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Article ; Online: Effect of Zhenxin Xingshui Yizhi Fang on Aβ

Wu, Ling / Zheng, Qin / Guo, Yuan-Yuan / Zhang, Ke-Nan / Luo, Jun / Xiao, Shuai / Li, Wen-Jing / Yang, Ming

2020 Volume 260, Page(s) 112783

Abstract: ... to be risk factors for Alzheimer's disease (AD). Zhenxin Xingshui Yizhi Fang (XSF), an ancient ...

Abstract	Ethnopharmacological relevance: Aβ (β-amyloid) deposition and abnormal transport were suggested to be risk factors for Alzheimer's disease (AD). Zhenxin Xingshui Yizhi Fang (XSF), an ancient prescription in traditional Chinese medicine, was first recorded in Qianjin Yifang for treating palpitation, hypnosia, amnesia. It is reported that XSF could improve mice learning memory ability, reduce the deposition of senile plaques in hippocampus of rat brain. In this study, the neuroprotective effect of XSF against Aβ Materials and methods: HBMEC cells were treated with Aβ Results: In Aβ Conclusion: The results suggest that XSF can reduce the cytotoxicity of HBMEC induced by Aβ
MeSH term(s)	Amyloid beta-Peptides/metabolism ; Amyloid beta-Peptides/toxicity ; Apoptosis/drug effects ; Brain/blood supply ; Caspase 3/genetics ; Caspase 3/metabolism ; Cells, Cultured ; Drugs, Chinese Herbal/pharmacology ; Endothelial Cells/drug effects ; Endothelial Cells/metabolism ; Endothelial Cells/pathology ; Gene Expression Regulation ; Glucose Transporter Type 1/genetics ; Glucose Transporter Type 1/metabolism ; Glucose Transporter Type 3/genetics ; Glucose Transporter Type 3/metabolism ; Low Density Lipoprotein Receptor-Related Protein-1/genetics ; Low Density Lipoprotein Receptor-Related Protein-1/metabolism ; Membrane Transport Proteins/genetics ; Membrane Transport Proteins/metabolism ; Neuroprotective Agents/pharmacology ; Peptide Fragments/metabolism ; Peptide Fragments/toxicity ; Receptor for Advanced Glycation End Products/genetics ; Receptor for Advanced Glycation End Products/metabolism ; Signal Transduction
Chemical Substances	AGER protein, human ; Amyloid beta-Peptides ; Drugs, Chinese Herbal ; Glucose Transporter Type 1 ; Glucose Transporter Type 3 ; LRP1 protein, human ; Low Density Lipoprotein Receptor-Related Protein-1 ; Membrane Transport Proteins ; Neuroprotective Agents ; Peptide Fragments ; Receptor for Advanced Glycation End Products ; SLC2A1 protein, human ; SLC2A3 protein, human ; amyloid beta-protein (1-42) ; amyloid beta-protein (25-35) ; CASP3 protein, human (EC 3.4.22.-) ; Caspase 3 (EC 3.4.22.-)
Language	English
Publishing date	2020-03-30
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2020.112783
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Zs.A 1494: Show issues

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Article: The therapeutic effects and mechanisms of Long Chai Fang on chronic hepatitis B.

Xu, Tingting / Wang, Pei / Zheng, Xue / Yan, Zhanpeng / Li, Kun / Xu, Jindi / Jiang, Cuihua / Zhu, Fangshi

Annals of translational medicine

2021 Volume 9, Issue 10, Page(s) 865

Abstract: Background: Long Chai Fang (LCF) is a traditional Chinese medicine (TCM) formula for treating ...

