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  1. Article ; Online: Correlation between positive airway pressure and medication adherence: the healthy user effect.

    Lettieri, Matthew J / Warren, Whittney A / Walter, Robert J / Lettieri, Christopher J

    Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

    2024  

    Abstract: Study objectives: Despite the efficacy of positive airway pressure (PAP) for the treatment of obstructive sleep apnea (OSA), adherence remains challenging and negatively impacts assessments of effectiveness. It is unclear if low adherence is due to ... ...

    Abstract Study objectives: Despite the efficacy of positive airway pressure (PAP) for the treatment of obstructive sleep apnea (OSA), adherence remains challenging and negatively impacts assessments of effectiveness. It is unclear if low adherence is due to intolerance of PAP, or if this reflects overall adherence with medical therapy. We sought to correlate PAP use with medication adherence to determine if poor adherence with PAP was specific to this treatment or represented global compliance with medical therapy.
    Methods: 600 consecutive OSA patients treated with PAP. Objective measures of PAP use were correlated with medication adherence. We included all chronically used medications, defined as medications used daily for at least ninety days prior to PAP initiation. Medication use was verified using an electronic health record. PAP adherence ("regular use") was defined as PAP use for ≥4 hours/night on ≥70% of nights. Medication adherence was defined as >70% of pills taken as prescribed.
    Results: Complete records were available for 566 patients, 361 (63.8%) utilized chronic medications. The cohort was primarily men (90.3%, age 44.6±10.2 years), with moderate OSA (AHI 18.1±13.9 events/h). In patients on chronic medications, PAP was used 55.8% of nights and 37.7% were regular users. Patients who were adherent with medications used PAP more hours/night (5.4 vs. 4.6, p<0.001) and were more likely to have regular PAP use compared to those non-adherent with medications (p=0.04).
    Conclusions: Adherence with PAP correlated with adherence to chronic medications. Low PAP adherence may reflect an individual's global adherence to medical care. This association may lead to better identification of patients who benefit from targeted therapy to improve overall healthcare adherence.
    Language English
    Publishing date 2024-02-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2397213-0
    ISSN 1550-9397 ; 1550-9389
    ISSN (online) 1550-9397
    ISSN 1550-9389
    DOI 10.5664/jcsm.11092
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  2. Article ; Online: Corrigendum to 'Impact of comprehensive state insurance mandates on in vitro fertilization utilization, embryo transfer practices, and outcomes in the United States' Am J Obstet Gynecol. 2022 Jul;227(1):64.e1-65.e8.

    Peipert, Benjamin J / Chung, Esther H / Harris, Benjamin S / Warren, Christopher M / Jain, Tarun

    American journal of obstetrics and gynecology

    2023  Volume 229, Issue 4, Page(s) 483

    Language English
    Publishing date 2023-06-05
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 80016-8
    ISSN 1097-6868 ; 0002-9378
    ISSN (online) 1097-6868
    ISSN 0002-9378
    DOI 10.1016/j.ajog.2023.05.017
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  3. Article ; Online: Fibers in smaller fascicles have lower activation thresholds with cuff electrodes due to thinner perineurium and smaller cross-sectional area.

    Davis, Christopher J / Musselman, Eric D / Grill, Warren M / Pelot, Nicole A

    Journal of neural engineering

    2023  Volume 20, Issue 2

    Abstract: ... ...

    Abstract Objective
    MeSH term(s) Animals ; Humans ; Models, Neurological ; Peripheral Nerves/physiology ; Nerve Tissue ; Axons/physiology ; Electrodes, Implanted ; Mammals
    Language English
    Publishing date 2023-04-04
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2170901-4
    ISSN 1741-2552 ; 1741-2560
    ISSN (online) 1741-2552
    ISSN 1741-2560
    DOI 10.1088/1741-2552/acc42b
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  4. Article ; Online: The impact of study type and sleep measurement on oxygen desaturation index calculation.

    Whenn, Carley B / Wilson, Danielle L / Ruehland, Warren R / Churchward, Thomas J / Worsnop, Christopher / Tolson, Julie

    Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

    2024  

    Abstract: Study objectives: The oxygen desaturation index (ODI) is an important measure of sleep disordered breathing during polysomnography (PSG) however the AASM Manual (V3) does not specify whether to include oxygen desaturations occurring during wake epochs. ... ...

