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  1. Article ; Online: Ecological studies of COVID-19 and air pollution: How useful are they?

    Villeneuve, Paul J / Goldberg, Mark S

    Environmental epidemiology (Philadelphia, Pa.)

    2022  Volume 6, Issue 1, Page(s) e195

    Abstract: Background: Results from ecological studies have suggested that air pollution increases the risk of developing and dying from COVID-19. Drawing causal inferences from the measures of association reported in ecological studies is fraught with challenges ... ...

    Abstract Background: Results from ecological studies have suggested that air pollution increases the risk of developing and dying from COVID-19. Drawing causal inferences from the measures of association reported in ecological studies is fraught with challenges given biases arising from an outcome whose ascertainment is incomplete, varies by region, time, and across sociodemographic characteristics, and cannot account for clustering or within-area heterogeneity. Through a series of analyses, we illustrate the dangers of using ecological studies to assess whether ambient air pollution increases the risk of dying from, or transmitting, COVID-19.
    Methods: We performed an ecological analysis in the continental United States using county-level ambient concentrations of fine particulate matter (PM
    Results: Our analyses revealed that the shape of the exposure-response curve between PM
    Conclusions: Our analyses indicated that ecological analyses are prone to showing spurious relationships between ambient air pollution and mortality from COVID-19 as well as the prevalence of HIV. We discuss the many potential biases inherent in any ecological-based analysis of air pollution and COVID-19.
    Language English
    Publishing date 2022-02-04
    Publishing country United States
    Document type Journal Article
    ISSN 2474-7882
    ISSN (online) 2474-7882
    DOI 10.1097/EE9.0000000000000195
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The association between the incidence of Lyme disease in the USA and indicators of greenness and land cover.

    Westra, Sydney / Goldberg, Mark S / Didan, Kamel

    Current research in parasitology & vector-borne diseases

    2023  Volume 4, Page(s) 100132

    Abstract: Lyme disease (LD) is the most common vector-borne illness in the USA. Incidence is related to specific environmental conditions such as temperature, metrics of land cover, and vertebrate species diversity. To determine whether greenness, as measured by ... ...

    Abstract Lyme disease (LD) is the most common vector-borne illness in the USA. Incidence is related to specific environmental conditions such as temperature, metrics of land cover, and vertebrate species diversity. To determine whether greenness, as measured by the Normalized Difference Vegetation Index (NDVI), and other selected indices of land cover were associated with the incidence of LD in the northeastern USA for the years 2000-2018, we conducted an ecological analysis of incidence rates of LD in counties of 15 "high" incidence states and the District of Columbia for 2000-2018. Annual counts of LD by county were obtained from the US Centers for Disease Control and values of NDVI were acquired from the Moderate Resolution Imaging Spectroradiometer instrument aboard Terra and Aqua Satellites. County-specific values of human population density, area of land and water were obtained from the US Census. Using quasi-Poisson regression, multivariable associations were estimated between the incidence of LD, NDVI, land cover variables, human population density, and calendar year. We found that LD incidence increased by 7.1% per year (95% confidence interval: 6.8-8.2%). Land cover variables showed complex non-linear associations with incidence: average county-specific NDVI showed a "u-shaped" association, the standard deviation of NDVI showed a monotonic upward relationship, population density showed a decreasing trend, areas of land and water showed "n-shaped" relationships. We found an interaction between average and standard deviation of NDVI, with the highest average NDVI category; increased standard deviation of NDVI showed the greatest increase in rates. These associations cannot be interpreted as causal but indicate that certain patterns of land cover may have the potential to increase exposure to infected ticks and thereby may contribute indirectly to increased rates of LD. Public health interventions could make use of these results in informing people where risks may be high.
    Language English
    Publishing date 2023-07-07
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2667-114X
    ISSN (online) 2667-114X
    DOI 10.1016/j.crpvbd.2023.100132
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Re: Links between air pollution and COVID-19 in England.

    Villeneuve, Paul J / Goldberg, Mark S

    Environmental pollution (Barking, Essex : 1987)

    2021  Volume 274, Page(s) 116576

    MeSH term(s) Air Pollutants/analysis ; Air Pollution/analysis ; COVID-19 ; England ; Humans ; Particulate Matter/analysis ; SARS-CoV-2
    Chemical Substances Air Pollutants ; Particulate Matter
    Language English
    Publishing date 2021-01-27
    Publishing country England
    Document type Letter
    ZDB-ID 280652-6
    ISSN 1873-6424 ; 0013-9327 ; 0269-7491
    ISSN (online) 1873-6424
    ISSN 0013-9327 ; 0269-7491
    DOI 10.1016/j.envpol.2021.116576
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Re: Long-term exposure to air-pollution and COVID-19 mortality in England: A hierarchical spatial analysis Long-term exposure to air-pollution and COVID-19 mortality in England: A hierarchical spatial analysis (Environment International 146 (2021) 106316).

