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  1. Article ; Online: Innate immunity-With an adaptive twist.

    Josefowicz, Steven Z / Sun, Joseph C

    Immunological reviews

    2024  

    Language English
    Publishing date 2024-04-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 391796-4
    ISSN 1600-065X ; 0105-2896
    ISSN (online) 1600-065X
    ISSN 0105-2896
    DOI 10.1111/imr.13334
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book ; Online: The Second Life of Natural Killer (NK) Cells

    Colonna, Marco / Sun, Joseph C. / Romagnani, Chiara

    2018  

    Abstract: Natural Killer (NK) cells are innate lymphocytes, now recognized as members of a larger family of "Innate lymphoid cells" (ILCs). Both murine and human NK cells are well characterized effector cells with cytotoxic as well as cytokine production ability ... ...

    Abstract Natural Killer (NK) cells are innate lymphocytes, now recognized as members of a larger family of "Innate lymphoid cells" (ILCs). Both murine and human NK cells are well characterized effector cells with cytotoxic as well as cytokine production ability which mainly react in response to microbial and cell stress stimuli, thus playing a central role in the defense against pathogen infection, in tumor surveillance and in regulating immune homeostasis. Despite these established concepts, our understanding of the complexity of NK cells, also in view of their developmental and functional relationship with other ILC subsets, is only recently emerging. This Research Topic highlights the recent advances in NK cell (and ILC) research in human and mouse from basic research to clinical applications
    Keywords Medicine (General) ; Immunologic diseases. Allergy
    Size 1 electronic resource (118 p.)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT020101860
    ISBN 9782889455461 ; 2889455467
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Metabolic programming of organ-specific natural killer cell responses.

    Delconte, Rebecca B / Sun, Joseph C

    Immunological reviews

    2024  

    Abstract: Cells of the mammalian innate immune system have evolved to protect the host from various environmental or internal insults and injuries which perturb the homeostatic state of the organism. Among the lymphocytes of the innate immune system are natural ... ...

    Abstract Cells of the mammalian innate immune system have evolved to protect the host from various environmental or internal insults and injuries which perturb the homeostatic state of the organism. Among the lymphocytes of the innate immune system are natural killer (NK) cells, which circulate and survey host tissues for signs of stress, including infection or transformation. NK cells rapidly eliminate damaged cells in the blood or within tissues through secretion of cytolytic machinery and production of proinflammatory cytokines. To perform these effector functions while traversing between the blood and tissues, patrolling NK cells require sufficient fuel to meet their energetic demands. Here, we highlight the ability of NK cells to metabolically adapt across tissues, during times of nutrient deprivation and within tumor microenvironments. Whether at steady state, or during viral infection and cancer, NK cells readily shift their nutrient uptake and usage in order to maintain metabolism, survival, and function.
    Language English
    Publishing date 2024-04-17
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 391796-4
    ISSN 1600-065X ; 0105-2896
    ISSN (online) 1600-065X
    ISSN 0105-2896
    DOI 10.1111/imr.13333
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Thanks for the NK cell memories.

    Grassmann, Simon / Sun, Joseph C

    Nature immunology

    2022  Volume 23, Issue 11, Page(s) 1512–1514

    MeSH term(s) Killer Cells, Natural ; Immunologic Memory ; Humans
    Language English
    Publishing date 2022-10-11
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2016987-5
    ISSN 1529-2916 ; 1529-2908
    ISSN (online) 1529-2916
    ISSN 1529-2908
    DOI 10.1038/s41590-022-01336-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Cardinal features of immune memory in innate lymphocytes.

    Santosa, Endi K / Sun, Joseph C

    Nature immunology

    2023  Volume 24, Issue 11, Page(s) 1803–1812

    Abstract: The ability of vertebrates to 'remember' previous infections had once been attributed exclusively to adaptive immunity. We now appreciate that innate lymphocytes also possess memory properties akin to those of adaptive immune cells. In this Review, we ... ...