    Abstract Study objectives: The oxygen desaturation index (ODI) is an important measure of sleep disordered breathing during polysomnography (PSG) however the AASM Manual (V3) does not specify whether to include oxygen desaturations occurring during wake epochs. Additionally ODI obtained from PSG can differ from ODI using home sleep apnea tests (HSAT) that do not measure sleep, hampering diagnostic and treatment decision reliability. This study aimed to (1) compare an ODI that included all desaturations to an ODI that excluded desaturations occurring during wake epochs in PSG, and (2) compare ODIs obtained from PSG to HSAT.
    Methods: 100 consecutive PSGs for investigation of OSA were compared. ODIs were calculated including all desaturations (ODI
    Results: The median (IQR) 3% ODI for ODI
    Conclusions: ODI was significantly reduced when desaturations in wake epochs were excluded, and when ODI was based on monitoring time rather than sleep time, with potential for underestimation of disease severity. Results suggest that ODI can differ substantially depending on the calculation and study type used, and that there is a need for standardization to ensure consistent diagnosis and treatment outcomes.
    Language English
    Publishing date 2024-01-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2397213-0
    ISSN 1550-9397 ; 1550-9389
    ISSN (online) 1550-9397
    ISSN 1550-9389
    DOI 10.5664/jcsm.10982
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  5. Article: The problematic syndrome of right temporal lobe atrophy: Unweaving the phenotypic rainbow.

    Belder, Christopher R S / Chokesuwattanaskul, Anthipa / Marshall, Charles R / Hardy, Chris J D / Rohrer, Jonathan D / Warren, Jason D

    Frontiers in neurology

    2023  Volume 13, Page(s) 1082828

    Language English
    Publishing date 2023-01-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2022.1082828
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  6. Article ; Online: Vitamin E Acetate is Associated with Select Proinflammatory Cytokines: An Analysis of a 2020-2022 Cohort of EVALI Patients.

    Callahan, Sean J / Beck, Emily / Blagev, Denitza / Harris, Dixie / Lanspa, Michael / Brown, Samuel / Reilly, Christopher A / Paine Iii, Robert / Warren, Kristi J

    American journal of respiratory and critical care medicine

    2024  

    Language English
    Publishing date 2024-03-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202311-2155LE
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  7. Article ; Online: Early outcomes of endovascular repairs of the aortic arch using thoracic branch endoprosthesis.

    Pang, Haley J / Warren, Andrew S / Dansey, Kirsten D / Burke, Christopher / DeRoo, Scott / Sweet, Matthew P / Smith, Matthew / Zettervall, Sara L

    Journal of vascular surgery

    2024  

    Abstract: Objective: The only commercially available thoracic branched endoprosthesis (TBE) for treatment of the aortic arch was released in 2022. Limited data outside of clinical trial results have been reported. This study describes the demographics, anatomic ... ...

