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  1. Article ; Online: Time to move away from an oxygen-centric model of pulmonary infarction? - Authors' reply.

    McGonagle, Dennis / Bridgewood, Charlie / Meaney, James F M

    The Lancet. Respiratory medicine

    2021  Volume 9, Issue 9, Page(s) e92

    MeSH term(s) Humans ; Oxygen ; Pulmonary Infarction
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2021-08-02
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2686754-0
    ISSN 2213-2619 ; 2213-2600
    ISSN (online) 2213-2619
    ISSN 2213-2600
    DOI 10.1016/S2213-2600(21)00329-5
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    Zs.A 7041: Show issues Location:
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  2. Article ; Online: Immune cartography of macrophage activation syndrome in the COVID-19 era.

    McGonagle, Dennis / Ramanan, Athimalaipet V / Bridgewood, Charlie

    Nature reviews. Rheumatology

    2021  Volume 17, Issue 3, Page(s) 145–157

    Abstract: A hyperinflammatory 'cytokine storm' state termed macrophage activation syndrome (MAS), culminating from a complex interplay of genetics, immunodeficiency, infectious triggers and dominant innate immune effector responses, can develop across disparate ... ...

    Abstract A hyperinflammatory 'cytokine storm' state termed macrophage activation syndrome (MAS), culminating from a complex interplay of genetics, immunodeficiency, infectious triggers and dominant innate immune effector responses, can develop across disparate entities including systemic juvenile idiopathic arthritis (sJIA) and its counterpart adult-onset Still disease (AOSD), connective tissue diseases, sepsis, infection, cancers and cancer immunotherapy. Classifying MAS using the immunological disease continuum model, with strict boundaries that define the limits of innate and adaptive immunity, at one boundary is MAS with loss of immune function, as occurs in the 'perforinopathies' and some cases of sJIA-AOSD. Conversely, at the other boundary, immune hypersensitivity with gain of immune function in MHC class II-associated sJIA-AOSD and with chimeric antigen receptor (CAR) T cell therapy also triggers MAS. This provides a benchmark for evaluating severe inflammation in some patients with COVID-19 pneumonia, which cripples primary type I interferon immunity and usually culminates in a lung-centric 'second wave' cytokine-driven alveolitis with associated immunothrombosis; this phenomenon is generally distinct from MAS but can share features with the proposed 'loss of immune function' MAS variant. This loss and gain of function MAS model offers immune cartography for a novel mechanistic classification of MAS with therapeutic implications.
    MeSH term(s) COVID-19/epidemiology ; COVID-19/immunology ; Cytokines/immunology ; Cytokines/metabolism ; Humans ; Macrophage Activation Syndrome/etiology ; Macrophage Activation Syndrome/immunology ; Macrophages/immunology ; Pandemics ; SARS-CoV-2
    Chemical Substances Cytokines
    Language English
    Publishing date 2021-02-05
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2491532-4
    ISSN 1759-4804 ; 1759-4790
    ISSN (online) 1759-4804
    ISSN 1759-4790
    DOI 10.1038/s41584-020-00571-1
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  3. Article ; Online: A tricompartmental model of lung oxygenation disruption to explain pulmonary and systemic pathology in severe COVID-19.

    McGonagle, Dennis / Bridgewood, Charlie / Meaney, James F M

    The Lancet. Respiratory medicine

    2021  Volume 9, Issue 6, Page(s) 665–672

    Abstract: The emergent 21st century betacoronaviruses, including SARS-CoV-2, lead to clinicopathological manifestations with unusual features, such as early-onset chest pain, pulmonary infarction, and pulmonary and systemic thromboembolism that is pathologically ... ...