Abstract	Background: Long Chai Fang (LCF) is a traditional Chinese medicine (TCM) formula for treating chronic hepatitis B (CHB) in clinical settings; however, its related mechanism remains unclear. Methods: To address this issue, network pharmacology and an integrative method that combines dot-blot hybridization and metabolomics analysis were employed. Network pharmacology was performed to investigate the material basis and potential mechanisms of LCF against CHB. The effect of LCF on Duck hepatitis B virus (DHBV) replication was evaluated. The metabolomics analysis was conducted to identify potential biomarkers in duck serum. Results: The network pharmacology approach revealed 133 potential active components, 897 drug targets, 979 disease targets, and 185 drug-disease targets, while the Kyoto Encyclopedia of Genes and Genomes enrichment analysis identified 165 pathways. LCF significantly inhibited DHBV-deoxyribonucleic acid replication on day 10 and day 3 after the cessation of treatment. Notably, the low-dose LCF group showed the best inhibitory effect. The obviously sustained anti-DHBV activity of LCF inhibited viral replication, and a rebound reaction was found. Phosphatidylcholine and phosphatidylethanolamine classes, which are mainly involved in liver cell repair and energy metabolism through phospholipid metabolic pathways, were identified by metabolomics analysis. Conclusions: our results showed that the main active ingredients of LCF appear to be metacarpi, isorhamnetin, glypallichalcone, and phaseolinisoflavan. This study provides novel strategies for using a LCF formula against CHB in future research.
Language	English
Publishing date	2021-06-07
Publishing country	China
Document type	Journal Article
ZDB-ID	2893931-1
ISSN	2305-5847 ; 2305-5839
ISSN (online)	2305-5847
ISSN	2305-5839
DOI	10.21037/atm-21-1923
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Article ; Online: Tong-Xie-Yao-Fang promotes dendritic cells maturation and retards tumor growth in colorectal cancer mice with chronic restraint stress.

Jiang, Yifang / Hu, Yane / Yang, Yi / Yan, Ran / Zheng, Lili / Fu, Xi / Xiao, Chong / You, Fengming

Journal of ethnopharmacology

2023 Volume 319, Issue Pt 1, Page(s) 117069

Abstract: ... the progression of colorectal cancer (CRC). Tong-Xie-Yao-Fang (TXYF) is a widely used classical formula ...

Abstract	Ethnopharmacological relevance: Depression is one of the important risk factors that accelerate the progression of colorectal cancer (CRC). Tong-Xie-Yao-Fang (TXYF) is a widely used classical formula for treating psychiatric-related intestinal diseases in traditional Chinese medicine, that is composed of four different herbs: Atractylodes macrocephala Koidz. (Baizhu), Paeonia lactiflora Pall. (Baishaoyao), Citrus reticulata Blanco (Chenpi), Saposhnikovia divaricata (Turcz.) Schischk (Fangfeng). TXYF has over a hundred years of history and can significantly improve depression and reduce intestinal symptoms. However, the intervention effect and mechanism of TXYF on colorectal cancer accompanied by psychological stress are not still clear. Aim of study: This study investigated the therapeutic effect of TXYF on CRC mice with chronic restraint stress (CRS) and to explore its mechanism. Materials and methods: We constructed a mouse model of chronic stress by CRS and subcutaneous injection of CT26-Luc cells, and administered TXYF by gavage. We measured the body weight, tumor size, and tumor weight of each group of mice. The tumor growth was monitored dynamically of by vivo bioluminescence analysis. The depressive state of each group of mice were evaluated by tail suspension test, forced swimming test, and hormone level changes. We used flow cytometry to detect the ratio of CD4 Results: TXYF can improve the body weight of CRC mice with CRS, inhibit tumor volume and weight, alleviate depressive state, upregulate 5-HT levels, and inhibit HPA axis hormone secretion. The results of flow cytometry showed that TXYF can promote the maturation of DCs phenotype and function, enhance antigen presentation ability, increase the ratio of CD4 Conclusions: This study shows that TXYF inhibits the growth of tumors in CRC mice with CRS by stimulating immune response. The mechanism may be inhibiting the HPA axis and promoting DCs maturation, thus activating T cells and enhancing anti-tumor immune response, ultimately preventing the progression of CRC.
MeSH term(s)	Mice ; Animals ; Interleukin-18 ; CD8-Positive T-Lymphocytes/metabolism ; Hypothalamo-Hypophyseal System/metabolism ; Pituitary-Adrenal System/metabolism ; Cytokines/metabolism ; Interleukin-12 ; Dendritic Cells ; Colorectal Neoplasms/drug therapy ; Hormones
Chemical Substances	Baizhu ; Interleukin-18 ; Cytokines ; Interleukin-12 (187348-17-0) ; Hormones
Language	English
Publishing date	2023-08-22
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2023.117069
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Zs.A 1494: Show issues

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Article ; Online: Integrating network pharmacology and experimental validation to decipher the mechanism of the Chinese herbal prescription modified Shen-Yan-Fang-Shuai formula in treating diabetic nephropathy.

