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Book ; Online: Chapter Sound E-scape

Duffy, Patrick Mark

An interactive, digital application for music therapy and soundscape generation

2023

Keywords	Product design ; design
Language	English
Size	1 electronic resource (1 pages)
Publisher	Academia Press
Publishing place	Ghent
Document type	Book ; Online
Note	English
HBZ-ID	HT030644850
ISBN	9789401496476 ; 9401496471
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Prostaglandin E

Crittenden, Siobhan / Goepp, Marie / Pollock, Jolinda / Robb, Calum T / Smyth, Danielle J / Zhou, You / Andrews, Robert / Tyrrell, Victoria / Gkikas, Konstantinos / Adima, Alexander / O'Connor, Richard A / Davies, Luke / Li, Xue-Feng / Yao, Hatti X / Ho, Gwo-Tzer / Zheng, Xiaozhong / Mair, Amil / Vermeren, Sonja / Qian, Bin-Zhi /

Mole, Damian J / Gerasimidis, Konstantinos / Schwarze, Jürgen K J / Breyer, Richard M / Arends, Mark J / O'Donnell, Valerie B / Iredale, John P / Anderton, Stephen M / Narumiya, Shuh / Maizels, Rick M / Rossi, Adriano G / Howie, Sarah E / Yao, Chengcan

Science advances

2021 Volume 7, Issue 7

Abstract: The gut microbiota fundamentally regulates intestinal homeostasis and disease partially through mechanisms that involve modulation of regulatory T cells ( ... ...

Abstract	The gut microbiota fundamentally regulates intestinal homeostasis and disease partially through mechanisms that involve modulation of regulatory T cells (T
MeSH term(s)	Dinoprostone/pharmacology ; Gastrointestinal Microbiome ; Humans ; Inflammation ; Receptors, Prostaglandin E, EP2 Subtype ; T-Lymphocytes, Regulatory
Chemical Substances	Receptors, Prostaglandin E, EP2 Subtype ; Dinoprostone (K7Q1JQR04M)
Language	English
Publishing date	2021-02-12
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2810933-8
ISSN	2375-2548 ; 2375-2548
ISSN (online)	2375-2548
ISSN	2375-2548
DOI	10.1126/sciadv.abd7954
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Article ; Online: The efficacy of vitamin E in preventing arthrofibrosis after joint replacement.

Fan, Yingfang / Yuh, Jean / Lekkala, Sashank / Asik, Mehmet D / Thomson, Andrew / McCanne, Madeline / Randolph, Mark A / Chen, Antonia F / Oral, Ebru

Animal models and experimental medicine

2024

Abstract: ... in the joint tissues. Vitamin E is an antioxidant with potential anti-fibroblastic effect. The aim ... of vitamin E supplementation on joint fibrosis.: Methods: We simulated knee replacement in 16 male ... at 2 and 12 weeks (n = 5 per group), and the test group was supplemented daily with vitamin E (0.2 mg ...

Abstract	Background: Arthrofibrosis is a joint disorder characterized by excessive scar formation in the joint tissues. Vitamin E is an antioxidant with potential anti-fibroblastic effect. The aim of this study was to establish an arthrofibrosis rat model after joint replacement and assess the effects of vitamin E supplementation on joint fibrosis. Methods: We simulated knee replacement in 16 male Sprague-Dawley rats. We immobilized the surgical leg with a suture in full flexion. The control groups were killed at 2 and 12 weeks (n = 5 per group), and the test group was supplemented daily with vitamin E (0.2 mg/mL) in their drinking water for 12 weeks (n = 6). We performed histological staining to investigate the presence and severity of arthrofibrosis. Immunofluorescent staining and α2-macroglobulin (α2M) enzyme-linked immunosorbent assay (ELISA) were used to assess local and systemic inflammation. Static weight bearing (total internal reflection) and range of motion (ROM) were collected for functional assessment. Results: The ROM and weight-bearing symmetry decreased after the procedure and recovered slowly with still significant deficit at the end of the study for both groups. Histological analysis confirmed fibrosis in both lateral and posterior periarticular tissue. Vitamin E supplementation showed a moderate anti-inflammatory effect on the local and systemic levels. The vitamin E group exhibited significant improvement in ROM and weight-bearing symmetry at day 84 compared to the control group. Conclusions: This model is viable for simulating arthrofibrosis after joint replacement. Vitamin E may benefit postsurgical arthrofibrosis, and further studies are needed for dosing requirements.
Language	English
Publishing date	2024-03-25
Publishing country	United States
Document type	Journal Article
ISSN	2576-2095
ISSN (online)	2576-2095
DOI	10.1002/ame2.12388
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Book ; Online: E-PANNs