    Abstract Objective: The only commercially available thoracic branched endoprosthesis (TBE) for treatment of the aortic arch was released in 2022. Limited data outside of clinical trial results have been reported. This study describes the demographics, anatomic details, and outcomes for patients treated for zone 0 to 2 using TBEs outside of a clinical trial.
    Methods: All patients treated using TBEs for zone 0 to 2 were included. Patients treated as part of the clinical trial for zone 0 to 1 (n = 6) were excluded. Patient demographics, comorbidities, anatomic and operative details, and outcomes were reported. Outcomes and survival were then compared between groups.
    Results: Of 40 patients, six patients underwent repair of zone 0, three of zone 1, and 31 of zone 2. There were no differences in demographics, comorbidities, or operative details by zone of treatment; however, the frequency of genetic aortopathy differed (zone 0: 0%; zone 1: 67%; and zone 2: 6.4%; P < .01). Seventy-three percent of patients were treated for dissection vs 27% with isolated aneurysms. Of the patients, 2.5% were treated for rupture, 22% were treated for symptomatic aneurysms, and 75% were treated electively. Forty-eight percent of repairs included a proximal cuff, and 83% received distal extension. Technical success was achieved in 100% of patients. Mean fluoroscopy time was 18 minutes, and median fluoroscopy dose was 416 mGy. Sixty percent of patients had prior aortic ascending/arch repair. TBE was planned as part of a complete thoracoabdominal repair in 45% of patients. Thirty-day mortality was 2.5% overall, with a single death in a zone 0 patient that occurred at day 1 due to a myocardial infarction. There were no reinterventions within 30 days. All other outcomes were similar. The 30-day stroke rate was 5.0%. The strokes occurred at day 6 (zone 1) and day 15 (zone 2); however, both were due to occlusion of a prior proximal surgical bypass and unrelated to the TBE side branch or embolization. Specifically, both patients had occlusion of a branch of their prior zone 1 or zone 2 arch replacement. An endoleak occurred in 7.5% of patients at 30-day follow-up (type II: 5.0%; unknown: 2.5%). At a mean follow-up of 6.6 months, 100% of side branches were patent.
    Conclusions: Repair of the aortic arch including TBE can be performed electively and urgently with acceptable stroke and death rates. TBE provides a valuable tool for patients requiring complete repair of a thoracoabdominal aneurysm. Continued investigation is underway to assess long-term safety and efficacy outside of the clinical trial.
    Language English
    Publishing date 2024-02-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 605700-7
    ISSN 1097-6809 ; 0741-5214
    ISSN (online) 1097-6809
    ISSN 0741-5214
    DOI 10.1016/j.jvs.2024.02.003
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  8. Article ; Online: Racial disparities in

    Warren, Bobby G / Burch, Christopher D / Barrett, Aaron / Graves, Amanda / Gettler, Erin / Turner, Nicholas A / Moehring, Rebekah W / Anderson, Deverick J

    Infection control and hospital epidemiology

    2023  Volume 45, Issue 4, Page(s) 429–433

    Abstract: Objective: To analyze : Methods: We completed a retrospective analysis of inpatient : Results: In total, 35,160 : Conclusion: White patients received ... ...

    Abstract Objective: To analyze
    Methods: We completed a retrospective analysis of inpatient
    Results: In total, 35,160
    Conclusion: White patients received more
    MeSH term(s) Humans ; Clostridioides difficile ; Retrospective Studies ; Hospitals ; Comorbidity ; White
    Language English
    Publishing date 2023-11-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639378-0
    ISSN 1559-6834 ; 0195-9417 ; 0899-823X
    ISSN (online) 1559-6834
    ISSN 0195-9417 ; 0899-823X
    DOI 10.1017/ice.2023.244
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  9. Article ; Online: Re: COVID-19 and the Urology Match: Perspectives and a Call to ActionA. T. Gabrielson, T. P. Kohn and M. M. Clifton

    Warren, Christopher J / Davis, Matthew / Sadeghi-Nejad, Hossein

    The Journal of urology

    2020  Volume 204, Issue 4, Page(s) 850–851

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2 ; Urology
    Keywords covid19
    Language English
    Publishing date 2020-05-27
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 3176-8
    ISSN 1527-3792 ; 0022-5347
    ISSN (online) 1527-3792
    ISSN 0022-5347
    DOI 10.1097/JU.0000000000001145
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  10. Article: Excision of recurrent penile schwannoma with neurovascular bundle sparing: A novel surgical approach.

    Voleti, Sandeep Sai / Warren, Christopher J / Parker, Nicholas R / Stanton, Melissa / Khan, Aqsa A / Noland, Shelley S / Punjani, Nahid

    Urology case reports

    2023  Volume 50, Page(s) 102458

    Abstract: Penile schwannomas are rare, often painless lesions usually growing on the dorsum of the penis. A young and otherwise healthy male with recurrent painful penile schwannomas and decreased libido was successfully treated with surgical excision. Through ... ...

    Abstract Penile schwannomas are rare, often painless lesions usually growing on the dorsum of the penis. A young and otherwise healthy male with recurrent painful penile schwannomas and decreased libido was successfully treated with surgical excision. Through fine dissection of the nerve fascicles leading to the primary schwannoma, the lesion was successfully removed without compromising erectile or ejaculatory function. This novel approach allowed for significant symptomatic relief and improved quality of life.
    Language English
    Publishing date 2023-06-12
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2745459-9
    ISSN 2214-4420
    ISSN 2214-4420
    DOI 10.1016/j.eucr.2023.102458
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