    Abstract The ability of vertebrates to 'remember' previous infections had once been attributed exclusively to adaptive immunity. We now appreciate that innate lymphocytes also possess memory properties akin to those of adaptive immune cells. In this Review, we draw parallels from T cell biology to explore the key features of immune memory in innate lymphocytes, including quantity, quality, and location. We discuss the signals that trigger clonal or clonal-like expansion in innate lymphocytes, and highlight recent studies that shed light on the complex cellular and molecular crosstalk between metabolism, epigenetics, and transcription responsible for differentiating innate lymphocyte responses towards a memory fate. Additionally, we explore emerging evidence that activated innate lymphocytes relocate and establish themselves in specific peripheral tissues during infection, which may facilitate an accelerated response program akin to those of tissue-resident memory T cells.
    MeSH term(s) Animals ; Immunologic Memory ; Immunity, Innate ; Lymphocytes ; Adaptive Immunity ; Clone Cells
    Language English
    Publishing date 2023-10-12
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2016987-5
    ISSN 1529-2916 ; 1529-2908
    ISSN (online) 1529-2916
    ISSN 1529-2908
    DOI 10.1038/s41590-023-01607-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Editorial overview: Innate immunity from a phylogenic perspective.

    Sun, Joseph C / Geissmann, Frederic

    Current opinion in immunology

    2020  Volume 62, Page(s) iii–v

    MeSH term(s) Animals ; Humans ; Immunity, Innate/immunology ; Phylogeny
    Language English
    Publishing date 2020-03-11
    Publishing country England
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 1035767-1
    ISSN 1879-0372 ; 0952-7915
    ISSN (online) 1879-0372
    ISSN 0952-7915
    DOI 10.1016/j.coi.2020.02.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Selective C-H Bond Cleavage with a High-Spin Fe

    Sun, Chen / Jaimes, Jennifer L / Follmer, Alec H / Ziller, Joseph W / Borovik, Andrew S

    Molecules (Basel, Switzerland)

    2023  Volume 28, Issue 12

    Abstract: Non-heme Fe monooxygenases activate C-H bonds using intermediates with high-spin Fe ...

    Abstract Non-heme Fe monooxygenases activate C-H bonds using intermediates with high-spin Fe
    Language English
    Publishing date 2023-06-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28124755
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  8. Article ; Online: Nilabh Shastri 1952-2021.

    Hammer, Gianna E / Schwab, Susan R / Sun, Joseph C

    Nature immunology

    2021  Volume 22, Issue 5, Page(s) 533–534

    Language English
    Publishing date 2021-03-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2016987-5
    ISSN 1529-2916 ; 1529-2908
    ISSN (online) 1529-2916
    ISSN 1529-2908
    DOI 10.1038/s41590-021-00912-6
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  9. Article ; Online: Chlamydia muridarum

    Mishkin, Noah / Miranda, Ileana C / Carrasco, Sebastian E / Cheleuitte-Nieves, Christopher / Ricart Arbona, Rodolfo J / Wingert, Claire / Sun, Joseph C / Lipman, Neil S

    Comparative medicine

    2024  

    Abstract: Chlamydia ... ...

    Abstract Chlamydia muridarum
    Language English
    Publishing date 2024-04-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2006425-1
    ISSN 2769-819X ; 0023-6764 ; 1532-0820
    ISSN (online) 2769-819X
    ISSN 0023-6764 ; 1532-0820
    DOI 10.30802/AALAS-CM-24-000002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Virus-specific NK cell memory.

    Sheppard, Sam / Sun, Joseph C

    The Journal of experimental medicine

    2021  Volume 218, Issue 4

    Abstract: NK cells express a limited number of germline-encoded receptors that identify infected or transformed cells, eliciting cytotoxicity, effector cytokine production, and in some circumstances clonal proliferation and memory. To maximize the functional ... ...

    Abstract NK cells express a limited number of germline-encoded receptors that identify infected or transformed cells, eliciting cytotoxicity, effector cytokine production, and in some circumstances clonal proliferation and memory. To maximize the functional diversity of NK cells, the array and expression level of surface receptors vary between individual NK cell "clones" in mice and humans. Cytomegalovirus infection in both species can expand a population of NK cells expressing receptors critical to the clearance of infected cells and generate a long-lived memory pool capable of targeting future infection with greater efficacy. Here, we discuss the pathways and factors that regulate the generation and maintenance of effector and memory NK cells and propose how this understanding may be harnessed therapeutically.
    MeSH term(s) Animals ; Cytomegalovirus/immunology ; Cytomegalovirus Infections/immunology ; Cytomegalovirus Infections/virology ; Humans ; Immunologic Memory ; Killer Cells, Natural/immunology ; Mice
    Language English
    Publishing date 2021-03-23
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 218343-2
    ISSN 1540-9538 ; 0022-1007
    ISSN (online) 1540-9538
    ISSN 0022-1007
    DOI 10.1084/jem.20201731
    Database MEDical Literature Analysis and Retrieval System OnLINE

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