Singh, Arshdeep / Liu, Haohe / Plumbley, Mark D.

Sound Recognition Using Efficient Pre-trained Audio Neural Networks

2023

Abstract: ... The resulting Efficient PANNs (E-PANNs) model, which requires 36\% less computations and 70\% less memory, also ... slightly improves the sound recognition (audio tagging) performance. The code for the E-PANNs model has ...

Abstract	Sounds carry an abundance of information about activities and events in our everyday environment, such as traffic noise, road works, music, or people talking. Recent machine learning methods, such as convolutional neural networks (CNNs), have been shown to be able to automatically recognize sound activities, a task known as audio tagging. One such method, pre-trained audio neural networks (PANNs), provides a neural network which has been pre-trained on over 500 sound classes from the publicly available AudioSet dataset, and can be used as a baseline or starting point for other tasks. However, the existing PANNs model has a high computational complexity and large storage requirement. This could limit the potential for deploying PANNs on resource-constrained devices, such as on-the-edge sound sensors, and could lead to high energy consumption if many such devices were deployed. In this paper, we reduce the computational complexity and memory requirement of the PANNs model by taking a pruning approach to eliminate redundant parameters from the PANNs model. The resulting Efficient PANNs (E-PANNs) model, which requires 36\% less computations and 70\% less memory, also slightly improves the sound recognition (audio tagging) performance. The code for the E-PANNs model has been released under an open source license. Comment: Accepted in Internoise 2023 conference
Keywords	Computer Science - Sound ; Computer Science - Artificial Intelligence ; Electrical Engineering and Systems Science - Audio and Speech Processing ; Electrical Engineering and Systems Science - Signal Processing
Subject code	780
Publishing date	2023-05-29
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Quality Improvement Report: Design and Implementation of a Radiology E-Consult Service.

Suresh, Kalpana / Hill, Paul A / Kahn, Charles E / Schnall, Mitchell D / Rosen, Mark A / Zafar, Hanna M / Trerotola, Scott O / Cook, Tessa S

Radiographics : a review publication of the Radiological Society of North America, Inc

2023 Volume 43, Issue 12, Page(s) e230139

Abstract: Electronic consultations (e-consults) mediated through an electronic health record system or web ... based platform allow synchronous or asynchronous physician-to-physician communication. E-consults have ... e-consults to connect health care providers directly with radiologists.The authors outline how ...

Abstract	Electronic consultations (e-consults) mediated through an electronic health record system or web-based platform allow synchronous or asynchronous physician-to-physician communication. E-consults have been explored in various clinical specialties, but relatively few instances in the literature describe e-consults to connect health care providers directly with radiologists.The authors outline how a radiology department can implement an e-consult service and review the development of such a service in a large academic health system. They describe the logistics, workflow, turnaround time expectations, stakeholder management, and pilot implementation and highlight challenges and lessons learned.
MeSH term(s)	Humans ; Quality Improvement ; Referral and Consultation ; Software ; Communication ; Radiology
Language	English
Publishing date	2023-11-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	603172-9
ISSN	1527-1323 ; 0271-5333
ISSN (online)	1527-1323
ISSN	0271-5333
DOI	10.1148/rg.230139
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Article ; Online: Effects of electronic cigarette E-liquid and device wattage on vascular function.

