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Article ; Online: SARS-CoV-2 persistence on common food covering materials: plastic wrap, fruit wax, and cardboard takeout containers.

Glasbrenner, David C / Choi, Young W / Middleton, Jason K

2023 Volume 134, Issue 2

Abstract: Aims: Assess the persistence of infectious SARS-CoV-2 virus and virus genomic material on three common food coverings.: Methods and results: The stability of infectious virus and genomic material on plastic wrap, fruit wax, and cardboard takeout ... ...

Abstract	Aims: Assess the persistence of infectious SARS-CoV-2 virus and virus genomic material on three common food coverings. Methods and results: The stability of infectious virus and genomic material on plastic wrap, fruit wax, and cardboard takeout containers was measured. SARS-CoV-2 in simulated saliva was applied to the surface of these materials and allowed to dry. Samples were stored at 4°C or 20°C and a relative humidity of 30%, 50%, 65%, or 70% for up to 7 days. Viability was measured by TCID50 and the half-life for infectious virus was determined to be ~24 hours and ~8 hours at 4°C and 20°C, respectively, on all surfaces and RH tested. There was no loss of virus genomic material as measured by qRT-PCR at all conditions evaluated. Conclusions: SARS-CoV-2 virus remains infectious on food coverings for hours to days. It is estimated that a 99.9% reduction in titer requires 10 days at 4°C and 3 days at 20°C for all RH tested. SARS-CoV-2 genomic material showed no loss when assayed by qRT-PCR. Significance and Impact of Study: SARS-CoV-2 virus on food coverings loses infectivity over a certain period, but PCR assays can still detect virus genomic material throughout the same time. Thus, testing and controls may need to consider the fact that virus genomic material may still be detected when no infectious virus is present.
MeSH term(s)	SARS-CoV-2 ; COVID-19 ; Fruit ; Plastics
Chemical Substances	Plastics
Language	English
Publishing date	2023-01-19
Publishing country	England
Document type	Journal Article
ZDB-ID	1358023-1
ISSN	1365-2672 ; 1364-5072
ISSN (online)	1365-2672
ISSN	1364-5072
DOI	10.1093/jambio/lxac071
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Article: Cancer-Causing Effects of Orthopaedic Metal Implants in Total Hip Arthroplasty.

Sun, Cherry W Y / Lau, Lawrence C M / Cheung, Jason P Y / Choi, Siu-Wai

Cancers

2024 Volume 16, Issue 7

Abstract: Background: Metal implants have been preferentially used in THA due to its biocompatibility, mechanical stability and durability. Yet concerns have emerged regarding their potential to release metallic ions, leading to long-term adverse effects, ... ...

Abstract	Background: Metal implants have been preferentially used in THA due to its biocompatibility, mechanical stability and durability. Yet concerns have emerged regarding their potential to release metallic ions, leading to long-term adverse effects, including carcinogenicity. This study aimed to investigate the risk of cancer development in patients with orthopaedic metal implants in total hip arthroplasty (THA). Methods: Patients with THA conducted at a local tertiary implant centre from 2001-2008 were linked to the local cancer registry and followed up to the end of 2023. Standardized incidence ratios (SIRs) for cancer incidence and its confidence interval by Poisson distribution were calculated. Survival analysis was depicted using the Kaplan-Meier method, and the log-rank test was used to assess the differences across groups. Results: The study cohort included 388 patients and 53 cancers diagnosed during follow-up, at least 5 years post THA. All-site cancer risks were increased in patients with THA (SIR: 1.97; 95% CI: 1.48-2.46), validated with chi-square analysis (chi-square = 15.2551, N = 100,388, Conclusions: Patients with THA were found to have an increased risk for cancer compared to the general population during a mean follow-up of 16 years.
Language	English
Publishing date	2024-03-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers16071339
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Article ; Online: Med25 Limits Master Regulators That Govern Adipogenesis.

Saunders, Jasmine / Sikder, Kunal / Phillips, Elizabeth / Ishwar, Anurag / Mothy, David / Margulies, Kenneth B / Choi, Jason C

International journal of molecular sciences

2023 Volume 24, Issue 7

Abstract: Mediator 25 (Med25) is a member of the mediator complex that relays signals from transcription factors to the RNA polymerase II machinery. Multiple transcription factors, particularly those involved in lipid metabolism, utilize the mediator complex, but ... ...

Abstract	Mediator 25 (Med25) is a member of the mediator complex that relays signals from transcription factors to the RNA polymerase II machinery. Multiple transcription factors, particularly those involved in lipid metabolism, utilize the mediator complex, but how Med25 is involved in this context is unclear. We previously identified Med25 in a translatome screen of adult cardiomyocytes (CMs) in a novel cell type-specific model of
MeSH term(s)	Animals ; Mice ; 3T3-L1 Cells ; Adipogenesis/genetics ; Cell Differentiation ; Lamin Type A/genetics ; Lamin Type A/metabolism ; Lipids/pharmacology ; Mediator Complex/genetics ; Mediator Complex/metabolism ; PPAR gamma/metabolism ; Transcription Factors/metabolism
Chemical Substances	Lamin Type A ; Lipids ; Mediator Complex ; PPAR gamma ; Transcription Factors ; Med25 protein, mouse
Language	English
Publishing date	2023-03-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24076155
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Article ; Online: Lowering P

Jimenez, Jose Victor / Ackrivo, Jason / Hsu, Jesse Y / Wilson, Mathew W / Labaki, Wassim W / Hansen-Flaschen, John / Hyzy, Robert C / Choi, Philip J

Respiratory care

2023 Volume 68, Issue 12, Page(s) 1613–1622

Abstract: Background: Chronic hypercapnic respiratory failure is associated with high mortality. Although previous work has demonstrated a mortality improvement with high-intensity noninvasive ventilation in COPD, it is unclear whether a P: Methods: The ... ...

