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  1. Article: Optimising IL-2 for Cancer Immunotherapy.

    Sprent, Jonathan / Boyman, Onur

    Immune network

    2024  Volume 24, Issue 1, Page(s) e5

    Abstract: The key role of T cells in cancer immunotherapy is well established and is highlighted by the remarkable capacity of Ab-mediated checkpoint blockade to overcome T-cell exhaustion and amplify anti-tumor responses. However, total or partial tumor remission ...

    Abstract The key role of T cells in cancer immunotherapy is well established and is highlighted by the remarkable capacity of Ab-mediated checkpoint blockade to overcome T-cell exhaustion and amplify anti-tumor responses. However, total or partial tumor remission following checkpoint blockade is still limited to only a few types of tumors. Hence, concerted attempts are being made to devise new methods for improving tumor immunity. Currently, much attention is being focused on therapy with IL-2. This cytokine is a powerful growth factor for T cells and optimises their effector functions. When used at therapeutic doses for cancer treatment, however, IL-2 is highly toxic. Nevertheless, recent work has shown that modifying the structure or presentation of IL-2 can reduce toxicity and lead to effective anti-tumor responses in synergy with checkpoint blockade. Here, we review the complex interaction of IL-2 with T cells: first during normal homeostasis, then during responses to pathogens, and finally in anti-tumor responses.
    Language English
    Publishing date 2024-01-26
    Publishing country Korea (South)
    Document type Journal Article ; Review
    ZDB-ID 2536191-0
    ISSN 2092-6685 ; 1598-2629
    ISSN (online) 2092-6685
    ISSN 1598-2629
    DOI 10.4110/in.2024.24.e5
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  2. Article ; Online: T cell-B cell collaboration.

    Sprent, Jonathan

    Nature reviews. Immunology

    2017  Volume 17, Issue 9, Page(s) 532

    Language English
    Publishing date 2017-05-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 2062776-2
    ISSN 1474-1741 ; 1474-1733
    ISSN (online) 1474-1741
    ISSN 1474-1733
    DOI 10.1038/nri.2017.62
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5565: Show issues Location:
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    Zs.MG 34: Show issues

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  3. Article ; Online: Treg Therapy for the Induction of Immune Tolerance in Transplantation-Not Lost in Translation?

    Pilat, Nina / Steiner, Romy / Sprent, Jonathan

    International journal of molecular sciences

    2023  Volume 24, Issue 2

    Abstract: The clinical success of solid organ transplantation is still limited by the insufficiency of immunosuppressive regimens to control chronic rejection and late graft loss. Moreover, serious side effects caused by chronic immunosuppressive treatment ... ...

    Abstract The clinical success of solid organ transplantation is still limited by the insufficiency of immunosuppressive regimens to control chronic rejection and late graft loss. Moreover, serious side effects caused by chronic immunosuppressive treatment increase morbidity and mortality in transplant patients. Regulatory T cells (Tregs) have proven to be efficient in the induction of allograft tolerance and prolongation of graft survival in numerous preclinical models, and treatment has now moved to the clinics. The results of the first Treg-based clinical trials seem promising, proving the feasibility and safety of Treg therapy in clinical organ transplantation. However, many questions regarding Treg phenotype, optimum dosage, antigen-specificity, adjunct immunosuppressants and efficacy remain open. This review summarizes the results of the first Treg-based clinical trials for tolerance induction in solid organ transplantation and recapitulates what we have learnt so far and which questions need to be resolved before Treg therapy can become part of daily clinical practice. In addition, we discuss new strategies being developed for induction of donor-specific tolerance in solid organ transplantation with the clinical aims of prolonged graft survival and minimization of immunosuppression.
    MeSH term(s) T-Lymphocytes, Regulatory ; Graft Rejection ; Immune Tolerance ; Organ Transplantation/adverse effects ; Immunosuppression Therapy/methods ; Transplantation Tolerance ; Immunosuppressive Agents/therapeutic use
    Chemical Substances Immunosuppressive Agents
    Language English
    Publishing date 2023-01-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24021752
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  4. Article ; Online: COVID-19 vaccine side effects: The positives about feeling bad.

    Sprent, Jonathan / King, Cecile

    Science immunology

    2021  Volume 6, Issue 60

    Abstract: The side effects of SARS-CoV-2 vaccines are often troubling but may merely reflect transient production of type I interferons, a normal physiological response to contact with invading microorganisms. ...

    Abstract The side effects of SARS-CoV-2 vaccines are often troubling but may merely reflect transient production of type I interferons, a normal physiological response to contact with invading microorganisms.
    MeSH term(s) COVID-19/immunology ; COVID-19/prevention & control ; COVID-19/psychology ; COVID-19 Vaccines/adverse effects ; COVID-19 Vaccines/immunology ; Humans ; Interferon Type I/biosynthesis
    Chemical Substances COVID-19 Vaccines ; Interferon Type I
    Language English
    Publishing date 2021-06-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2470-9468
    ISSN (online) 2470-9468
    DOI 10.1126/sciimmunol.abj9256
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  5. Article ; Online: Treg Therapies Revisited: Tolerance Beyond Deletion.

    Pilat, Nina / Sprent, Jonathan

    Frontiers in immunology

    2021  Volume 11, Page(s) 622810

    Abstract: Induction of immune tolerance is the Holy Grail in transplantation medicine and autoimmunity. Currently, patients are required to use immunosuppressive drugs for the rest of their lives, resulting in unwanted side effects and complication from global ... ...

