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Article: PTH resistance

Mantovani, Giovanna / Elli, Francesca Marta

Molecular and cellular endocrinology. 2021 July 01, v. 531

2021

Abstract: Parathyroid hormone (PTH), which is primarily regulated by extracellular calcium changes, controls calcium and phosphate homeostasis. Different diseases are derived from PTH deficiency (hypoparathyroidism), excess (hyperparathyroidism) and resistance ( ... ...

Abstract	Parathyroid hormone (PTH), which is primarily regulated by extracellular calcium changes, controls calcium and phosphate homeostasis. Different diseases are derived from PTH deficiency (hypoparathyroidism), excess (hyperparathyroidism) and resistance (pseudohypoparathyroidism, PHP). Pseudohypoparathyroidism was historically classified into subtypes according to the presence or not of inherited PTH resistance associated or not with features of Albright's hereditary osteodystrophy and deep and progressive ectopic ossifications. The growing knowledge on the PTH/PTHrP signaling pathway showed that molecular defects affecting different members of this pathway determined distinct, yet clinically related disorders, leading to the proposal of a new nomenclature and classification encompassing all disorders, collectively termed inactivating PTH/PTHrP signaling disorders (iPPSD).
Keywords	calcium ; homeostasis ; hyperparathyroidism ; hypoparathyroidism ; parathyroid hormone ; phosphates
Language	English
Dates of publication	2021-0701
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	187438-x
ISSN	1872-8057 ; 0303-7207
ISSN (online)	1872-8057
ISSN	0303-7207
DOI	10.1016/j.mce.2021.111311
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Article: Ceramides and risk of major adverse cardiovascular events: A meta-analysis of longitudinal studies.

Mantovani, Alessandro / Dugo, Clementina

Journal of clinical lipidology

2020 Volume 14, Issue 2, Page(s) 176–185

Abstract: ... We searched publication databases using appropriate keywords to identify cohort studies (published up to July ...

Abstract	Background: Recent cohort studies evaluated the association between some previously identified high-risk ceramides [Cer(d18:1/16:0), Cer(d18:1/18:0), Cer(d18:1/22:0), Cer(d18:1/24:0) and Cer(d18:1/24:1)] and risk of major adverse cardiovascular events in adult population. Objective: The objective of this meta-analysis was to investigate the magnitude of such associations. Methods: We searched publication databases using appropriate keywords to identify cohort studies (published up to July 30, 2019), in which association between previously identified high-risk ceramides and major adverse cardiovascular events was reported. Data from eligible studies were extracted and meta-analysis was performed using random-effects modeling. Results: Seven cohort studies with aggregate data on 29,818 individuals (2736 new cases of cardiovascular events over a median follow-up of 6 years) were included. Higher plasma levels of Cer(d18:1/16:0) (random effects hazard ratio [HR] per standard deviation 1.21, 95% confidence interval [CI] 1.11-1.32, I Conclusions: Higher plasma levels of Cer(d18:1/16:0), Cer(d18:1/18:0) and Cer(d18:1/24:1) were associated with major adverse cardiovascular events, whereas plasma levels of Cer(d18:1/22:0) and Cer(d18:1/24:0) were not. Additional research is required to elucidate the different role of ceramides on pathways involved in cardiovascular disease.
MeSH term(s)	Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/metabolism ; Ceramides/metabolism ; Humans ; Longitudinal Studies ; Risk
Chemical Substances	Ceramides
Language	English
Publishing date	2020-01-23
Publishing country	United States
Document type	Journal Article ; Meta-Analysis ; Review
ZDB-ID	2365061-8
ISSN	1876-4789 ; 1933-2874
ISSN (online)	1876-4789
ISSN	1933-2874
DOI	10.1016/j.jacl.2020.01.005
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Article ; Online: Synthesis of azide/alkyne-terminal polymers and application for surface functionalisation through a [2 + 3] Huisgen cycloaddition process, "click chemistry".

Chen, Gaojian / Tao, Lei / Mantovani, Giuseppe / Ladmiral, Vincent / Burt, David P / Macpherson, Julie V / Haddleton, David M

Soft matter

2020 Volume 3, Issue 6, Page(s) 732–739

Abstract: Living radical polymerization of methyl methacrylate (MMA) and a fluorescent comonomer with 2-bromo-2-methylpropionic acid 3-azidopropyl ester and 2-bromo-2-methylhept-6-yn-3-one as initiators has been successfully employed for the synthesis of ... ...

