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  1. Article ; Online: COVID-19 in a kidney transplant recipient treated with eculizumab for atypical hemolytic uremic syndrome: a case report.

    Cognard, Noëlle / Gautier-Vargas, Gabriela / Perrin, Peggy / Benotmane, Ilies / Caillard, Sophie

    Journal of nephrology

    2021  Volume 34, Issue 4, Page(s) 1045–1048

    MeSH term(s) Antibodies, Monoclonal, Humanized ; Atypical Hemolytic Uremic Syndrome/diagnosis ; Atypical Hemolytic Uremic Syndrome/drug therapy ; COVID-19 ; Humans ; Kidney Transplantation/adverse effects ; SARS-CoV-2
    Chemical Substances Antibodies, Monoclonal, Humanized ; eculizumab (A3ULP0F556)
    Language English
    Publishing date 2021-05-17
    Publishing country Italy
    Document type Case Reports ; Journal Article
    ZDB-ID 1093991-x
    ISSN 1724-6059 ; 1120-3625 ; 1121-8428
    ISSN (online) 1724-6059
    ISSN 1120-3625 ; 1121-8428
    DOI 10.1007/s40620-021-01057-3
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    Zs.A 3369: Show issues Location:
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  2. Article ; Online: Pre-exposure prophylaxis with 300 mg Evusheld elicits limited neutralizing activity against the Omicron variant.

    Benotmane, Ilies / Velay, Aurélie / Gautier-Vargas, Gabriela / Olagne, Jérôme / Thaunat, Olivier / Fafi-Kremer, Samira / Caillard, Sophie

    Kidney international

    2022  Volume 102, Issue 2, Page(s) 442–444

    MeSH term(s) Antibodies, Neutralizing ; Antibodies, Viral ; HIV Infections ; Humans ; Pre-Exposure Prophylaxis
    Chemical Substances Antibodies, Neutralizing ; Antibodies, Viral
    Language English
    Publishing date 2022-05-24
    Publishing country United States
    Document type Letter
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2022.05.008
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    Zs.A 797: Show issues Location:
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  3. Article ; Online: Tixagevimab-cilgavimab as an Early Treatment for COVID-19 in Kidney Transplant Recipients.

    Benotmane, Ilies / Olagne, Jérôme / Gautier-Vargas, Gabriela / Cognard, Noëlle / Heibel, Françoise / Braun-Parvez, Laura / Keller, Nicolas / Martzloff, Jonas / Perrin, Peggy / Pszczolinski, Romain / Moulin, Bruno / Fafi-Kremer, Samira / Caillard, Sophie

    Transplantation

    2023  Volume 107, Issue 8, Page(s) e215–e218

    MeSH term(s) Humans ; COVID-19 ; Kidney Transplantation/adverse effects ; Antibodies, Monoclonal ; Transplant Recipients
    Chemical Substances tixagevimab ; cilgavimab (1KUR4BN70F) ; Antibodies, Monoclonal
    Language English
    Publishing date 2023-07-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208424-7
    ISSN 1534-6080 ; 0041-1337
    ISSN (online) 1534-6080
    ISSN 0041-1337
    DOI 10.1097/TP.0000000000004655
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    Zs.A 488: Show issues Location:
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  4. Article ; Online: Occurrence of

    Masset, Christophe / Gautier-Vargas, Gabriela / Cantarovich, Diego / Ville, Simon / Dantal, Jacques / Delbos, Florent / Walencik, Alexandre / Kerleau, Clarisse / Hourmant, Maryvonne / Garandeau, Claire / Meurette, Aurélie / Giral, Magali / Benotmane, Ilies / Caillard, Sophie / Blancho, Gilles

    Kidney international reports

    2022  Volume 7, Issue 5, Page(s) 983–992

    Abstract: Introduction: Decreased immunosuppression has been proposed for kidney transplant recipients infected with coronavirus disease 2019 (COVID-19), but the impact on the alloreactive immune response during and after infection has been poorly investigated. ... ...

    Abstract Introduction: Decreased immunosuppression has been proposed for kidney transplant recipients infected with coronavirus disease 2019 (COVID-19), but the impact on the alloreactive immune response during and after infection has been poorly investigated. We evaluated the occurrence of antihuman leukocyte antigen (HLA) donor-specific antibodies (DSAs) (post-COVID-19) and rejection episodes after COVID-19 with particular focus on immunosuppression modulation.
    Methods: Kidney transplant recipients from 2 French institutions had anti-HLA antibody screening before and after COVID-19. Management of immunosuppression, rejection episodes, COVID-19 severity, inflammatory markers, and antiviral therapies were recorded.
    Results: From 251 recruited patients, 72 were excluded because of COVID-19-related death (
    Conclusion: The incidence of post-COVID-19 DSA among COVID-19-positive kidney transplant recipients was low (4%) despite a significant decrease in immunosuppression and was mainly restricted to high-risk immunologic patient's status. COVID-19 severity was not associated with post-COVID-19 DSA and/or rejection.
    Language English
    Publishing date 2022-02-07
    Publishing country United States
    Document type Journal Article
    ISSN 2468-0249
    ISSN (online) 2468-0249
    DOI 10.1016/j.ekir.2022.01.1072
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  5. Article: Prediction of Vaccine Response and Development of a Personalized Anti-SARS-CoV-2 Vaccination Strategy in Kidney Transplant Recipients: Results from a Large Single-Center Study.