Yu, Borui / Zhou, Mengqi / Dong, Zhaocheng / Zheng, Huijuan / Zhao, Yuxue / Zhou, Jingwei / Zhang, Chao / Wei, Fudong / Yu, Guoyong / Liu, Wei Jing / Liu, Hongfang / Wang, Yaoxian

Pharmaceutical biology

2023 Volume 61, Issue 1, Page(s) 1222–1233

Abstract: ... Fang-Shuai formula (M-SYFSF) has excellent clinical efficacy in treating diabetic kidney disease ...

Abstract	Context: Diabetic nephropathy (DN) is the main cause of end-stage renal disease. Modified Shen-Yan-Fang-Shuai formula (M-SYFSF) has excellent clinical efficacy in treating diabetic kidney disease. However, the potential mechanism of M-SYFSF remains unknown. Objective: To investigate the mechanism of M-SYFSF against DN by network pharmacological analysis and biological experiments. Materials and methods: Utilizing a web-based pharmacology database, the potential mechanisms of M-SYFSF against DN were identified. Results: Network pharmacological analysis showed that MAPK pathway was the potential pathway. Results showed that compared with the Model group, M-SYFSF significantly reduced 24h urine albumin, UACR, and serum creatinine levels (54.90 ± 26.67 vs. 111.78 ± 4.28, 8.87 ± 1.69 vs. 53.94 ± 16.01, 11.56 ± 1.70 vs. 118.70 ± 49.57, respectively), and improved renal pathological changes. Furthermore, the intervention of M-SYFSF reduced the expression of pro-inflammatory cytokines and inhibited the activation of MAPK pathway in AGEs-treated HK-2 cells. Discussion and conclusion: M-SYFSF is likely to reduce inflammation in DN by inhibiting the MAPK pathway. It provides a theoretical basis for the clinical application of M-SYFSF in the treatment of DN.
MeSH term(s)	Rats ; Male ; Humans ; Animals ; Diabetic Nephropathies/metabolism ; Network Pharmacology ; Rats, Sprague-Dawley ; Diabetes Mellitus, Experimental/complications ; Diabetes Mellitus, Experimental/drug therapy ; Diabetes Mellitus, Experimental/metabolism ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Glycation End Products, Advanced/metabolism
Chemical Substances	Drugs, Chinese Herbal ; Glycation End Products, Advanced
Language	English
Publishing date	2023-08-11
Publishing country	England
Document type	Journal Article
ZDB-ID	1440131-9
ISSN	1744-5116 ; 1388-0209
ISSN (online)	1744-5116
ISSN	1388-0209
DOI	10.1080/13880209.2023.2241521
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Article: Mechanism of the Treatment of Irritable Bowel Syndrome with Sini Powder and Tong Xie Yao Fang Decoction Based on Network Pharmacology.

Tang, Rong / Peng, Xiaoqing / Zhou, Xiaohong / Zheng, Zhimin / Yin, Jiayu / Liu, Hong

Evidence-based complementary and alternative medicine : eCAM

2022 Volume 2022, Page(s) 3598856

Abstract: ... of Sini Powder and Tong xie yao fang decoction and the underlying mechanisms in irritable bowel syndrome ... IBS) treatment. The potential active ingredients of Sini Powder and Tong xie yao fang decoction were ...

Abstract	This study used a network pharmacology approach to investigate the potential active ingredients of Sini Powder and Tong xie yao fang decoction and the underlying mechanisms in irritable bowel syndrome (IBS) treatment. The potential active ingredients of Sini Powder and Tong xie yao fang decoction were obtained from TCMSP databases, and the potential targets of the active ingredients were predicted and analyzed by using the Swiss Target Prediction database. T Genecard, DisGeNET, and OMIM databases were processed to screen the potential therapeutic targets in IBS. The interaction of overlapped candidates between the potential biotarget of herb extracts and the potential therapeutic target of IBS were analyzed by STRING website and visualized by the Cytoscape V3.8.0 software. Gene ontology (GO) analysis and Kyoto Genomics and Genomics Encyclopedia (KEGG) pathway were processed to categorize and map the potential biofunctions and effects of these candidates by using David database.
Language	English
Publishing date	2022-04-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2022/3598856
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Zs.A 5995: Show issues

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Article: Jian-Pi-Yi-Qi-Fang ameliorates chronic atrophic gastritis in rats through promoting the proliferation and differentiation of gastric stem cells.