Abstract	Living radical polymerization of methyl methacrylate (MMA) and a fluorescent comonomer with 2-bromo-2-methylpropionic acid 3-azidopropyl ester and 2-bromo-2-methylhept-6-yn-3-one as initiators has been successfully employed for the synthesis of fluorescently tagged azide and alkyne terminated PMMA with close to that predicted, PDI < 1.20, and good first order kinetics as expected for a living polymerisation. Cotton and organic resin surfaces have been functionalised with alkyne groups using a condensation with 4-chlorocarbonylbutyric acid prop-2-ynyl ester. The surfaces have been further modified using a Huisgen [2 + 3] cycloaddition ("click") reaction of polymeric and small molecule azides. Different functional azides, mono azido-PEG and a new fluorescent hostasol derivative have been prepared and tested as model substrates for cotton surface modification. FTIR, tensiometry, FE-SEM and confocal spectroscopy have been used to characterize the modified surfaces. Tensiometry shows an increase in the hydrophobicity of the surface; verified by FE-SEM which shows a change in surface morphology. The use of the fluorescence label allows fluorescent and confocal microscopy to demonstrate the surface reactions. This approach is shown to be very general allowing soft and hard surfaces with different geometries to be modified. In particular it is an excellent method to alter the nature of organic resins allowing the incorporation of many different functionalities.
Language	English
Publishing date	2020-09-04
Publishing country	England
Document type	Journal Article
ZDB-ID	2191476-X
ISSN	1744-6848 ; 1744-683X
ISSN (online)	1744-6848
ISSN	1744-683X
DOI	10.1039/b618325e
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Article ; Online: Re-evaluating the general(ized) roles of AMPK in cellular metabolism.

Mantovani, Julie / Roy, Richard

FEBS letters

2011 Volume 585, Issue 7, Page(s) 967–972

Abstract: AMPK is a protein kinase activated by various cellular stresses such as glucose deprivation, hypoxia or exercise. Despite having been studied for decades only a limited number of targets have been well described in tissues as varied as liver, muscle, and ...

Abstract	AMPK is a protein kinase activated by various cellular stresses such as glucose deprivation, hypoxia or exercise. Despite having been studied for decades only a limited number of targets have been well described in tissues as varied as liver, muscle, and adipose tissue. Recent studies have shown that AMPK does not function in a similar manner, or through identical targets, in all cellular situations, posing challenges to some accepted paradigms describing AMPK function. A combination of genetic models and cell biological analysis of AMPK function in specific cell/developmental/environmental contexts will be required to accurately complement our understanding of the role(s) of AMPK in cancer, diabetes and other diseases.
MeSH term(s)	Adenylate Kinase/metabolism ; Animals ; Cell Line ; Cells/enzymology ; Cells/metabolism ; Humans
Chemical Substances	Adenylate Kinase (EC 2.7.4.3)
Language	English
Publishing date	2011-04-06
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	212746-5
ISSN	1873-3468 ; 0014-5793
ISSN (online)	1873-3468
ISSN	0014-5793
DOI	10.1016/j.febslet.2010.12.015
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Article ; Online: Clinical risk factors and features on computed tomography angiography in high-risk carotid artery plaque in patients with type 2 diabetes.

Mezzetto, Luca / Mastrorilli, Davide / Zanetti, Elisa / Scoccia, Enrico / Pecoraro, Barbara / Sboarina, Andrea / Mantovani, Alessandro / Veraldi, Gian F

International angiology : a journal of the International Union of Angiology

2024

Abstract: ... carotid endarterectomy (CEA) from January 2018 to July 2021. The carotid atherosclerotic plaque (CAP) was assessed ...