    Benotmane, Ilies / Gautier-Vargas, Gabriela / Cognard, Noëlle / Olagne, Jérôme / Heibel, Françoise / Braun-Parvez, Laura / Martzloff, Jonas / Perrin, Peggy / Pszczolinski, Romain / Moulin, Bruno / Fafi-Kremer, Samira / Caillard, Sophie

    Journal of personalized medicine

    2022  Volume 12, Issue 7

    Abstract: Kidney transplant recipients (KTRs) displays marked inter-individual variations in magnitude of immune responses to anti-SARS-CoV-2 vaccination. The aim of this large single-center study was to identify the predictive factors for serological response to ... ...

    Abstract Kidney transplant recipients (KTRs) displays marked inter-individual variations in magnitude of immune responses to anti-SARS-CoV-2 vaccination. The aim of this large single-center study was to identify the predictive factors for serological response to the mRNA-1273 vaccine in KTRs. We also devised a score to optimize prediction with the goal of implementing a personalized vaccination strategy. The study population consisted of 564 KTRs who received at least two doses of the mRNA-1273 vaccine. Anti-RBD IgG titers were quantified one month after each vaccine dose and until six months thereafter. A third dose vaccine was given when the antibody titer after the second dose was <143 BAU/mL. A score to optimize prediction of vaccine response was devised using the independent predictors identified in multivariate analysis. The seropositivity rate after the second dose was 46.6% and 22.2% of participants were classified as good responders (titers ≥ 143 BAU/mL). On analyzing the 477 patients for whom serology testing was available after the second or third dose, the global seropositivity rate was 69% (good responders: 46.3%). Immunosuppressive drugs, graft function, age, interval from transplantation, body mass index, and sex were associated with vaccine response. The devised score was strongly associated with the seropositivity rate (AUC = 0.752, p < 0.0001) and the occurrence of a good antibody response (AUC = 0.785, p < 0.0001). Notably, antibody titers declined over time both after the second and third vaccine doses. In summary, a high burden of comorbidities and immunosuppression was correlated with a weaker antibody response. A fourth vaccine dose and/or pre-exposure prophylaxis with monoclonal antibodies should be considered for KTRs who remain unprotected.
    Language English
    Publishing date 2022-07-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm12071107
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  6. Article ; Online: Rapid resolution of cytokine release syndrome and favorable clinical course of severe COVID-19 in a kidney transplant recipient treated with tocilizumab.

    Gautier-Vargas, Gabriela / Baldacini, Clement / Benotmane, Ilies / Keller, Nicolas / Perrin, Peggy / Moulin, Bruno / Caillard, Sophie

    Kidney international

    2020  Volume 98, Issue 2, Page(s) 508–509

    MeSH term(s) Aged ; Antibodies, Monoclonal, Humanized/therapeutic use ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/immunology ; Cytokine Release Syndrome/drug therapy ; Humans ; Kidney Transplantation ; Male ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/immunology ; SARS-CoV-2
    Chemical Substances Antibodies, Monoclonal, Humanized ; tocilizumab (I031V2H011)
    Keywords covid19
    Language English
    Publishing date 2020-06-04
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2020.05.022
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    Zs.A 797: Show issues Location:
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  7. Article ; Online: Pre-exposure prophylaxis with Evusheld™ elicits limited neutralizing activity against the omicron variant in kidney transplant patients

    Benotmane, Ilies / Velay, Aurélie / Thaunant, Olivier / Gautier-Vargas, Gabriela / Olagne, Jérôme / Fafi-Kremer, Samira / Caillard, Sophie

    medRxiv

    Abstract: The combination of cilgavimab–tixagevimab (Evusheld™, Astra Zeneca) became the mainstay for protecting transplant recipients with poor response to vaccination against the omicron variant. Serum neutralizing capacity against SARS-CoV-2 is positively ... ...

