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Article: Ostéoporose et douleur.

Gayraud, Martine

2009 , Issue 740, Page(s) 19–22

Title translation	Osteoporosis and pain.
MeSH term(s)	Absorptiometry, Photon ; Accidental Falls ; Algorithms ; Analgesia/methods ; Analgesia/nursing ; Causality ; Decision Trees ; Diphosphonates/therapeutic use ; Fractures, Bone/diagnosis ; Fractures, Bone/etiology ; Fractures, Bone/therapy ; France/epidemiology ; Humans ; Mass Screening ; Nurse's Role ; Osteoporosis/complications ; Osteoporosis/diagnosis ; Osteoporosis/epidemiology ; Osteoporosis/therapy ; Pain/diagnosis ; Pain/etiology ; Pain Management ; Selective Estrogen Receptor Modulators/therapeutic use
Chemical Substances	Diphosphonates ; Selective Estrogen Receptor Modulators
Language	French
Publishing date	2009-11
Publishing country	France
Document type	Journal Article
ZDB-ID	604655-1
ISSN	0038-0814
ISSN	0038-0814
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Article ; Online: Raynaud's phenomenon.

Gayraud, Martine

Joint bone spine

2006 Volume 74, Issue 1, Page(s) e1–8

Abstract: Vascular acrosyndromes constitute a common reason for physician visits. They are associated with connective tissue disease; for example, 90% of patients with scleroderma experience Raynaud's phenomenon. The rheumatologist must strive to establish the ... ...

Abstract	Vascular acrosyndromes constitute a common reason for physician visits. They are associated with connective tissue disease; for example, 90% of patients with scleroderma experience Raynaud's phenomenon. The rheumatologist must strive to establish the diagnosis, to identify a potential underlying cause, and to prescribe effective treatment when the symptoms are incapacitating. Raynaud's phenomenon is the acrosyndrome most commonly encountered by rheumatologists. The diagnosis of Raynaud's phenomenon rests on clinical grounds. Nailfold capillaroscopy and immunological tests are useful chiefly for determining the cause. Calcium-channel antagonists are the treatment of reference for Raynaud's phenomenon. Drugs introduced over the last few years for severe refractory forms include prostacyclin and its derivatives, endothelin receptor antagonists, and phosphodiesterase inhibitors. These drugs were developed as a result of new knowledge on the pathogenesis of Raynaud's phenomenon. Acrocyanosis, which is extremely common, and erythromelalgia are the other main vascular acrosyndromes.
MeSH term(s)	Adrenergic alpha-Antagonists/therapeutic use ; Angiotensin Receptor Antagonists ; Connective Tissue Diseases/complications ; Endocrine System Diseases/complications ; Endothelin Receptor Antagonists ; Female ; Hematologic Agents/therapeutic use ; Humans ; Male ; Neoplasms/complications ; Nitrates/therapeutic use ; Phosphodiesterase Inhibitors/therapeutic use ; Prostaglandins/therapeutic use ; Raynaud Disease/diagnosis ; Raynaud Disease/etiology ; Raynaud Disease/therapy ; Serotonin Uptake Inhibitors/therapeutic use ; Vascular Diseases/complications ; Vasodilator Agents/therapeutic use ; Wounds and Injuries/complications
Chemical Substances	Adrenergic alpha-Antagonists ; Angiotensin Receptor Antagonists ; Endothelin Receptor Antagonists ; Hematologic Agents ; Nitrates ; Phosphodiesterase Inhibitors ; Prostaglandins ; Serotonin Uptake Inhibitors ; Vasodilator Agents
Language	English
Publishing date	2006-12-04
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	2020487-5
ISSN	1778-7254 ; 1297-319X
ISSN (online)	1778-7254
ISSN	1297-319X
DOI	10.1016/j.jbspin.2006.07.002
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Article ; Online: Remission and low disease activity in psoriatic arthritis publications: a systematic literature review with meta-analysis.