Mills, Amber / Frazier, James / Plants, Rachel / Burrage, Emily / Coblentz, Tyler / Nassabeh, Sydney / Robinson, Madison / Chantler, Paul D / Olfert, I Mark

Toxicology and applied pharmacology

2023 Volume 474, Page(s) 116631

Abstract: Electronic cigarettes (e-cigs) are customizable tobacco products that allow users to select e ... liquid composition, flavors, and (in some devices) adjust wattage or heat used to generate e-cig aerosol ... artery (middle cerebral artery, MCA) in C57Bl/6 mice exposed to e-cig aerosol generated from either pure vegetable ...

Abstract	Electronic cigarettes (e-cigs) are customizable tobacco products that allow users to select e-liquid composition, flavors, and (in some devices) adjust wattage or heat used to generate e-cig aerosol. This study compared vascular outcomes in a conducting vessel (thoracic aorta) and a resistance artery (middle cerebral artery, MCA) in C57Bl/6 mice exposed to e-cig aerosol generated from either pure vegetable glycerin (VG) or pure propylene glycol (PG) over 60-min (Study 1), and separately the effect of using 5- vs. 30-watt settings with an exposure of 100-min (Study 2). In Study 1, aortic endothelial-dependent-dilation (EDD) was only impaired with PG- exposure (p < 0.05) compared with air. In the MCA, EDD response was impaired by ∼50% in both VG and PG groups compared with air (p < 0.05). In Study 2, the aortic EDD responses were not different for either 5- or 30-watt exposed groups compared with air controls; however, in the MCA, both 5- and 30-watt groups were impaired by 32% and 55%, respectively, compared with air controls (p < 0.05). These pre-clinical data provide evidence that chronic exposure to aerosol produced by either VG or PG, and regardless of the wattage used, leads to vascular dysfunction at multiple levels within the arterial system. For all exposures, we observed greater impairment of arterial reactivity in a resistance artery (i.e. MCA) compared with the aorta. These data could suggest the smaller arteries may be more sensitive or first to be affected, or that different mechanism(s) for impairment may be involved depending on arterial hierarchy.
MeSH term(s)	Animals ; Mice ; Electronic Nicotine Delivery Systems ; Propylene Glycol/toxicity ; Vaping/adverse effects ; Glycerol/toxicity ; Aerosols
Chemical Substances	Propylene Glycol (6DC9Q167V3) ; Glycerol (PDC6A3C0OX) ; Aerosols
Language	English
Publishing date	2023-07-17
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	204477-8
ISSN	1096-0333 ; 0041-008X
ISSN (online)	1096-0333
ISSN	0041-008X
DOI	10.1016/j.taap.2023.116631
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Article ; Online: Interventions for Preventing E-Cigarette Use Among Children and Youth: A Systematic Review.

Mylocopos, Genevieve / Wennberg, Erica / Reiter, Anna / Hébert-Losier, Andréa / Filion, Kristian B / Windle, Sarah B / Gore, Genevieve / O'Loughlin, Jennifer L / Grad, Roland / Eisenberg, Mark J

American journal of preventive medicine

2023 Volume 66, Issue 2, Page(s) 351–370

Abstract: ... at three levels: directed at the individual (e.g., interactive video games), delivered to students ... at school (e.g., campus bans), and launched in the community (e.g., mass media campaigns). This systematic ... review aims to synthesize the evidence on the effectiveness of interventions aimed at preventing e ...

