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  1. Article: Evaluation of Self-Collected Versus Health Care Professional (HCP)-Performed Sampling and the Potential Impact on the Diagnostic Results of Asymptomatic Sexually Transmitted Infections (STIs) in High-Risk Individuals.

    Weidlich, Simon / Schellberg, Sven / Scholten, Stefan / Schneider, Jochen / Lee, Marcel / Rothe, Kathrin / Wantia, Nina / Spinner, Christoph D / Noe, Sebastian

    Infectious disease reports

    2023  Volume 15, Issue 5, Page(s) 470–477

    Abstract: Sexually transmitted infections (STIs) are increasing among men who have sex with men (MSM). Screening can improve the detection and outcome of asymptomatic STIs in high-risk populations. Self-sampling may be a resource-optimized strategy; however, its ... ...

    Abstract Sexually transmitted infections (STIs) are increasing among men who have sex with men (MSM). Screening can improve the detection and outcome of asymptomatic STIs in high-risk populations. Self-sampling may be a resource-optimized strategy; however, its diagnostic reliability compared to testing by healthcare professionals (HCPs) requires further investigation. In this prospective, multicenter cohort study in a high-income country, asymptomatic MSM with a sexual risk profile for STIs were included. Sequential swabs for STI nucleic acid-based diagnosis of
    Language English
    Publishing date 2023-08-25
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2036-7430
    ISSN 2036-7430
    DOI 10.3390/idr15050047
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  2. Article: Galactomannan-Antigen Testing from Non-Directed Bronchial Lavage for Rapid Detection of Invasive Pulmonary Aspergillosis in Critically Ill Patients: A Proof-of-Concept Study.

    Rothe, Kathrin / Dibos, Miriam / Haschka, Stefanie J / Schmid, Roland M / Busch, Dirk / Rasch, Sebastian / Lahmer, Tobias

    Diagnostics (Basel, Switzerland)

    2023  Volume 13, Issue 6

    Abstract: Invasive pulmonary aspergillosis is associated with high mortality. For diagnosis, galactomannan-antigen in serum and bronchoalveolar lavage fluid is recommended, with higher sensitivity in bronchoalveolar lavage fluid. Because of invasiveness, ... ...

    Abstract Invasive pulmonary aspergillosis is associated with high mortality. For diagnosis, galactomannan-antigen in serum and bronchoalveolar lavage fluid is recommended, with higher sensitivity in bronchoalveolar lavage fluid. Because of invasiveness, bronchoalveolar lavage might be withheld due to patients' or technical limitations, leading to a delay in diagnosis while early diagnosis is crucial for patient outcome. To address this problem, we performed an analysis of patient characteristics of intubated patients with invasive pulmonary aspergillosis with comparison of galactomannan-antigen testing between non-directed bronchial lavage (NBL) and bronchoalveolar lavage fluid. A total of 32 intubated ICU patients with suspected invasive pulmonary aspergillosis could be identified. Mycological cultures were positive in 37.5% for
    Language English
    Publishing date 2023-03-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics13061190
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  3. Conference proceedings: Increased SLAMF7 expression on monocytes in rheumatoid arthritis

    Spatzier, Hannah Rebekka / Braune, Laurin / Glimm, Anne-Marie / Seifert, Olga / Krasselt, Marco / Pierer, Matthias / Wagner, Ulf / Rothe, Kathrin

    2023  , Page(s) ET.05

    Event/congress Deutscher Rheumatologiekongress 2023, 51. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 37. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), 33. Jahrestagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR); Leipzig; ; Gesellschaft für Kinder- und Jugendrheumatologie; 2023
    Keywords Medizin, Gesundheit
    Publishing date 2023-08-30
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/23dgrh025
    Database German Medical Science

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  4. Article ; Online: Influence of a chronic beta-blocker therapy on perioperative opioid consumption - a post hoc secondary analysis.

    Trauzeddel, Ralf F / Rothe, Luisa M / Nordine, Michael / Dehé, Lukas / Scholtz, Kathrin / Spies, Claudia / Hadzidiakos, Daniel / Winterer, Georg / Borchers, Friedrich / Kruppa, Jochen / Treskatsch, Sascha

    BMC anesthesiology

    2024  Volume 24, Issue 1, Page(s) 80

    Abstract: Background: Beta-blocker (BB) therapy plays a central role in the treatment of cardiovascular diseases. An increasing number of patients with cardiovascular diseases undergoe noncardiac surgery, where opioids are an integral part of the ... ...