Abstract	Background: High-risk carotid artery plaque (HPR) is associated with a markedly increased risk of ischemic stroke. The aims of this study were: 1) to examine the prevalence of HRP in a cohort of asymptomatic adults with type 2 diabetes (T2D); 2) to investigate the relationship between HRP, established cardiovascular risk factors and computed tomography angiography (CTA) profile; and 3) to assess whether the presence of HRP is associated with an increased risk of major adverse cardiovascular events (MACE). Methods: This was a retrospective cohort study of T2D asymptomatic patients who underwent carotid endarterectomy (CEA) from January 2018 to July 2021. The carotid atherosclerotic plaque (CAP) was assessed for the presence of ulceration, the presence of lipids, fibrosis, thrombotic deposits, hemorrhage, neovascularization, and inflammation. A CAP presenting at least five of these histological features was defined as a HRP (Group A); in all other cases it was defined as a mild to moderate heterogeneous plaque and no-HRP (Group B). CTA features included the presence of rim sign consisting of thin peripheral adventitial calcification (<2 mm) and internal soft plaque (≥2 mm), NASCET percent diameter stenosis, maximum plaque thickness, ulceration, calcification, and intraluminal thrombus were recorded. Binary logistic regression with Uni- and Multivariate was used to evaluate possible predictors for HRP while multivariable Cox Proportional Hazards was used to assess independent predictors for MACE. Results: One hundred eighty-five asymptomatic patients (mean age 73±8 years, 131 men), undergoing carotid endarterectomy, were included. Of these, 124 (67%) had HRP, and the 61 (33%) did not. Diabetic complications (OR 2.4, 95% CI: 1.1-5.1, P=0.01), NASCET stenosis ≥75% (OR 2.4, 95% CI: 1.2-3.7, P=0.02) and carotid RIM sign (OR 4.3, 95% CI: 3.9-7.3, P<0.001) were independently associated with HRP. However, HRP was not associated with a higher risk of MACE (freedom from MACE at 5 years: HRP 83.4% vs. non HRP 87.8%, P=0.72) or a reduction of survival (5-year survival estimates: HRP 96.4% vs. non HRP: 94.6%, P=0.76). Conclusions: A high prevalence of HRP (67%) was observed in asymptomatic and elderly T2D patients. Independent predictors of HRP were diabetic complications, NASCET stenosis ≥75% and carotid RIM sign (OR 4.3, 95% CI: 3.9-7.3, P<0.001). HRP was not associated with an increased risk of MACE during a mean follow-up of 39±24 years.
Language	English
Publishing date	2024-03-12
Publishing country	Italy
Document type	Journal Article
ZDB-ID	604910-2
ISSN	1827-1839 ; 0392-9590
ISSN (online)	1827-1839
ISSN	0392-9590
DOI	10.23736/S0392-9590.24.05154-X
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Article: Re-evaluating the general(ized) roles of AMPK in cellular metabolism

Mantovani, Julie / Roy, Richard

FEBS letters. 2011 Apr. 6, v. 585, no. 7

2011

Abstract	AMPK is a protein kinase activated by various cellular stresses such as glucose deprivation, hypoxia or exercise. Despite having been studied for decades only a limited number of targets have been well described in tissues as varied as liver, muscle, and adipose tissue. Recent studies have shown that AMPK does not function in a similar manner, or through identical targets, in all cellular situations, posing challenges to some accepted paradigms describing AMPK function. A combination of genetic models and cell biological analysis of AMPK function in specific cell/developmental/environmental contexts will be required to accurately complement our understanding of the role(s) of AMPK in cancer, diabetes and other diseases.
Keywords	adipose tissue ; diabetes ; exercise ; glucose ; hypoxia ; liver ; metabolism ; models ; muscles ; protein kinases
Language	English
Dates of publication	2011-0406
Size	p. 967-972.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	212746-5
ISSN	1873-3468 ; 0014-5793
ISSN (online)	1873-3468
ISSN	0014-5793
DOI	10.1016/j.febslet.2010.12.015
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Article: In-Person Education During the Early COVID-19 Pandemic at Wichita Collegiate School.

Mantovani, Emma / Meyer, Christopher / Sandid, Adam / Weeks, Kerri / Dedeaux, Julian / Assi, Maha

Kansas journal of medicine

2022 Volume 15, Page(s) 202–204

Abstract: Introduction: The COVID-19 pandemic forced most Kansas schools to adopt remote or hybrid learning in 2020-2021. Wichita Collegiate School proceeded with an in-person teaching model. The purpose of this study was to determine if in-person learning can be ...

