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  1. Book ; Online ; E-Book: Nutrients and nutraceuticals for active & healthy ageing

    Nabavi, Seyed Mohammad / D'Onofrio, Grazia / Nabavi, Seyed Fazel

    2020  

    Author's details Seyed Mohammad Nabavi, Grazia D'Onofrio, Seyed Fazel Nabavi, editors
    Keywords Human physiology ; Food—Biotechnology ; Nutrition    ; Geriatrics ; Health promotion
    Subject code 612
    Language English
    Size 1 Online-Ressource (VII, 282 Seiten)
    Edition 1st ed. 2020
    Publisher Springer Singapore
    Publishing place Singapore
    Publishing country Singapore
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer ; Zugriff auf angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020621386
    ISBN 978-981-15-3552-9 ; 9789811535512 ; 9789811535536 ; 9789811535543 ; 981-15-3552-3 ; 9811535515 ; 9811535531 ; 981153554X
    DOI 10.1007/978-981-15-3552-9
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Reactive oxygen species modulators in pulmonary medicine.

    Sharma, Ankush / Tewari, Devesh / Nabavi, Seyed Fazel / Nabavi, Seyed Mohammad / Habtemariam, Solomon

    Current opinion in pharmacology

    2021  Volume 57, Page(s) 157–164

    Abstract: Adapted to effectively capture oxygen from inhaled air and deliver it to all other parts of the body, the lungs constitute the organ with the largest surface area. This makes the lungs more susceptible to airborne pathogens and pollutants that mediate ... ...

    Abstract Adapted to effectively capture oxygen from inhaled air and deliver it to all other parts of the body, the lungs constitute the organ with the largest surface area. This makes the lungs more susceptible to airborne pathogens and pollutants that mediate pathologies through generation of reactive oxygen species (ROS). One pathological consequence of excessive levels of ROS production is pulmonary diseases that account for a large number of mortality and morbidity in the world. Of the various mechanisms involved in pulmonary disease pathogenesis, mitochondrial dysfunction takes prominent importance. Herein, we briefly describe the significance of oxidative stress caused by ROS in pulmonary diseases and some possible therapeutic strategies.
    MeSH term(s) Antioxidants/therapeutic use ; Humans ; Lung ; Oxidative Stress ; Pulmonary Medicine ; Reactive Oxygen Species
    Chemical Substances Antioxidants ; Reactive Oxygen Species
    Language English
    Publishing date 2021-03-17
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2037057-X
    ISSN 1471-4973 ; 1471-4892
    ISSN (online) 1471-4973
    ISSN 1471-4892
    DOI 10.1016/j.coph.2021.02.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: COVID-19 and antimalarials. Have we been doing it wrong all along?

    Cismaru, Cosmin Andrei / Cismaru, Gabriel Laurentiu / Seyed Nabavi, Fazel / Seyed Nabavi, Mohammad / Berindan-Neagoe, Ioana

    European journal of pharmacology

    2020  Volume 891, Page(s) 173694

    Abstract: In the context of the current SARS-CoV-2 pandemic, associations of drugs which interfere with specific steps of the viral infectious cycle are currently being exploited as therapeutic strategies since a specific treatment by vaccination is still ... ...

    Abstract In the context of the current SARS-CoV-2 pandemic, associations of drugs which interfere with specific steps of the viral infectious cycle are currently being exploited as therapeutic strategies since a specific treatment by vaccination is still unavailable. A widespread association of repurposed agents is the combination of the antimalarial drug Hydroxychloroquine and the macrolide antibiotic Azithromycin in the setting of clinical trials. But a closer analysis of their mechanism of action suggests that their concomitant administration may be impractical, and this is supported by experimental data with other agents of the same classes. However a sequential administration of the lysosomotropic antimalarial with the addition of the macrolide proton pump inhibitor after the first has reached a certain threshold could better exploit their antiviral potential.
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Antimalarials/pharmacology ; Azithromycin/pharmacology ; COVID-19/drug therapy ; COVID-19/virology ; Drug Interactions/physiology ; Drug Repositioning/methods ; Drug Repositioning/trends ; Humans ; Hydroxychloroquine/pharmacology ; SARS-CoV-2/drug effects ; SARS-CoV-2/physiology
    Chemical Substances Anti-Bacterial Agents ; Antimalarials ; Hydroxychloroquine (4QWG6N8QKH) ; Azithromycin (83905-01-5)
    Keywords covid19
    Language English
    Publishing date 2020-10-31
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 80121-5
    ISSN 1879-0712 ; 0014-2999
    ISSN (online) 1879-0712
    ISSN 0014-2999
    DOI 10.1016/j.ejphar.2020.173694
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Short interfering RNA in colorectal cancer: is it wise to shoot the messenger?