Abstract	Introduction: Many nonregulatory interventions targeting children and youth have been implemented at three levels: directed at the individual (e.g., interactive video games), delivered to students at school (e.g., campus bans), and launched in the community (e.g., mass media campaigns). This systematic review aims to synthesize the evidence on the effectiveness of interventions aimed at preventing e-cigarette initiation among children and youth. Methods: MEDLINE, CINAHL, Embase, APA PsycINFO, and Web of Science Core Collection were searched for papers published between January 1, 2004 and September 1, 2022 that reported more than one outcome on vaping prevention among individuals aged less than 21-years-old: vaping prevalence/incidence, initiation intentions, knowledge/attitudes, and other tobacco product use prevalence/initiation intentions. Interventions were at the individual, school, or community level. The risk of bias was assessed using ROBINS-I and RoB 1. Results: Thirty-nine publications met the eligibility criteria. Fourteen individually-based (4 parental monitoring, 3 video games, 2 text messages, 3 graphic message themes, 2 healthcare), 19 school-based (14 educational and skill interventions, 5 vape-free policies/bans), and 6 community-based (3 social media, 3 mass media campaigns) interventions were reported. E-cigarette initiation prevention was observed with high perceived parental monitoring; however, the cross-sectional study designs precluded causal claims. There was promising but limited evidence that social-emotional skills curricula and peer leader programming prevented vaping initiation. Discussion: Some individual- and school-based interventions showed promise for preventing e-cigarette initiation among children and youth.
MeSH term(s)	Adolescent ; Child ; Humans ; Young Adult ; Cross-Sectional Studies ; Electronic Nicotine Delivery Systems ; Smoking Prevention ; Students ; Vaping/epidemiology ; Vaping/prevention & control ; Vaping/psychology
Language	English
Publishing date	2023-10-05
Publishing country	Netherlands
Document type	Systematic Review ; Journal Article ; Review
ZDB-ID	632646-8
ISSN	1873-2607 ; 0749-3797
ISSN (online)	1873-2607
ISSN	0749-3797
DOI	10.1016/j.amepre.2023.09.028
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Article ; Online: Heparanase promotes the onset and progression of atherosclerosis in apolipoprotein E gene knockout mice.

Nguyen, Tien K / Paone, Stephanie / Baxter, Amy A / Mayfosh, Alyce J / Phan, Thanh Kha / Chan, Enoch / Peter, Karlheinz / Poon, Ivan K H / Thomas, Shane R / Hulett, Mark D

Atherosclerosis

2024 Volume 392, Page(s) 117519

Abstract: ... We generated Hpse gene-deficient mice on the atherosclerosis-prone apolipoprotein E gene knockout (ApoE ...

Abstract	Background and aims: Atherosclerosis is the primary underlying cause of myocardial infarction and stroke, which are the major causes of death globally. Heparanase (Hpse) is a pro-inflammatory extracellular matrix degrading enzyme that has been implicated in atherogenesis. However, to date the precise roles of Hpse in atherosclerosis and its mechanisms of action are not well defined. This study aims to provide new insights into the contribution of Hpse in different stages of atherosclerosis in vivo. Methods: We generated Hpse gene-deficient mice on the atherosclerosis-prone apolipoprotein E gene knockout (ApoE Results: Hpse-deficient mice exhibited significantly reduced atherosclerotic lesion burden in the aortic sinus and aorta at both time-points, independent of changes in plasma cholesterol levels. A significant reduction in the necrotic core size and an increase in smooth muscle cell content were also observed in advanced atherosclerotic plaques of Hpse-deficient mice. Additionally, Hpse deficiency reduced circulating and aortic levels of VCAM-1 at the initiation and progression stages of disease and circulating MCP-1 levels in the initiation but not progression stage. Moreover, the aortic levels of total leukocytes and dendritic cells in Hpse-deficient ApoE Conclusions: This study identifies Hpse as a key pro-inflammatory enzyme driving the initiation and progression of atherosclerosis and highlighting the potential of Hpse inhibitors as novel anti-inflammatory treatments for cardiovascular disease.
Language	English
Publishing date	2024-03-19
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	80061-2
ISSN	1879-1484 ; 0021-9150
ISSN (online)	1879-1484
ISSN	0021-9150
DOI	10.1016/j.atherosclerosis.2024.117519
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Article ; Online: Improved detection of colibactin-induced mutations by genotoxic E. coli in organoids and colorectal cancer.

