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  1. Article ; Online: Re-analysis of SARS-CoV-2-infected host cell proteomics time-course data by impact pathway analysis and network analysis: a potential link with inflammatory response.

    Bock, Jens-Ole / Ortea, Ignacio

    Aging

    2020  Volume 12, Issue 12, Page(s) 11277–11286

    Abstract: Coronavirus disease 2019 (COVID-19), caused by an outbreak of the severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) in Wuhan, China, has led to an unprecedented health and economic crisis worldwide. To develop treatments that can stop or ... ...

    Abstract Coronavirus disease 2019 (COVID-19), caused by an outbreak of the severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) in Wuhan, China, has led to an unprecedented health and economic crisis worldwide. To develop treatments that can stop or lessen the symptoms and severity of SARS-CoV-2 infection, it is critical to understand how the virus behaves inside human cells, and so far studies in this area remain scarce. A recent study investigated translatome and proteome host cell changes induced
    MeSH term(s) Aging ; Angiotensin-Converting Enzyme 2 ; Betacoronavirus/physiology ; COVID-19 ; Coronavirus Infections/virology ; Gene Expression Regulation ; Gene Regulatory Networks ; Humans ; Inflammation ; Pandemics ; Peptidyl-Dipeptidase A/metabolism ; Pneumonia, Viral/virology ; Proteomics ; SARS-CoV-2 ; Virus Replication
    Chemical Substances Peptidyl-Dipeptidase A (EC 3.4.15.1) ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
    Keywords covid19
    Language English
    Publishing date 2020-06-23
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1945-4589
    ISSN (online) 1945-4589
    DOI 10.18632/aging.103524
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Re-analysis of SARS-CoV-2 infected host cell proteomics time-course data by impact pathway analysis and network analysis. A potential link with inflammatory response

    Ortea, Ignacio / Bock, Jens-Ole

    bioRxiv

    Abstract: The disease known as coronavirus disease 19 (COVID-19), potentially caused by an outbreak of the severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) in Wuhan, China, has hit the world hard, and has led to an unprecedent health and economic ... ...

    Abstract The disease known as coronavirus disease 19 (COVID-19), potentially caused by an outbreak of the severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) in Wuhan, China, has hit the world hard, and has led to an unprecedent health and economic crisis. In order to develop treatment options able to stop or ameliorate SARS-CoV-2 effects, we need to understand the biology of the virus inside cells, but this kind of studies are still scarce. A recent study investigated translatome and proteome host cell changes induced in vitro by SARS-CoV-2. In the present study, we use the publicly available proteomics data from this study to re-analyze the mechanisms altered by the virus infection by impact pathways analysis and network analysis. Proteins linked to inflammatory response, but also proteins related to chromosome segregation during mitosis, were found to be regulated. The up-regulation of the inflammatory-related proteins observed could be linked to the propagation of inflammatory reaction and lung injury that is observed in advanced stages of COVID-19 patients.
    Keywords covid19
    Publisher BioRxiv; WHO
    Document type Article ; Online
    DOI 10.1101/2020.03.26.009605
    Database COVID19

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  3. Article ; Online: Re-analysis of SARS-CoV-2 infected host cell proteomics time-course data by impact pathway analysis and network analysis. A potential link with inflammatory response.

    Ortea, Ignacio / Bock, Jens-Ole

    bioRxiv

    Abstract: The disease known as coronavirus disease 19 (COVID-19), potentially caused by an outbreak of the severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) in Wuhan, China, has hit the world hard, and has led to an unprecedent health and economic ... ...

    Abstract The disease known as coronavirus disease 19 (COVID-19), potentially caused by an outbreak of the severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) in Wuhan, China, has hit the world hard, and has led to an unprecedent health and economic crisis. In order to develop treatment options able to stop or ameliorate SARS-CoV-2 effects, we need to understand the biology of the virus inside cells, but this kind of studies are still scarce. A recent study investigated translatome and proteome host cell changes induced in vitro by SARS-CoV-2. In the present study, we use the publicly available proteomics data from this study to re-analyze the mechanisms altered by the virus infection by impact pathways analysis and network analysis. Proteins linked to inflammatory response, but also proteins related to chromosome segregation during mitosis, were found to be regulated. The up-regulation of the inflammatory-related proteins observed could be linked to the propagation of inflammatory reaction and lung injury that is observed in advanced stages of COVID-19 patients.
    Keywords covid19
    Language English
    Publishing date 2020-03-28
    Publisher Cold Spring Harbor Laboratory
    Document type Article ; Online
    DOI 10.1101/2020.03.26.009605
    Database COVID19

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  4. Article ; Online: Diversification of the CRISPR Toolbox: Applications of CRISPR-Cas Systems Beyond Genome Editing.

