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Article ; Online: A case of leprosy in a nonendemic country.

Asperges, Erika / Bagnarino, Jessica / Ancarani, Cinzia / Baggini, Ginevra / Filardo, Matteo / Monzillo, Vincenzina / Barbarini, Daniela / Bruno, Raffaele / Paulli, Marco / Baldanti, Fausto

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

2024 Volume 143, Page(s) 107004

Language	English
Publishing date	2024-03-11
Publishing country	Canada
Document type	Journal Article
ZDB-ID	1331197-9
ISSN	1878-3511 ; 1201-9712
ISSN (online)	1878-3511
ISSN	1201-9712
DOI	10.1016/j.ijid.2024.107004
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Article: The Prognostic Role of Diagnostic Criteria for COVID-19-Associated Pulmonary Aspergillosis: A Cross-Sectional Retrospective Study.

Asperges, Erika / Pesare, Rebecca / Bassoli, Cecilia / Calia, Matteo / Lerta, Sonia / Citiolo, Francesco / Albi, Giuseppe / Cavanna, Caterina / Sacchi, Paolo / Bruno, Raffaele

Antibiotics (Basel, Switzerland)

2024 Volume 13, Issue 2

Abstract: Several criteria exist to diagnose pulmonary aspergillosis with varying degrees of certainty in specific populations, including oncohaematological patients (EORTC/MSG), ICU patients (mAspICU) and COVID-19 patients (ECMM). At the beginning of the pandemic, ...

Abstract	Several criteria exist to diagnose pulmonary aspergillosis with varying degrees of certainty in specific populations, including oncohaematological patients (EORTC/MSG), ICU patients (mAspICU) and COVID-19 patients (ECMM). At the beginning of the pandemic, however, the diagnosis of COVID-19-Associated Pulmonary Aspergillosis (CAPA) could not be performed easily, and the decision to treat (DTT) was empirical. In this cross-sectional retrospective study including patients with SARS-CoV-2 infection and suspicion of CAPA, we studied the concordance between the DTT and the three diagnostic criteria using Cohen's coefficient, and then we identified the factors associated with the DTT and corrected them by treatment to study the influence of the diagnostic criteria on survival. We showed good concordance of the DTT and mAspICU and ECMM criteria, with "compatible signs", "positive culture" and "positive galactomannan" influencing the DTT. Treatment also showed a positive effect on survival once corrected for a putative, possible or probable diagnosis of CAPA using mAspICU and ECMM criteria. We conclude that EORTC/MSGERC are not considered applicable in clinical practice due to the lack of inclusion of signs and symptoms and do not lead to improved survival. mAspICU and ECMM criteria showed a good degree of agreement with the DTT and a positive correlation with patient recovery.
Language	English
Publishing date	2024-02-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2681345-2
ISSN	2079-6382
ISSN	2079-6382
DOI	10.3390/antibiotics13020150
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Article ; Online: A Case Report of Disseminated Histoplasmosis in AIDS Diagnosed Through Peripheral Blood Smear.

Asperges, Erika / Cavanna, Caterina / Mollaschi, Eva M G / Seminari, Elena M

Current HIV research

2021 Volume 19, Issue 5, Page(s) 457–459

Abstract: Background: Histoplasma capsulatum is an environmental fungus that causes opportunistic infections in AIDS patients in endemic areas but is uncommon in Europe. It shares clinical features with other opportunistic infections and lymphoproliferative ... ...