Hagège, Benjamin / Tan, Elina / Gayraud, Martine / Fautrel, Bruno / Gossec, Laure / Mitrovic, Stéphane

Rheumatology (Oxford, England)

2020 Volume 59, Issue 8, Page(s) 1818–1825

Abstract: Objectives: Remission (REM) or low disease activity (LDA) is the treatment target in psoriatic arthritis (PsA). The objective of this study was to assess the reporting and prevalence of REM/LDA in published studies of PsA.: Methods: This was a ... ...

Abstract	Objectives: Remission (REM) or low disease activity (LDA) is the treatment target in psoriatic arthritis (PsA). The objective of this study was to assess the reporting and prevalence of REM/LDA in published studies of PsA. Methods: This was a systematic literature review of all clinical papers published in PubMed, EMBASE or Cochrane database in English between 2012 and 2019 in the field of PsA. Data were collected regarding reporting of REM/LDA by very low disease activity/minimal disease activity (VLDA/MDA), Disease Activity index for Psoriatic Arthritis (DAPSA), or Disease Activity Score 28 joints (DAS28). The pooled rates of REM and LDA by each definition were calculated by random effect meta-analysis. Results: In all, 258 publications (corresponding to 114 651 patients), of which 81 (31%) were randomized controlled trials, were analysed: patients' mean age was 49.4 ( 4.4) years; with a mean disease duration of 8.5 ( 3.8) years. REM/LDA was reported in 91/258 (35.3%) publications. VLDA/MDA was used in 61/91 (67.0%) studies, DAPSA in 27/91 (29.6%) and DAS28 in 28/91 (30.7%), with 40/91 (43.9%) papers reporting several of these definitions. The pooled prevalence (lower-upper limits) of REM was 13.1% (10.9-15.4), 23.1% (16.8-30.1) and 42.1% (33.9-50.4) using VLDA, DAPSA-REM and DAS28, respectively. For LDA the pooled prevalence was 36.3% (32.3-40.5), 52.8% (41.8-63.6) and 60.4% (52.5-68.0) using MDA, DAPSA-LDA and DAS28, respectively. Conclusion: REM/LDA status was reported in only1/3 of recent studies on PsA, with important variations in the frequency of these outcomes according to the definition used: 13.1-42.1% for REM, and 36.3-60.4% for LDA. This highlights the need for consensus.
MeSH term(s)	Antirheumatic Agents/therapeutic use ; Arthritis, Psoriatic/diagnosis ; Arthritis, Psoriatic/drug therapy ; Humans ; Remission Induction ; Severity of Illness Index ; Treatment Outcome
Chemical Substances	Antirheumatic Agents
Language	English
Publishing date	2020-03-19
Publishing country	England
Document type	Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't ; Systematic Review
ZDB-ID	1464822-2
ISSN	1462-0332 ; 1462-0324
ISSN (online)	1462-0332
ISSN	1462-0324
DOI	10.1093/rheumatology/keaa030
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Article: A French cohort of patients with giant cell arteritis: glucocorticoid treatment and its associated side effects.

Perrineau, Ségolène / Ghesquière, Thibault / Charles, Pierre / Paule, Romain / Samson, Maxime / Gayraud, Martine / Chauvin, Anthony / Terrier, Benjamin / Guillevin, Loic / Bonnotte, Bernard / Mouthon, Luc / Régent, Alexis

Clinical and experimental rheumatology

2021 Volume 39 Suppl 129, Issue 2, Page(s) 155–160

Abstract: Objectives: Giant cell arteritis (GCA) is the most common primary large-vessel vasculitis. Glucocorticoids (GC) therapy remains the standard of care for GCA despite frequent side effects (SEs). However, treatment modality changes, prophylactic treatment ...