    Balderston, Sarah / Clouse, Gabrielle / Ripoll, Juan-José / Pratt, Grace K / Gasiunas, Giedrius / Bock, Jens-Ole / Bennett, Eric Paul / Aran, Kiana

    The CRISPR journal

    2021  Volume 4, Issue 3, Page(s) 400–415

    Abstract: The discovery of CRISPR has revolutionized the field of genome engineering, but the potential of this technology is far from reaching its limits. In this review, we explore the broad range of applications of CRISPR technology to highlight the rapid ... ...

    Abstract The discovery of CRISPR has revolutionized the field of genome engineering, but the potential of this technology is far from reaching its limits. In this review, we explore the broad range of applications of CRISPR technology to highlight the rapid expansion of the field beyond gene editing alone. It has been demonstrated that CRISPR technology can control gene expression, spatiotemporally image the genome
    MeSH term(s) CRISPR-Cas Systems ; Clustered Regularly Interspaced Short Palindromic Repeats ; Gene Editing/methods ; Gene Expression ; Genetic Techniques ; Genome ; Pathology, Molecular/methods ; RNA, Guide, CRISPR-Cas Systems/genetics ; Reproducibility of Results
    Chemical Substances RNA, Guide, CRISPR-Cas Systems
    Language English
    Publishing date 2021-06-24
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 3017891-5
    ISSN 2573-1602 ; 2573-1599
    ISSN (online) 2573-1602
    ISSN 2573-1599
    DOI 10.1089/crispr.2020.0137
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  5. Article ; Online: Patientforsikringens aktiviteter.

    Bock, Johannes / Christoffersen, Jens Krogh / Hansen, Ole Hart

    Ugeskrift for laeger

    2006  Volume 168, Issue 4, Page(s) 397; author reply 397

    Title translation Patient insurance activities.
    MeSH term(s) Denmark ; Humans ; Insurance Claim Review ; Malpractice/statistics & numerical data ; Medical Errors/prevention & control ; Medical Errors/statistics & numerical data ; Registries ; Risk Management ; Safety Management
    Language Danish
    Publishing date 2006-01-23
    Publishing country Denmark
    Document type Comment ; Letter
    ZDB-ID 124102-3
    ISSN 1603-6824 ; 0041-5782
    ISSN (online) 1603-6824
    ISSN 0041-5782
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  6. Article ; Online: Genetiske variationers betydning for effekten af selektive serotoningenoptagelseshaemmere.

    Bukh, Jens O Drachmann / Bock, Camilla / Mors, Niels Peter Ole / Kessing, Lars Vedel

    Ugeskrift for laeger

    2007  Volume 169, Issue 16, Page(s) 1439–1441

    Abstract: The outcome of psychopharmacological treatment may depend on genetic polymorphisms of various neurotransmitter systems. We summarize studies of associations between genetic variations with relation to the serotonin system and response to selective ... ...

    Title translation The influence of genetic variations on the effect of selective serotonin reuptake inhibitors.
    Abstract The outcome of psychopharmacological treatment may depend on genetic polymorphisms of various neurotransmitter systems. We summarize studies of associations between genetic variations with relation to the serotonin system and response to selective serotonin reuptake inhibitors. The results are still preliminary but suggest that treatment response to antidepressant drugs is influenced by genetic factors. They also indicate that the genetic component is polygenic and highly complex and might manifest itself in interaction with other biological and environmental factors.
    MeSH term(s) Antidepressive Agents, Second-Generation/therapeutic use ; Depression/drug therapy ; Depressive Disorder/drug therapy ; Humans ; Pharmacogenetics ; Polymorphism, Genetic ; Receptors, Serotonin/genetics ; Receptors, Serotonin/metabolism ; Serotonin Plasma Membrane Transport Proteins/genetics ; Serotonin Plasma Membrane Transport Proteins/metabolism ; Serotonin Uptake Inhibitors/therapeutic use ; Treatment Outcome
    Chemical Substances Antidepressive Agents, Second-Generation ; Receptors, Serotonin ; Serotonin Plasma Membrane Transport Proteins ; Serotonin Uptake Inhibitors
    Language Danish
    Publishing date 2007-04-16
    Publishing country Denmark
    Document type English Abstract ; Journal Article
    ZDB-ID 124102-3
    ISSN 1603-6824 ; 0041-5782
    ISSN (online) 1603-6824
    ISSN 0041-5782
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  7. Article ; Online: Crystal structure of the Ig1 domain of the neural cell adhesion molecule NCAM2 displays domain swapping.