Abstract	Background: Histoplasma capsulatum is an environmental fungus that causes opportunistic infections in AIDS patients in endemic areas but is uncommon in Europe. It shares clinical features with other opportunistic infections and lymphoproliferative disorders common in AIDS patients. The World Health Organization included Histoplasma antigen tests on the Lists of Essential In Vitro Diagnostics, however, they are not routinely available in non-endemic countries. Consequently, mycoses can be a great challenge for clinicians in non-endemic countries. Case presentation: We report the case of a 42-year-old Colombian woman admitted to an Italian university hospital with diarrhea, acute renal failure, psychomotor impairment and fever. When a screening HIV test came back positive, she was screened for opportunistic infections with no results. Given the severity of her clinical condition a broad spectrum antibacterial and antifungal therapy was started in addition to HAART. A blood smear documented leucocytes inclusions, identified as capsular structures. On suspicion of Histoplasma capsulatum the patient was started on empiric amphotericin B. The diagnosis was confirmed by positive serology. Despite therapy, the patient died shortly after. In the following days, the mycology laboratory managed to grow Histoplasma capsulatum, thus confirming the diagnosis of invasive histoplasmosis in AIDS. Conclusion: The case highlights the need for a high index of suspicion for the diagnosis of endemic mycosis outside of endemic areas, and the necessity of expanding access to tests. Even if antigen/ antibody tests are not available, however, blood smear has worldwide feasibility and allows a rapid diagnosis.
MeSH term(s)	AIDS-Related Opportunistic Infections/diagnosis ; AIDS-Related Opportunistic Infections/drug therapy ; AIDS-Related Opportunistic Infections/epidemiology ; Acquired Immunodeficiency Syndrome/complications ; Adult ; Female ; HIV Infections/complications ; Histoplasma ; Histoplasmosis/diagnosis ; Histoplasmosis/drug therapy ; Humans
Language	English
Publishing date	2021-06-10
Publishing country	Netherlands
Document type	Case Reports
ZDB-ID	2192348-6
ISSN	1873-4251 ; 1570-162X
ISSN (online)	1873-4251
ISSN	1570-162X
DOI	10.2174/1570162X19666210607120404
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Article ; Online: Performance of existing definitions and tests for the diagnosis of invasive aspergillosis in critically ill, non-neutropenic, adult patients: An update including COVID-19 data.

Bassetti, Matteo / Zuccaro, Valentina / Asperges, Erika / Scudeller, Luigia / Giacobbe, Daniele Roberto

The Journal of infection

2022 Volume 85, Issue 5, Page(s) 573–607

MeSH term(s)	Adult ; Aspergillosis/diagnosis ; COVID-19 ; COVID-19 Testing ; Critical Illness ; Humans ; Intensive Care Units ; Invasive Fungal Infections ; Invasive Pulmonary Aspergillosis/diagnosis
Language	English
Publishing date	2022-08-05
Publishing country	England
Document type	Letter
ZDB-ID	424417-5
ISSN	1532-2742 ; 0163-4453
ISSN (online)	1532-2742
ISSN	0163-4453
DOI	10.1016/j.jinf.2022.08.003
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Zs.A 1501: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: PK/PD and antiviral activity of anti-HCV therapy: is there still a role in the choice of treatment?

Zuccaro, Valentina / Lombardi, Andrea / Asperges, Erika / Sacchi, Paolo / Bruno, Raffaele

Expert opinion on drug metabolism & toxicology

2020 Volume 16, Issue 2, Page(s) 97–101

Abstract: ... ...

Abstract	Introduction
MeSH term(s)	Antiviral Agents/pharmacokinetics ; Antiviral Agents/pharmacology ; Drug Resistance, Viral ; Hepacivirus/drug effects ; Hepatitis C/drug therapy ; Hepatitis C/virology ; Humans
Chemical Substances	Antiviral Agents
Language	English
Publishing date	2020-01-31
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2214462-6
ISSN	1744-7607 ; 1742-5255
ISSN (online)	1744-7607
ISSN	1742-5255
DOI	10.1080/17425255.2020.1721459
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Article: HBV and HDV: New Treatments on the Horizon.

Zuccaro, Valentina / Asperges, Erika / Colaneri, Marta / Marvulli, Lea Nadia / Bruno, Raffaele

Journal of clinical medicine

2021 Volume 10, Issue 18

Abstract: Despite the accumulating knowledge, chronic hepatitis B (CHB) and HDV infection represent a global health problem, and there are still several critical issues, which frequently remain uncovered. In this paper, we provided an overview of the current ... ...

