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Article ; Online: A case of hypoparathyroidism, sensorineural deafness, and renal dysplasia syndrome with kidney failure and recurrent pancreatitis: Questions.

Yoshino, Atsunori / Kawamoto, Shinya / Abe, Toshihiro / Hidaka, Yuji / Muroya, Koji / Tokumoto, Tadahiko / Takeda, Tetsuro

Pediatric nephrology (Berlin, Germany)

2021 Volume 36, Issue 12, Page(s) 4067–4069

Language	English
Publishing date	2021-07-29
Publishing country	Germany
Document type	Journal Article
ZDB-ID	631932-4
ISSN	1432-198X ; 0931-041X
ISSN (online)	1432-198X
ISSN	0931-041X
DOI	10.1007/s00467-021-05183-9
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Zs.A 2196: Show issues

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Article ; Online: A case of hypoparathyroidism, sensorineural deafness, and renal dysplasia syndrome with kidney failure and recurrent pancreatitis: Answers.

Yoshino, Atsunori / Kawamoto, Shinya / Abe, Toshihiro / Hidaka, Yuji / Muroya, Koji / Tokumoto, Tadahiko / Takeda, Tetsuro

Pediatric nephrology (Berlin, Germany)

2021 Volume 36, Issue 12, Page(s) 4071–4075

Language	English
Publishing date	2021-07-29
Publishing country	Germany
Document type	Journal Article
ZDB-ID	631932-4
ISSN	1432-198X ; 0931-041X
ISSN (online)	1432-198X
ISSN	0931-041X
DOI	10.1007/s00467-021-05190-w
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 2196: Show issues

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Article: Effect of Pemafibrate on Hemorheology in Patients with Hypertriglyceridemia and Aggravated Blood Fluidity Associated with Type 2 Diabetes or Metabolic Syndrome.

Iwakura, Tomohiro / Yasu, Takanori / Tomoe, Takashi / Ueno, Asuka / Sugiyama, Takushi / Otani, Naoyuki / Kawamoto, Shinya / Nakajima, Hiroyuki

Journal of clinical medicine

2023 Volume 12, Issue 4

Abstract: Persistent high serum triglyceride (TG) and free fatty acid (FFA) levels, which are common in metabolic syndrome and type 2 diabetes, are risk factors for cardiovascular events because of exacerbated hemorheology. To explore the effects of pemafibrate, a ...

Abstract	Persistent high serum triglyceride (TG) and free fatty acid (FFA) levels, which are common in metabolic syndrome and type 2 diabetes, are risk factors for cardiovascular events because of exacerbated hemorheology. To explore the effects of pemafibrate, a selective peroxisome proliferator-activated receptor alpha modulator, on hemorheology, we performed a single-center, nonrandomized, controlled study in patients with type 2 diabetes (HbA1c 6-10%) or metabolic syndrome, with fasting TG levels of ≥ 150 mg/dL and a whole blood transit time of > 45 s on a microarray channel flow analyzer (MCFAN). Patients were divided into a study group, receiving 0.2 mg/day of pemafibrate (
Language	English
Publishing date	2023-02-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12041481
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Article ; Online: Five-year trends in bacterial contamination of dialysis equipment.

Osono, Eiichi / Honda, Kazumi / Inoue, Yuki / Ichimura, Kyouko / Kamano, Chisako / Kawamoto, Shinya / Norose, Yoshihiko / Takaku, Shun / Morita, Rimpei / Tsuchido, Tetsuaki

Journal of microorganism control

2023 Volume 28, Issue 3, Page(s) 69–75

Abstract: Bedside dialysis monitoring equipment for hemodialysis are located in the bioburden section upstream of the endotoxin-retentive filter for dialysis fluid sterilization. We observed 26 equipment at our institution for bacterial contamination at least once ...

Abstract	Bedside dialysis monitoring equipment for hemodialysis are located in the bioburden section upstream of the endotoxin-retentive filter for dialysis fluid sterilization. We observed 26 equipment at our institution for bacterial contamination at least once every 4 weeks for 5 years with another ultrafiltration membrane upstream to prevent bacterial contamination. Bacterial contamination levels were highest and most diverse at the time of the first flush. During subsequent initial cleanng, the contamination level decreased, and bacterial species converged almost exclusively to one genus, namely Methylobacterium spp. During clinical use, the equipment were cleaned and disinfected daily after dialysis, and daily operations and maintenance were performed using aseptic techniques. Although the frequency of bacterial detection decreased annually, the same bacterial genotypes observed at the first flush were isolated even after long time periods and were thought to persist in the equipment possibly by forming biofilm. Pseudomonas aeruginosa was newly detected after the replacement of parts during breakdown maintenance, indicating the need to sterilize replacement parts. Thus, the bioburden should be assessed regularly as part of the management of in-house-produced dialysis fluid.
MeSH term(s)	Renal Dialysis ; Bacteria/genetics ; Dialysis Solutions ; Ultrafiltration ; Endotoxins
Chemical Substances	Dialysis Solutions ; Endotoxins
Language	English
Publishing date	2023-08-31
Publishing country	Japan
Document type	Journal Article
ISSN	2758-6391
ISSN (online)	2758-6391
DOI	10.4265/jmc.28.3_69
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Article ; Online: Transitional dynamics in oncology clinical trials: evaluating the impact of Clinical Trials Act on cooperative groups.