    Rasmussen, Kim K / Kulahin, Nikolaj / Kristensen, Ole / Poulsen, Jens-Christian N / Sigurskjold, Bent W / Kastrup, Jette S / Berezin, Vladimir / Bock, Elisabeth / Walmod, Peter S / Gajhede, Michael

    Journal of molecular biology

    2008  Volume 382, Issue 5, Page(s) 1113–1120

    Abstract: The crystal structure of the first immunoglobulin (Ig1) domain of neural cell adhesion molecule 2 (NCAM2/OCAM/RNCAM) is presented at a resolution of 2.7 A. NCAM2 is a member of the immunoglobulin superfamily of cell adhesion molecules (IgCAMs). In the ... ...

    Abstract The crystal structure of the first immunoglobulin (Ig1) domain of neural cell adhesion molecule 2 (NCAM2/OCAM/RNCAM) is presented at a resolution of 2.7 A. NCAM2 is a member of the immunoglobulin superfamily of cell adhesion molecules (IgCAMs). In the structure, two Ig domains interact by domain swapping, as the two N-terminal beta-strands are interchanged. beta-Strand swapping at the terminal domain is the accepted mechanism of homophilic interactions amongst the cadherins, another class of CAMs, but it has not been observed within the IgCAM superfamily. Gel-filtration chromatography demonstrated the ability of NCAM2 Ig1 to form dimers in solution. Taken together, these observations suggest that beta-strand swapping could have a role in the molecular mechanism of homophilic binding for NCAM2.
    MeSH term(s) Cadherins/chemistry ; Cell Adhesion/physiology ; Chromatography, Gel ; Crystallography, X-Ray ; Dimerization ; Humans ; Immunoglobulins/chemistry ; Models, Molecular ; Neural Cell Adhesion Molecule L1/chemistry ; Neural Cell Adhesion Molecule L1/physiology ; Neural Cell Adhesion Molecules/chemistry ; Protein Structure, Quaternary ; Protein Structure, Secondary ; Protein Structure, Tertiary ; Solutions ; Thermodynamics
    Chemical Substances Cadherins ; Immunoglobulins ; NCAM2 protein, human ; Neural Cell Adhesion Molecule L1 ; Neural Cell Adhesion Molecules ; Solutions
    Language English
    Publishing date 2008-10-24
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80229-3
    ISSN 1089-8638 ; 0022-2836
    ISSN (online) 1089-8638
    ISSN 0022-2836
    DOI 10.1016/j.jmb.2008.07.084
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  8. Article: Association of the leucine-7 to proline-7 variation in the signal sequence of neuropeptide Y with major depression.

    Koefoed, Pernille / Woldbye, David P D / Hansen, Thomas V O / Eplov, Lene F / Christiansen, Søren H / Mors, Ole / Kessing, Lars V / Werge, Thomas / Kaipio, Katja / Pesonen, Ullamari / Fahmy, Thomas / Mellerup, Erling / Jakobsen, Klaus D / Hansen, Elsebeth S / Knudsen, Gitte M / Bukh, Jens D / Bock, Camilla / Lindberg, Camilla / Kristensen, Ann S /
    Dam, Henrik / Nordentoft, Merete / Als, Thomas D / Wang, August G / Gether, Ulrik / Rehfeld, Jens F / Bolwig, Tom G

    Acta neuropsychiatrica

    2012  Volume 24, Issue 2, Page(s) 81–90

    Abstract: Objective: There is clear evidence of a genetic component in major depression, and several studies indicate that neuropeptide Y (NPY) could play an important role in the pathophysiology of the disease. A well-known polymorphism encoding the substitution ...

    Abstract Objective: There is clear evidence of a genetic component in major depression, and several studies indicate that neuropeptide Y (NPY) could play an important role in the pathophysiology of the disease. A well-known polymorphism encoding the substitution of leucine to proline in the signal peptide sequence of NPY (Leu7Pro variation) was previously found to protect against depression. Our study aimed at replicating this association in a large Danish population with major depression.
    Method: Leu7Pro was studied in a sample of depressed patients and ethnically matched controls, as well as psychiatric disease controls with schizophrenia. Possible functional consequences of Leu7Pro were explored in vitro.
    Results: In contrast to previous studies, Pro7 appeared to be a risk allele for depression, being significantly more frequent in the depression sample (5.5%, n = 593; p = 0.009; odds ratio, OR: 1.46) as compared to ethnically matched controls (3.8%, n = 2912), while schizophrenia patients (4.1%, n = 503) did not differ. In vitro, the Pro7 substitution appeared to be associated with reduced levels of NPY without affecting its mRNA level.
    Conclusion: The Leu7Pro variation may increase the risk of major depression, possibly by affecting the biosynthesis of NPY.
    Language English
    Publishing date 2012-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 1154361-9
    ISSN 1601-5215 ; 0924-2708
    ISSN (online) 1601-5215
    ISSN 0924-2708
    DOI 10.1111/j.1601-5215.2011.00600.x
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