    Abstract Background: Beta-blocker (BB) therapy plays a central role in the treatment of cardiovascular diseases. An increasing number of patients with cardiovascular diseases undergoe noncardiac surgery, where opioids are an integral part of the anesthesiological management. There is evidence to suggest that short-term intravenous BB therapy may influence perioperative opioid requirements due to an assumed cross-talk between G-protein coupled beta-adrenergic and opioid receptors. Whether chronic BB therapy could also have an influence on perioperative opioid requirements is unclear.
    Methods: A post hoc analysis of prospectively collected data from a multicenter observational (BioCog) study was performed. Inclusion criteria consisted of elderly patients (≥ 65 years) undergoing elective noncardiac surgery as well as total intravenous general anesthesia without the use of regional anesthesia and duration of anesthesia ≥ 60 min. Two groups were defined: patients with and without BB in their regular preopreative medication. The administered opioids were converted to their respective morphine equivalent doses. Multiple regression analysis was performed using the morphine-index to identify independent predictors.
    Results: A total of 747 patients were included in the BioCog study in the study center Berlin. 106 patients fulfilled the inclusion criteria. Of these, 37 were on chronic BB. The latter were preoperatively significantly more likely to have arterial hypertension (94.6%), chronic renal failure (27%) and hyperlipoproteinemia (51.4%) compared to patients without BB. Both groups did not differ in terms of cumulative perioperative morphine equivalent dose (230.9 (BB group) vs. 214.8 mg (Non-BB group)). Predictive factors for increased morphine-index were older age, male sex, longer duration of anesthesia and surgery of the trunk. In a model with logarithmised morphine index, only gender (female) and duration of anesthesia remained predictive factors.
    Conclusions: Chronic BB therapy was not associated with a reduced perioperative opioid consumption.
    Trial registration: This study was registered at ClinicalTrials.gov ( NCT02265263 ) on the 15.10.2014 with the principal investigator being Univ.-Prof. Dr. med. Claudia Spies.
    MeSH term(s) Humans ; Male ; Female ; Aged ; Analgesics, Opioid/therapeutic use ; Cardiovascular Diseases ; Morphine ; Pain, Postoperative/drug therapy
    Chemical Substances Analgesics, Opioid ; Morphine (76I7G6D29C)
    Language English
    Publishing date 2024-02-27
    Publishing country England
    Document type Multicenter Study ; Journal Article
    ZDB-ID 2091252-3
    ISSN 1471-2253 ; 1471-2253
    ISSN (online) 1471-2253
    ISSN 1471-2253
    DOI 10.1186/s12871-024-02456-2
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  5. Conference proceedings: CD4+CD8+ double-positive T cells of RA patients exhibit a memory phenotype with high proliferative potential

    Braune, Laurin / Pierer, Matthias / Glimm, Anne-Marie / Krasselt, Marco / Rothe, Kathrin / Spatzier, Hannah Rebekka / Wagner, Ulf / Seifert, Olga

    2023  , Page(s) RA.24

    Event/congress Deutscher Rheumatologiekongress 2023, 51. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 37. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), 33. Jahrestagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR); Leipzig; ; Gesellschaft für Kinder- und Jugendrheumatologie; 2023
    Keywords Medizin, Gesundheit
    Publishing date 2023-08-30
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/23dgrh171
    Database German Medical Science

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  6. Article ; Online: Galactomannan-Antigen Testing from Non-Directed Bronchial Lavage for Rapid Detection of Invasive Pulmonary Aspergillosis in Critically Ill Patients

    Kathrin Rothe / Miriam Dibos / Stefanie J. Haschka / Roland M. Schmid / Dirk Busch / Sebastian Rasch / Tobias Lahmer

    Diagnostics, Vol 13, Iss 1190, p

    A Proof-of-Concept Study

    2023  Volume 1190

    Abstract: Invasive pulmonary aspergillosis is associated with high mortality. For diagnosis, galactomannan-antigen in serum and bronchoalveolar lavage fluid is recommended, with higher sensitivity in bronchoalveolar lavage fluid. Because of invasiveness, ... ...