Nakamura, Kenichi / Takeda, Koji / Saito, Akiko M / Kato, Miho / Sato, Shinya / Nakagawa, Satoshi / Kawamoto, Yasuyuki / Oki, Eiji / Okamoto, Isamu / Okamoto, Hiroaki / Katayama, Hiroshi / Mizusawa, Junki / Kaba, Harumi / Shibata, Taro / Fukuda, Haruhiko

Japanese journal of clinical oncology

2024

Abstract: Objective: large-scale multicentre clinical trials conducted by cooperative groups have generated a lot of evidence to establish better standard treatments. The Clinical Trials Act was enforced on 1 April 2018, in Japan, and it has remarkably increased ... ...

Abstract	Objective: large-scale multicentre clinical trials conducted by cooperative groups have generated a lot of evidence to establish better standard treatments. The Clinical Trials Act was enforced on 1 April 2018, in Japan, and it has remarkably increased the operational burden on investigators, but its long-term impact on cancer cooperative groups is unknown. Methods: a survey was conducted across the nine major cooperative groups that constitute the Japan Cancer Trials Network to assess the impact of Clinical Trials Act on the number of newly initiated trials from fiscal year (from 1 April to 31 March) 2017 to 2022 and that of ongoing trials on 1 April in each year from 2018 to 2023. Results: the number of newly initiated trials dropped from 38 trials in fiscal year 2017 to 26 trials in fiscal year 2018, surged to 50 trials in fiscal year 2019, but then gradually decreased to 25 trials by fiscal year 2022. Specified clinical trials decreased from 32 trials in fiscal year 2019 to 12 trials in fiscal year 2022. The number of ongoing trials was 220 trials in 2018, peaked at 245 trials in 2020, but then gradually decreased to 219 trials by 2023. The number of specified clinical trials has been in consistent decline. By April 2023, of the 20 ongoing non-specified clinical trials, nine adhered to Clinical Trials Act and 11 followed the Ethical Guidelines for Medical and Health Research Involving Human Subjects. Conclusion: the number of multicentre clinical trials in oncology gradually decreased after the Clinical Trials Act's enforcement, which underscores the need for comprehensive amendment of the Clinical Trials Act to streamline the operational process.
Language	English
Publishing date	2024-03-26
Publishing country	England
Document type	Journal Article
ZDB-ID	190978-2
ISSN	1465-3621 ; 0368-2811
ISSN (online)	1465-3621
ISSN	0368-2811
DOI	10.1093/jjco/hyae034
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Zs.A 1298: Show issues

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Article ; Online: Effects of salt intake reduction by urinary sodium to potassium ratio self-monitoring method.

Shimoyama, Masahiro / Kawamoto, Shinya / Nakatani, Yuki / Banba, Nobuyuki / Nagashima, Yasuko / Tomoe, Takashi / Sugiyama, Takushi / Ueno, Asuka / Kitahara, Keijiro / Kawabe, Atsuhiko / Otani, Naoyuki / Sugimura, Hiroyuki / Yasu, Takanori

Hypertension research : official journal of the Japanese Society of Hypertension

2024

Abstract: Effective and feasible educational methods are needed to control salt intake. We performed a single-center, non-randomized controlled study to investigate the effectiveness and feasibility of self-monitoring using a urinary sodium/potassium (Na/K) ratio- ... ...

Abstract	Effective and feasible educational methods are needed to control salt intake. We performed a single-center, non-randomized controlled study to investigate the effectiveness and feasibility of self-monitoring using a urinary sodium/potassium (Na/K) ratio-measuring device in patients with difficulty in reducing salt intake. This study included 160 patients with hypertension, chronic kidney disease, or heart disease who were followed up in the outpatient clinic of the Dokkyo Medical University Nikko Medical Center. Urinary Na/K ratio measuring Na/K ratio meter were loaned for 2-6 weeks to the treatment (T) group (n = 80) and not to the patients in the control (C) group (n = 80). In the T group, patients were instructed to measure the urinary Na/K ratio at least three times a day and maintain a Na/K ratio below 2.0. Salt reduction education and home blood pressure measurement guidance continued in both groups. The mean device loan period in the T group was 25.1 days, the mean number of measurements was 3.0 times/day, and the proportion of patients achieving three measurements per day was 48.8% (39/80). Self-monitoring using the urinary Na/K ratio meter successfully reduced salt intake by -1.9 g/day at the second visit (p < 0.001) in the T group. In contrast, no change was observed over time in the C group. Self-monitoring using the urinary Na/K ratio meter successfully reduced salt intake in patients with difficulty reducing salt intake.
Language	English
Publishing date	2024-04-10
Publishing country	England
Document type	Journal Article
ZDB-ID	1175297-x
ISSN	1348-4214 ; 0916-9636
ISSN (online)	1348-4214
ISSN	0916-9636
DOI	10.1038/s41440-024-01655-1
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Zs.A 3898: Show issues

