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Article ; Online: Imaging-guided prognostic score-based approach to assess the benefits of combotherapy versus monotherapy with immune checkpoint inhibitors in metastatic MSI-H colorectal cancer patients.

European journal of cancer (Oxford, England : 1990)

2024 Volume 202, Page(s) 114020

Abstract: ... with microsatellite instability-high (MSI-H) metastatic colorectal cancer (mCRC) by analyzing quantitative imaging data and ... tumor volume, lesion count, the presence of peritoneal carcinomatosis, and age can guide MSI-H mCRC treatment ...

Abstract	Background: This retrospective study determined survival responses to immune checkpoint inhibitors (ICIs), comparing mono- (mono) and combo-immunotherapy (combo) in patients with microsatellite instability-high (MSI-H) metastatic colorectal cancer (mCRC) by analyzing quantitative imaging data and clinical factors. Methods: One hundred fifty patients were included from two centers and divided into training (n = 105) and validation (n = 45) cohorts. Radiologists manually annotated chest-abdomen-pelvis computed tomography and calculated tumor burden. Progression-free survival (PFS) was assessed, and variables were selected through Recursive Feature Elimination. Cutoff values were determined using maximally selected rank statistics to binarize features, forming a risk score with hazard ratio-derived weights. Results: In total, 2258 lesions were annotated with excellent reproducibility. Key variables in the training cohort included: total tumor volume (cutoff: 73 cm Conclusions: A score based on total tumor volume, lesion count, the presence of peritoneal carcinomatosis, and age can guide MSI-H mCRC treatment decisions, allowing oncologists to identify suitable candidates for mono and combo ICI therapies.
MeSH term(s)	Humans ; Immune Checkpoint Inhibitors/therapeutic use ; Prognosis ; Colorectal Neoplasms/diagnostic imaging ; Colorectal Neoplasms/drug therapy ; Peritoneal Neoplasms/drug therapy ; Retrospective Studies ; Reproducibility of Results ; Colonic Neoplasms/drug therapy ; Microsatellite Instability ; DNA Mismatch Repair
Chemical Substances	Immune Checkpoint Inhibitors
Language	English
Publishing date	2024-03-16
Publishing country	England
Document type	Journal Article
ZDB-ID	82061-1
ISSN	1879-0852 ; 0277-5379 ; 0959-8049 ; 0964-1947
ISSN (online)	1879-0852
ISSN	0277-5379 ; 0959-8049 ; 0964-1947
DOI	10.1016/j.ejca.2024.114020
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Article ; Online: The chemistry of Vernonanthura nudiflora (Less.) H. Rob. flowers and its antimicrobial activities

Ramos, Anderson Valdiney Gomes / de Sá, Nathália / Araújo, Débora Larissa Oliveira / Cabral, Márcia Regina Pereira / Costacurta, Giovana Ferreira / de Freitas, Beatriz Cardoso / Vilegas, Lenisa Vieira / Scodro, Regiane Bertin de Lima / Siqueira, Vera Lucia Dias / Cotica, Erika Seki Kioshima / do Carmo, Marta Regina Barrotto / Sarragiotto, Maria Helena / Baldoqui, Debora Cristina

Natural Product Research. 2023 Feb. 1, v. 37, no. 3 p.502-507

2023

Abstract: ... Less.) H. Rob., the structures of the compounds were established based on 1 D and 2 D NMR spectroscopic ...

Abstract	Twenty-one known specialised metabolites were isolated from the flowers of Vernonanthura nudiflora (Less.) H. Rob., the structures of the compounds were established based on 1 D and 2 D NMR spectroscopic experiments. Others 28 compounds were putatively identified using the dereplication technique by UHPLC-HRMS/MS. Twenty-three of the compounds are being reported for the first time in this species. The mixture of sesquiterpene lactones piptocarphins A and B (17 + 18), and the flavone velutin (14) were tested against several microorganisms and showed promising activity against Mycobacterium tuberculosis with MIC of 15.6 μg/mL and 31.2 μg/mL, respectively. Furthermore, 17 + 18 showed greater cytotoxicity against VERO cells (IC₅₀ = 7.0 ± 1.73) compared to compound 14 (IC₅₀ 85.0 ± 10.6 µg/mL). These findings reveal the feasibility of using the UHPLC-ESI-HRMS/MS-based dereplication strategy in complex fractions to identify specialised metabolites, moreover to V. nudiflora flowers being a source of compounds with antimycobacterial potential.
Keywords	Mycobacterium tuberculosis ; chemistry ; cytotoxicity ; flavones ; metabolites ; research ; sesquiterpenoid lactones ; spectroscopy ; Sesquiterpene lactones ; piptocarphins ; velutin ; UHPLC-HRMS/MS ; antimicrobial activity
Language	English
Dates of publication	2023-0201
Size	p. 502-507.
Publishing place	Taylor & Francis
Document type	Article ; Online
ZDB-ID	2185747-7
ISSN	1478-6427 ; 1478-6419
ISSN (online)	1478-6427
ISSN	1478-6419
DOI	10.1080/14786419.2021.1980790
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Confinement Effects on the Nuclear Spin Isomer Conversion of H