    Abstract The combination of cilgavimab–tixagevimab (Evusheld™, Astra Zeneca) became the mainstay for protecting transplant recipients with poor response to vaccination against the omicron variant. Serum neutralizing capacity against SARS-CoV-2 is positively associated with protection against severe forms of Covid-19. Both anti-RBD IgG titers and neutralizing antibody titers against the omicron BA.1 variant were measured in serum samples collected from 63 adult kidney transplant recipients who received prophylactic injections of Evusheld™. Patients who received prophylactic Ronapreve™ (casirivimab–imdevimab, n = 39) and those who were infected with SARS-CoV-2 during the fifth wave of the pandemic (n = 14) served as negative and positive controls, respectively. After a median interval from injection of 29 days (interquartile range 29–33 days), only 9.5% of patients who received Evusheld™ were able to neutralize the omicron variant compared to 71% of patients who were infected with SARS-CoV-2 and 2.6% of those who received Ronapreve™. Interestingly, convalescent patients displayed higher levels of neutralizing antibodies than those who received Evusheld™ (median: 2.3 log IC50, IQR: 1.5–2.7 versus 0.00 log IC50, IQR: 0– 0.05; p<0.001). A high interindividual variability in anti-RBD IgG titers was observed after Evusheld™ (range: 262–7032 BAU/mL). This variability was largely explained by the patients′ body mass index, which showed an inverse correlation with anti–RBD IgG titers. These findings suggest that Evusheld™ given at a dose of 300 mg is not sufficient to elicit an anti-RDB titer that confers in vivo neutralizing activity and support recent FDA recommendations, derived from in vitro models, regarding the need to increase the dose of Evusheld™.
    Keywords covid19
    Language English
    Publishing date 2022-03-23
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2022.03.21.22272669
    Database COVID19

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  8. Article ; Online: Low immunization rates among kidney transplant recipients who received 2 doses of the mRNA-1273 SARS-CoV-2 vaccine.

    Benotmane, Ilies / Gautier-Vargas, Gabriela / Cognard, Noëlle / Olagne, Jérôme / Heibel, Françoise / Braun-Parvez, Laura / Martzloff, Jonas / Perrin, Peggy / Moulin, Bruno / Fafi-Kremer, Samira / Caillard, Sophie

    Kidney international

    2021  Volume 99, Issue 6, Page(s) 1498–1500

    MeSH term(s) COVID-19 ; COVID-19 Vaccines ; Humans ; Immunity ; Immunization ; Kidney Transplantation/adverse effects ; RNA, Messenger ; Renal Replacement Therapy ; SARS-CoV-2 ; Transplant Recipients ; Vaccination
    Chemical Substances COVID-19 Vaccines ; RNA, Messenger
    Language English
    Publishing date 2021-04-20
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2021.04.005
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  9. Article ; Online: Weak anti-SARS-CoV-2 antibody response after the first injection of an mRNA COVID-19 vaccine in kidney transplant recipients.

    Benotmane, Ilies / Gautier-Vargas, Gabriela / Cognard, Noëlle / Olagne, Jérôme / Heibel, Françoise / Braun-Parvez, Laura / Martzloff, Jonas / Perrin, Peggy / Moulin, Bruno / Fafi-Kremer, Samira / Caillard, Sophie

    Kidney international

    2021  Volume 99, Issue 6, Page(s) 1487–1489

    MeSH term(s) Antibody Formation ; COVID-19 ; COVID-19 Vaccines ; Humans ; Kidney Transplantation/adverse effects ; RNA, Messenger ; Renal Replacement Therapy ; SARS-CoV-2 ; Transplant Recipients ; Vaccination
    Chemical Substances COVID-19 Vaccines ; RNA, Messenger
    Language English
    Publishing date 2021-03-26
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2021.03.014
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  10. Article ; Online: Strong antibody response after a first dose of a SARS-CoV-2 mRNA-based vaccine in kidney transplant recipients with a previous history of COVID-19.

    Benotmane, Ilies / Gautier-Vargas, Gabriela / Gallais, Floriane / Gantner, Pierre / Cognard, Noëlle / Olagne, Jérôme / Velay, Aurélie / Heibel, Françoise / Braun-Parvez, Laura / Martzloff, Jonas / Perrin, Peggy / Moulin, Bruno / Fafi-Kremer, Samira / Caillard, Sophie

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

    2021  Volume 21, Issue 11, Page(s) 3808–3810

    MeSH term(s) Antibody Formation ; COVID-19 ; COVID-19 Vaccines ; Humans ; Kidney Transplantation ; RNA, Messenger/genetics ; SARS-CoV-2 ; Transplant Recipients
    Chemical Substances COVID-19 Vaccines ; RNA, Messenger
    Language English
    Publishing date 2021-07-23
    Publishing country United States
    Document type Letter
    ZDB-ID 2060594-8
    ISSN 1600-6143 ; 1600-6135
    ISSN (online) 1600-6143
    ISSN 1600-6135
    DOI 10.1111/ajt.16764
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