Rosendahl Huber, Axel / Pleguezuelos-Manzano, Cayetano / Puschhof, Jens / Ubels, Joske / Boot, Charelle / Saftien, Aurelia / Verheul, Mark / Trabut, Laurianne T / Groenen, Niels / van Roosmalen, Markus / Ouyang, Kyanna S / Wood, Henry / Quirke, Phil / Meijer, Gerrit / Cuppen, Edwin / Clevers, Hans / van Boxtel, Ruben

Cancer cell

2024 Volume 42, Issue 3, Page(s) 487–496.e6

Abstract: Co-culture of intestinal organoids with a colibactin-producing ... ...

Abstract	Co-culture of intestinal organoids with a colibactin-producing pks
MeSH term(s)	Humans ; Escherichia coli/genetics ; Mutation ; DNA Damage ; Mutagens ; Colorectal Neoplasms ; Organoids ; Peptides ; Polyketides
Chemical Substances	colibactin ; Mutagens ; Peptides ; Polyketides
Language	English
Publishing date	2024-03-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2078448-X
ISSN	1878-3686 ; 1535-6108
ISSN (online)	1878-3686
ISSN	1535-6108
DOI	10.1016/j.ccell.2024.02.009
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Zs.A 5650: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: "Evaluating trends in pharmacist e-prescribing: 2019-2022.

Reidt, Shannon / Hsieh, Mark / Roufael, Joud / Kim, Sharon / Panwalkar, Geeta / Sow, Max

Journal of the American Pharmacists Association : JAPhA

2024 , Page(s) 102092

Abstract: ... them to primary care provider (PCP) prescribing trends by analyzing e-prescriptions initiated ... from electronic health records systems (EHRs) from 2019 through 2022.: Methods: This cross-sectional study used e ... prescriptions from a national health information network to identify e-prescriptions ordered by pharmacists and ...

Abstract	Background: Pharmacists have some prescriptive authority in all fifty states through dependent and independent prescribing. Data describing the volume and characteristics of pharmacist prescribing are not widely available, and these insights are critical to gauge the impact of regulations supporting pharmacist prescriptive authority. Objective: To identify trends in pharmacist prescribing and compare them to primary care provider (PCP) prescribing trends by analyzing e-prescriptions initiated from electronic health records systems (EHRs) from 2019 through 2022. Methods: This cross-sectional study used e-prescriptions from a national health information network to identify e-prescriptions ordered by pharmacists and PCPs from January 7, 2019, to January 1, 2023. E-prescriptions ordered by pharmacists and PCPs were analyzed to identify annual volume by prescriber type and most prescribed therapeutic classes. States with the highest volume of e-prescriptions ordered by pharmacists were identified. Results: The number of e-prescriptions prescribed by a pharmacist increased 47% from 2019 (n=814,726) to 2022 (n=1,199,601). The number of pharmacists prescribing in 2019 was 1650, and this increased by 122% to 3664 in 2022. The number of e-prescriptions prescribed by PCPs increased by 4% from 2019 (n=927,890,123) to 2022 (n=965,803,376) while the number of PCPs prescribing increased by 8% from 2019 (n=364,995) to 2022 (n=394,753). Conclusion: Pharmacist e-prescribing increased across the four years studied while PCP e-prescribing modestly increased. Factors like access to technology, such as electronic health records, state regulations, and reimbursement impact a pharmacist's ability to prescribe.
Language	English
Publishing date	2024-04-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	2118585-2
ISSN	1544-3450 ; 1544-3191 ; 1086-5802
ISSN (online)	1544-3450
ISSN	1544-3191 ; 1086-5802
DOI	10.1016/j.japh.2024.102092
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