    Abstract The emergent 21st century betacoronaviruses, including SARS-CoV-2, lead to clinicopathological manifestations with unusual features, such as early-onset chest pain, pulmonary infarction, and pulmonary and systemic thromboembolism that is pathologically linked to extensive capillary, arteriolar, and venular thrombosis. Early ground glass opacities detected by CT, which are reminiscent of lung infarcts associated with pulmonary embolism, point to a novel vascular pathology in COVID-19. Under physiological conditions, normal parenchymal oxygenation is maintained by three sources: the alveolus itself and dual oxygen supply from the pulmonary and bronchial artery circulations. We propose a model in which these three components are disrupted in COVID-19 pneumonia, with severe viral alveolitis and concomitant immunothrombotic obstruction of the pulmonary and bronchiolar circulation. Tricompartmental disruption might have two main consequences: systemic clot embolisation from pulmonary vein territory immunothrombosis, and alveolar-capillary barrier disruption with systemic access of thrombogenic viral material. Our model encompasses the known pathological and clinical features of severe COVID-19, and has implications for understanding patient responses to immunomodulatory therapies, which might exert an anti-inflammatory effect within the vascular compartments.
    MeSH term(s) COVID-19/complications ; COVID-19/immunology ; COVID-19/physiopathology ; Humans ; Lung/immunology ; Lung/physiopathology ; Models, Biological ; Oxygen Consumption ; Pulmonary Circulation ; Pulmonary Embolism/virology ; SARS-CoV-2/pathogenicity
    Language English
    Publishing date 2021-05-14
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2686754-0
    ISSN 2213-2619 ; 2213-2600
    ISSN (online) 2213-2619
    ISSN 2213-2600
    DOI 10.1016/S2213-2600(21)00213-7
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  4. Article ; Online: Correspondence on 'Safety and efficacy of faecal microbiota transplantation for active peripheral psoriatic arthritis: an exploratory randomised placebo-controlled trial'.

    McGonagle, Dennis G / Bridgewood, Charlie / Marzo-Ortega, Helena

    Annals of the rheumatic diseases

    2021  Volume 82, Issue 7, Page(s) e164

    MeSH term(s) Humans ; Arthritis, Psoriatic ; Fecal Microbiota Transplantation ; Treatment Outcome ; Randomized Controlled Trials as Topic
    Language English
    Publishing date 2021-06-22
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 7090-7
    ISSN 1468-2060 ; 0003-4967
    ISSN (online) 1468-2060
    ISSN 0003-4967
    DOI 10.1136/annrheumdis-2021-220871
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  5. Article ; Online: Response to: 'Correspondence to 'Normal human enthesis harbours conventional CD4+ and CD8+ T cells with regulatory features and inducible IL-17A and TNF expression'' by Wang and Ma.

    Watad, Abdulla / Bridgewood, Charlie / McGonagle, Dennis G

    Annals of the rheumatic diseases

    2020  Volume 81, Issue 12, Page(s) e255

    MeSH term(s) Humans ; Interleukin-17 ; CD8-Positive T-Lymphocytes ; T-Lymphocyte Subsets ; CD4-Positive T-Lymphocytes
    Chemical Substances Interleukin-17
    Language English
    Publishing date 2020-10-06
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 7090-7
    ISSN 1468-2060 ; 0003-4967
    ISSN (online) 1468-2060
    ISSN 0003-4967
    DOI 10.1136/annrheumdis-2020-219047
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  6. Article ; Online: Dupilumab: An Opportunity to Unravel In Vivo Actions of IL-4 and IL-13 in Humans.

    Roesner, Lennart M / Bridgewood, Charlie / McGonagle, Dennis / Wittmann, Miriam

    The Journal of investigative dermatology

    2021  Volume 141, Issue 8, Page(s) 1879–1881

    Abstract: The application of biologics in clinical practice allows immunological observations under real-life conditions. In a new article in the Journal of Investigative Dermatology, Bakker et al. (2021) use deep immune cell phenotyping to demonstrate how ... ...

    Abstract The application of biologics in clinical practice allows immunological observations under real-life conditions. In a new article in the Journal of Investigative Dermatology, Bakker et al. (2021) use deep immune cell phenotyping to demonstrate how dupilumab acts in a targeted fashion on skin-homing T cells, the driver cells of atopic dermatitis.
    MeSH term(s) Antibodies, Monoclonal ; Antibodies, Monoclonal, Humanized ; Humans ; Interleukin-13 ; Interleukin-4
    Chemical Substances Antibodies, Monoclonal ; Antibodies, Monoclonal, Humanized ; Interleukin-13 ; Interleukin-4 (207137-56-2) ; dupilumab (420K487FSG)
    Language English
    Publishing date 2021-07-21
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80136-7
    ISSN 1523-1747 ; 0022-202X
    ISSN (online) 1523-1747
    ISSN 0022-202X
    DOI 10.1016/j.jid.2021.02.007
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  7. Article ; Online: Corrigendum to: Intestinal and enthesis innate immunity in early axial spondyloarthropathy.