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Article: [ANCA-related glomerulonephritis in an aged patient with diabetes mellitus successfully released from hemodialysis by low dose steroid therapy: a case report].

Kawamoto, Shinya

Nihon Jinzo Gakkai shi

2011 Volume 53, Issue 4, Page(s) 642–647

Abstract: A 86-year-old man had been treated for hypertension, diabetes mellitus (DM), and dyslipidemia in Nihonkoukan Hospital. His renal function was within the normal range in August 2007. He showed common cold-like symptoms, which were not improved by anti- ... ...

Abstract	A 86-year-old man had been treated for hypertension, diabetes mellitus (DM), and dyslipidemia in Nihonkoukan Hospital. His renal function was within the normal range in August 2007. He showed common cold-like symptoms, which were not improved by anti-inflammatory drugs in December 2007. He was admitted to our hospital because of renal failure, urine protein and urine occult blood. He was also positive for anti-myeloperoxidase antibody (MPO-ANCA; 129 IU/mL). A renal biopsy revealed idiopathic crescentic glomerulonephritis of the pauci immune type. Considering his advanced age and DM, he was treated with the low dose of 20 mg/day of prednisolone. Although his symptoms, such as low grade fever and general fatigue, were improved after steroid therapy, renal failure accelerated, necessitating hemodialysis (HD), and insulin administration was needed for his DM. Subsequently, an AV fistule operation for HD was performed. Prednisolone was tapered to 17.5 mg/day after 4 weeks, and his MPO-ANCA titer decreased to 87 IU/mL. After steroid treatment and HD, his condition gradually recovered and he was discharged on March 5, 2008. Following about 6 months of treatment with prednisolone (3.5 months after HD administration), his renal function gradually recovered, allowing the discontinuation of HD. High-dose steroid therapy is very effective for ANCA-related glomerulonephritis. However, there is a high risk of infection, especially in aged and DM patients. Low-dose steroid therapy (PSL 20 mg/day) is safe and effective in such high-risk patients and in some cases, they can be released from HD.
MeSH term(s)	Aged, 80 and over ; Antibodies, Antineutrophil Cytoplasmic/blood ; Biomarkers/blood ; Diabetes Complications/drug therapy ; Drug Administration Schedule ; Glomerulonephritis/immunology ; Glomerulonephritis/therapy ; Humans ; Insulin/administration & dosage ; Male ; Peroxidase/immunology ; Prednisolone/administration & dosage ; Renal Dialysis ; Risk ; Treatment Outcome
Chemical Substances	Antibodies, Antineutrophil Cytoplasmic ; Biomarkers ; Insulin ; Prednisolone (9PHQ9Y1OLM) ; Peroxidase (EC 1.11.1.7)
Language	Japanese
Publishing date	2011
Publishing country	Japan
Document type	Case Reports ; English Abstract ; Journal Article
ZDB-ID	1195538-7
ISSN	0385-2385
ISSN	0385-2385
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Zs.A 1383: Show issues

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Article: Correction to: Catalytic pyrolysis of cellulose in sulfolane with some acidic catalysts

Kawamoto, Haruo / Hatanaka, Wataru / Saito, Shinya / Saka, Shiro

Journal of wood science. 2018 Dec., v. 64, no. 6

2018

Abstract: The article Catalytic pyrolysis of cellulose in sulfolane with some acidic catalysts. ...

Abstract	The article Catalytic pyrolysis of cellulose in sulfolane with some acidic catalysts.
Keywords	catalysts ; cellulose ; pyrolysis
Language	English
Dates of publication	2018-12
Size	p. 880.
Publishing place	Springer Singapore
Document type	Article
Note	Published Erratum
ZDB-ID	1429032-7
ISSN	1435-0211
ISSN	1435-0211
DOI	10.1007/s10086-018-1778-9
Database	NAL-Catalogue (AGRICOLA)

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Z 6929: Show issues

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Article: CA125 Kinetics as a Potential Biomarker for Peritoneal Metastasis Progression following Taxane-Plus-Ramucirumab Administration in Patients with Advanced Gastric Cancer.

