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  1. Book: Head and neck cancer: United Kingdom national multidisciplinary guidelines

    Paleri, Vinidh

    (The journal of laryngology & otology ; volume 130, number S2 (May 2016))

    2016  

    Title variant Head and Neck cancer
    Author's details edited by: Vinidh Paleri, Nick Roland
    Series title The journal of laryngology & otology ; volume 130, number S2 (May 2016)
    The journal of laryngology and otology
    Collection The journal of laryngology and otology
    Language English
    Size S224 Seiten
    Publisher Cambridge University Press
    Publishing place Cambridge
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT019060357
    Database Catalogue ZB MED Medicine, Health

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  2. Article ; Online: Vascularized Tissue to Reduce Fistula After Salvage Total Laryngectomy: A Network Meta-analysis.

    Williamson, Andrew / Shah, Faizan / Benaran, Irene / Paleri, Vinidh

    The Laryngoscope

    2024  

    Abstract: Objective: Salvage laryngectomy is more predisposed to complications than primary operations, with pharyngocutaneous fistula (PCF) being among the most challenging to manage. Vascularized flaps are increasingly employed during salvage laryngectomy, with ...

    Abstract Objective: Salvage laryngectomy is more predisposed to complications than primary operations, with pharyngocutaneous fistula (PCF) being among the most challenging to manage. Vascularized flaps are increasingly employed during salvage laryngectomy, with a previous review finding a PCF incidence of 31.2% and 22.2% after primary and flap-assisted closure respectively. We aim to better define the role of vascularized flaps after salvage laryngectomy by performing an updated review comparing the rate of PCF in those undergoing primary or vascularized flap-assisted closure.
    Data sources: Pubmed/Medline, CINAHL, and CENTRAL.
    Review methods: An updated literature review was conducted of English language literature from 2003 to 2023. A random effects and network meta-analysis of odds ratios (OR) and pooled proportions were conducted.
    Results: Literature search found 31 studies, including seven from the previous review. Overall random effects pooled PCF rate was 25% (95% CI 0.21; 0.30, I
    Conclusion: The updated analysis has demonstrated a widening in the rates of PCF between primary and vascularized flap-assisted closure. Surgeons should strongly consider the use of free or pedicled flaps in any salvage laryngectomy procedure. Laryngoscope, 2024.
    Language English
    Publishing date 2024-01-18
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 80180-x
    ISSN 1531-4995 ; 0023-852X
    ISSN (online) 1531-4995
    ISSN 0023-852X
    DOI 10.1002/lary.31287
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Collaboration for improved cancer care.

    Paleri, Vinidh / McCaul, Lorna K

    British dental journal

    2022  Volume 233, Issue 9, Page(s) 697

    MeSH term(s) Interprofessional Relations ; Cooperative Behavior ; Patient Care Team ; Neoplasms/therapy
    Language English
    Publishing date 2022-11-11
    Publishing country England
    Document type Editorial
    ZDB-ID 218090-x
    ISSN 1476-5373 ; 0007-0610
    ISSN (online) 1476-5373
    ISSN 0007-0610
    DOI 10.1038/s41415-022-5216-4
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  4. Article ; Online: Caution Regarding Assessment of Toxic Effects and Survival in Treatment De-escalation With Radiotherapy vs Transoral Surgery for Human Papillomavirus-Associated Oropharyngeal Cancer.

    Paleri, Vinidh / Simon, Christian / Gorphe, Philippe

    JAMA oncology

    2022  Volume 8, Issue 10, Page(s) 1512–1513

    MeSH term(s) Humans ; Papillomaviridae ; Alphapapillomavirus ; Oropharyngeal Neoplasms/radiotherapy ; Oropharyngeal Neoplasms/surgery ; Papillomavirus Infections/surgery
    Language English
    Publishing date 2022-08-18
    Publishing country United States
    Document type Journal Article ; Comment
    ISSN 2374-2445
    ISSN (online) 2374-2445
    DOI 10.1001/jamaoncol.2022.3461
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  5. Article ; Online: Factors shaping the implementation and use of Clinical Cancer Decision Tools by GPs in primary care

    Paula Theresa Bradley / Vinidh Paleri

    BMJ Open, Vol 11, Iss

    a qualitative framework synthesis

    2021  Volume 2

    Abstract: Objective Clinical Cancer Decision Tools (CCDTs) aim to alert general practitioners (GPs) to signs and symptoms of cancer, supporting prompt investigation and onward referral. CCDTs are available in primary care in the UK but are not widely utilised. ... ...