    Chandramohan, Kiruthiga / Balan, Devasahayam Jaya / Devi, Kasi Pandima / Nabavi, Seyed Fazel / Reshadat, Sara / Khayatkashani, Maryam / Mahmoodifar, Sepideh / Filosa, Rosanna / Amirkhalili, Niloufar / Pishvaei, Soroush / Sargazi-Aval, Omolbanin / Nabavi, Seyed Mohammad

    European journal of pharmacology

    2023  Volume 949, Page(s) 175699

    Abstract: Colorectal cancer (CRC) is the third most common cancer and the leading cause of gastrointestinal cancer death. 90% of people diagnosed with colorectal cancer are over the age of 50; nevertheless, the illness is more aggressive among those detected at a ... ...

    Abstract Colorectal cancer (CRC) is the third most common cancer and the leading cause of gastrointestinal cancer death. 90% of people diagnosed with colorectal cancer are over the age of 50; nevertheless, the illness is more aggressive among those detected at a younger age. Chemotherapy-based treatment has several adverse effects on both normal and malignant cells. The primary signaling pathways implicated in the advancement of CRC include hedgehog (Hh), janus kinase and signal transducer and activator of transcription (JAK/STAT), Wingless-related integration site (Wnt)/β-catenin, transforming growth factor-β (TNF-β), epidermal growth factor receptor (EGFR)/Mitogen-activated protein kinases (MAPK), phosphoinositide 3-kinase (PI3K), nuclear factor kappa B (NF-κB), and Notch. Loss of heterozygosity in tumor suppressor genes like adenomatous polyposis coli, as well as mutation or deletion of genes like p53 and Kirsten rat sarcoma viral oncogene (KRAS), are all responsible for the occurrence of CRC. Novel therapeutic targets linked to these signal-transduction cascades have been identified as a consequence of advances in small interfering RNA (siRNA) treatments. This study focuses on many innovative siRNA therapies and methodologies for delivering siRNA therapeutics to the malignant site safely and effectively for the treatment of CRC. Treatment of CRC using siRNA-associated nanoparticles (NPs) may inhibit the activity of oncogenes and MDR-related genes by targeting a range of signaling mechanisms. This study summarizes several siRNAs targeting signaling molecules, as well as the therapeutic approaches that might be employed to treat CRC in the future.
    MeSH term(s) Humans ; RNA, Small Interfering/genetics ; Phosphatidylinositol 3-Kinases/metabolism ; Hedgehog Proteins ; Signal Transduction ; ErbB Receptors/metabolism ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/genetics
    Chemical Substances RNA, Small Interfering ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Hedgehog Proteins ; ErbB Receptors (EC 2.7.10.1)
    Language English
    Publishing date 2023-04-01
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 80121-5
    ISSN 1879-0712 ; 0014-2999
    ISSN (online) 1879-0712
    ISSN 0014-2999
    DOI 10.1016/j.ejphar.2023.175699
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: New perspective on DNA response pathway (DDR) in glioblastoma, focus on classic biomarkers and emerging roles of ncRNAs.

    Pirlog, Bianca Oana / Ilut, Silvina / Pirlog, Radu / Chiroi, Paul / Nutu, Andreea / Radutiu, Delia Ioana / Cuc, George Daniel / Berindan-Neagoe, Ioana / Nabavi, Seyed Fazel / Filosa, Rosanna / Nabavi, Seyed Mohammad

    Expert reviews in molecular medicine

    2023  Volume 25, Page(s) e18

    Abstract: Background: Glioblastoma (GBM) is the most frequent type of primary brain cancer, having a median survival of only 15 months. The current standard of care includes a combination of surgery, radiotherapy (RT) and chemotherapy with temozolomide, but with ... ...