Abstract	Introduction: The COVID-19 pandemic forced most Kansas schools to adopt remote or hybrid learning in 2020-2021. Wichita Collegiate School proceeded with an in-person teaching model. The purpose of this study was to determine if in-person learning can be done safely during the COVID-19 pandemic prior to vaccine use. Methods: Wichita Collegiate is a private school located in Sedgwick County, Kansas. The study population included 671 students (grades 1 - 12) and 130 staff. The procedures implemented during the school year (August 19, 2020 - May 21, 2021) included: mandatory face coverings, six feet physical distancing, and daily temperature checks. A registered nurse performed contact tracing and executed quarantine requirements per the U.S. Centers for Disease Control and Prevention guidelines. Results: Over the study period, 487 students and staff were tested for COVID-19 and 18.5% (n = 90) were positive. Overall, students and staff rate of COVID-19 infection was lower than the expected rate when compared to the surrounding community of Sedgwick County. Thorough contract tracing of positive cases revealed that 2.2% (n = 2) individuals were likely exposed to COVID-19 at school. Conclusions: This study suggested that transmission of COVID-19 was infrequent in a school setting with in-person attendance, even before widespread vaccine availability. By following public health guidelines and utilizing contact tracing, it was possible to limit the spread of COVID-19 during in-person learning. This has immediate implications for how schools safely returned to in-person learning in the post-vaccine era.
Language	English
Publishing date	2022-06-20
Publishing country	United States
Document type	Journal Article
ISSN	1948-2035
ISSN	1948-2035
DOI	10.17161/kjm.vol15.16320
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Article: Cadaver Homologous Banked Fascia Lata in Skull Base Reconstruction: Preliminary Multidisciplinary Experiences.

Alicandri-Ciufelli, Matteo / Serafini, Edoardo / Pavesi, Giacomo / Marchioni, Daniele / Mantovani, Matteo / Dallari, Dante / Iaccarino, Corrado

Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India

2023 Volume 75, Issue Suppl 1, Page(s) 941–946

Abstract: ... of skull base defects with Cadaver homologous banked fascia lata between January 2020 until July 2021 were ...

Abstract	Skull base reconstruction has been a widely debated issue. Both autologous and heterologous materials have been proposed, however the formers are usually preferred due to their optimal healing outcomes and integration. Nevertheless they are still associated with donor-site functional and aesthetic morbidity. The aim of this study is to report a preliminary experience of different sites defects skull base repair with Cadaver homologous banked fascia lata graft. Patients who underwent reconstruction of skull base defects with Cadaver homologous banked fascia lata between January 2020 until July 2021 were included in the study. Three patients were finally identified for the study. Patient 1 underwent combined craniotomic-endoscopic surgical access for extended anterior skull base neoplasm with subsequent repair with homologous cadaver fascia lata. Patient 2 underwent endoscopic transphenoidal surgery for sellar-parasellar neoplasm. After tumor debulking the surgical cavity was obliterated with homologous cadaver fascia lata. Patient 3 finally had politrauma with otic capsule-violating fracture with profused CSF leak. An endoscopic obliteration of external and middle ear was performed using homologous cadaver fascia lata with blind sac closure of external auditory canal. No graft displacement or reabsorption was observed in these patients at the last follow-up. Cadaver homologous banked fascia lata has proved safety, efficacy and ductility in reconstruction of different skull base defects.
Language	English
Publishing date	2023-01-31
Publishing country	India
Document type	Journal Article
ZDB-ID	1471137-0
ISSN	0973-7707 ; 2231-3796 ; 0019-5421
ISSN (online)	0973-7707
ISSN	2231-3796 ; 0019-5421
DOI	10.1007/s12070-023-03517-7
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Article ; Online: Wearables, sensors, and smart devices for the detection and monitoring of chemotherapy-induced peripheral neurotoxicity: Systematic review and directions for future research.

Mantovani, Elisa / Demrozi, Florenc / Hertz, Daniel L / Turetta, Cristian / Ferro, Omar / Argyriou, Andreas A / Pravadelli, Graziano / Tamburin, Stefano

Journal of the peripheral nervous system : JPNS

2022 Volume 27, Issue 4, Page(s) 238–258

Abstract: ... from database inception until March 2021. The search was further updated in July 2022 to ensure currency ...