    Abstract Objective Clinical Cancer Decision Tools (CCDTs) aim to alert general practitioners (GPs) to signs and symptoms of cancer, supporting prompt investigation and onward referral. CCDTs are available in primary care in the UK but are not widely utilised. Qualitative research has highlighted the complexities and mechanisms surrounding their implementation and use; this has focused on specific cancer types, formats, systems or settings. This study aims to synthesise qualitative data of GPs’ attitudes to and experience with a range of CCDTs to gain better understanding of the factors shaping their implementation and use.Design A systematic search of the published (MEDLINE, CINAHL, Web of Science and EMBASE) and grey literature (July 2020). Following screening, selection and assessment of suitability, the data were analysed and synthesised using normalisation process theory.Results Six studies (2011 to 2019), exploring the views of GPs were included for analysis. Studies focused on the use of several different types of CCDTs (Risk Assessment Tools (RAT) or electronic version of RAT (eRAT), QCancer and the 7-point checklist). GPs agreed CCDTs were useful to increase awareness of signs and symptoms of undiagnosed cancer. They had concerns about the impact on trust in their own clinical acumen, whether secondary care clinicians would consider referrals generated by CCDT as valid and whether integration of the CCDTs within existing systems was achievable.Conclusions CCDTs might be a helpful adjunct to clinical work in primary care, but without careful development to legitimise their use GPs are likely to give precedence to clinical acumen and gut instinct. Stakeholder consultation with secondary care clinicians and consideration of how the CCDTs fit into a GP consultation are crucial to successful uptake. The role and responsibilities of a GP as a clinician, gatekeeper, health promoter and resource manager affect the interaction with and implementation of innovations such as CCDTs.
    Keywords Medicine ; R
    Subject code 380
    Language English
    Publishing date 2021-02-01T00:00:00Z
    Publisher BMJ Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Functional and quality-of-life outcomes following salvage surgery for recurrent squamous cell carcinoma of the head and neck: a systematic review and meta-analysis.

    Williamson, Andrew / Jashek-Ahmed, Farizeh / Hardman, John / Paleri, Vinidh

    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

    2023  Volume 280, Issue 10, Page(s) 4597–4618

    Abstract: Background: Recurrent head and neck squamous cell carcinomas (HNSCC) are frequently managed with salvage surgery, but the impact these operations have on function and quality-of-life (QoL) is understudied. This review aimed to provide a quantitative and ...

    Abstract Background: Recurrent head and neck squamous cell carcinomas (HNSCC) are frequently managed with salvage surgery, but the impact these operations have on function and quality-of-life (QoL) is understudied. This review aimed to provide a quantitative and qualitative assessment of the functional and QoL effects of salvage surgical procedures.
    Methods: Systematic review and meta-analysis were conducted of studies reporting QoL and function following salvage HNSCC resections.
    Results: The search identified 415 articles and 34 were selected for inclusion. Pooled random effects analysis revealed long-term feeding and tracheostomy tube rates of 18% and 7%. Pooled long-term feeding tube rates in open oral and oropharyngeal, transoral robotic, total and partial laryngectomy surgeries were 41%, 25%, 11% and 4%. Eight studies used validated QoL questionnaires.
    Conclusions: Functional and QoL outcomes from salvage surgery are acceptable, but appear to be worse following open procedures. Prospective studies measuring changes over time are needed to assess these procedures impact on patient well-being.
    MeSH term(s) Humans ; Head and Neck Neoplasms/surgery ; Salvage Therapy/methods ; Quality of Life ; Squamous Cell Carcinoma of Head and Neck/surgery ; Neoplasm Recurrence, Local
    Language English
    Publishing date 2023-06-17
    Publishing country Germany
    Document type Meta-Analysis ; Systematic Review ; Journal Article
    ZDB-ID 1017359-6
    ISSN 1434-4726 ; 0937-4477
    ISSN (online) 1434-4726
    ISSN 0937-4477
    DOI 10.1007/s00405-023-08056-z
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  7. Article ; Online: Head and neck cancer explained: an overview of management pathways.

    Owens, David / Paleri, Vinidh / Jones, Adam V

    British dental journal

    2022  Volume 233, Issue 9, Page(s) 721–725

    Abstract: Head and neck cancer is a rare disease and general dental practitioners (GDPs) are at the forefront of head and neck assessment for malignancy in the community. Having an awareness of the signs and symptoms with which head and neck cancers can present ... ...

    Abstract Head and neck cancer is a rare disease and general dental practitioners (GDPs) are at the forefront of head and neck assessment for malignancy in the community. Having an awareness of the signs and symptoms with which head and neck cancers can present promotes earlier diagnosis and increases the potential for better prognosis and quality of life. This article will outline the head and neck cancer pathway from presentation, diagnosis and management planning, to treatment and beyond. This should help to give GDPs insight into the process their patients will experience while under the care of the multidisciplinary team and enable them to give patients returning to primary care the best support. This article is part of a larger series that will explore each facet of care in greater detail to give a significantly greater understanding of the pathway.
    MeSH term(s) Humans ; Quality of Life ; Dentists ; Professional Role ; Head and Neck Neoplasms/diagnosis ; Head and Neck Neoplasms/therapy
    Language English
    Publishing date 2022-11-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 218090-x
    ISSN 1476-5373 ; 0007-0610
    ISSN (online) 1476-5373
    ISSN 0007-0610
    DOI 10.1038/s41415-022-5199-1
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  8. Article ; Online: Letter to the editor in reference to: "A web-based prediction score for head and neck cancer referrals".