Wang, Pei / Xu, Tingting / Yan, Zhanpeng / Zheng, Xue / Zhu, Fangshi

Annals of translational medicine

2022 Volume 10, Issue 17, Page(s) 932

Abstract: Background: Jian-Pi-Yi-Qi-Fang (JPYQF) is a traditional Chinese medicine (TCM) herbal formula ...

Abstract	Background: Jian-Pi-Yi-Qi-Fang (JPYQF) is a traditional Chinese medicine (TCM) herbal formula for treating chronic atrophic gastritis (CAG) in the clinic; however, its related mechanism remains unclear. The purpose of this study was to explore the potential mechanisms of JPYQF in treating CAG by examining proteins and genes related to the proliferation and differentiation of gastric stem cells and Wnt signaling. Methods: A CAG model was established in Sprague-Dawley (SD) rats which were induced by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) and ranitidine. We randomly divided 25 CAG rats into 5 groups: the model group, positive drug group, low-dose group of JPYQF (JPYQF-L), middle-dose group of JPYQF (JPYQF-M), and high-dose group of JPYQF (JPYQF-H), with 5 rats of the same age classified into the control group. The body weight of rats was measured and their gastric morphology was visually assessed. Furthermore, pathological analysis of rat gastric tissue was performed. The expression levels of proteins and genes associated with the proliferation and differentiation of gastric stem cells and Wnt signaling were measured via immunohistochemistry and reverse transcription quantitative polymerase chain reaction (RT-qPCR). Results: Compared with the model group, treatment with JPYQF increased the body weight of the rats, and relieved the gastric atrophy and inflammation. Compared with the control group, the protein and messenger RNA (mRNA) expression levels of gastric stem cell proliferation and differentiation markers Lgr5, Sox2, Ki67, PCNA, Muc5AC, and Wnt signaling initiator Wnt3A and enhancer R-spondin-1 (Rspo1) were decreased in the model group. Treatment with JPYQF increased the protein and mRNA expression levels of these markers. Conclusions: The Wnt signaling of CAG rats may be in a low activation state, which inhibits the proliferation and differentiation of gastric stem cells, so that gland cells cannot be replenished in time to repair the damaged gastric mucosa. The TCM formula JPYQF could enhance Wnt signaling to promote the restricted proliferation and normal differentiation of gastric stem cells, thereby improving gastric mucosal atrophy in CAG rats, which provides a novel and robust theoretical basis for CAG treatment.
Language	English
Publishing date	2022-09-22
Publishing country	China
Document type	Journal Article
ZDB-ID	2893931-1
ISSN	2305-5847 ; 2305-5839
ISSN (online)	2305-5847
ISSN	2305-5839
DOI	10.21037/atm-22-3749
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Article: Network Pharmacology and Metabolomics Studies on Antimigraine Mechanisms of Da Chuan Xiong Fang (DCXF).

Ma, Shiyu / Zheng, Lin / Lin, Xiao / Feng, Yi / Yang, Ming / Shen, Lan

Evidence-based complementary and alternative medicine : eCAM

2021 Volume 2021, Page(s) 6665137

Abstract: Background: Da Chuan Xiong Fang (DCXF) is a traditional Chinese medicine (TCM) formula used ...

Abstract	Background: Da Chuan Xiong Fang (DCXF) is a traditional Chinese medicine (TCM) formula used to treat migraines. Previously, we uncovered partial mechanisms involved in the therapeutic actions of DCXF on migraines. Methods: In this study, we further elucidated its antimigraine mechanisms in vivo by using an integrated strategy coupling with network pharmacology and metabolomics techniques. Results: Network pharmacology identified 33 genes linked with both migraine and DCXF, most of which were 5-hydroxytryptamine receptors, dopamine, and peptide receptors. The results of GO and KEGG enrichment analysis showed that DCXF significantly regulated tyrosine metabolism, tryptophan metabolism, dopamine metabolic process, glucose transmembrane transport, lipid metabolism, and fatty acid transport. The results of metabolomics analysis found that the metabolism of tryptophan and tyrosine in the brain tissue and energy and lipid metabolism of rats tended towards normal and reached normal levels after administering DCXF. The metabolomics and network pharmacology approaches demonstrated similar antimigraine effects of DCXF on endogenous neurotransmitters and overall trends in serum and brain tissue. Using both approaches, 62 hub genes were identified from the protein-protein interaction (PPI) network of DCXF and gene-metabolite interaction network, with hub genes and different metabolites in serum and brain tissue. The hub genes of DCXF, which were mostly linked with inflammation, might affect mainly neurotransmitters in serum and brain tissue metabolisms. Conclusion: Network pharmacology and metabolomics study may help identify hub genes, metabolites, and possible pathways of disease and treatment. Additionally, two parts of the results were integrated to confirm each other. Their combination may help elucidate the relationship between hub genes and metabolites and provide the further understanding of TCM mechanisms.
Language	English
Publishing date	2021-04-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2021/6665137
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Article ; Online: Tong-Xie-Yao-Fang alleviates diarrhea-predominant irritable bowel syndrome in rats via the GCN2/PERK-eIF2α-ATF4 signaling pathway.