Abstract	Objectives: Giant cell arteritis (GCA) is the most common primary large-vessel vasculitis. Glucocorticoids (GC) therapy remains the standard of care for GCA despite frequent side effects (SEs). However, treatment modality changes, prophylactic treatment of osteoporosis, or vaccinations might have decreased the frequency of GC-related SEs. This study aims to describe GCA treatment and GC-related SEs in a recent cohort. Methods: Patients with a diagnosis of GCA between May 2009 and March 2018 were included in this multicentric retrospective study. Characteristics of patients, treatment modalities and GC-related SEs were collected and analysed. Risk factors associated with the occurrence of SE were studied. Results: We analysed the files from 206 patients (153 women, 53 men; median age 74 years). Median follow-up was 34 months. Patients received GC for a median of 25 months, starting at 0.7 mg/kg/day, with tapering to 5 mg/day after 11 months follow-up. Flares occurred in 83/201 (41%) patients. Among the 132 patients who stopped GC, 29 (22%) experienced a relapse. SEs occurred in 129 (64%) patients: bone fractures and infections in 13% each and hypertension onset in 9%. Age >75 years, treatment duration >2 years, past medical history of diabetes were risk factors associated with GC-related SEs. Conclusions: Flares occur in 41% of patients during GC withdrawal. As much as 64% of patients had treatment related SEs. An age> 75 year and a past medical history of diabetes were predictive of SEs during follow-up.
MeSH term(s)	Aged ; Cohort Studies ; Female ; Giant Cell Arteritis/drug therapy ; Giant Cell Arteritis/epidemiology ; Glucocorticoids/adverse effects ; Humans ; Male ; Recurrence ; Retrospective Studies
Chemical Substances	Glucocorticoids
Language	English
Publishing date	2021-04-30
Publishing country	Italy
Document type	Journal Article ; Multicenter Study
ZDB-ID	605886-3
ISSN	1593-098X ; 0392-856X
ISSN (online)	1593-098X
ISSN	0392-856X
DOI	10.55563/clinexprheumatol/0nd4kk
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Article ; Online: Intrathecal antibody kinetics in neuroborreliosis: A report on three cases and a literature review.

Jeantin, L / Rodriguez-Regent, C / De Martino, S / Gayraud, M / Cosserat, J

Infectious diseases now

2021 Volume 51, Issue 7, Page(s) 627–629

Abstract: Borreliosis is a common affliction in northern countries and its neurological manifestations often mislead trained clinicians. We present three cases of Lyme neuroborreliosis, with intrathecal synthesis of specific antibodies, lymphocytic meningitis and ... ...

Abstract	Borreliosis is a common affliction in northern countries and its neurological manifestations often mislead trained clinicians. We present three cases of Lyme neuroborreliosis, with intrathecal synthesis of specific antibodies, lymphocytic meningitis and magnetic-resonance imaging (MRI) findings. Our description aims at illustrating the natural history of the infection, highlighting persistent intrathecal synthesis of anti-Borrelia antibodies months after treatment completion, and its clinical significance. We then review the literature on MRI findings in neuroborreliosis and the kinetics of intrathecal synthesis of specific anti-Borrelia antibodies.
MeSH term(s)	Antibodies, Bacterial ; Borrelia ; Humans ; Immunoglobulin G ; Kinetics ; Lyme Neuroborreliosis/diagnosis
Chemical Substances	Antibodies, Bacterial ; Immunoglobulin G
Language	English
Publishing date	2021-02-23
Publishing country	France
Document type	Journal Article ; Review
ISSN	2666-9919
ISSN (online)	2666-9919
DOI	10.1016/j.idnow.2021.02.006
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Book: Maladies infectieuses/VIH

Gayraud, Michel / Lortholary, Olivier / Gayraud, Martine

soins infirmiers

(Nouveaux cahiers de l'infirmière ; 17)

2006

Title variant	Maladies infectieuses, VIH
Author's details	Martine Gayraud, Olivier Lortholary
Series title	Nouveaux cahiers de l'infirmière ; 17
MeSH term(s)	Communicable Diseases/nursing ; HIV Infections/nursing
Language	French
Size	xviii, 268 p. :, ill. (some col.), col. maps ;, 27 cm.
Edition	4e éd.
Publisher	Masson
Publishing place	Paris
Document type	Book
Note	"Avec à l'intérieur un 'cahier d'entraînement.'" ; Includes index. ; Previously published under the title: Soins infirmiers aux personnes atteintes de maladies infectieuses et aux personnes atteintes de l'infection par le VIH.
ISBN	9782294064968 ; 2294064968
Database	Catalogue of the US National Library of Medicine (NLM)

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Article ; Online: Direct Access to Highly Enantioenriched α-Branched Acrylonitriles through a One-Pot Sequential Asymmetric Michael Addition/Retro-Dieckmann/Retro-Michael Fragmentation Cascade.

