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  1. Article ; Online: Rapid onset honeycombing fibrosis in spontaneously breathing patient with COVID-19.

    Combet, Margot / Pavot, Arthur / Savale, Laurent / Humbert, Marc / Monnet, Xavier

    The European respiratory journal

    2020  Volume 56, Issue 2

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus ; Coronavirus Infections ; Fibrosis ; Humans ; Lung Transplantation ; Pandemics ; Pneumonia, Viral ; Pulmonary Fibrosis ; Respiratory Distress Syndrome ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-08-27
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.01808-2020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2322: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 292: Show issues

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  2. Article ; Online: Pulmonary vein stenosis: An unusual cause of hypoxemia after lung transplantation.

    Combet, Margot / Mouren, Domitille / Motiejunaite, Justina / Bunel, Vincent / Mordant, Pierre / Castier, Yves / Snauwaert, Aurélie / Montravers, Philippe / Khalil, Antoine / Hascoet, Sébastien / Brenot, Philippe / Messika, Jonathan

    Respiratory medicine and research

    2023  Volume 84, Page(s) 101041

    MeSH term(s) Humans ; Stenosis, Pulmonary Vein/diagnostic imaging ; Stenosis, Pulmonary Vein/etiology ; Lung Transplantation/adverse effects ; Respiration Disorders ; Hypoxia/etiology
    Language English
    Publishing date 2023-08-23
    Publishing country France
    Document type Letter
    ISSN 2590-0412
    ISSN (online) 2590-0412
    DOI 10.1016/j.resmer.2023.101041
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Patient-Self Inflicted Lung Injury: A Practical Review.

    Carteaux, Guillaume / Parfait, Mélodie / Combet, Margot / Haudebourg, Anne-Fleur / Tuffet, Samuel / Mekontso Dessap, Armand

    Journal of clinical medicine

    2021  Volume 10, Issue 12

    Abstract: Patients with severe lung injury usually have a high respiratory drive, resulting in intense inspiratory effort that may even worsen lung damage by several mechanisms gathered under the name "patient-self inflicted lung injury" (P-SILI). Even though no ... ...

    Abstract Patients with severe lung injury usually have a high respiratory drive, resulting in intense inspiratory effort that may even worsen lung damage by several mechanisms gathered under the name "patient-self inflicted lung injury" (P-SILI). Even though no clinical study has yet demonstrated that a ventilatory strategy to limit the risk of P-SILI can improve the outcome, the concept of P-SILI relies on sound physiological reasoning, an accumulation of clinical observations and some consistent experimental data. In this review, we detail the main pathophysiological mechanisms by which the patient's respiratory effort could become deleterious: excessive transpulmonary pressure resulting in over-distension; inhomogeneous distribution of transpulmonary pressure variations across the lung leading to cyclic opening/closing of nondependent regions and pendelluft phenomenon; increase in the transvascular pressure favoring the aggravation of pulmonary edema. We also describe potentially harmful patient-ventilator interactions. Finally, we discuss in a practical way how to detect in the clinical setting situations at risk for P-SILI and to what extent this recognition can help personalize the treatment strategy.
    Language English
    Publishing date 2021-06-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm10122738
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Rapid onset honeycombing fibrosis in spontaneously breathing patient with COVID-19

    Combet, Margot / Pavot, Arthur / Savale, Laurent / Humbert, Marc / Monnet, Xavier

    Eur. respir. j

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #635638
    Database COVID19

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  5. Article ; Online: Patient-Self Inflicted Lung Injury

    Guillaume Carteaux / Mélodie Parfait / Margot Combet / Anne-Fleur Haudebourg / Samuel Tuffet / Armand Mekontso Dessap

    Journal of Clinical Medicine, Vol 10, Iss 2738, p

    A Practical Review

    2021  Volume 2738

    Abstract: Patients with severe lung injury usually have a high respiratory drive, resulting in intense inspiratory effort that may even worsen lung damage by several mechanisms gathered under the name “patient-self inflicted lung injury” (P-SILI). Even though no ... ...

    Abstract Patients with severe lung injury usually have a high respiratory drive, resulting in intense inspiratory effort that may even worsen lung damage by several mechanisms gathered under the name “patient-self inflicted lung injury” (P-SILI). Even though no clinical study has yet demonstrated that a ventilatory strategy to limit the risk of P-SILI can improve the outcome, the concept of P-SILI relies on sound physiological reasoning, an accumulation of clinical observations and some consistent experimental data. In this review, we detail the main pathophysiological mechanisms by which the patient’s respiratory effort could become deleterious: excessive transpulmonary pressure resulting in over-distension; inhomogeneous distribution of transpulmonary pressure variations across the lung leading to cyclic opening/closing of nondependent regions and pendelluft phenomenon; increase in the transvascular pressure favoring the aggravation of pulmonary edema. We also describe potentially harmful patient-ventilator interactions. Finally, we discuss in a practical way how to detect in the clinical setting situations at risk for P-SILI and to what extent this recognition can help personalize the treatment strategy.
    Keywords patient-self inflicted lung injury ; ventilator induced lung injury ; acute respiratory failure ; acute respiratory distress syndrome ; artificial ventilation ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2021-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Relationship of Extravascular Lung Water and Pulmonary Vascular Permeability to Respiratory Mechanics in Patients with COVID-19-Induced ARDS.

    Lardet, Florian / Monnet, Xavier / Teboul, Jean-Louis / Shi, Rui / Lai, Christopher / Fossé, Quentin / Moretto, Francesca / Gobé, Thibaut / Jelinski, Ludwik / Combet, Margot / Pavot, Arthur / Guérin, Laurent / Pham, Tài

    Journal of clinical medicine

    2023  Volume 12, Issue 5

    Abstract: During acute respiratory distress syndrome (ARDS), the increase in pulmonary vascular permeability and lung water induced by pulmonary inflammation may be related to altered lung compliance. A better understanding of the interactions between respiratory ... ...

    Abstract During acute respiratory distress syndrome (ARDS), the increase in pulmonary vascular permeability and lung water induced by pulmonary inflammation may be related to altered lung compliance. A better understanding of the interactions between respiratory mechanics variables and lung water or capillary permeability would allow a more personalized monitoring and adaptation of therapies for patients with ARDS. Therefore, our main objective was to investigate the relationship between extravascular lung water (EVLW) and/or pulmonary vascular permeability index (PVPI) and respiratory mechanic variables in patients with COVID-19-induced ARDS. This is a retrospective observational study from prospectively collected data in a cohort of 107 critically ill patients with COVID-19-induced ARDS from March 2020 to May 2021. We analyzed relationships between variables using repeated measurements correlations. We found no clinically relevant correlations between EVLW and the respiratory mechanics variables (driving pressure (correlation coefficient [CI 95%]: 0.017 [-0.064; 0.098]), plateau pressure (0.123 [0.043; 0.202]), respiratory system compliance (-0.003 [-0.084; 0.079]) or positive end-expiratory pressure (0.203 [0.126; 0.278])). Similarly, there were no relevant correlations between PVPI and these same respiratory mechanics variables (0.051 [-0.131; 0.035], 0.059 [-0.022; 0.140], 0.072 [-0.090; 0.153] and 0.22 [0.141; 0.293], respectively). In a cohort of patients with COVID-19-induced ARDS, EVLW and PVPI values are independent from respiratory system compliance and driving pressure. Optimal monitoring of these patients should combine both respiratory and TPTD variables.
    Language English
    Publishing date 2023-03-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12052028
    Database MEDical Literature Analysis and Retrieval System OnLINE

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