Zhang, Min / Zheng, Yijun / Li, Xia / Wu, Haomeng / Liu, Ping / Zhang, Kunli / Shi, Zhongfei / Lv, Mi / Wang, Fengyun / Tang, Xudong

Phytomedicine : international journal of phytotherapy and phytopharmacology

2022 Volume 107, Page(s) 154350

Abstract: ... gastrointestinal disease. Tong-Xie-Yao-Fang (TXYF), the traditional Chinese herbal medicine prescription, is a classic and ...

Abstract	Background: Diarrhea-predominant irritable bowel syndrome (IBS-D) is a common functional gastrointestinal disease. Tong-Xie-Yao-Fang (TXYF), the traditional Chinese herbal medicine prescription, is a classic and effective prescription for the treatment of IBS-D, but its mechanism of action is not fully clarified. Objective: To evaluate the efficacy of TXYF in the treatment of IBS-D and to explore its potential mechanism of action. Methods: Changes in the serum levels of 50 free amino acids were targeted for detection by high-performance liquid chromatography (HPLC), and the expression of glucose-regulated protein 78 (GRP78), general control nonderepressible 2 (GCN2), and endoplasmic reticulum-resident kinase (PERK) was detected by immunohistochemistry examinations in healthy volunteers and IBS-D patients. The IBS-D rat was constructed by the three-factor superposition method of neonatal maternal separation, 2,4,6-trinitrobenzene sulfonic acid enema, and chronic unpredictable stress stimulation. The treatment effect of TXYF on IBS-D rats was observed by recording the body weight, grasp force, fecal water content (FWC), and abdominal withdrawal reflex (AWR) of rats before and after treatment. The effects of GCN2/PERK-eukaryotic initiation factor-2 (eIF2α) -activating transcription Factor 4 (ATF4) pathway proteins and gene expression were analyzed by western blotting, reverse transcription-polymerase chain reaction (RT-qPCR), and immunohistochemistry evaluations. Results: Compared with healthy volunteers, IBS-D patients exhibited lower levels of cysteine, γ-aminoacetic acid (GABA), homoproline, and lysine, and immunohistochemistry showed strong activation of GRP78, a marker of endoplasmic reticulum stress. Differential expression of GCN2 and PERK proteins was detected in IBS-D patients and rat colons. In the IBS-D rats, TXYF improved the body weight and grasp force, reduced the FWC, and improved the AWR score. TXYF increased the levels of p-GCN2 and GCN2 and reduced the levels of GRP78, p-PERK, PERK, p-eIF2α, and eIF2α, thereby affecting the expression of the apoptosis-related transcription factors ATF4, CHOP, Caspase-3, and Bcl-2. Conclusion: Our study showed that TXYF improved IBS-D by inhibiting apoptosis. The anti-apoptosis effects were potentially mediated by regulating the GCN2/PERK-eIF2a-ATF4 signaling pathway.
MeSH term(s)	Activating Transcription Factor 4/metabolism ; Animals ; Body Weight ; Caspase 3/metabolism ; Cysteine/pharmacology ; Cysteine/therapeutic use ; Diarrhea/drug therapy ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Eukaryotic Initiation Factor-2/metabolism ; Glycine/pharmacology ; Glycine/therapeutic use ; Irritable Bowel Syndrome/drug therapy ; Irritable Bowel Syndrome/metabolism ; Lysine ; Maternal Deprivation ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Rats ; Signal Transduction ; Trinitrobenzenesulfonic Acid/pharmacology ; Trinitrobenzenesulfonic Acid/therapeutic use ; Water ; eIF-2 Kinase/metabolism ; gamma-Aminobutyric Acid
Chemical Substances	Atf4 protein, rat ; Drugs, Chinese Herbal ; Eukaryotic Initiation Factor-2 ; Proto-Oncogene Proteins c-bcl-2 ; Water (059QF0KO0R) ; Activating Transcription Factor 4 (145891-90-3) ; gamma-Aminobutyric Acid (56-12-2) ; Trinitrobenzenesulfonic Acid (8T3HQG2ZC4) ; eIF-2 Kinase (EC 2.7.11.1) ; Caspase 3 (EC 3.4.22.-) ; Lysine (K3Z4F929H6) ; Cysteine (K848JZ4886) ; Glycine (TE7660XO1C)
Language	English
Publishing date	2022-07-22
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1205240-1
ISSN	1618-095X ; 0944-7113
ISSN (online)	1618-095X
ISSN	0944-7113
DOI	10.1016/j.phymed.2022.154350
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Article: SHAO-YANG-XI-BI-FANG INHIBITS CHONDROCYTE INJURY AND INFLAMMATION IN A RAT MODEL OF OSTEOARTHRITIS