Turgeon, Pierre-Alexandre / Vermette, Jonathan / Alexandrowicz, Gil / Peperstraete, Yoann / Philippe, Laurent / Bertin, Mathieu / Fillion, Jean-Hugues / Michaut, Xavier / Ayotte, Patrick

The journal of physical chemistry. A

2017 Volume 121, Issue 8, Page(s) 1571–1576

Abstract: The mechanism for interconversion between the nuclear spin isomers (NSI) of H ...

Abstract	The mechanism for interconversion between the nuclear spin isomers (NSI) of H
Language	English
Publishing date	2017-03-02
Publishing country	United States
Document type	Journal Article
ISSN	1520-5215
ISSN (online)	1520-5215
DOI	10.1021/acs.jpca.7b00893
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Article ; Online: Rôles, fonctions et avis de l’association « Connaître et Combattre les Myélodysplasies ».

Bertin, Hervé

Bulletin du cancer

2023 Volume 110, Issue 11, Page(s) 1196–1203

Title translation	Roles, fonctions and opinions of the patient association "Connaître et Combattre les Myélodysplasies".
Language	French
Publishing date	2023-07-04
Publishing country	France
Document type	Editorial
ZDB-ID	213270-9
ISSN	1769-6917 ; 0007-4551
ISSN (online)	1769-6917
ISSN	0007-4551
DOI	10.1016/j.bulcan.2023.02.028
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Article ; Online: Modelo de clasificación sobre el impacto social de los emprendimientos sociales digitales

Bertín Valadés García

AD Research, Vol 29, Pp e229-e

2023 Volume 229

Abstract: Objetivo del estudio: El emprendimiento social puede ser visto como un modelo de negocio y como una forma de promover solución a problemas sociales. Este doble discurso que lo caracteriza también es viable en el entorno digital. El objetivo de esta ... ...

Abstract	Objetivo del estudio: El emprendimiento social puede ser visto como un modelo de negocio y como una forma de promover solución a problemas sociales. Este doble discurso que lo caracteriza también es viable en el entorno digital. El objetivo de esta investigación es clasificar los elementos que inciden en el impacto social para que los emprendimientos sociales en medios digitales consigan coadyuvar en la solución de los problemas sociales que abordan. Diseño/Metodología/Enfoque: El presente estudio empleó un enfoque mixto para diseñar un modelo predictivo basado en una red neuronal alimentada por una base de conocimiento en la que se llevó a cabo una observación no participante a quince emprendimientos sociales en medios digitales. Resultados: El modelo pronosticó un impacto social bajo para este tipo de emprendimientos. No obstante, en segundo lugar determinó la probabilidad de un impacto social alto lo que permitió identificar no sólo las características de los proyectos con mayores posibilidades, sino qué dimensiones son determinantes para generar un impacto social positivo. Limitaciones e implicaciones: Si bien la metodología puede aplicarse a otros emprendimientos sociales en medios digitales, solo se analizaron proyectos originarios de México. También podrían investigarse más casos, además de ampliar el tiempo en que se llevó a cabo la observación no participante. Originalidad / Contribución: En la revisión del Estado del arte no se encontró referencia al concepto Emprendimientos sociales en medios digitales, de modo que se pone en evidencia la existencia de este tipo de proyectos donde a través de espacios, como las redes sociodigitales, los emprendedores informan y promueven la acción hacia sus audiencias. Además, se trabaja sobre los impactos sociales que pueden generar este tipo de proyectos para conocer no solo sus acciones sino sus implicaciones.
Keywords	emprendimiento social en medios digitales ; impacto social ; red neuronal ; problemas sociales ; redes sociodigitales ; Social Sciences ; H ; Communication. Mass media ; P87-96
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	ESIC University
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Acclimation to hypoxia in Chlamydomonas reinhardtii: can biophotolysis be the major trigger for long‐term H₂ production?

Scoma, Alberto / Durante, Lorenzo / Bertin, Lorenzo / Fava, Fabio

new phytologist. 2014 Dec., v. 204, no. 4

2014

Abstract: ... medium under low light and high chlorophyll content. After a 250‐h acclimation phase, a 350‐h H₂ ... In anaerobiosis, the microalga Chlamydomonas reinhardtii is able to produce H₂ gas. Electrons ... state has been achieved, H₂ production is eventually observed. To avoid nutrient depletion, which would ...