Abstract	Despite the accumulating knowledge, chronic hepatitis B (CHB) and HDV infection represent a global health problem, and there are still several critical issues, which frequently remain uncovered. In this paper, we provided an overview of the current therapeutic options and summarized the investigational therapies in the pipeline. Furthermore, we discussed some critical issues such as a "functional cure" approach, the futility of long-term NA therapy and the relevance of understanding drug actions and safety of antivirals, especially in special populations.
Language	English
Publishing date	2021-09-08
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm10184054
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Article: Despite Vaccination: A Real-Life Experience of Severe and Life-Threatening COVID-19 in Vaccinated and Unvaccinated Patients.

Colaneri, Marta / Asperges, Erika / Calia, Matteo / Sacchi, Paolo / Rettani, Marco / Cutti, Sara / Albi, Giuseppe / Bruno, Raffaele

Vaccines

2022 Volume 10, Issue 9

Abstract: ... associated to the vaccination status (e.g., p = 0.2 with three doses), while older age, sepsis, and non ...

Abstract	Some vaccinated individuals still develop severe COVID-19, and the underlying causes are not entirely understood. We aimed at identifying demographic, clinical, and coinfection characteristics of vaccinated patients who were hospitalized. We also hypothesized that coinfections might play a role in disease severity and mortality. We retrospectively collected data from our COVID-19 registry for whom vaccination data were available. Patients were split into groups based on the number of administered doses (zero, one, two, or three). Data were assessed with Chi-square and Kruskal−Wallis tests and multiple logistic regression analysis. We collected data from 1686 patients and found that intra-hospital mortality was not associated to the vaccination status (e.g., p = 0.2 with three doses), while older age, sepsis, and non-viral pneumonia were (p < 0.001). Unvaccinated patients needed mechanical ventilation more often (8.5%) than vaccinated patients, in whom the probability of mechanical ventilation decreased with increasing doses (8.7%, 2.8%, 0%). We did not find more coinfections in vaccinated people. We concluded that there is a lack of real-life data to adequately characterize the pathophysiology and risk factors of patients who develop severe COVID-19, but coinfections do not appear to play a role in disease severity.
Language	English
Publishing date	2022-09-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2703319-3
ISSN	2076-393X
ISSN	2076-393X
DOI	10.3390/vaccines10091540
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Article: Psychological Support in a COVID-19 Hospital: A Community Case Study.

Rizzi, Damiano / Asperges, Erika / Rovati, Anna / Bigoni, Francesca / Pistillo, Elena / Corsico, Angelo / Mojoli, Francesco / Perlini, Stefano / Bruno, Raffaele

Frontiers in psychology

2022 Volume 12, Page(s) 820074

Abstract: Burnout is a well-documented entity in Care Workers population, affecting up to 50% of physicians, just as it is equally well established that managing an infectious disease outbreaks, such as confirmed in the COVID-19 pandemic, increases Post-Traumatic ... ...

Abstract	Burnout is a well-documented entity in Care Workers population, affecting up to 50% of physicians, just as it is equally well established that managing an infectious disease outbreaks, such as confirmed in the COVID-19 pandemic, increases Post-Traumatic Stress Disorder (PTSD) and the psychological burden. Mental health support, in the form of formal or remote sessions, has been shown to be helpful to health care staff, despite the organizational difficulties in an emergency. During the first emergence of COVID-19 in Italy, the Scientific Institute for Research, Hospitalization and Health Care
Language	English
Publishing date	2022-02-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2021.820074
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Article ; Online: Performance of existing clinical scores and laboratory tests for the diagnosis of invasive candidiasis in critically ill, nonneutropenic, adult patients: A systematic review with qualitative evidence synthesis.

Giacobbe, Daniele Roberto / Asperges, Erika / Cortegiani, Andrea / Grecchi, Cecilia / Rebuffi, Chiara / Zuccaro, Valentina / Scudeller, Luigia / Bassetti, Matteo

Mycoses

2022 Volume 65, Issue 12, Page(s) 1073–1111

Abstract: Background: The Fungal Infections Definitions in Intensive Care Unit (ICU) patients (FUNDICU) project aims to provide standard sets of definitions for invasive fungal diseases in critically ill, adult patients.: Objectives: To summarise the available ...