Shen, Pengfei / Wang, Bin / Zheng, Chong / Xie, Zikang

Current topics in nutraceutical research

2022 Volume 20, Issue 2, Page(s) 239

Language	English
Document type	Article
ZDB-ID	2116319-4
ISSN	1540-7535
Database	Current Contents Nutrition, Environment, Agriculture

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Article ; Online: Integrating network pharmacology and experimental validation to decipher the mechanism of the Chinese herbal prescription modified Shen-Yan-Fang-Shuai formula in treating diabetic nephropathy

Borui Yu / Mengqi Zhou / Zhaocheng Dong / Huijuan Zheng / Yuxue Zhao / Jingwei Zhou / Chao Zhang / Fudong Wei / Guoyong Yu / Wei Jing Liu / Hongfang Liu / Yaoxian Wang

Pharmaceutical Biology, Vol 61, Iss 1, Pp 1222-

2023 Volume 1233

Abstract: ... Shen-Yan-Fang-Shuai formula (M-SYFSF) has excellent clinical efficacy in treating ...

Abstract	AbstractContext Diabetic nephropathy (DN) is the main cause of end-stage renal disease. Modified Shen-Yan-Fang-Shuai formula (M-SYFSF) has excellent clinical efficacy in treating diabetic kidney disease. However, the potential mechanism of M-SYFSF remains unknown.Objective To investigate the mechanism of M-SYFSF against DN by network pharmacological analysis and biological experiments.Materials and methods Utilizing a web-based pharmacology database, the potential mechanisms of M-SYFSF against DN were identified. In vivo experiments, male SD rats were injected with streptozotocin (50 mg/kg) and got uninephrectomy to construct a model of DN. M-SYFSF (11.34 g/kg/d) was gavaged once per day for 12 weeks after model establishment. In vitro experiments, human proximal tubular cells (HK-2) were performed with advanced glycation end-products (AGEs) (100 μg/mL), then intervened with M-SYFSF freeze-dried powder. Pathological staining, WB, IHC, ELISA were conducted to explore the mechanism of M-SYFSF against DN.Results Network pharmacological analysis showed that MAPK pathway was the potential pathway. Results showed that compared with the Model group, M-SYFSF significantly reduced 24h urine albumin, UACR, and serum creatinine levels (54.90 ± 26.67 vs. 111.78 ± 4.28, 8.87 ± 1.69 vs. 53.94 ± 16.01, 11.56 ± 1.70 vs. 118.70 ± 49.57, respectively), and improved renal pathological changes. Furthermore, the intervention of M-SYFSF reduced the expression of pro-inflammatory cytokines and inhibited the activation of MAPK pathway in AGEs-treated HK-2 cells.Discussion and conclusion M-SYFSF is likely to reduce inflammation in DN by inhibiting the MAPK pathway. It provides a theoretical basis for the clinical application of M-SYFSF in the treatment of DN.
Keywords	Traditional Chinese medicine formula ; protein-protein interaction network ; MAPK signaling pathway ; inflammation ; Therapeutics. Pharmacology ; RM1-950
Subject code	616
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	Taylor & Francis Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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