Abstract	In anaerobiosis, the microalga Chlamydomonas reinhardtii is able to produce H₂ gas. Electrons mainly derive from mobilization of internal reserves or from water through biophotolysis. However, the exact mechanisms triggering this process are still unclear. Our hypothesis was that, once a proper redox state has been achieved, H₂ production is eventually observed. To avoid nutrient depletion, which would result in enhanced fermentative pathways, we aimed to induce long‐lasting H₂ production solely through a photosynthesis : respiration equilibrium. Thus, growing cells were incubated in Tris Acetate Phosphate (TAP) medium under low light and high chlorophyll content. After a 250‐h acclimation phase, a 350‐h H₂ production phase was observed. The light‐to‐H₂ conversion efficiency was comparable to that given in some reports operating under sulphur starvation. Electron sources were found to be water, through biophotolysis, and proteins, particularly through photofermentation. Nonetheless, a substantial contribution from acetate could not be ruled out. In addition, photosystem II (PSII) inhibition by 3‐(3,4‐dichlorophenyl)‐1,1‐dimethylurea (DCMU) showed that it actively contributed to maintaining a redox balance during cell acclimation. In appropriate conditions, PSII may represent the major source of reducing power to feed the H₂ evolution process, by inducing and maintaining an ideal excess of reducing power.
Keywords	Chlamydomonas reinhardtii ; acclimation ; acetates ; anaerobiosis ; chlorophyll ; electrons ; hydrogen ; hypoxia ; microalgae ; photosystem II ; proteins ; starvation ; sulfur
Language	English
Dates of publication	2014-12
Size	p. 890-900.
Publishing place	Academic Press.
Document type	Article
ZDB-ID	208885-x
ISSN	1469-8137 ; 0028-646X
ISSN (online)	1469-8137
ISSN	0028-646X
DOI	10.1111/nph.12964
Database	NAL-Catalogue (AGRICOLA)

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Article: H-NS in Gram-negative bacteria: a family of multifaceted proteins.

Tendeng, Christian / Bertin, Philippe N

Trends in microbiology

2003 Volume 11, Issue 11, Page(s) 511–518

Abstract: ... could explain the presence of various nucleoid-associated proteins in bacteria. H-NS, one of these proteins, has ... with a mutation in its structural gene. However, the role of H-NS in bacterial physiology and its mechanism ... of action are still a matter of debate. The expanding number of H-NS-related proteins identified ...

Abstract	DNA-packaging and the control of gene expression constitute a major challenge for bacteria to survive and adapt to environmental changes. The use of multiple strategies to solve these problems could explain the presence of various nucleoid-associated proteins in bacteria. H-NS, one of these proteins, has been extensively studied in Escherichia coli, and a variety of phenotypes have been associated with a mutation in its structural gene. However, the role of H-NS in bacterial physiology and its mechanism of action are still a matter of debate. The expanding number of H-NS-related proteins identified in Gram-negative bacteria reveals interesting clues about their structure-function-evolution relationship.
MeSH term(s)	Bacterial Proteins/genetics ; Bacterial Proteins/isolation & purification ; Bacterial Proteins/physiology ; DNA-Binding Proteins/chemistry ; DNA-Binding Proteins/classification ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/isolation & purification ; DNA-Binding Proteins/physiology ; Evolution, Molecular ; Forecasting ; Gram-Negative Bacteria/genetics ; Gram-Negative Bacteria/physiology
Chemical Substances	Bacterial Proteins ; DNA-Binding Proteins ; H-NS protein, bacteria
Language	English
Publishing date	2003-10-29
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1158963-2
ISSN	1878-4380 ; 0966-842X
ISSN (online)	1878-4380
ISSN	0966-842X
DOI	10.1016/j.tim.2003.09.005
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Article: DNA bridging: a property shared among H-NS-like proteins.

Dame, Remus T / Luijsterburg, Martijn S / Krin, Evelyne / Bertin, Philippe N / Wagner, Rolf / Wuite, Gijs J L

Journal of bacteriology

2005 Volume 187, Issue 5, Page(s) 1845–1848

Abstract: The nucleoid-associated protein H-NS is thought to play an essential role in the organization ...

Abstract	The nucleoid-associated protein H-NS is thought to play an essential role in the organization of bacterial chromatin in Escherichia coli. Homologues, often with very low sequence identity, are found in most gram-negative bacteria. Microscopic analysis reveals that, despite limited sequence identity, their structural organization results in similar DNA binding properties.
MeSH term(s)	Bacterial Proteins/chemistry ; Bacterial Proteins/physiology ; Consensus Sequence ; DNA, Bacterial/chemistry ; DNA-Binding Proteins/chemistry ; DNA-Binding Proteins/physiology ; Escherichia coli Proteins/chemistry ; Escherichia coli Proteins/physiology ; Microscopy, Atomic Force ; Molecular Chaperones/chemistry ; Molecular Chaperones/physiology ; Protein Binding ; Trans-Activators/chemistry ; Trans-Activators/physiology
Chemical Substances	Bacterial Proteins ; DNA, Bacterial ; DNA-Binding Proteins ; Escherichia coli Proteins ; H-NS protein, bacteria ; Molecular Chaperones ; MvaT protein, Pseudomonas ; StpA protein, E coli ; Trans-Activators
Language	English
Publishing date	2005-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2968-3
ISSN	1098-5530 ; 0021-9193
ISSN (online)	1098-5530
ISSN	0021-9193
DOI	10.1128/JB.187.5.1845-1848.2005
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Article: Theoretical study of the H(2) reaction with a Pt(4) (111) cluster.