Duchemin, Nicolas / Cattoen, Martin / Gayraud, Oscar / Anselmi, Silvia / Siddiq, Bilal / Buccafusca, Roberto / Daumas, Marc / Ferey, Vincent / Smietana, Michael / Arseniyadis, Stellios

Organic letters

2020 Volume 22, Issue 15, Page(s) 5995–6000

Abstract: A highly enantioselective synthesis of α-branched acrylonitriles is reported featuring a one-pot sequential asymmetric Michael addition/retro-Dieckmann/retro-Michael fragmentation cascade. The method, which relies on a solid, bench-stable, and ... ...

Abstract	A highly enantioselective synthesis of α-branched acrylonitriles is reported featuring a one-pot sequential asymmetric Michael addition/retro-Dieckmann/retro-Michael fragmentation cascade. The method, which relies on a solid, bench-stable, and commercially available acrylonitrile surrogate, is practical, scalable, and highly versatile and provides a direct access to a wide range of enantioenriched nitrile-containing building blocks. Most importantly, the method offers a new tool to incorporate an acrylonitrile moiety in an asymmetric fashion.
Language	English
Publishing date	2020-07-28
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1523-7052
ISSN (online)	1523-7052
DOI	10.1021/acs.orglett.0c02079
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Article: Infliximab or rituximab for refractory Wegener's granulomatosis: long-term follow up. A prospective randomised multicentre study on 17 patients.

de Menthon, Mathilde / Cohen, Pascal / Pagnoux, Christian / Buchler, Matthias / Sibilia, Jean / Détrée, Frédérick / Gayraud, Martine / Khellaf, Mehdi / Penalba, Christian / Legallicier, Bruno / Mouthon, Luc / Guillevin, Loïc

Clinical and experimental rheumatology

2011 Volume 29, Issue 1 Suppl 64, Page(s) S63–71

Abstract: Objectives: To compare efficacy and tolerance of infliximab versus rituximab to treat refractory Wegener's granulomatosis (WG), and clarify their respective indications.: Methods: Patients with systemic WG refractory to, or intolerant to steroids and ...

