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Article ; Online: Cotrimoxazole and targeted antibiotic prophylaxis for transrectal prostate biopsy: a single-center study.

Jahnen, Matthias / Amiel, Thomas / Kirchoff, Florian / Büchler, Jacob W / Herkommer, Kathleen / Rothe, Kathrin / Meissner, Valentin H / Gschwend, Jürgen E / Lunger, Lukas

World journal of urology

2024 Volume 42, Issue 1, Page(s) 260

Abstract: Purpose: The recent restriction on the use of fluoroquinolones for prophylaxis by the European Commission has left a gap in clear recommendations for practical antibiotic prophylaxis (PAP) for transrectal prostate biopsy (TRPB). This analysis ... ...

Abstract	Purpose: The recent restriction on the use of fluoroquinolones for prophylaxis by the European Commission has left a gap in clear recommendations for practical antibiotic prophylaxis (PAP) for transrectal prostate biopsy (TRPB). This analysis investigated the viability of cotrimoxazole for PAP in TRPB. Methods: This analysis included n = 697 patients who underwent TRPB for suspected prostate cancer (PCa). All patients received either empiric PAP with four doses of cotrimoxazole 960 mg or targeted antibiotic prophylaxis in case of a positive rectal or urine screening for multiresistant gram-negatives. Infectious complications after TRPB, microbiological findings, and clinical characteristics were evaluated. A multivariable logistic regression model was calculated to identify variables associated with infectious complications. Results: Of the cohort, 86% (600/697) received PAP with cotrimoxazole, 1% (8/697) received cotrimoxazole plus an additional antibiotic, 4% (28/697) received amoxicillin + clavulanic acid, 4% (28/697) received fluoroquinolones, and 5% (33/697) received a single shot intravenous antibiotic prophylaxis with meropenem or piperacillin + tazobactam due to multiresistant microbiological findings in either pre-interventional urine culture or rectal swab. Infectious complications occurred in 2.6% (18/697) of patients. Fever was noted in 89% (16/18) of cases. Inpatient treatment was given to 67% (12/18) of affected patients, with 38% (7/18) having positive blood cultures, identifying cotrimoxazole-resistant E. coli strains in six out of seven cases. Multivariable logistic regression analysis revealed no clinically significant variables, including PAP with cotrimoxazole, as independent risk factors for an infectious complication. Conclusions: Using cotrimoxazole as PAP for TRPB in cases without multiresistant gram-negatives in pre-interventional urine cultures or rectal swabs seems feasible and practical.
MeSH term(s)	Humans ; Male ; Trimethoprim, Sulfamethoxazole Drug Combination/therapeutic use ; Antibiotic Prophylaxis/methods ; Aged ; Middle Aged ; Prostate/pathology ; Rectum/microbiology ; Anti-Bacterial Agents/therapeutic use ; Prostatic Neoplasms/pathology ; Retrospective Studies ; Biopsy/methods ; Biopsy/adverse effects
Chemical Substances	Trimethoprim, Sulfamethoxazole Drug Combination (8064-90-2) ; Anti-Bacterial Agents
Language	English
Publishing date	2024-04-25
Publishing country	Germany
Document type	Journal Article
ZDB-ID	380333-8
ISSN	1433-8726 ; 0724-4983
ISSN (online)	1433-8726
ISSN	0724-4983
DOI	10.1007/s00345-024-04969-4
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Article: Evaluation of Self-Collected Versus Health Care Professional (HCP)-Performed Sampling and the Potential Impact on the Diagnostic Results of Asymptomatic Sexually Transmitted Infections (STIs) in High-Risk Individuals.

Weidlich, Simon / Schellberg, Sven / Scholten, Stefan / Schneider, Jochen / Lee, Marcel / Rothe, Kathrin / Wantia, Nina / Spinner, Christoph D / Noe, Sebastian

Infectious disease reports

2023 Volume 15, Issue 5, Page(s) 470–477

Abstract: Sexually transmitted infections (STIs) are increasing among men who have sex with men (MSM). Screening can improve the detection and outcome of asymptomatic STIs in high-risk populations. Self-sampling may be a resource-optimized strategy; however, its ... ...

Abstract	Sexually transmitted infections (STIs) are increasing among men who have sex with men (MSM). Screening can improve the detection and outcome of asymptomatic STIs in high-risk populations. Self-sampling may be a resource-optimized strategy; however, its diagnostic reliability compared to testing by healthcare professionals (HCPs) requires further investigation. In this prospective, multicenter cohort study in a high-income country, asymptomatic MSM with a sexual risk profile for STIs were included. Sequential swabs for STI nucleic acid-based diagnosis of
Language	English
Publishing date	2023-08-25
Publishing country	Switzerland
Document type	Journal Article
ISSN	2036-7430
ISSN	2036-7430
DOI	10.3390/idr15050047
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Galactomannan-Antigen Testing from Non-Directed Bronchial Lavage for Rapid Detection of Invasive Pulmonary Aspergillosis in Critically Ill Patients: A Proof-of-Concept Study.