    Abstract Invasive pulmonary aspergillosis is associated with high mortality. For diagnosis, galactomannan-antigen in serum and bronchoalveolar lavage fluid is recommended, with higher sensitivity in bronchoalveolar lavage fluid. Because of invasiveness, bronchoalveolar lavage might be withheld due to patients’ or technical limitations, leading to a delay in diagnosis while early diagnosis is crucial for patient outcome. To address this problem, we performed an analysis of patient characteristics of intubated patients with invasive pulmonary aspergillosis with comparison of galactomannan-antigen testing between non-directed bronchial lavage (NBL) and bronchoalveolar lavage fluid. A total of 32 intubated ICU patients with suspected invasive pulmonary aspergillosis could be identified. Mycological cultures were positive in 37.5% for A. fumigatus . Galactomannan-antigen in NBL (ODI 4.3 ± 2.4) and bronchoalveolar lavage fluid (ODI 3.6 ± 2.2) showed consistent results ( p -value 0.697). Galactomannan-antigen testing for detection of invasive pulmonary aspergillosis using deep tracheal secretion showed comparable results to bronchoalveolar lavage fluid. Because of widespread availability in intubated patients, galactomannan-antigen from NBL can be used as a screening parameter in critical risk groups with high pretest probability for invasive aspergillosis to accelerate diagnosis and initiation of treatment. Bronchoalveolar lavage remains the gold standard for diagnosis of invasive aspergillosis to be completed to confirm diagnosis, but results from NBL remove time sensitivity.
    Keywords invasive pulmonary aspergillosis ; galactomannan ; BAL-fluid ; non-directed bronchial lavage ; Medicine (General) ; R5-920
    Subject code 610
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Conference proceedings: Outpatient antibiotic treatment in neurosurgical patients – a prospective case series

    Butenschoen, Vicki / Rothe, Kathrin / Querbach, Christiane / Meyer, Bernhard / Negwer, Chiara

    2021  , Page(s) V253

    Title translation Ambulante parenterale Antibiotika-Therapie (APAT) bei neurochirurgischen Patienten
    Event/congress 72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie; sine loco [digital]; Deutsche Gesellschaft für Neurochirurgie; 2021
    Keywords Medizin, Gesundheit
    Publishing date 2021-06-04
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/21dgnc238
    Database German Medical Science

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  8. Article ; Online: New EUCAST definitions of S, I and R from 2019 - German physicians are largely not aware of the changes.

    Wantia, Nina / Gatermann, Sören G / Rothe, Kathrin / Laufenberg, Rebekka

    Infection

    2020  Volume 48, Issue 4, Page(s) 597–606

    Abstract: Purpose: On January 1st 2019, the new EUCAST definitions of susceptibility testing categories S, I and R took effect. The changes in the I category have considerable clinical impact because they lead to major changes in the antibiogram, and ... ...

    Abstract Purpose: On January 1st 2019, the new EUCAST definitions of susceptibility testing categories S, I and R took effect. The changes in the I category have considerable clinical impact because they lead to major changes in the antibiogram, and misinterpretation may result in inappropriate selection and dosing of antibiotics hampering effective treatment of infectious diseases. We assessed if German physicians are aware of the new definitions and their consequences.
    Methods: We conducted a nationwide web-based survey to assess the knowledge on the new definitions of S, I and R. The survey was addressed to clinicians across all medical specialties working in Germany and was open from May 9th to July 30th 2019.
    Results: The answers of 902 participants were included in the analysis. Most participants were employed at hospitals (79.3%) and had already completed specialist training (86.1%). The predominant specialty was internal medicine (50.6%). Of all participants, 45.7% did not know that there was a change in the definitions of S, I and R, and 65.4% did not feel well-informed about the changes. When the participants had to identify true and false statements regarding the new I, substantial knowledge gaps were apparent. Worst results were achieved by those physicians who are not employed in a hospital but work in their own practice.
    Conclusion: Our survey shows that German physicians are insufficiently informed about the new definitions of S, I and R. Further education is strongly needed to ensure optimal treatment of infectious diseases.
    MeSH term(s) Clinical Competence/statistics & numerical data ; Communicable Diseases/drug therapy ; Germany ; Microbial Sensitivity Tests/standards ; Physicians/statistics & numerical data ; Practice Guidelines as Topic
    Language English
    Publishing date 2020-06-06
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 185104-4
    ISSN 1439-0973 ; 0300-8126 ; 0173-2129
    ISSN (online) 1439-0973
    ISSN 0300-8126 ; 0173-2129
    DOI 10.1007/s15010-020-01456-x
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  9. Article: Effect of ultrasonic welding process parameters on hydrostatic pressure resistance of hybrid textiles for weather protection

    Hussen, Muktar Seid / Kyosev, Yordan Kostadinov / Pietsch, Kathrin / Rothe, Stefan / Kechi, Abera

    Textile research journal. 2022 Aug., v. 92, no. 15-16

    2022  

    Abstract: In the research project presented in this paper, the effects of welding width, pressure force, power, and speed of ultrasonic welding parameters on hydrostatic pressure resistance were examined. A flexible and lightweight PVC-coated hybrid textile ... ...

