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  1. Article ; Online: A breath of humanity in the era of Covid-19 vaccine.

    Vanhems, Philippe

    Vaccine

    2021  Volume 39, Issue 28, Page(s) 3649

    MeSH term(s) COVID-19 ; COVID-19 Vaccines ; Humans ; Respiratory System ; SARS-CoV-2
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2021-05-24
    Publishing country Netherlands
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 605674-x
    ISSN 1873-2518 ; 0264-410X
    ISSN (online) 1873-2518
    ISSN 0264-410X
    DOI 10.1016/j.vaccine.2021.05.052
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  2. Article ; Online: SARS-CoV2 infection and primary school closure.

    Vanhems, Philippe

    Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin

    2020  Volume 25, Issue 15

    MeSH term(s) Child ; Coronavirus Infections ; Humans ; Pneumonia, Viral ; Schools ; Severe Acute Respiratory Syndrome
    Keywords covid19
    Language English
    Publishing date 2020-04-09
    Publishing country Sweden
    Document type Letter ; Comment
    ZDB-ID 1338803-4
    ISSN 1560-7917 ; 1025-496X
    ISSN (online) 1560-7917
    ISSN 1025-496X
    DOI 10.2807/1560-7917.ES.2020.25.15.2000617
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  3. Article ; Online: Further Cautions When Modeling the Public Health Impact of Infectious Diseases.

    Vanhems, Philippe / Nunes, Marta C

    American journal of public health

    2022  Volume 112, Issue 11, Page(s) e1–e2

    MeSH term(s) Communicable Diseases/epidemiology ; Humans ; Public Health
    Language English
    Publishing date 2022-10-08
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 121100-6
    ISSN 1541-0048 ; 0090-0036 ; 0002-9572
    ISSN (online) 1541-0048
    ISSN 0090-0036 ; 0002-9572
    DOI 10.2105/AJPH.2022.307086
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  5. Article ; Online: Influenza transmissibility among patients and health-care professionals in a geriatric short-stay unit using individual contact data.

    Gustin, Marie-Paule / Pujo-Menjouet, Laurent / Vanhems, Philippe

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 10547

    Abstract: Detailed information are lacking on influenza transmissibility in hospital although clusters are regularly reported. In this pilot study, our goal was to estimate the transmission rate of H3N2 2012-influenza, among patients and health care professionals ... ...

    Abstract Detailed information are lacking on influenza transmissibility in hospital although clusters are regularly reported. In this pilot study, our goal was to estimate the transmission rate of H3N2 2012-influenza, among patients and health care professionals in a short-term Acute Care for the Elderly Unit by using a stochastic approach and a simple susceptible-exposed-infectious-removed model. Transmission parameters were derived from documented individual contact data collected by Radio Frequency IDentification technology at the epidemic peak. From our model, nurses appeared to transmit infection to a patient more frequently with a transmission rate of 1.04 per day on average compared to 0.38 from medical doctors. This transmission rate was 0.34 between nurses. These results, even obtained in this specific context, might give a relevant insight of the influenza dynamics in hospitals and will help to improve and to target control measures for preventing nosocomial transmission of influenza. The investigation of nosocomial transmission of SARS-COV-2 might gain from similar approaches.
    MeSH term(s) Aged ; Humans ; Influenza A Virus, H3N2 Subtype ; Influenza, Human/epidemiology ; Pilot Projects ; COVID-19/epidemiology ; SARS-CoV-2 ; Health Personnel ; Cross Infection/epidemiology
    Language English
    Publishing date 2023-06-29
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-36908-5
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  6. Article ; Online: Burden of influenza in the elderly: a narrative review.

    Conrad, Anne / Valour, Florent / Vanhems, Philippe

    Current opinion in infectious diseases

    2023  Volume 36, Issue 4, Page(s) 296–302

    Abstract: Purpose of review: This review provides an update on specificities of influenza in older adults (≥65-year-old), including epidemiology, burden in terms of hospitalization and mortality, extra-respiratory complications and specific challenges of ... ...