    Goldberg, Mark S / Villeneuve, Paul J

    Environment international

    2021  Volume 150, Page(s) 106422

    MeSH term(s) Air Pollution ; COVID-19 ; England/epidemiology ; Humans ; Particulate Matter/analysis ; SARS-CoV-2 ; Spatial Analysis
    Chemical Substances Particulate Matter
    Language English
    Publishing date 2021-02-03
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 554791-x
    ISSN 1873-6750 ; 0160-4120
    ISSN (online) 1873-6750
    ISSN 0160-4120
    DOI 10.1016/j.envint.2021.106422
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Re: An ecological analysis of long-term exposure to PM

    Goldberg, Mark S / Villeneuve, Paul J

    Environmental research

    2020  Volume 194, Page(s) 110610

    MeSH term(s) Air Pollution ; COVID-19 ; Canada/epidemiology ; Humans ; Incidence ; Particulate Matter/analysis ; Particulate Matter/toxicity ; SARS-CoV-2
    Chemical Substances Particulate Matter
    Language English
    Publishing date 2020-12-15
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 205699-9
    ISSN 1096-0953 ; 0013-9351
    ISSN (online) 1096-0953
    ISSN 0013-9351
    DOI 10.1016/j.envres.2020.110610
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book: Identifying subgroups of the general population that may be susceptible to short term increases in particulate air pollution

    Goldberg, Mark S.

    a time series study in Montreal, Quebec

    (Research report / Health Effects Institute ; 97)

    2000  

    Title variant Identifying subgroups of the general population that may be susceptible to short-term increases in particulate air pollution
    Author's details Mark S. Goldberg
    Series title Research report / Health Effects Institute ; 97
    Collection
    Language English
    Size 122 S. : graph. Darst.
    Publisher Health Effects Inst
    Publishing place Cambridge MA
    Publishing country United States
    Document type Book
    HBZ-ID HT013009510
    Database Catalogue ZB MED Medicine, Health

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  7. Article: Statistical adjustments of environmental pollutants arising from multiple sources in epidemiologic studies: The role of markers of complex mixtures

    Goldberg, Mark S. / Baumgartner, Jill / Chevrier, Jonathan

    Atmospheric environment. 2022 Feb. 01, v. 270

    2022  

    Abstract: Studies of the effects of environmental exposures on human health are complicated by the fact that populations are exposed to complex mixtures of toxic and non-toxic substances that vary spatially and temporally in their composition and concentrations. ... ...

    Abstract Studies of the effects of environmental exposures on human health are complicated by the fact that populations are exposed to complex mixtures of toxic and non-toxic substances that vary spatially and temporally in their composition and concentrations. The identification of causal components of mixtures requires accurate measurements of all components, an appreciation of the sources from which they derive and resulting correlations between components. Recent work has suggested that the usual methods of handling multiple exposures in statistical models is much more complicated than in classical problems, such as considering alcohol as a confounding factor in the association between tobacco smoking and breast cancer. Herein, we use directed acyclic graphs (DAG) to analyse several hypothetical examples to illustrate the problems encountered in the statistical analysis of pollutant mixtures. In some instances, the results may be biased regardless as to whether one adjusts or does not adjust for co-exposures. We suggest that use of markers that are amenable to public health interventions may reduce this problem. Before starting a study one should identify the key environmental sources, develop a DAG to assist with framing the statistical models, estimate correlations between components, report results for all measured components (e.g., unadjusted and adjusted for each other), and incorporate toxicological and mechanistic investigations. As it is likely that one may not know what the “correct” model is, one could consider reporting different models containing various combinations of the measured exposure variables.
    Keywords alcohols ; breast neoplasms ; environment ; human health ; pollutants ; public health ; statistical analysis ; tobacco ; toxicity ; toxicology
    Language English
    Dates of publication 2022-0201
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 216368-8
    ISSN 0004-6981 ; 1352-2310
    ISSN 0004-6981 ; 1352-2310
    DOI 10.1016/j.atmosenv.2021.118788
    Database NAL-Catalogue (AGRICOLA)

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  8. Article ; Online: The effects of outdoor air pollution on chronic illnesses

    Hong Chen / Mark S Goldberg

    McGill Journal of Medicine, Vol 12, Iss

    2020  Volume 1

    Abstract: ... N/ ... ...

    Abstract N/A
    Keywords pollution ; health ; chronic illness ; environment ; Medicine ; R
    Language English
    Publishing date 2020-12-01T00:00:00Z
    Publisher McGill University
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: A review of nonsurgical facial rejuvenation and the role of oxymetazoline hydrochloride ophthalmic solution, 0.1% in periorbital revitalization.

    Goldberg, David J / Andriessen, Anneke / Gold, Michael / Lolis, Margarita S / Marchbein, Shari / Nestor, Mark S / Ros, Adriana

    Journal of cosmetic dermatology

    2024  Volume 23, Issue 4, Page(s) 1122–1130

    Abstract: Background: The demand for nonsurgical facial rejuvenation options is growing, yet the periorbital region remains an area of relative unmet need. This review explores nonsurgical options for facial rejuvenation and the role of oxymetazoline ... ...