    Abstract Induction of immune tolerance is the Holy Grail in transplantation medicine and autoimmunity. Currently, patients are required to use immunosuppressive drugs for the rest of their lives, resulting in unwanted side effects and complication from global suppression of the immune response. It is well established that regulatory T cells (Tregs) are critical for the maintenance of immune tolerance towards self-antigens by several mechanisms of immune regulation, in parallel with intrathymic deletion of self-reactive T cells during ontogeny. Therefore, approaches for increasing Treg numbers or function
    MeSH term(s) Animals ; Autoimmune Diseases/immunology ; Autoimmune Diseases/pathology ; Autoimmune Diseases/therapy ; Clonal Deletion ; Graft Rejection/immunology ; Graft Rejection/pathology ; Graft Rejection/therapy ; Humans ; Immunotherapy ; T-Lymphocytes, Regulatory/transplantation ; Transplantation, Homologous
    Language English
    Publishing date 2021-01-28
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2020.622810
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Dual Nature of Type I Interferons in SARS-CoV-2-Induced Inflammation.

    King, Cecile / Sprent, Jonathan

    Trends in immunology

    2021  Volume 42, Issue 4, Page(s) 312–322

    Abstract: Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The ability of our cells to secrete type I interferons (IFN-Is) is essential for the control of virus replication and for ...

    Abstract Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The ability of our cells to secrete type I interferons (IFN-Is) is essential for the control of virus replication and for effective antiviral immune responses; for this reason, viruses have evolved the means to antagonize IFN-I. Inhibition of IFN-I production is pronounced in SARS-CoV-2 infection, which can impair the adaptive immune response and exacerbate inflammatory disease at late stages of infection. However, therapeutic boosting of IFN-I offers a narrow time window for efficacy and safety. Here, we discuss how limits placed on IFN-I by SARS-CoV-2 shape the immune response and whether this might be countered with therapeutic approaches and vaccine design.
    MeSH term(s) COVID-19/complications ; COVID-19/immunology ; Humans ; Inflammation/immunology ; Inflammation/virology ; Interferon Type I/immunology ; Virus Replication
    Chemical Substances Interferon Type I
    Language English
    Publishing date 2021-02-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2036831-8
    ISSN 1471-4981 ; 1471-4906
    ISSN (online) 1471-4981
    ISSN 1471-4906
    DOI 10.1016/j.it.2021.02.003
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1601: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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    Zs.MG 2: Show issues

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  7. Article ; Online: Treg Therapy for the Induction of Immune Tolerance in Transplantation—Not Lost in Translation?

    Nina Pilat / Romy Steiner / Jonathan Sprent

    International Journal of Molecular Sciences, Vol 24, Iss 1752, p

    2023  Volume 1752

    Abstract: The clinical success of solid organ transplantation is still limited by the insufficiency of immunosuppressive regimens to control chronic rejection and late graft loss. Moreover, serious side effects caused by chronic immunosuppressive treatment ... ...

    Abstract The clinical success of solid organ transplantation is still limited by the insufficiency of immunosuppressive regimens to control chronic rejection and late graft loss. Moreover, serious side effects caused by chronic immunosuppressive treatment increase morbidity and mortality in transplant patients. Regulatory T cells (Tregs) have proven to be efficient in the induction of allograft tolerance and prolongation of graft survival in numerous preclinical models, and treatment has now moved to the clinics. The results of the first Treg-based clinical trials seem promising, proving the feasibility and safety of Treg therapy in clinical organ transplantation. However, many questions regarding Treg phenotype, optimum dosage, antigen-specificity, adjunct immunosuppressants and efficacy remain open. This review summarizes the results of the first Treg-based clinical trials for tolerance induction in solid organ transplantation and recapitulates what we have learnt so far and which questions need to be resolved before Treg therapy can become part of daily clinical practice. In addition, we discuss new strategies being developed for induction of donor-specific tolerance in solid organ transplantation with the clinical aims of prolonged graft survival and minimization of immunosuppression.
    Keywords transplantation ; regulatory T cells ; tolerance ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 610
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Editorial: Immunological Tolerance in Transplantation: More Than Deletion.

    Pilat, Nina / Wekerle, Thomas / Geissler, Edward K / Sprent, Jonathan

    Frontiers in immunology

    2022  Volume 13, Page(s) 959115

    MeSH term(s) Immune Tolerance ; Transplantation Tolerance
    Language English
    Publishing date 2022-06-30
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.959115
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  9. Article ; Online: Homeostasis of Naive and Memory T Lymphocytes.

    Kawabe, Takeshi / Yi, Jaeu / Sprent, Jonathan

    Cold Spring Harbor perspectives in biology

    2021  Volume 13, Issue 9

    Abstract: Conventional ... ...

    Abstract Conventional CD4
    MeSH term(s) Animals ; Homeostasis ; Humans ; Immunologic Memory ; Memory T Cells/physiology ; Phenotype
    Language English
    Publishing date 2021-09-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ISSN 1943-0264
    ISSN (online) 1943-0264
    DOI 10.1101/cshperspect.a037879
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  10. Article ; Online: The power of dilution: using adoptive transfer to study TCR transgenic T cells.

    Sprent, Jonathan

    Journal of immunology (Baltimore, Md. : 1950)

    2013  Volume 191, Issue 11, Page(s) 5325–5326

    MeSH term(s) Animals ; Peripheral Tolerance ; Receptors, Antigen, T-Cell, alpha-beta/immunology ; T-Lymphocytes/immunology
    Chemical Substances Receptors, Antigen, T-Cell, alpha-beta
    Language English
    Publishing date 2013-12-01
    Publishing country United States
    Document type Comment ; Introductory Journal Article
    ZDB-ID 3056-9
    ISSN 1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
    ISSN (online) 1550-6606
    ISSN 0022-1767 ; 1048-3233 ; 1047-7381
    DOI 10.4049/jimmunol.1302679
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    Ud II Zs.37: Show issues Location:
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