Rothe, Kathrin / Dibos, Miriam / Haschka, Stefanie J / Schmid, Roland M / Busch, Dirk / Rasch, Sebastian / Lahmer, Tobias

Diagnostics (Basel, Switzerland)

2023 Volume 13, Issue 6

Abstract: Invasive pulmonary aspergillosis is associated with high mortality. For diagnosis, galactomannan-antigen in serum and bronchoalveolar lavage fluid is recommended, with higher sensitivity in bronchoalveolar lavage fluid. Because of invasiveness, ... ...

Abstract	Invasive pulmonary aspergillosis is associated with high mortality. For diagnosis, galactomannan-antigen in serum and bronchoalveolar lavage fluid is recommended, with higher sensitivity in bronchoalveolar lavage fluid. Because of invasiveness, bronchoalveolar lavage might be withheld due to patients' or technical limitations, leading to a delay in diagnosis while early diagnosis is crucial for patient outcome. To address this problem, we performed an analysis of patient characteristics of intubated patients with invasive pulmonary aspergillosis with comparison of galactomannan-antigen testing between non-directed bronchial lavage (NBL) and bronchoalveolar lavage fluid. A total of 32 intubated ICU patients with suspected invasive pulmonary aspergillosis could be identified. Mycological cultures were positive in 37.5% for
Language	English
Publishing date	2023-03-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics13061190
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Conference proceedings: Increased SLAMF7 expression on monocytes in rheumatoid arthritis

Spatzier, Hannah Rebekka / Braune, Laurin / Glimm, Anne-Marie / Seifert, Olga / Krasselt, Marco / Pierer, Matthias / Wagner, Ulf / Rothe, Kathrin

2023 , Page(s) ET.05

Event/congress	Deutscher Rheumatologiekongress 2023, 51. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 37. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), 33. Jahrestagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR); Leipzig; ; Gesellschaft für Kinder- und Jugendrheumatologie; 2023
Keywords	Medizin, Gesundheit
Publishing date	2023-08-30
Publisher	German Medical Science GMS Publishing House; Düsseldorf
Document type	Conference proceedings
DOI	10.3205/23dgrh025
Database	German Medical Science

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Article ; Online: Influence of a chronic beta-blocker therapy on perioperative opioid consumption - a post hoc secondary analysis.

Trauzeddel, Ralf F / Rothe, Luisa M / Nordine, Michael / Dehé, Lukas / Scholtz, Kathrin / Spies, Claudia / Hadzidiakos, Daniel / Winterer, Georg / Borchers, Friedrich / Kruppa, Jochen / Treskatsch, Sascha

BMC anesthesiology

2024 Volume 24, Issue 1, Page(s) 80

Abstract: Background: Beta-blocker (BB) therapy plays a central role in the treatment of cardiovascular diseases. An increasing number of patients with cardiovascular diseases undergoe noncardiac surgery, where opioids are an integral part of the ... ...

Abstract	Background: Beta-blocker (BB) therapy plays a central role in the treatment of cardiovascular diseases. An increasing number of patients with cardiovascular diseases undergoe noncardiac surgery, where opioids are an integral part of the anesthesiological management. There is evidence to suggest that short-term intravenous BB therapy may influence perioperative opioid requirements due to an assumed cross-talk between G-protein coupled beta-adrenergic and opioid receptors. Whether chronic BB therapy could also have an influence on perioperative opioid requirements is unclear. Methods: A post hoc analysis of prospectively collected data from a multicenter observational (BioCog) study was performed. Inclusion criteria consisted of elderly patients (≥ 65 years) undergoing elective noncardiac surgery as well as total intravenous general anesthesia without the use of regional anesthesia and duration of anesthesia ≥ 60 min. Two groups were defined: patients with and without BB in their regular preopreative medication. The administered opioids were converted to their respective morphine equivalent doses. Multiple regression analysis was performed using the morphine-index to identify independent predictors. Results: A total of 747 patients were included in the BioCog study in the study center Berlin. 106 patients fulfilled the inclusion criteria. Of these, 37 were on chronic BB. The latter were preoperatively significantly more likely to have arterial hypertension (94.6%), chronic renal failure (27%) and hyperlipoproteinemia (51.4%) compared to patients without BB. Both groups did not differ in terms of cumulative perioperative morphine equivalent dose (230.9 (BB group) vs. 214.8 mg (Non-BB group)). Predictive factors for increased morphine-index were older age, male sex, longer duration of anesthesia and surgery of the trunk. In a model with logarithmised morphine index, only gender (female) and duration of anesthesia remained predictive factors. Conclusions: Chronic BB therapy was not associated with a reduced perioperative opioid consumption. Trial registration: This study was registered at ClinicalTrials.gov ( NCT02265263 ) on the 15.10.2014 with the principal investigator being Univ.-Prof. Dr. med. Claudia Spies.
MeSH term(s)	Humans ; Male ; Female ; Aged ; Analgesics, Opioid/therapeutic use ; Cardiovascular Diseases ; Morphine ; Pain, Postoperative/drug therapy
Chemical Substances	Analgesics, Opioid ; Morphine (76I7G6D29C)
Language	English
Publishing date	2024-02-27
Publishing country	England
Document type	Multicenter Study ; Journal Article
ZDB-ID	2091252-3
ISSN	1471-2253 ; 1471-2253
ISSN (online)	1471-2253
ISSN	1471-2253
DOI	10.1186/s12871-024-02456-2
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Conference proceedings: CD4+CD8+ double-positive T cells of RA patients exhibit a memory phenotype with high proliferative potential