    Abstract Purpose of review: This review provides an update on specificities of influenza in older adults (≥65-year-old), including epidemiology, burden in terms of hospitalization and mortality, extra-respiratory complications and specific challenges of prevention.
    Recent findings: In the past 2 years, influenza activity was drastically reduced by barrier measures implemented during the COVID-19 pandemic. A recent French epidemiological study covering 2010-2018 epidemic seasons estimated that 75% of costs induced by influenza-associated hospitalizations and complications were attributable to older adults, a population bearing more than 90% of influenza-associated excess mortality.In addition to their age, comorbidities and reduced vaccine response, long-term facility residents are at risk for nosocomial outbreaks. Beyond respiratory complications, influenza triggers acute myocardial infarction and ischemic stroke. Influenza might drive significant functional loss in frail older adults, which can lead to "catastrophic" or severe disability in up to 10% of patients. Vaccination remains the cornerstone of prevention, with enhanced immunization strategies (i.e., high-dose or adjuvanted formulations) to be largely implemented in older adults. Efforts to increase influenza vaccination uptake during the COVID-19 pandemic should be consolidated.
    Summary: Burden of influenza in the elderly is largely under-recognized, especially the cardiovascular complications and the impact on functional status, justifying more effective preventive strategies.
    MeSH term(s) Aged ; Humans ; Influenza, Human/complications ; Influenza, Human/epidemiology ; Influenza, Human/prevention & control ; Pandemics ; COVID-19/epidemiology ; COVID-19/prevention & control ; Influenza Vaccines ; Adjuvants, Immunologic
    Chemical Substances Influenza Vaccines ; Adjuvants, Immunologic
    Language English
    Publishing date 2023-06-22
    Publishing country United States
    Document type Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 645085-4
    ISSN 1473-6527 ; 1535-3877 ; 0951-7375 ; 1355-834X
    ISSN (online) 1473-6527 ; 1535-3877
    ISSN 0951-7375 ; 1355-834X
    DOI 10.1097/QCO.0000000000000931
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  7. Article ; Online: Influenza transmissibility among patients and health-care professionals in a geriatric short-stay unit using individual contact data

    Marie-Paule Gustin / Laurent Pujo-Menjouet / Philippe Vanhems

    Scientific Reports, Vol 13, Iss 1, Pp 1-

    2023  Volume 11

    Abstract: Abstract Detailed information are lacking on influenza transmissibility in hospital although clusters are regularly reported. In this pilot study, our goal was to estimate the transmission rate of H3N2 2012-influenza, among patients and health care ... ...

    Abstract Abstract Detailed information are lacking on influenza transmissibility in hospital although clusters are regularly reported. In this pilot study, our goal was to estimate the transmission rate of H3N2 2012-influenza, among patients and health care professionals in a short-term Acute Care for the Elderly Unit by using a stochastic approach and a simple susceptible-exposed-infectious-removed model. Transmission parameters were derived from documented individual contact data collected by Radio Frequency IDentification technology at the epidemic peak. From our model, nurses appeared to transmit infection to a patient more frequently with a transmission rate of 1.04 per day on average compared to 0.38 from medical doctors. This transmission rate was 0.34 between nurses. These results, even obtained in this specific context, might give a relevant insight of the influenza dynamics in hospitals and will help to improve and to target control measures for preventing nosocomial transmission of influenza. The investigation of nosocomial transmission of SARS-COV-2 might gain from similar approaches.
    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: American Society of Anesthesiologists-Physical Status Classification As An Independent Risk Factor of Surgical Site Infection After Infra-Inguinal Arterial Bypass.

    Tresson, Philippe / Quiquandon, Samuel / Rivoire, Emeraude / Boibieux, André / Vanhems, Philippe / Bordet, Marine / Long, Anne

    Annals of surgery

    2023  Volume 277, Issue 5, Page(s) e1157–e1163

    Abstract: Objectives: The present study aimed to assess whether high-risk American Society of Anesthesiologists (ASA)-Physical Status was an independent risk factor for the development of surgical site infection (SSI) after infra-inguinal lower extremity bypass ( ... ...