Cruz, A / Bertin, V / Poulain, E / Benitez, J I / Castillo, S

The Journal of chemical physics

2004 Volume 120, Issue 13, Page(s) 6222–6228

Abstract: The C(s) symmetry reaction of the H(2) molecule on a Pt(4) (111) clusters, has been studied using ... interaction variational and perturbative calculations. The H(2) interaction by the vertex and by the base ... 1)B(2), (1)A(1) (3)A(1), (1)A(1), respectively, may capture and dissociate the H(2) molecule ...

Abstract	The C(s) symmetry reaction of the H(2) molecule on a Pt(4) (111) clusters, has been studied using ab initio multiconfiguration self-consistent field plus extensive multireference configuration interaction variational and perturbative calculations. The H(2) interaction by the vertex and by the base of a tetrahedral Pt(4) cluster were studied in ground and excited triplet and singlet states (closed and open shells), where the reaction curves are obtained through many avoided crossings. The Pt(4) cluster captures and activates the hydrogen molecule; it shows a similar behavior compared with other Pt(n) (n=1,2,3) systems. The Pt(4) cluster in their lowest five open and closed shell electronic states: (3)B(2), (1)B(2), (1)A(1) (3)A(1), (1)A(1), respectively, may capture and dissociate the H(2) molecule without activation barriers for the hydrogen molecule vertex approach. For the threefolded site reaction, i.e., by the base, the situation is different, the hydrogen adsorption presents some barriers. The potential energy minima occur outside and inside the cluster, with strong activation of the H-H bond. In all cases studied, the Pt(4) cluster does not absorb the hydrogen molecule.
Language	English
Publishing date	2004-04-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	3113-6
ISSN	1089-7690 ; 0021-9606
ISSN (online)	1089-7690
ISSN	0021-9606
DOI	10.1063/1.1630298
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Article: H-NS and H-NS-like proteins in Gram-negative bacteria and their multiple role in the regulation of bacterial metabolism.

Bertin, P / Hommais, F / Krin, E / Soutourina, O / Tendeng, C / Derzelle, S / Danchin, A

Biochimie

2001 Volume 83, Issue 2, Page(s) 235–241

Abstract: In Escherichia coli, the H-NS protein plays an important role in the structure and the functioning ... we identified H-NS-like proteins in various microorganisms by different procedures. In silico analysis ... in a H-NS deficient strain, resulting in an increased resistance to acidic stress. Finally, expression ...

Abstract	In Escherichia coli, the H-NS protein plays an important role in the structure and the functioning of bacterial chromosome. A homologous protein has also been identified in several enteric bacteria and in closely related organisms such as Haemophilus influenzae. To get information on their structure and their function, we identified H-NS-like proteins in various microorganisms by different procedures. In silico analysis of their amino acid sequence and/or in vivo experiments provide evidence that more than 20 proteins belong to the same class of regulatory proteins. Moreover, large scale technologies demonstrate that, at least in E. coli, the loss of motility in hns mutants results from a lack of flagellin biosynthesis, due to the in vivo repression of flagellar gene expression. In contrast, several genes involved in adaptation to low pH are strongly induced in a H-NS deficient strain, resulting in an increased resistance to acidic stress. Finally, expression profiling and phenotypic analysis suggest that, unlike H-NS, its paralogous protein StpA does not play any role in these processes.
MeSH term(s)	Amino Acid Sequence ; Bacterial Proteins/physiology ; Base Sequence ; Conserved Sequence ; DNA-Binding Proteins/physiology ; Databases, Factual ; Gene Expression Profiling ; Genomic Library ; Gram-Negative Bacteria/metabolism ; Molecular Sequence Data ; Mutagenesis ; Oligonucleotide Array Sequence Analysis ; Phenotype ; Protein Conformation ; Sequence Homology, Amino Acid ; Sequence Homology, Nucleic Acid
Chemical Substances	Bacterial Proteins ; DNA-Binding Proteins ; H-NS protein, bacteria
Language	English
Publishing date	2001-02
Publishing country	France
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	120345-9
ISSN	0300-9084
ISSN	0300-9084
DOI	10.1016/s0300-9084(01)01247-0
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