Braune, Laurin / Pierer, Matthias / Glimm, Anne-Marie / Krasselt, Marco / Rothe, Kathrin / Spatzier, Hannah Rebekka / Wagner, Ulf / Seifert, Olga

2023 , Page(s) RA.24

Event/congress	Deutscher Rheumatologiekongress 2023, 51. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 37. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), 33. Jahrestagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR); Leipzig; ; Gesellschaft für Kinder- und Jugendrheumatologie; 2023
Keywords	Medizin, Gesundheit
Publishing date	2023-08-30
Publisher	German Medical Science GMS Publishing House; Düsseldorf
Document type	Conference proceedings
DOI	10.3205/23dgrh171
Database	German Medical Science

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Article ; Online: Galactomannan-Antigen Testing from Non-Directed Bronchial Lavage for Rapid Detection of Invasive Pulmonary Aspergillosis in Critically Ill Patients

Kathrin Rothe / Miriam Dibos / Stefanie J. Haschka / Roland M. Schmid / Dirk Busch / Sebastian Rasch / Tobias Lahmer

Diagnostics, Vol 13, Iss 1190, p

A Proof-of-Concept Study

2023 Volume 1190

Abstract	Invasive pulmonary aspergillosis is associated with high mortality. For diagnosis, galactomannan-antigen in serum and bronchoalveolar lavage fluid is recommended, with higher sensitivity in bronchoalveolar lavage fluid. Because of invasiveness, bronchoalveolar lavage might be withheld due to patients’ or technical limitations, leading to a delay in diagnosis while early diagnosis is crucial for patient outcome. To address this problem, we performed an analysis of patient characteristics of intubated patients with invasive pulmonary aspergillosis with comparison of galactomannan-antigen testing between non-directed bronchial lavage (NBL) and bronchoalveolar lavage fluid. A total of 32 intubated ICU patients with suspected invasive pulmonary aspergillosis could be identified. Mycological cultures were positive in 37.5% for A. fumigatus . Galactomannan-antigen in NBL (ODI 4.3 ± 2.4) and bronchoalveolar lavage fluid (ODI 3.6 ± 2.2) showed consistent results ( p -value 0.697). Galactomannan-antigen testing for detection of invasive pulmonary aspergillosis using deep tracheal secretion showed comparable results to bronchoalveolar lavage fluid. Because of widespread availability in intubated patients, galactomannan-antigen from NBL can be used as a screening parameter in critical risk groups with high pretest probability for invasive aspergillosis to accelerate diagnosis and initiation of treatment. Bronchoalveolar lavage remains the gold standard for diagnosis of invasive aspergillosis to be completed to confirm diagnosis, but results from NBL remove time sensitivity.
Keywords	invasive pulmonary aspergillosis ; galactomannan ; BAL-fluid ; non-directed bronchial lavage ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Conference proceedings: Outpatient antibiotic treatment in neurosurgical patients – a prospective case series

Butenschoen, Vicki / Rothe, Kathrin / Querbach, Christiane / Meyer, Bernhard / Negwer, Chiara

2021 , Page(s) V253

Title translation	Ambulante parenterale Antibiotika-Therapie (APAT) bei neurochirurgischen Patienten
Event/congress	72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie; sine loco [digital]; Deutsche Gesellschaft für Neurochirurgie; 2021
Keywords	Medizin, Gesundheit
Publishing date	2021-06-04
Publisher	German Medical Science GMS Publishing House; Düsseldorf
Document type	Conference proceedings
DOI	10.3205/21dgnc238
Database	German Medical Science

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Article ; Online: New EUCAST definitions of S, I and R from 2019 - German physicians are largely not aware of the changes.