Abstract	Chemotherapy-induced peripheral neurotoxicity (CIPN) diagnosis is largely based on patient reported outcomes. Wearables, sensors, and smart devices may potentially provide early detection and monitoring of CIPN. We systematically reviewed data on wearables, sensors, and smart devices to detect and/or monitor signs and symptoms of CIPN. Moreover, we provide directions and recommendations for future studies. A literature search using PubMed/MEDLINE, Web of Science, IEEE Xplore, and CINHAL databases was conducted from database inception until March 2021. The search was further updated in July 2022 to ensure currency of results. A total of 1885 records were title-abstract screened, 33 full texts were assessed, and 16 were included. The retrieved papers were heterogeneous in terms of study design, sample size, CIPN severity, chemotherapy agents, type of wearable/sensor/device applied, parameters of interest, and purpose. Data are promising and provide preliminary evidence on wearables, sensors, and smart devices for CIPN detection and monitoring. There are several issues and knowledge gaps that should be addressed. We propose a framework for future studies.
MeSH term(s)	Humans ; Wearable Electronic Devices ; Antineoplastic Agents/adverse effects ; Neurotoxicity Syndromes/diagnosis ; Neurotoxicity Syndromes/etiology ; Neurotoxicity Syndromes/therapy
Chemical Substances	Antineoplastic Agents
Language	English
Publishing date	2022-11-01
Publishing country	United States
Document type	Systematic Review ; Journal Article ; Review
ZDB-ID	1364009-4
ISSN	1529-8027 ; 1085-9489
ISSN (online)	1529-8027
ISSN	1085-9489
DOI	10.1111/jns.12518
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Article: Diabetes as a risk factor for greater COVID-19 severity and in-hospital death: A meta-analysis of observational studies

Mantovani, Alessandro / Byrne, Christopher D / Zheng, Ming-Hua / Targher, Giovanni

The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University Nutrition, metabolism, and cardiovascular diseases. 2020 July 24, v. 30, no. 8

2020

Abstract: To estimate the prevalence of established diabetes and its association with the clinical severity and in-hospital mortality associated with COVID-19.We systematically searched PubMed, Scopus and Web of Science, from 1st January 2020 to 15th May 2020, for ...

Abstract	To estimate the prevalence of established diabetes and its association with the clinical severity and in-hospital mortality associated with COVID-19.We systematically searched PubMed, Scopus and Web of Science, from 1st January 2020 to 15th May 2020, for observational studies of patients admitted to hospital with COVID-19. Meta-analysis was performed using random-effects modeling. A total of 83 eligible studies with 78,874 hospitalized patients with laboratory-confirmed COVID-19 were included. The pooled prevalence of established diabetes was 14.34% (95% CI 12.62–16.06%). However, the prevalence of diabetes was higher in non-Asian vs. Asian countries (23.34% [95% CI 16.40–30.28] vs. 11.06% [95% CI 9.73–12.39]), and in patients aged ≥60 years vs. those aged <60 years (23.30% [95% CI 19.65–26.94] vs. 8.79% [95% CI 7.56–10.02]). Pre-existing diabetes was associated with an approximate twofold higher risk of having severe/critical COVID-19 illness (n = 22 studies; random-effects odds ratio 2.10, 95% CI 1.71–2.57; I² = 41.5%) and ~threefold increased risk of in-hospital mortality (n = 15 studies; random-effects odds ratio 2.68, 95% CI 2.09–3.44; I² = 46.7%). Funnel plots and Egger's tests did not reveal any significant publication bias.Pre-existing diabetes is significantly associated with greater risk of severe/critical illness and in-hospital mortality in patients admitted to hospital with COVID-19.
Keywords	Coronavirus infections ; cardiovascular diseases ; death ; diabetes ; hospitals ; meta-analysis ; metabolism ; mortality ; nutrition ; observational studies ; odds ratio ; patients ; prevalence ; risk factors ; testing ; Asia
Language	English
Dates of publication	2020-0724
Size	p. 1236-1248.
Publishing place	Elsevier B.V.
Document type	Article
Note	NAL-light
ZDB-ID	1067704-5
ISSN	0939-4753
ISSN	0939-4753
DOI	10.1016/j.numecd.2020.05.014
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