    Tikka, Theofano / Paleri, Vinidh

    Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery

    2019  Volume 45, Issue 1, Page(s) 156

    MeSH term(s) Head and Neck Neoplasms ; Humans ; Internet ; Neck ; Referral and Consultation
    Language English
    Publishing date 2019-10-31
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2205891-6
    ISSN 1749-4486 ; 1749-4478 ; 0307-7772 ; 1365-2273
    ISSN (online) 1749-4486
    ISSN 1749-4478 ; 0307-7772 ; 1365-2273
    DOI 10.1111/coa.13461
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  9. Article ; Online: Impact of COVID-19 on the mental health of surgeons and coping strategies.

    Balasubramanian, Anusha / Paleri, Vigneshwar / Bennett, Robin / Paleri, Vinidh

    Head & neck

    2020  Volume 42, Issue 7, Page(s) 1638–1644

    Abstract: Unprecedented times call for extraordinary measures. While surgeons across the globe try to comprehend the evolving facade of the COVID-19 pandemic and improvise surgical practice to the best of their ability, the psychological impact of the stress on ... ...

    Abstract Unprecedented times call for extraordinary measures. While surgeons across the globe try to comprehend the evolving facade of the COVID-19 pandemic and improvise surgical practice to the best of their ability, the psychological impact of the stress on their own mental health and well-being has been underestimated. This paper aims to review the indirect and overt factors that may affect the mental health of a surgeon in the present circumstances. Furthermore, it will aim to highlight key coping mechanisms at an individual and institutional level, so as to mitigate the negative psychological impact on surgeons.
    MeSH term(s) Adaptation, Psychological ; Anxiety/etiology ; Betacoronavirus ; Burnout, Professional/prevention & control ; COVID-19 ; Communicable Disease Control ; Coronavirus Infections/epidemiology ; Coronavirus Infections/psychology ; Coronavirus Infections/transmission ; Health Behavior ; Humans ; Infection Control ; Infectious Disease Transmission, Patient-to-Professional/prevention & control ; Life Style ; Mindfulness ; Occupational Exposure/prevention & control ; Pandemics ; Personal Protective Equipment ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/psychology ; Pneumonia, Viral/transmission ; SARS-CoV-2 ; Self Care ; Social Isolation ; Social Support ; Stress, Psychological/etiology ; Surgeons/psychology
    Keywords covid19
    Language English
    Publishing date 2020-05-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645165-2
    ISSN 1097-0347 ; 0148-6403 ; 1043-3074
    ISSN (online) 1097-0347
    ISSN 0148-6403 ; 1043-3074
    DOI 10.1002/hed.26291
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  10. Article ; Online: Current evidences in poorly differentiated thyroid carcinoma: a systematic review and subsection meta-analysis for clinical decision making.

    Chatterjee, Sataksi / Mair, Manish / Shaha, Ashok R / Paleri, Vinidh / Sawhney, Shikhar / Mishra, Aananya / Bhandarkar, Swayambhu / D'Cruz, Anil Keith

    Endocrine

    2024  

    Abstract: Background: Poorly differentiated thyroid carcinoma (PDTC) is a distinct entity with intermediate prognosis between indolent follicular thyroid cancers and anaplastic carcinoma. The management guidelines are not standardized for these cancers due its ... ...

    Abstract Background: Poorly differentiated thyroid carcinoma (PDTC) is a distinct entity with intermediate prognosis between indolent follicular thyroid cancers and anaplastic carcinoma. The management guidelines are not standardized for these cancers due its low prevalence and limited available literature. Therefore, we did this systematic review with emphasis on current evidence on diagnosis, imaging, molecular markers, and management of these carcinomas.
    Materials and methods: We searched four databases, PubMed, Medline, EMBASE, and Emcare to identify studies published till October 2023. All studies reporting diagnostic tests, imaging, molecular marker expression and management of PDTC were included in the review. The meta-analysis was conducted on expression of molecular markers in these cancers following recommendations of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Random-effects meta-analysis was used to calculate pooled estimated prevalence with 95% confidence intervals. Based on the inclusion criteria, 62 articles were selected to be incorporated for the review. Differences in pathological diagnostic criteria of PDTC was noted in literature which was addressed in WHO 2022 diagnostic terminologies with expansion of the definition. Surgical management is uniformly recommended for early stage PDTC. However, literature is divided and anecdotal for recommendations on radioactive iodine (RAI), extent of neck dissection and adjuvant treatment in PDTC. Evidence for Next Generation Sequencing (NGS), novel theragnostic approaches, immunotherapy targets are evolving. Based on the subset analysis for expression of molecular markers, we found the most common markers expressed were TERT (41%), BRAF (28%) and P 53 (25%).
    Conclusion: Poorly differentiated thyroid carcinomas have a high case fatality rate (up to 31%). Eighty-five % of the patients who succumb to the disease have distant metastasis. Even though under-represented in literature, evidence-based management of these aggressive tumors can help personalize the treatment for optimal outcomes.
    Language English
    Publishing date 2024-03-19
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1194484-5
    ISSN 1559-0100 ; 1355-008X ; 0969-711X
    ISSN (online) 1559-0100
    ISSN 1355-008X ; 0969-711X
    DOI 10.1007/s12020-024-03771-x
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