Wantia, Nina / Gatermann, Sören G / Rothe, Kathrin / Laufenberg, Rebekka

Infection

2020 Volume 48, Issue 4, Page(s) 597–606

Abstract: Purpose: On January 1st 2019, the new EUCAST definitions of susceptibility testing categories S, I and R took effect. The changes in the I category have considerable clinical impact because they lead to major changes in the antibiogram, and ... ...

Abstract	Purpose: On January 1st 2019, the new EUCAST definitions of susceptibility testing categories S, I and R took effect. The changes in the I category have considerable clinical impact because they lead to major changes in the antibiogram, and misinterpretation may result in inappropriate selection and dosing of antibiotics hampering effective treatment of infectious diseases. We assessed if German physicians are aware of the new definitions and their consequences. Methods: We conducted a nationwide web-based survey to assess the knowledge on the new definitions of S, I and R. The survey was addressed to clinicians across all medical specialties working in Germany and was open from May 9th to July 30th 2019. Results: The answers of 902 participants were included in the analysis. Most participants were employed at hospitals (79.3%) and had already completed specialist training (86.1%). The predominant specialty was internal medicine (50.6%). Of all participants, 45.7% did not know that there was a change in the definitions of S, I and R, and 65.4% did not feel well-informed about the changes. When the participants had to identify true and false statements regarding the new I, substantial knowledge gaps were apparent. Worst results were achieved by those physicians who are not employed in a hospital but work in their own practice. Conclusion: Our survey shows that German physicians are insufficiently informed about the new definitions of S, I and R. Further education is strongly needed to ensure optimal treatment of infectious diseases.
MeSH term(s)	Clinical Competence/statistics & numerical data ; Communicable Diseases/drug therapy ; Germany ; Microbial Sensitivity Tests/standards ; Physicians/statistics & numerical data ; Practice Guidelines as Topic
Language	English
Publishing date	2020-06-06
Publishing country	Germany
Document type	Journal Article
ZDB-ID	185104-4
ISSN	1439-0973 ; 0300-8126 ; 0173-2129
ISSN (online)	1439-0973
ISSN	0300-8126 ; 0173-2129
DOI	10.1007/s15010-020-01456-x
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Zs.A 881: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Effect of ultrasonic welding process parameters on hydrostatic pressure resistance of hybrid textiles for weather protection

Hussen, Muktar Seid / Kyosev, Yordan Kostadinov / Pietsch, Kathrin / Rothe, Stefan / Kechi, Abera

Textile research journal. 2022 Aug., v. 92, no. 15-16

2022

Abstract: In the research project presented in this paper, the effects of welding width, pressure force, power, and speed of ultrasonic welding parameters on hydrostatic pressure resistance were examined. A flexible and lightweight PVC-coated hybrid textile ... ...

Abstract	In the research project presented in this paper, the effects of welding width, pressure force, power, and speed of ultrasonic welding parameters on hydrostatic pressure resistance were examined. A flexible and lightweight PVC-coated hybrid textile material with uniform thickness was used for weather protection purposes. Three main welding parameters at three different levels were selected based on the preliminary test results involving welding widths of 6 and 12 mm. A lapped type of seam was applied for ultrasonic welding and conventional joining techniques. A conventionally sewn zigzag seam was produced using three main factors at two different levels according to the application area. To avoid seam permeability, the conventional seam was sealed with tape by means of hot-air tape welding and subsequently investigated regarding its hydrostatic pressure resistance. The hydrostatic pressure resistance value of the conventional seam was then compared with ultrasonic weld seams of 6 and 12 mm welding width, and its parametric influence on the quality of the seam was analyzed. The result shows that the ultrasonic weld seam with a 12 mm welding width provided a higher hydrostatic pressure resistance than the 6 mm welding width and the conventionally sewn seam. Statistical analyses were also carried out to prove the significant effect of welding process parameters on hydrostatic pressure resistance, whereby the obtained results were statistically significant. A suitable nonlinear numerical model was also developed to predict the hydrostatic pressure resistance.
Keywords	fabrics ; hybrids ; hydrostatic pressure ; mathematical models ; permeability ; research projects ; ultrasonics ; weather
Language	English
Dates of publication	2022-08
Size	p. 2553-2568.
Publishing place	SAGE Publications
Document type	Article
ZDB-ID	2209596-2
ISSN	1746-7748 ; 0040-5175
ISSN (online)	1746-7748
ISSN	0040-5175
DOI	10.1177/0040517520988124
Database	NAL-Catalogue (AGRICOLA)

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