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  1. Book ; Online ; E-Book: HER2-positive breast cancer

    Hurvitz, Sara A. / McCann, Kelly

    2019  

    Title variant HER2 positive breast cancer
    Author's details Sara Hurvitz, MD; Kelly McCann, MD, PHD
    Keywords Breast/Cancer/Genetic aspects ; HER-2 gene ; HER-2 protein
    Subject code 616.99449042
    Language English
    Size 1 Online Ressource (xvi, 247 Seiten), Illustrationen, Diagramme
    Publisher Elsevier
    Publishing place St. Louis, Missouri
    Publishing country United States
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019825072
    ISBN 978-0-323-58123-3 ; 9780323581226 ; 0-323-58123-4 ; 0323581226
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: DESTINY-Changing Results for Advanced Breast Cancer.

    Hurvitz, Sara A

    The New England journal of medicine

    2022  Volume 387, Issue 1, Page(s) 75–76

    MeSH term(s) Breast Neoplasms/pathology ; Breast Neoplasms/therapy ; Female ; Humans
    Language English
    Publishing date 2022-07-06
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMe2206661
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.34: Show issues Location:
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  3. Article ; Online: Finding the Sweet Spot in the Management of Early HER2+ Breast Cancer.

    Hurvitz, Sara A

    JCO oncology practice

    2021  Volume 17, Issue 6, Page(s) 331–333

    Language English
    Publishing date 2021-06-10
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 3028198-2
    ISSN 2688-1535 ; 2688-1527
    ISSN (online) 2688-1535
    ISSN 2688-1527
    DOI 10.1200/OP.21.00159
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 7198: Show issues Location:
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  4. Book ; Online ; E-Book: Antibody-Drug conjugates

    Olivier, Kenneth J. / Hurvitz, Sara A.

    fundamentals, drug development, and clinical outcomes to target cancer

    2016  

    Author's details editors Kenneth J. Olivier, Sara A. Hurvitz
    Keywords Biotechnologie i. d. Biowissenschaften ; Biotechnology ; Biowissenschaften ; Chemie ; Chemistry ; Drug Discovery & Development ; Life Sciences ; Medical Science ; Medizin ; Oncology & Radiotherapy ; Onkologie u. Strahlentherapie ; Wirkstoffforschung u. -entwicklung ; CH61: Wirkstoffforschung u. -entwicklung ; LS35: Biotechnologie i. d. Biowissenschaften ; MDH0: Onkologie u. Strahlentherapie
    Language English
    Size 1 Online-Ressource (566 Seiten)
    Publisher John Wiley & Sons
    Publishing place New York, NY
    Publishing country Germany
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019316395
    ISBN 978-1-119-06080-2 ; 9781119060680 ; 1-119-06080-X ; 1119060680
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  5. Article ; Online: Anthracycline Use in ERBB2-Positive Breast Cancer: It Is Time to Re-TRAIN.

    Hurvitz, Sara A

    JAMA oncology

    2021  Volume 7, Issue 7, Page(s) 975–977

    MeSH term(s) Anthracyclines/adverse effects ; Antibiotics, Antineoplastic ; Breast Neoplasms/drug therapy ; Female ; Humans ; Receptor, ErbB-2
    Chemical Substances Anthracyclines ; Antibiotics, Antineoplastic ; ERBB2 protein, human (EC 2.7.10.1) ; Receptor, ErbB-2 (EC 2.7.10.1)
    Language English
    Publishing date 2021-05-20
    Publishing country United States
    Document type Editorial ; Comment
    ISSN 2374-2445
    ISSN (online) 2374-2445
    DOI 10.1001/jamaoncol.2021.1314
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Pathological changes in oral epithelium and the expression of SARS-CoV-2 entry receptors, ACE2 and furin.

    Grinstein-Koren, Osnat / Lusthaus, Michal / Tabibian-Keissar, Hilla / Kaplan, Ilana / Buchner, Amos / Ilatov, Ron / Vered, Marilena / Zlotogorski-Hurvitz, Ayelet

    PloS one

    2024  Volume 19, Issue 3, Page(s) e0300269

    Abstract: ... key-roles in entry of SARS-CoV-2 into host cells. Furin is also involved in oral carcinogenesis ... and furin expression might increase susceptibility of patients with these lesions for SARS-CoV-2 ... at higher risk for SARS-CoV-2 infection. Overall, results show that oral mucosae do not seem to be a major ...