Abstract	Objectives: To compare efficacy and tolerance of infliximab versus rituximab to treat refractory Wegener's granulomatosis (WG), and clarify their respective indications. Methods: Patients with systemic WG refractory to, or intolerant to steroids and consecutive immunosuppressant lines, including oral cyclophosphamide, were randomly assigned to receive infliximab or rituximab and their ongoing regimen. The primary endpoint was partial (PR) or complete remission (CR) at month 12. The secondary endpoint was the occurrence of adverse events. Long-term follow-up data were subjected to post-hoc analysis. Results: Between 2004 and 2007, 9 infliximab and 8 rituximab patients were included. At M12, we observed 2 infliximab and 4 rituximab CR, 1 infliximab and 1 rituximab PR, 5 infliximab and 2 rituximab failures and 2 deaths (NS). Post-hoc analysis was conducted after 30.6±15.4 months of follow-up. Among the 15 survivors, 2 infliximab patients and 1 rituximab patient relapsed. Among 5 infliximab non-responders, 4 were successfully switched to rituximab. During follow-up, one patient from each group died. Over the long term, 10/17 (59%) patients responded to rituximab, 1 to infliximab, 2 to other strategies and 2 died. Despite the 2 deaths, tolerance of both drugs was considered acceptable in terms of WG severity before treatment and previous treatment lines. Conclusions: Our observations demonstrate the usefulness of infliximab and/or rituximab to obtain remission of refractory WG with a trend at M12 favouring rituximab. During long-term follow-up, rituximab was better able at obtaining and maintaining remission.
MeSH term(s)	Adult ; Aged ; Antibodies, Monoclonal/adverse effects ; Antibodies, Monoclonal/therapeutic use ; Antibodies, Monoclonal, Murine-Derived/adverse effects ; Antibodies, Monoclonal, Murine-Derived/therapeutic use ; Chi-Square Distribution ; Drug Resistance ; Drug Substitution ; Female ; France ; Granulomatosis with Polyangiitis/diagnosis ; Granulomatosis with Polyangiitis/drug therapy ; Granulomatosis with Polyangiitis/mortality ; Humans ; Immunosuppressive Agents/adverse effects ; Immunosuppressive Agents/therapeutic use ; Infliximab ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Patient Selection ; Prospective Studies ; Recurrence ; Remission Induction ; Risk Assessment ; Risk Factors ; Rituximab ; Severity of Illness Index ; Time Factors ; Treatment Outcome ; Young Adult
Chemical Substances	Antibodies, Monoclonal ; Antibodies, Monoclonal, Murine-Derived ; Immunosuppressive Agents ; Rituximab (4F4X42SYQ6) ; Infliximab (B72HH48FLU)
Language	English
Publishing date	2011-01
Publishing country	Italy
Document type	Comparative Study ; Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	605886-3
ISSN	1593-098X ; 0392-856X
ISSN (online)	1593-098X
ISSN	0392-856X
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Article: Direct Access to Highly Enantioenriched α-Branched Acrylonitriles through a One-Pot Sequential Asymmetric Michael Addition/Retro-Dieckmann/Retro-Michael Fragmentation Cascade

Duchemin, Nicolas / Cattoen, Martin / Gayraud, Oscar / Anselmi, Silvia / Siddiq, Bilal / Buccafusca, Roberto / Daumas, Marc / Ferey, Vincent / Smietana, Michael / Arseniyadis, Stellios

Organic letters. 2020 July 28, v. 22, no. 15

2020

Abstract	A highly enantioselective synthesis of α-branched acrylonitriles is reported featuring a one-pot sequential asymmetric Michael addition/retro-Dieckmann/retro-Michael fragmentation cascade. The method, which relies on a solid, bench-stable, and commercially available acrylonitrile surrogate, is practical, scalable, and highly versatile and provides a direct access to a wide range of enantioenriched nitrile-containing building blocks. Most importantly, the method offers a new tool to incorporate an acrylonitrile moiety in an asymmetric fashion.
Keywords	enantioselective synthesis ; methodology ; moieties ; solids
Language	English
Dates of publication	2020-0728
Size	p. 5995-6000.
Publishing place	American Chemical Society
Document type	Article
Note	NALT-AP-4-rerunAP2-fuzzy
ISSN	1523-7052
DOI	10.1021/acs.orglett.0c02079
Database	NAL-Catalogue (AGRICOLA)

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Article: Polyarteritis nodosa and Churg-Strauss angiitis: characteristics and outcome in 38 patients over 65 years.

Mouthon, Luc / Le Toumelin, Philippe / Andre, Marie Helene / Gayraud, Martine / Casassus, Philippe / Guillevin, Loïc

Medicine

2001 Volume 81, Issue 1, Page(s) 27–40

MeSH term(s)	Adolescent ; Adult ; Age of Onset ; Aged ; Aged, 80 and over ; Churg-Strauss Syndrome/complications ; Churg-Strauss Syndrome/diagnosis ; Churg-Strauss Syndrome/mortality ; Churg-Strauss Syndrome/therapy ; Female ; Glucocorticoids/adverse effects ; Glucocorticoids/therapeutic use ; Humans ; Male ; Middle Aged ; Polyarteritis Nodosa/complications ; Polyarteritis Nodosa/diagnosis ; Polyarteritis Nodosa/mortality ; Polyarteritis Nodosa/therapy ; Prognosis ; Retrospective Studies ; Risk Factors ; Survival Rate
Chemical Substances	Glucocorticoids
Language	English
Publishing date	2001-12-20
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/00005792-200201000-00002
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