    Abstract Objectives: The present study aimed to assess whether high-risk American Society of Anesthesiologists (ASA)-Physical Status was an independent risk factor for the development of surgical site infection (SSI) after infra-inguinal lower extremity bypass (LEB).
    Summary of background data: The ASA-Physical Status Classification System assesses the overall physical status preoperatively. ASA-Physical Status is associated with postoperative morbidity and mortality. However, limited data are available on how ASA-Physical Status Class affects the development of SSI after infra-inguinal LEB.
    Methods: Patients who had undergone infra-inguinal LEB from January 1, 2015 to December 31, 2018, for obliterative arteriopathy or popliteal aneurysm at our university hospital were included. SSI risk factors were identified using multivariable logistic regression. The length of hospital stay, major limb events (MALE), major adverse cardiovascular events (MACE), and all-cause mortality were compared for patients with SSI versus those without SSI 3 months and 1- year of follow-up after the index surgery.
    Results: Among the 267 patients included, 30 (11.2%) developed SSI during the 3-month period and 32 (12%) at 1 year. ASA-Physical Status ≥3 [odds ratio (OR): 3.7, 95% confidence interval CI) 1.5-11.1], emergency surgery (OR: 2.7, 95% CI 1.2-6.0), general anesthesia (OR: 2.8, 95% CI 1.3-6.1), and procedure performed by a junior surgeon (OR: 2.7, 95% CI 1.3-6.0) were independently associated with SSI. At 3 months and 1 year, SSI was significantly associated with MALE (including surgical wound debridement, subsequent thrombectomy, major amputation), length of hospital stay, and all-cause mortality.
    Conclusion: The ASA-Physical Status should be considered in medical management when an infra-inguinal LEB is considered in frail patients, to prevent surgical complications.
    MeSH term(s) Humans ; Surgical Wound Infection/epidemiology ; Surgical Wound Infection/etiology ; Surgical Wound Infection/prevention & control ; Anesthesiologists ; Risk Factors ; Lower Extremity/surgery ; Lower Extremity/blood supply ; Retrospective Studies
    Language English
    Publishing date 2023-04-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 340-2
    ISSN 1528-1140 ; 0003-4932
    ISSN (online) 1528-1140
    ISSN 0003-4932
    DOI 10.1097/SLA.0000000000005182
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  9. Article ; Online: Heterogeneity in practices to reduce the risk of transmission of Clostridioides difficile in healthcare settings: a survey of ESCMID Study Group for Clostridioides difficile (ESGCD) members.

    Khanafer, Nagham Léa / Fitzpatrick, Fidelma / Barbut, Frédéric / Krutova, Marcela / Davies, Kerrie / Guery, Benoit / Vanhems, Philippe

    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology

    2024  Volume 43, Issue 4, Page(s) 785–789

    Abstract: Clostridioides difficile is a leading cause of healthcare-associated infections. The main objective was to assess the current landscape of CDI infection prevention and control (IPC) practices. An anonymous survey of IPC practices for CDI was conducted ... ...

    Abstract Clostridioides difficile is a leading cause of healthcare-associated infections. The main objective was to assess the current landscape of CDI infection prevention and control (IPC) practices. An anonymous survey of IPC practices for CDI was conducted between July 25 and October 31, 2022. Precautions for symptomatic patients were applicable for 75.9% and were discontinued 48 h minimum after the resolution of diarrhea for 40.7% of respondents. Daily cleaning of CDI patients' rooms was reported by 23 (42.6%). There was unexpected heterogeneity in IPC practices regarding the hospital management of CDI.
    MeSH term(s) Humans ; Clostridioides difficile ; Clostridioides ; Cross Infection/prevention & control ; Diarrhea/prevention & control ; Health Facilities ; Clostridium Infections/prevention & control
    Language English
    Publishing date 2024-02-09
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 603155-9
    ISSN 1435-4373 ; 0934-9723 ; 0722-2211
    ISSN (online) 1435-4373
    ISSN 0934-9723 ; 0722-2211
    DOI 10.1007/s10096-024-04767-1
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  10. Article ; Online: COVID-19 vaccine is correlated with favourable epidemiological indicators in the Auvergne-Rhône-Alpes region (France): An ecological study.

    Romain-Scelle, Nicolas / Elias, Christelle / Vanhems, Philippe

    Vaccine

    2021  Volume 40, Issue 5, Page(s) 695–700

    Abstract: COVID-19 vaccination has proven to be effective in preventing severe cases, reducing viral load, and transmissibility. The aim of this study was to evaluate the impact of vaccination 11 months after implementation on epidemiological indicators and the ... ...

    Abstract COVID-19 vaccination has proven to be effective in preventing severe cases, reducing viral load, and transmissibility. The aim of this study was to evaluate the impact of vaccination 11 months after implementation on epidemiological indicators and the effective reproduction number in one French region. We plotted four indicators with vaccination coverage as the explaining variable and estimated the impact of vaccination using the reduction rates in infections and hospital admissions. A reduction of 98% in COVID-19-related hospitalisation 11 months after the vaccine campaign began in January 2021 has been reported while vaccine coverage increased over time. Those results do not make it possible to postulate a causal relationship but do support the effect of vaccination against multiple variants of concern. Non-pharmaceutical measures remain necessary to attain complete epidemic control. Open epidemiological data should be considered to monitor vaccine effectiveness wherever possible.
    MeSH term(s) COVID-19 ; COVID-19 Vaccines ; Humans ; SARS-CoV-2 ; Vaccination ; Vaccination Coverage ; Vaccine Efficacy
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2021-12-22
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 605674-x
    ISSN 1873-2518 ; 0264-410X
    ISSN (online) 1873-2518
    ISSN 0264-410X
    DOI 10.1016/j.vaccine.2021.12.036
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