    Abstract Background: Expression of angiotensin-converting enzyme (ACE)-2 and co-factors like furin, play key-roles in entry of SARS-CoV-2 into host cells. Furin is also involved in oral carcinogenesis. We investigated their expression in oral pre-malignant/malignant epithelial pathologies to evaluate whether ACE2 and furin expression might increase susceptibility of patients with these lesions for SARS-CoV-2 infection.
    Methods: Study included normal oral mucosa (N = 14), epithelial hyperplasia-mild dysplasia (N = 27), moderate-to-severe dysplasia (N = 24), squamous cell carcinoma (SCC, N = 34) and oral lichen planus (N = 51). Evaluation of ACE2/furin membranous/membranous-cytoplasmic immunohistochemical expression was divided by epithelial thirds (basal/middle/upper), on a 5-tier scale (0, 1-weak, 1.5 -weak-to-moderate, 2-moderate, 3-strong). Total score per case was the sum of all epithelial thirds, and the mean staining score per group was calculated. Real time-polymerase chain reaction was performed for ACE2-RNA. Statistical differences were analyzed by One-way ANOVA, significance at p<0.05.
    Results: All oral mucosa samples were negative for ACE2 immuno-expression and its transcripts. Overall, furin expression was weakly present with total mean expression being higher in moderate-to-severe dysplasia and hyperplasia-mild dysplasia than in normal epithelium (p = 0.01, each) and SCC (p = 0.008, p = 0.009, respectively).
    Conclusions: Oral mucosa, normal or with epithelial pathologies lacked ACE2 expression. Furin was weak and mainly expressed in dysplastic lesions. Thus, patients with epithelial pathologies do not seem to be at higher risk for SARS-CoV-2 infection. Overall, results show that oral mucosae do not seem to be a major site of SARS-CoV-2 entry and these were discussed vis-à-vis a comprehensive analysis of the literature.
    Language English
    Publishing date 2024-03-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0300269
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: HER2DX: a tool that might inform treatment choices for HER2-positive breast cancer.

    Hurvitz, Sara A

    The Lancet. Oncology

    2020  Volume 21, Issue 11, Page(s) 1392–1393

    MeSH term(s) Breast Neoplasms/drug therapy ; Breast Neoplasms/genetics ; Humans ; Patient Selection ; Prognosis ; Receptor, ErbB-2 ; Retrospective Studies
    Chemical Substances Receptor, ErbB-2 (EC 2.7.10.1)
    Language English
    Publishing date 2020-10-01
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2049730-1
    ISSN 1474-5488 ; 1470-2045
    ISSN (online) 1474-5488
    ISSN 1470-2045
    DOI 10.1016/S1470-2045(20)30552-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5696: Show issues Location:
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    Zs.MO 460: Show issues

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  8. Article ; Online: Is the duration of adjuvant trastuzumab debate still clinically relevant?

    Hurvitz, Sara A

    Lancet (London, England)

    2019  Volume 393, Issue 10191, Page(s) 2565–2567

    MeSH term(s) Breast Neoplasms ; Disease-Free Survival ; Humans ; Receptor, ErbB-2 ; Trastuzumab
    Chemical Substances Receptor, ErbB-2 (EC 2.7.10.1) ; Trastuzumab (P188ANX8CK)
    Language English
    Publishing date 2019-06-06
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(19)30946-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MG 94: Show issues

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  9. Article ; Online: Dose intensification of chemotherapy for early breast cancer in the age of de-escalation.

    Hurvitz, Sara A

    Lancet (London, England)

    2019  Volume 393, Issue 10179, Page(s) 1390–1392

    MeSH term(s) Antineoplastic Agents/administration & dosage ; Breast Neoplasms/drug therapy ; Breast Neoplasms/genetics ; Breast Neoplasms/pathology ; Dose-Response Relationship, Drug ; Female ; Humans
    Chemical Substances Antineoplastic Agents
    Language English
    Publishing date 2019-02-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(19)30197-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Neratinib Plus Capecitabine Provides a Glimmer of Hope for a Daunting Disease.

    Hurvitz, Sara A

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2019  Volume 37, Issue 13, Page(s) 1044–1046

    MeSH term(s) Brain Neoplasms ; Breast Neoplasms ; Capecitabine ; Humans ; Quinolines ; Receptor, ErbB-2
    Chemical Substances Quinolines ; Capecitabine (6804DJ8Z9U) ; ERBB2 protein, human (EC 2.7.10.1) ; Receptor, ErbB-2 (EC 2.7.10.1) ; neratinib (JJH94R3PWB)
    Language English
    Publishing date 2019-03-15
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.19.00083
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 650: Show issues

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