Abstract	Background: The Fungal Infections Definitions in Intensive Care Unit (ICU) patients (FUNDICU) project aims to provide standard sets of definitions for invasive fungal diseases in critically ill, adult patients. Objectives: To summarise the available evidence on the diagnostic performance of clinical scores and laboratory tests for invasive candidiasis (IC) in nonneutropenic, adult critically ill patients. Methods: A systematic review was performed to evaluate studies assessing the diagnostic performance for IC of clinical scores and/or laboratory tests vs. a reference standard or a reference definition in critically ill, nonneutropenic, adult patients in ICU. Results: Clinical scores, despite the heterogeneity of study populations and IC prevalences, constantly showed a high negative predictive value (NPV) and a low positive predictive value (PPV) for the diagnosis of IC in the target population. Fungal antigen-based biomarkers (with most studies assessing serum beta-D-glucan) retained a high NPV similar to that of clinical scores, with a higher PPV, although the latter showed important heterogeneity across studies, possibly reflecting the targeted or untargeted use of these tests in patients with a consistent clinical picture and risk factors for IC. Conclusions: Both clinical scores and laboratory tests showed high NPV for the diagnosis of IC in nonneutropenic critically ill patients. The PPV of laboratory tests varies significantly according to the baseline patients' risk of IC. This qualitative synthesis will provide the FUNDICU panel with baseline evidence to be considered during the development of definitions of IC in critically ill, nonneutropenic adult patients in ICU.
MeSH term(s)	Adult ; Humans ; Critical Illness ; Prospective Studies ; Candidiasis, Invasive/microbiology ; Critical Care ; Intensive Care Units ; Antifungal Agents/therapeutic use
Chemical Substances	Antifungal Agents
Language	English
Publishing date	2022-09-04
Publishing country	Germany
Document type	Systematic Review ; Journal Article ; Review
ZDB-ID	392487-7
ISSN	1439-0507 ; 0933-7407
ISSN (online)	1439-0507
ISSN	0933-7407
DOI	10.1111/myc.13515
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Article ; Online: The infection risk after transjugular intrahepatic portosystemic shunt: A multiple competing risk analysis from a tertiary care center.

Colaneri, Marta / Lombardi, Andrea / Maffezzoni, Marcello / Sambo, Margherita / Fabbiani, Massimiliano / Quaretti, Pietro / Asperges, Erika / Moramarco, Lorenzo / Sacchi, Paolo / Bruno, Raffaele

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver

2022 Volume 54, Issue 12, Page(s) 1686–1690

Abstract: Background: Infections following transjugular intrahepatic portosystemic shunt (TIPS) placement have been poorly described. We aim to investigate the rate and the potential predictors of infections occurring after TIPS placement.: Methods: Single ... ...

Abstract	Background: Infections following transjugular intrahepatic portosystemic shunt (TIPS) placement have been poorly described. We aim to investigate the rate and the potential predictors of infections occurring after TIPS placement. Methods: Single center, retrospective, observational study. All patients who had undergone TIPS placement in the last 10 years with a minimum 1-year FU, were considered. Multiple competing risk analyses were performed to identify infection risk factors and a multivariable Cox proportional-hazard regression model to evaluate the predictors of death. Results: Forty-nine patients were considered. Among these, 23 (46%) developed at least 1 infection during the FU, at a median time of 237.7 days (IQR 151.5) from the TIPS placement. We did not find any predictor of infection, while MELD score and cancer were associated with death (p = .04; HR 1.14; CI 1.00- 1.30). Conclusion: We found a high rate of all-type infections during the FU times. However, most of these infections occurred as late-onset infections and were caused by Gram-positive microorganisms. Thus, TIPS procedure itself does not seem to be burdened with high infectious perioperative risk.
MeSH term(s)	Humans ; Portasystemic Shunt, Transjugular Intrahepatic/adverse effects ; Portasystemic Shunt, Transjugular Intrahepatic/methods ; Retrospective Studies ; Tertiary Care Centers ; Proportional Hazards Models ; Risk Assessment ; Treatment Outcome
Language	English
Publishing date	2022-06-11
Publishing country	Netherlands
Document type	Observational Study ; Journal Article
ZDB-ID	1459373-7
ISSN	1878-3562 ; 1125-8055
ISSN (online)	1878-3562
ISSN	1125-8055
DOI	10.1016/j.dld.2022.05.005
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