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  1. Article ; Online: Antitrypanosomal Chloronitrobenzamides.

    Carrillo, Angela K / Kadayat, Tara Man / Hwang, Jong Yeon / Chen, Yizhe / Zhu, Fangyi / Holbrook, Gloria / Gillingwater, Kirsten / Connelly, Michele C / Yang, Lei / Kaiser, Marcel / Guy, R Kiplin

    Journal of medicinal chemistry

    2024  Volume 67, Issue 5, Page(s) 3437–3447

    Abstract: Human African trypanosomiasis (HAT), a neglected tropical disease caused ... ...

    Abstract Human African trypanosomiasis (HAT), a neglected tropical disease caused by
    MeSH term(s) Humans ; Animals ; Mice ; Trypanosomiasis, African/drug therapy ; Trypanosoma brucei rhodesiense ; Trypanosoma brucei gambiense ; Trypanosoma brucei brucei ; Trypanocidal Agents/toxicity ; Trypanocidal Agents/therapeutic use
    Chemical Substances Trypanocidal Agents
    Language English
    Publishing date 2024-02-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 218133-2
    ISSN 1520-4804 ; 0022-2623
    ISSN (online) 1520-4804
    ISSN 0022-2623
    DOI 10.1021/acs.jmedchem.3c01680
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Article ; Online: University-pharmacy partnerships for COVID-19.

    Venditto, Vincent J / Hudspeth, Brooke / Freeman, Patricia R / Kebodeaux, Clark / Guy, R Kiplin

    Science (New York, N.Y.)

    2020  Volume 369, Issue 6510, Page(s) 1441

    MeSH term(s) COVID-19 ; Coronavirus Infections/epidemiology ; Emergency Responders ; Humans ; Pandemics ; Pharmacy ; Pneumonia, Viral/epidemiology ; Universities
    Keywords covid19
    Language English
    Publishing date 2020-11-19
    Publishing country United States
    Document type Letter
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.abe3339
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Optimization of Orally Bioavailable Antileishmanial 2,4,5-Trisubstituted Benzamides.

    Kim, Ho Shin / Ortiz, Diana / Kadayat, Tara Man / Fargo, Corinne M / Hammill, Jared T / Chen, Yizhe / Rice, Amy L / Begley, Kristin L / Shoeran, Gaurav / Pistel, William / Yates, Phillip A / Sanchez, Marco A / Landfear, Scott M / Guy, R Kiplin

    Journal of medicinal chemistry

    2023  Volume 66, Issue 11, Page(s) 7374–7386

    Abstract: Leishmaniasis, a neglected tropical disease caused ... ...

    Abstract Leishmaniasis, a neglected tropical disease caused by
    MeSH term(s) Humans ; Animals ; Mice ; Leishmania ; Leishmaniasis/drug therapy ; Leishmaniasis/chemically induced ; Leishmaniasis/parasitology ; Antiprotozoal Agents/chemistry ; Benzamides/pharmacology ; Benzamides/therapeutic use
    Chemical Substances benzamide (6X80438640) ; Antiprotozoal Agents ; Benzamides
    Language English
    Publishing date 2023-05-22
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 218133-2
    ISSN 1520-4804 ; 0022-2623
    ISSN (online) 1520-4804
    ISSN 0022-2623
    DOI 10.1021/acs.jmedchem.3c00056
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Antimalarials in development in 2014.

    Barnett, David S / Guy, R Kiplin

    Chemical reviews

    2014  Volume 114, Issue 22, Page(s) 11221–11241

    MeSH term(s) Animals ; Antimalarials/chemical synthesis ; Antimalarials/pharmacology ; Drug Design ; High-Throughput Screening Assays ; Humans
    Chemical Substances Antimalarials
    Language English
    Publishing date 2014-11-26
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 207949-5
    ISSN 1520-6890 ; 0009-2665
    ISSN (online) 1520-6890
    ISSN 0009-2665
    DOI 10.1021/cr500543f
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Rapid repurposing of drugs for COVID-19.