Ueda, Akira / Yuki, Satoshi / Ando, Takayuki / Hosokawa, Ayumu / Nakada, Naokatsu / Kito, Yosuke / Motoo, Iori / Ito, Ken / Sakumura, Miho / Nakayama, Yurika / Ueda, Yuko / Kajiura, Shinya / Nakashima, Koji / Harada, Kazuaki / Kawamoto, Yasuyuki / Komatsu, Yoshito / Yasuda, Ichiro

Cancers

2024 Volume 16, Issue 5

Abstract: Currently, no established marker exists for predicting peritoneal metastasis progression during chemotherapy, although they are major interruptive factors in sequential chemotherapy in patients with advanced gastric cancer (AGC). This multicenter ... ...

Abstract	Currently, no established marker exists for predicting peritoneal metastasis progression during chemotherapy, although they are major interruptive factors in sequential chemotherapy in patients with advanced gastric cancer (AGC). This multicenter retrospective study was conducted from June 2015 to July 2019, analyzing 73 patients with AGC who underwent taxane-plus-ramucirumab (TAX/RAM) therapy and had their serum carbohydrate antigen 125 (CA125) concentrations measured. Of 31 patients with elevated CA125 levels above a cutoff of 35 U/mL, 25 (80.6%) had peritoneal metastasis. The CA125 concentrations before TAX/RAM treatment were associated with ascites burden. The overall survival was significantly shorter in the CA125-elevated group. CA125 kinetics, measured at a median of 28 days after chemotherapy, were associated with the ascites response (complete or partial response: -1.86%/day; stable disease: 0.28%/day; progressive disease: 2.33%/day). Progression-free survival in the CA125-increased group, defined by an increase of 0.0067%/day using receiver operating characteristic curve analysis, was significantly poorer among patients with peritoneal metastases. In conclusion, this study highlights that CA125 kinetics can serve as an early predictor for the progression of peritoneal metastasis during TAX/RAM treatment.
Language	English
Publishing date	2024-02-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers16050871
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Article: A Case of Femoral Neck Insufficiency Fracture due to Tumor-Induced Osteomalacia.

Inoue, Yu / Fukui, Tomoaki / Oe, Keisuke / Hayashi, Shinya / Kawamoto, Teruya / Kuroda, Ryosuke / Niikura, Takahiro

Case reports in orthopedics

2021 Volume 2021, Page(s) 6668006

Abstract: Tumor-induced osteomalacia (TIO) is a rare skeletal disease caused by hypersecretion of fibroblast growth factor 23 (FGF-23) from neoplasms of mesenchymal origin; patients with TIO present with insufficiency fractures, progressive bone pain, and delayed ... ...

Abstract	Tumor-induced osteomalacia (TIO) is a rare skeletal disease caused by hypersecretion of fibroblast growth factor 23 (FGF-23) from neoplasms of mesenchymal origin; patients with TIO present with insufficiency fractures, progressive bone pain, and delayed fracture unions. Herein, we report the case of a 48-year-old man with an insufficiency fracture in his left femoral neck associated with TIO. The causative tumor located in the patient's maxillary sinus had been resected; however, complete resection was impossible due to the location of the tumor. Therefore, the patient's osteomalacia persisted, and he experienced a left femoral neck fracture in the absence of severe trauma. Because delayed fracture union was anticipated in this patient, we performed an internal fixation using an implant with a lateral plate for angular stability and multiple screws for rotational stability. Although fracture union took 15 months, the patient's postoperative course was uneventful, and he could walk without any symptoms or assistance at his most recent follow-up 30 months after surgery. In TIO, hypersecretion of FGF-23 leads to increased renal excretion of phosphorus, increased bone resorption of calcium and phosphorus, decreased osteoblastic bone mineralization, and decreased gastrointestinal absorption of calcium and phosphorus, leading to insufficiency fractures and delayed fracture unions. Diagnosis of TIO is often delayed due to its rarity and vague symptoms. Total resection of the causative tumor is the optimal treatment; however, in cases wherein complete tumor resection is impossible, drug therapy may be insufficient, and the underlying TIO pathology, including bone fragility, may persist. Early diagnosis of TIO is important for preventing insufficiency fractures; however, when fractures are unavoidable, the surgical treatment of femoral neck fractures in patients with osteomalacia should account for a longer time frame for complete fracture union and therefore utilize implants with sufficient stability.
Language	English
Publishing date	2021-10-06
Publishing country	United States
Document type	Case Reports
ZDB-ID	2684648-2
ISSN	2090-6757 ; 2090-6749
ISSN (online)	2090-6757
ISSN	2090-6749
DOI	10.1155/2021/6668006
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