations of fibrotic-like patterns with clinical characteristics and biomarkers, and with time to mechanical ventilator liberation and 6-month survival, controlling for demographics, comorbidities, and COVID-19 therapies. A total of 141 of 616 adults (23%) with COVID-19-related ARDS developed chronic critical illness, and 64 of 141 (46%) had a chest CT a median (interquartile range) 66 days (42-82 d) after intubation. Fifty-five percent had fibrotic-like patterns characterized by reticulations and/or traction bronchiectasis. In adjusted analyses, interleukin-6 level on the day of intubation was associated with fibrotic-like patterns (odds ratio, 4.40 per quartile change; 95% CI, 1.90-10.1 per quartile change). Other inflammatory biomarkers, Sequential Organ Failure Assessment score, age, tidal volume, driving pressure, and ventilator days were not. Fibrotic-like patterns were not associated with longer time to mechanical ventilator liberation or worse 6-month survival.
    Conclusions: Approximately half of adults with COVID-19-associated chronic critical illness have fibrotic-like patterns that are associated with higher interleukin-6 levels at intubation. Fibrotic-like patterns are not associated with longer time to liberation from mechanical ventilation or worse 6-month survival.
    MeSH term(s) Adult ; Humans ; COVID-19/diagnostic imaging ; COVID-19/complications ; Critical Illness/therapy ; Prospective Studies ; Interleukin-6 ; Respiratory Distress Syndrome/diagnostic imaging ; Respiratory Distress Syndrome/etiology ; Respiratory Distress Syndrome/therapy ; Respiration, Artificial/adverse effects ; Biomarkers
    Chemical Substances Interleukin-6 ; Biomarkers
    Language English
    Publishing date 2023-06-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0000000000005954
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  8. Article ; Online: Early Mobilization during Extracorporeal Membrane Oxygenation for Cardiopulmonary Failure in Adults: Factors Associated with Intensity of Treatment.

    Abrams, Darryl / Madahar, Purnema / Eckhardt, Christina M / Short, Briana / Yip, Natalie H / Parekh, Madhavi / Serra, Alexis / Dubois, Richard L / Saleem, Danial / Agerstrand, Cara / Scala, Peter / Benvenuto, Luke / Arcasoy, Selim M / Sonett, Joshua R / Takeda, Koji / Meier, Anne / Beck, James / Ryan, Patrick / Fan, Eddy /
    Hodgson, Carol L / Bacchetta, Matthew / Brodie, Daniel

    Annals of the American Thoracic Society

    2021  Volume 19, Issue 1, Page(s) 90–98

    Abstract: Rationale: ...

    Abstract Rationale:
    MeSH term(s) Adult ; Early Ambulation ; Extracorporeal Membrane Oxygenation ; Humans ; Intensive Care Units ; Lung Transplantation ; Retrospective Studies
    Language English
    Publishing date 2021-05-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2717461-X
    ISSN 2325-6621 ; 1943-5665 ; 2325-6621
    ISSN (online) 2325-6621 ; 1943-5665
    ISSN 2325-6621
    DOI 10.1513/AnnalsATS.202102-151OC
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  9. Article ; Online: Rapid implementation of a mobile prone team during the COVID-19 pandemic.

    Short, Briana / Parekh, Madhavi / Ryan, Patrick / Chiu, Maggie / Fine, Cynthia / Scala, Peter / Moses, Shirah / Jackson, Emily / Brodie, Daniel / Yip, Natalie H

    Journal of critical care

    2020  Volume 60, Page(s) 230–234

    Abstract: Purpose: The coronavirus disease 2019 (COVID-19) is associated with high rates of acute respiratory distress syndrome (ARDS). Prone positioning improves mortality in moderate-to-severe ARDS. Strategies to increase prone positioning under crisis ... ...

    Abstract Purpose: The coronavirus disease 2019 (COVID-19) is associated with high rates of acute respiratory distress syndrome (ARDS). Prone positioning improves mortality in moderate-to-severe ARDS. Strategies to increase prone positioning under crisis conditions are needed.
    Material and methods: We describe the development of a mobile prone team during the height of the crisis in New York City and describe characteristics and outcomes of mechanically ventilated patients who received prone positioning between April 2, 2020 and April 30, 2020.
    Results: Ninety patients underwent prone positioning for moderate-to-severe ARDS. Sixty-six patients (73.3%) were men, with a median age of 64 years (IQR 53-71), and the median PaO
    Conclusion: The rapid development of a mobile prone team safely provided prone positioning to a large number of COVID-19 patients with moderate-to-severe ARDS.
    MeSH term(s) Aged ; COVID-19/epidemiology ; COVID-19/mortality ; COVID-19/therapy ; Female ; Humans ; Male ; Middle Aged ; New York City ; Pandemics ; Patient Positioning/methods ; Prone Position ; Respiration, Artificial ; Respiratory Distress Syndrome/mortality ; Respiratory Distress Syndrome/therapy
    Keywords covid19
    Language English
    Publishing date 2020-08-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632818-0
    ISSN 1557-8615 ; 0883-9441
    ISSN (online) 1557-8615
    ISSN 0883-9441
    DOI 10.1016/j.jcrc.2020.08.020
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  10. Article: Implementation of lung protective ventilation order to improve adherence to low tidal volume ventilation: A RE-AIM evaluation

    Short, Briana / Serra, Alexis / Tariq, Abdul / Moitra, Vivek / Brodie, Daniel / Patel, Sapana / Baldwin, Matthew R / Yip, Natalie H

    J. crit. care

    Abstract: PURPOSE: Lung protective ventilation (LPV), defined as a tidal volume (Vt) ≤8 cc/kg of predicted body weight, reduces ventilator-induced lung injury but is applied inconsistently. MATERIALS AND METHODS: We conducted a prospective, quasi-experimental, ... ...

    Abstract PURPOSE: Lung protective ventilation (LPV), defined as a tidal volume (Vt) ≤8 cc/kg of predicted body weight, reduces ventilator-induced lung injury but is applied inconsistently. MATERIALS AND METHODS: We conducted a prospective, quasi-experimental, cohort study of adults mechanically ventilated admitted to intensive care units (ICU) in the year before, year after, and second year after implementation of an electronic medical record based LPV order, and a cross-sectional qualitative study of ICU providers regarding their perceptions of the order. We applied the Reach, Efficacy, Adoption, Implementation, and Maintenance (RE-AIM) framework to evaluate the implementation. RESULTS: There were 1405, 1424, and 1342 in the control, adoption, and maintenance cohorts, representing 95% of mechanically ventilated adult ICU patients. The overall prevalence of LPV increased from 65% to 73% (p < 0.001, adjusted-OR for LPV adherence: 1.9, 95% CI 1.5-2.3), but LPV adherence in women was approximately 30% worse than in men (women: 44% to 56% [p < 0.001],men: 79% to 86% [p < 0.001]). ICU providers noted difficulty obtaining an accurate height measurement and mistrust of the Vt calculation as barriers to implementation. LPV adherence increased further in the second year post implementation. CONCLUSION: We designed and implemented an LPV order that sustainably improved LPV adherence across diverse ICUs.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #33004237
    Database COVID19

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