    Guy, R Kiplin / DiPaola, Robert S / Romanelli, Frank / Dutch, Rebecca E

    Science (New York, N.Y.)

    2020  Volume 368, Issue 6493, Page(s) 829–830

    MeSH term(s) Antiviral Agents/adverse effects ; Antiviral Agents/therapeutic use ; Betacoronavirus/drug effects ; Betacoronavirus/growth & development ; COVID-19 ; Clinical Trials as Topic ; Coronavirus Infections/drug therapy ; Coronavirus Infections/virology ; Drug Delivery Systems ; Drug Repositioning ; Humans ; Pandemics ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/virology ; SARS-CoV-2
    Chemical Substances Antiviral Agents
    Keywords covid19
    Language English
    Publishing date 2020-05-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.abb9332
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: University–pharmacy partnerships for COVID-19

    Venditto, Vincent J. / Hudspeth, Brooke / Freeman, Patricia R. / Kebodeaux, Clark / Guy, R. Kiplin

    Science

    2020  Volume 369, Issue 6510, Page(s) 1441–1441

    Keywords Multidisciplinary ; covid19
    Language English
    Publisher American Association for the Advancement of Science (AAAS)
    Publishing country us
    Document type Article ; Online
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.abe3339
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Rapid repurposing of drugs for COVID-19

    Guy, R. Kiplin / DiPaola, Robert S. / Romanelli, Frank / Dutch, Rebecca E.

    Science

    2020  Volume 368, Issue 6493, Page(s) 829–830

    Keywords Multidisciplinary ; covid19
    Language English
    Publisher American Association for the Advancement of Science (AAAS)
    Publishing country us
    Document type Article ; Online
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.abb9332
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    In stock of ZB MED Cologne/Königswinter

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  10. Article ; Online: Seeking the Elusive Long-Acting Ozonide: Discovery of Artefenomel (OZ439).

    Kim, Ho Shin / Hammill, Jared T / Guy, R Kiplin

    Journal of medicinal chemistry

    2017  Volume 60, Issue 7, Page(s) 2651–2653

    Abstract: The majority of frontline therapies for the treatment of malaria are combination drugs containing artemisinin (or its semisynthetic analogs), known as artemisinin combination therapies (ACTs). While generally efficacious, ACTs and the first generation ... ...

    Abstract The majority of frontline therapies for the treatment of malaria are combination drugs containing artemisinin (or its semisynthetic analogs), known as artemisinin combination therapies (ACTs). While generally efficacious, ACTs and the first generation fully synthetic ozonide, arterolane (OZ277, 1), suffer from rapid clearance requiring 3-day dosing regimens. Extensive structure-activity studies led to the discovery of a second-generation ozonide, artefenomel (OZ439, 2), which has overcome this limitation, maintaining the rapid onset of action and potent activity of the artemisinin derivatives while exhibiting greatly improved pharmacokinetics, low projected cost of goods, prophylactic activity, and the potential for a single dose cure.
    MeSH term(s) Adamantane/analogs & derivatives ; Adamantane/chemistry ; Adamantane/pharmacology ; Adamantane/therapeutic use ; Animals ; Antimalarials/chemistry ; Antimalarials/pharmacology ; Antimalarials/therapeutic use ; Drug Discovery ; Humans ; Malaria/drug therapy ; Peroxides/chemistry ; Peroxides/pharmacology ; Peroxides/therapeutic use ; Plasmodium/drug effects
    Chemical Substances Antimalarials ; Peroxides ; Adamantane (PJY633525U) ; artefenomel (RIK029813G)
    Language English
    Publishing date 2017-03-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 218133-2
    ISSN 1520-4804 ; 0022-2623
    ISSN (online) 1520-4804
    ISSN 0022-2623
    DOI 10.1021/acs.jmedchem.7b00299
    Database MEDical Literature Analysis and Retrieval System OnLINE

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