    Abstract In the research project presented in this paper, the effects of welding width, pressure force, power, and speed of ultrasonic welding parameters on hydrostatic pressure resistance were examined. A flexible and lightweight PVC-coated hybrid textile material with uniform thickness was used for weather protection purposes. Three main welding parameters at three different levels were selected based on the preliminary test results involving welding widths of 6 and 12 mm. A lapped type of seam was applied for ultrasonic welding and conventional joining techniques. A conventionally sewn zigzag seam was produced using three main factors at two different levels according to the application area. To avoid seam permeability, the conventional seam was sealed with tape by means of hot-air tape welding and subsequently investigated regarding its hydrostatic pressure resistance. The hydrostatic pressure resistance value of the conventional seam was then compared with ultrasonic weld seams of 6 and 12 mm welding width, and its parametric influence on the quality of the seam was analyzed. The result shows that the ultrasonic weld seam with a 12 mm welding width provided a higher hydrostatic pressure resistance than the 6 mm welding width and the conventionally sewn seam. Statistical analyses were also carried out to prove the significant effect of welding process parameters on hydrostatic pressure resistance, whereby the obtained results were statistically significant. A suitable nonlinear numerical model was also developed to predict the hydrostatic pressure resistance.
    Keywords fabrics ; hybrids ; hydrostatic pressure ; mathematical models ; permeability ; research projects ; ultrasonics ; weather
    Language English
    Dates of publication 2022-08
    Size p. 2553-2568.
    Publishing place SAGE Publications
    Document type Article
    ZDB-ID 2209596-2
    ISSN 1746-7748 ; 0040-5175
    ISSN (online) 1746-7748
    ISSN 0040-5175
    DOI 10.1177/0040517520988124
    Database NAL-Catalogue (AGRICOLA)

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  10. Article ; Online: Antibiotikaprophylaxe bei transrektaler Prostatabiopsie : Im Kontext von Fluorchinolon-Indikationsrücknahme und Antibiotic Stewardship.

    Rothe, Kathrin / Querbach, Christiane / Busch, Dirk H / Gschwend, Jürgen E / Hauner, Katharina

    Der Urologe. Ausg. A

    2021  Volume 61, Issue 2, Page(s) 160–166

    Abstract: Background: Transrectal prostate biopsy (TRPB) is the gold standard for prostate cancer diagnosis and among the most common urological interventions. Short-term antibiotic prophylaxis (PAP) is recommended for TRPB. Fluoroquinolone-PAP as standard of ... ...

    Title translation Antibiotic prophylaxis for transrectal prostate biopsy : In the context of restricted indications for fluoroquinolones and antibiotic stewardship.
    Abstract Background: Transrectal prostate biopsy (TRPB) is the gold standard for prostate cancer diagnosis and among the most common urological interventions. Short-term antibiotic prophylaxis (PAP) is recommended for TRPB. Fluoroquinolone-PAP as standard of care needs to be revaluated due to the restrictions on the use of fluoroquinolone antibiotics by the German Federal Institute for Drugs and Medical Devices.
    Objectives: The aim of the study was to analyze clinical practice of PAP for TRPB with focus on infectious complications and potential differences between fluoroquinolone-PAP and cotrimoxazole-PAP.
    Methods: We performed a retrospective monocentric study of clinical and microbiological characteristics of patients with TRPB between 3 January 2019 and 28 January 2021.
    Results: A total of 508 men were included; median age was 68 years. In all, 55.9% of our cohort received cotrimoxazole-PAP and 40.0% fluoroquinolone-PAP. Postinterventional complications occurred in 5.5%, of those 50.0% were infectious complications. Complication rate did not differ between patients with fluoroquinolone-PAP and cotrimoxazole-PAP. Urinary cultures in case of postinterventional complications yielded pathogens with antimicrobial resistance against the used PAP substance indicating selection of resistant bacteria.
    Conclusion: Cotrimoxazole-PAP for TRPB is not associated with an increase of infectious complications compared to fluoroquinolone-PAP. Cultures obtained prior to TRPB to identify antimicrobial resistance facilitate targeted PAP and therefore can reduce complications.
    MeSH term(s) Aged ; Anti-Bacterial Agents/therapeutic use ; Antibiotic Prophylaxis ; Antimicrobial Stewardship ; Bacterial Infections/drug therapy ; Bacterial Infections/prevention & control ; Biopsy ; Fluoroquinolones ; Humans ; Male ; Postoperative Complications ; Prostate ; Rectum ; Retrospective Studies
    Chemical Substances Anti-Bacterial Agents ; Fluoroquinolones
    Language German
    Publishing date 2021-08-18
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 204041-4
    ISSN 1433-0563 ; 0340-2592 ; 0375-4685
    ISSN (online) 1433-0563
    ISSN 0340-2592 ; 0375-4685
    DOI 10.1007/s00120-021-01618-1
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