    Abstract Background: Glioblastoma (GBM) is the most frequent type of primary brain cancer, having a median survival of only 15 months. The current standard of care includes a combination of surgery, radiotherapy (RT) and chemotherapy with temozolomide, but with limited results. Moreover, multiple studies have shown that tumour relapse and resistance to classic therapeutic approaches are common events that occur in the majority of patients, and eventually leading to death. New approaches to better understand the intricated tumour biology involved in GBM are needed in order to develop personalised treatment approaches. Advances in cancer biology have widen our understanding over the GBM genome and allowing a better classification of these tumours based on their molecular profile.
    Methods: A new targeted therapeutic approach that is currently investigated in multiple clinical trials in GBM is represented by molecules that target various defects in the DNA damage repair (DDR) pathway, a mechanism activated by endogenous and exogenous factors that induce alteration of DNA, and is involved for the development of chemotherapy and RT resistance. This intricate pathway is regulated by p53, two important kinases ATR and ATM and non-coding RNAs including microRNAs, long-non-coding RNAs and circular RNAs that regulate the expression of all the proteins involved in the pathway.
    Results: Currently, the most studied DDR inhibitors are represented by PARP inhibitors (PARPi) with important results in ovarian and breast cancer. PARPi are a class of tumour agnostic drugs that showed their efficacy also in other localisations such as colon and prostate tumours that have a molecular signature associated with genomic instability. These inhibitors induce the accumulation of intracellular DNA damage, cell cycle arrest, mitotic catastrophe and apoptosis.
    Conclusions: This study aims to provide an integrated image of the DDR pathway in glioblastoma under physiological and treatment pressure with a focus of the regulatory roles of ncRNAs. The DDR inhibitors are emerging as an important new therapeutic approach for tumours with genomic instability and alterations in DDR pathways. The first clinical trials with PARPi in GBM are currently ongoing and will be presented in the article. Moreover, we consider that by incorporating the regulatory network in the DDR pathway in GBM we can fill the missing gaps that limited previous attempts to effectively target it in brain tumours. An overview of the importance of ncRNAs in GBM and DDR physiology and how they are interconnected is presented.
    MeSH term(s) Male ; Humans ; Glioblastoma/therapy ; Glioblastoma/drug therapy ; Neoplasm Recurrence, Local/drug therapy ; DNA Damage ; RNA, Untranslated/genetics ; Biomarkers ; Poly(ADP-ribose) Polymerase Inhibitors/pharmacology ; Poly(ADP-ribose) Polymerase Inhibitors/therapeutic use ; Genomic Instability ; DNA ; DNA Repair/genetics
    Chemical Substances RNA, Untranslated ; Biomarkers ; Poly(ADP-ribose) Polymerase Inhibitors ; DNA (9007-49-2)
    Language English
    Publishing date 2023-05-08
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ISSN 1462-3994
    ISSN (online) 1462-3994
    DOI 10.1017/erm.2023.10
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: COVID-19 and antimalarials. Have we been doing it wrong all along?

    Andrei, Cismaru Cosmin / Laurentiu, Cismaru Gabriel / Fazel, Nabavi Seyed / Mohammad, Nabavi Seyed / Ioana, Berindan-Neagoe

    European Journal of Pharmacology

    2020  , Page(s) 173694

    Keywords Pharmacology ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 80121-5
    ISSN 1879-0712 ; 0014-2999
    ISSN (online) 1879-0712
    ISSN 0014-2999
    DOI 10.1016/j.ejphar.2020.173694
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Putative Therapeutic Impact of Inflammasome Inhibitors against COVID-19-Induced ARDS.

    Nabavi, Seyed Fazel / Sahebnasagh, Adeleh / Shahbazi, Ahad / Nabavi, Seyed Mohammad / Azimi, Saeid / Kashani, Malihe Khayat / Habtemariam, Solomon / Rahmani, Mojde / Badiee, Mohadese / Hashemi, Javad / Saghafi, Fatemeh / Amini, Kiumarth / Azimi, Mina / Rezabakhsh, Aysa

    Current medicinal chemistry

    2022  Volume 30, Issue 12, Page(s) 1406–1419

    Abstract: Given the importance of COVID-19-induced ARDS, recently, researchers have strived to determine underlying mechanisms involved in the inflammatory responses. In this regard, inflammasomes possess a distinct priority for cytokine storm occurrence and, ... ...

    Abstract Given the importance of COVID-19-induced ARDS, recently, researchers have strived to determine underlying mechanisms involved in the inflammatory responses. In this regard, inflammasomes possess a distinct priority for cytokine storm occurrence and, subsequently, ARDS progression in ill patients with SARS-CoV-2 infection. In this minireview, the characteristics of known inflammasome inhibitors and designed research in this field were concretely deciphered.
    MeSH term(s) Humans ; COVID-19/complications ; Inflammasomes ; SARS-CoV-2 ; NLR Family, Pyrin Domain-Containing 3 Protein ; Respiratory Distress Syndrome/drug therapy
    Chemical Substances Inflammasomes ; NLR Family, Pyrin Domain-Containing 3 Protein
    Language English
    Publishing date 2022-09-05
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 1319315-6
    ISSN 1875-533X ; 0929-8673
    ISSN (online) 1875-533X
    ISSN 0929-8673
    DOI 10.2174/0929867329666220906111550
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  8. Article ; Online: Should we try the antiinflammatory natural product, celastrol, for COVID-19?