    Abstract Background: The demand for nonsurgical facial rejuvenation options is growing, yet the periorbital region remains an area of relative unmet need. This review explores nonsurgical options for facial rejuvenation and the role of oxymetazoline hydrochloride ophthalmic solution, 0.1%, in treating age-related blepharoptosis as part of periorbital rejuvenation.
    Methods: Advisors experienced in facial rejuvenation met to discuss existing literature on the upper face and periorbital rejuvenation and the role of oxymetazoline hydrochloride ophthalmic solution, 0.1%, in treating facial aging.
    Results: An array of nonsurgical options exist to address the signs of aging, including minimally invasive treatments, such as botulinum toxin injections and dermal fillers, and noninvasive therapy, such as lasers, chemical peels, and microdermabrasion. However, treating age-related ptosis in periorbital rejuvenation is mainly addressed surgically. The newly approved α-adrenergic receptor agonist oxymetazoline hydrochloride ophthalmic solution, 0.1%, provides a novel non-interventional approach to blepharoptosis.
    Conclusions: Facial rejuvenation is highly sought-after in this post-pandemic era. Each nonsurgical treatment option has its advantages and drawbacks. A patient-centered approach is necessary to select the appropriate procedure considering the patient's concerns and aesthetic sensibilities. The eyes are an area of primary concern for patients, yet surgery is the gold standard for treating ptosis. Oxymetazoline hydrochloride ophthalmic solution, 0.1%, is a safe and effective nonsurgical treatment for blepharoptosis.
    MeSH term(s) Humans ; Cosmetic Techniques/adverse effects ; Oxymetazoline/therapeutic use ; Dermal Fillers ; Botulinum Toxins, Type A ; Rejuvenation ; Blepharoptosis/etiology ; Blepharoptosis/therapy ; Skin Aging ; Ophthalmic Solutions
    Chemical Substances Oxymetazoline (8VLN5B44ZY) ; Dermal Fillers ; Botulinum Toxins, Type A (EC 3.4.24.69) ; Ophthalmic Solutions
    Language English
    Publishing date 2024-02-13
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2280551-5
    ISSN 1473-2165 ; 1473-2130
    ISSN (online) 1473-2165
    ISSN 1473-2130
    DOI 10.1111/jocd.16018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Methodological Considerations for Epidemiological Studies of Air Pollution and the SARS and COVID-19 Coronavirus Outbreaks.

    Villeneuve, Paul J / Goldberg, Mark S

    Environmental health perspectives

    2020  Volume 128, Issue 9, Page(s) 95001

    Abstract: Background: Studies have reported that ambient air pollution is associated with an increased risk of developing or dying from coronavirus-2 (COVID-19). Methodological approaches to investigate the health impacts of air pollution on epidemics should ... ...

    Abstract Background: Studies have reported that ambient air pollution is associated with an increased risk of developing or dying from coronavirus-2 (COVID-19). Methodological approaches to investigate the health impacts of air pollution on epidemics should differ from those used for chronic diseases, but the methods used in these studies have not been appraised critically.
    Objectives: Our study aimed to identify and critique the methodological approaches of studies of air pollution on infections and mortality due to COVID-19 and to identify and critique the methodological approaches of similar studies concerning severe acute respiratory syndrome (SARS).
    Methods: Published and unpublished papers of associations between air pollution and developing or dying from COVID-19 or SARS that were reported as of 10 May 2020 were identified through electronic databases, internet searches, and other sources.
    Results: All six COVID-19 studies and two of three SARS studies reported positive associations. Two were time series studies that estimated associations between daily changes in air pollution, one was a cohort that assessed associations between air pollution and the secondary spread of SARS, and six were ecological studies that used area-wide exposures and outcomes. Common shortcomings included possible cross-level bias in ecological studies, underreporting of health outcomes, using grouped data, the lack of highly spatially resolved air pollution measures, inadequate control for confounding and evaluation of effect modification, not accounting for regional variations in the timing of outbreaks' temporal changes in at-risk populations, and not accounting for nonindependence of outcomes.
    Discussion: Studies of air pollution and novel coronaviruses have relied mainly on ecological measures of exposures and outcomes and are susceptible to important sources of bias. Although longitudinal studies with individual-level data may be imperfect, they are needed to adequately address this topic. The complexities involved in these types of studies underscore the need for careful design and for peer review. https://doi.org/10.1289/EHP7411.
    MeSH term(s) Air Pollution/adverse effects ; Air Pollution/analysis ; Bias ; COVID-19 ; Coronavirus Infections/epidemiology ; Disease Outbreaks ; Epidemiologic Studies ; Humans ; Pandemics ; Pneumonia, Viral/epidemiology ; Research Design ; Risk Factors ; Severe Acute Respiratory Syndrome/epidemiology
    Keywords covid19
    Language English
    Publishing date 2020-09-09
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 195189-0
    ISSN 1552-9924 ; 0091-6765 ; 1078-0475
    ISSN (online) 1552-9924
    ISSN 0091-6765 ; 1078-0475
    DOI 10.1289/EHP7411
    Database MEDical Literature Analysis and Retrieval System OnLINE

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