    Sharif, Kassem / Bridgewood, Charlie / Dubash, Sayam / McGonagle, Dennis

    Rheumatology (Oxford, England)

    2020  Volume 59, Issue Suppl4, Page(s) iv90

    Language English
    Publishing date 2020-11-11
    Publishing country England
    Document type Journal Article ; Published Erratum
    ZDB-ID 1464822-2
    ISSN 1462-0332 ; 1462-0324
    ISSN (online) 1462-0332
    ISSN 1462-0324
    DOI 10.1093/rheumatology/keaa731
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    Zs.MO 497: Show issues

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  8. Article ; Online: Re: Patiently waiting for the results of anti-IL 6 therapy in severe COVID-19 infection.

    McGonagle, Dennis / Sharif, Kassem / O'Regan, Anthony / Bridgewood, Charlie

    Autoimmunity reviews

    2020  Volume 19, Issue 7, Page(s) 102560

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-05-01
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 2144145-5
    ISSN 1873-0183 ; 1568-9972
    ISSN (online) 1873-0183
    ISSN 1568-9972
    DOI 10.1016/j.autrev.2020.102560
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    Zs.A 5913: Show issues Location:
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  9. Article ; Online: Sex-Based Medicine Meets Psoriatic Arthritis: Lessons Learned and to Learn.

    Bragazzi, Nicola Luigi / Bridgewood, Charlie / Watad, Abdulla / Damiani, Giovanni / McGonagle, Dennis

    Frontiers in immunology

    2022  Volume 13, Page(s) 849560

    Abstract: Humorally associated autoimmune diseases generally show a female predominance whereas ankylosing spondylitis, a disease that overlaps with psoriatic arthritis (PsA), shows a male predominance. The present review ascertains the current knowledge of sex- ... ...

    Abstract Humorally associated autoimmune diseases generally show a female predominance whereas ankylosing spondylitis, a disease that overlaps with psoriatic arthritis (PsA), shows a male predominance. The present review ascertains the current knowledge of sex-specific differences related to psoriatic arthritis (PsA), a chronic, inflammatory condition associated with psoriasis. Sex differences may have important implications for clinical research in PsA and in terms of epidemiology (incidence, prevalence, lifetime risk, survival, and mortality), clinical, radiological, and laboratory features, and response to treatment. While nationwide surveys and large-scale databases and registries show no sex-specific differences, varying male/female ratios have been reported, ranging from 0.42 to 2.75 (comparable with those reported for psoriasis vulgaris: ranging from 0.28 to 2.38). This may reflect subtle, complex, nonlinear interactions between the biological make-up of the individual (genetic and epigenetic differences), hormonal components including menopausal status, environmental exposures including skeletal physical stressing, and psychological variables. There exists methodological heterogeneity and paucity of data concerning sex-specific differences, in terms of the specific population studied, study design, and the diagnostic criteria utilized. Harmonizing and reconciling these discrepancies would be of crucial importance in achieving the ambitious goals of personalized/individualized medicine and further standardized meta-data and Big Data could help disentangle and elucidate the precise mechanisms of underlying potential PsA sex-specific differences.
    MeSH term(s) Arthritis, Psoriatic/drug therapy ; Female ; Humans ; Incidence ; Male ; Psoriasis ; Spondylitis, Ankylosing/diagnosis
    Language English
    Publishing date 2022-04-22
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.849560
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  10. Article ; Online: COVID-19: angiotensin II in development of lung immunothrombosis and vasculitis mimics - Author's reply.

    McGonagle, Dennis / Bridgewood, Charlie / Ramanan, Athimalaipet V / Meaney, James F M / Watad, Abdulla

    The Lancet. Rheumatology

    2021  Volume 3, Issue 5, Page(s) e326

    Language English
    Publishing date 2021-03-17
    Publishing country England
    Document type Journal Article
    ISSN 2665-9913
    ISSN (online) 2665-9913
    DOI 10.1016/S2665-9913(21)00065-5
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