    Habtemariam, Solomon / Nabavi, Seyed Fazel / Berindan-Neagoe, Ioana / Cismaru, Cosmin Andrei / Izadi, Morteza / Sureda, Antoni / Nabavi, Seyed Mohammad

    Phytotherapy research : PTR

    2020  Volume 34, Issue 6, Page(s) 1189–1190

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Pandemics ; Pentacyclic Triterpenes ; Peptidyl-Dipeptidase A ; Pneumonia, Viral ; Protease Inhibitors ; SARS Virus ; SARS-CoV-2 ; Triterpenes ; Virus Internalization
    Chemical Substances Pentacyclic Triterpenes ; Protease Inhibitors ; Triterpenes ; Peptidyl-Dipeptidase A (EC 3.4.15.1) ; celastrol (L8GG98663L)
    Keywords covid19
    Language English
    Publishing date 2020-04-29
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 639136-9
    ISSN 1099-1573 ; 0951-418X
    ISSN (online) 1099-1573
    ISSN 0951-418X
    DOI 10.1002/ptr.6711
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  9. Article ; Online: Possible use of the mucolytic drug, bromhexine hydrochloride, as a prophylactic agent against SARS-CoV-2 infection based on its action on the Transmembrane Serine Protease 2.

    Habtemariam, Solomon / Nabavi, Seyed Fazel / Ghavami, Saeid / Cismaru, Cosmin Andrei / Berindan-Neagoe, Ioana / Nabavi, Seyed Mohammad

    Pharmacological research

    2020  Volume 157, Page(s) 104853

    MeSH term(s) Betacoronavirus ; Bromhexine ; COVID-19 ; Coronavirus Infections ; Expectorants ; Humans ; Pandemics ; Pneumonia, Viral ; SARS Virus ; SARS-CoV-2 ; Serine Proteases
    Chemical Substances Expectorants ; Serine Proteases (EC 3.4.-) ; Bromhexine (Q1J152VB1P)
    Keywords covid19
    Language English
    Publishing date 2020-04-30
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 1003347-6
    ISSN 1096-1186 ; 0031-6989 ; 1043-6618
    ISSN (online) 1096-1186
    ISSN 0031-6989 ; 1043-6618
    DOI 10.1016/j.phrs.2020.104853
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  10. Article ; Online: Lessons from SARS and MERS remind us of the possible therapeutic effects of implementing a siRNA strategy to target COVID-19: Shoot the messenger!

    Habtemariam, Solomon / Berindan-Neagoe, Ioana / Cismaru, Cosmin Andrei / Schaafsma, Dedmer / Nabavi, Seyed Fazel / Ghavami, Saeid / Banach, Maciej / Nabavi, Seyed Mohammad

    Journal of cellular and molecular medicine

    2020  Volume 24, Issue 17, Page(s) 10267–10269

    MeSH term(s) Animals ; Antiviral Agents/pharmacology ; COVID-19/genetics ; COVID-19/therapy ; Coronavirus Infections/genetics ; Coronavirus Infections/therapy ; Disease Models, Animal ; Gene Expression Regulation, Viral ; Genetic Therapy/methods ; Genome, Viral ; Humans ; Macaca mulatta ; Open Reading Frames ; RNA, Small Interfering/pharmacology ; RNA, Viral/genetics ; SARS-CoV-2/genetics ; Severe Acute Respiratory Syndrome/genetics ; Severe Acute Respiratory Syndrome/therapy ; Spike Glycoprotein, Coronavirus/genetics
    Chemical Substances Antiviral Agents ; RNA, Small Interfering ; RNA, Viral ; Spike Glycoprotein, Coronavirus
    Keywords covid19
    Language English
    Publishing date 2020-07-17
    Publishing country England
    Document type Letter
    ZDB-ID 2074559-X
    ISSN 1582-4934 ; 1582-4934 ; 1582-1838
    ISSN (online) 1582-4934
    ISSN 1582-4934 ; 1582-1838
    DOI 10.1111/jcmm.15652
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