Abstract	Background: Chronic hypercapnic respiratory failure is associated with high mortality. Although previous work has demonstrated a mortality improvement with high-intensity noninvasive ventilation in COPD, it is unclear whether a P Methods: The objective of this study was to investigate the association between P Results: The mean ± SD age of 337 subjects was 57 ± 16 years, 37% women, and 85% white. In a univariate analysis, survival probability increased with reductions in P Conclusions: Reduction in P
MeSH term(s)	Humans ; Female ; Adult ; Middle Aged ; Aged ; Male ; Noninvasive Ventilation/adverse effects ; Hypercapnia/therapy ; Hypercapnia/complications ; Carbon Dioxide ; Pulmonary Disease, Chronic Obstructive/therapy ; Cohort Studies ; Prospective Studies ; Respiratory Insufficiency/etiology ; Respiratory Insufficiency/therapy ; Respiratory Insufficiency/diagnosis
Chemical Substances	Carbon Dioxide (142M471B3J)
Language	English
Publishing date	2023-11-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	603252-7
ISSN	1943-3654 ; 0098-9142 ; 0020-1324
ISSN (online)	1943-3654
ISSN	0098-9142 ; 0020-1324
DOI	10.4187/respcare.10813
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Article: Perinuclear damage from nuclear envelope deterioration elicits stress responses that contribute to

Sikder, Kunal / Phillips, Elizabeth / Zhong, Zhijiu / Wang, Nadan / Saunders, Jasmine / Mothy, David / Kossenkov, Andrew / Schneider, Timothy / Nichtova, Zuzana / Csordas, Gyorgy / Margulies, Kenneth B / Choi, Jason C

bioRxiv : the preprint server for biology

2023

Abstract: Mutations in the : Teaser: Interplay of stress responses underlying the development ... ...

Abstract	Mutations in the Teaser: Interplay of stress responses underlying the development of
Language	English
Publishing date	2023-06-07
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.02.14.528563
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Article ; Online: Med25 Limits Master Regulators That Govern Adipogenesis

Jasmine Saunders / Kunal Sikder / Elizabeth Phillips / Anurag Ishwar / David Mothy / Kenneth B. Margulies / Jason C. Choi

International Journal of Molecular Sciences, Vol 24, Iss 6155, p

2023 Volume 6155

Abstract: ... to recapitulate the in vivo phenotype by depleting lamins A and C (lamin A/C) in vitro. Although lamin A/C ... mediators driving adipogenesis revealed that C/EBPα and PPARγ are super-induced by Med25 silencing ...

Abstract	Mediator 25 (Med25) is a member of the mediator complex that relays signals from transcription factors to the RNA polymerase II machinery. Multiple transcription factors, particularly those involved in lipid metabolism, utilize the mediator complex, but how Med25 is involved in this context is unclear. We previously identified Med25 in a translatome screen of adult cardiomyocytes (CMs) in a novel cell type-specific model of LMNA cardiomyopathy. In this study, we show that Med25 upregulation is coincident with myocardial lipid accumulation. To ascertain the role of Med25 in lipid accumulation, we utilized iPSC-derived and neonatal CMs to recapitulate the in vivo phenotype by depleting lamins A and C (lamin A/C) in vitro. Although lamin A/C depletion elicits lipid accumulation, this effect appears to be mediated by divergent mechanisms dependent on the CM developmental state. To directly investigate Med25 in lipid accumulation, we induced adipogenesis in Med25 -silenced 3T3-L1 preadipocytes and detected enhanced lipid accumulation. Assessment of pertinent mediators driving adipogenesis revealed that C/EBPα and PPARγ are super-induced by Med25 silencing. Our results indicate that Med25 limits adipogenic potential by suppressing the levels of master regulators that govern adipogenesis. Furthermore, we caution the use of early-developmental-stage cardiomyocytes to model adult-stage cells, particularly for dissecting metabolic perturbations emanating from LMNA mutations.
Keywords	LMNA ; mediator complex ; lipid accumulation ; adipogenesis ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	570
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Patterns of interventions for central venous catheter-associated deep vein thrombosis and outcomes in cancer patients.

Ngo, Dat / Chen, Jason / Nguyen, Chris / Choi, Kathy / Pullarkat, Vinod

Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners

2024 , Page(s) 10781552231219995

Abstract: Purpose: This letter evaluated the impact of different management strategies, specifically the presence or absence of therapeutic anticoagulation, on clinical outcomes for central venous catheter (CVC)-associated deep vein thrombosis (DVT) in cancer ... ...

Abstract	Purpose: This letter evaluated the impact of different management strategies, specifically the presence or absence of therapeutic anticoagulation, on clinical outcomes for central venous catheter (CVC)-associated deep vein thrombosis (DVT) in cancer patients. Methods: One-hundred ninety-eight adult cancer patients with a confirmed CVC-associated DVT diagnosis from February 2013 and February 2021 were included. Results: Incidence of symptomatic recurrent venous thromboembolism (VTE) was similar between patients who received therapeutic anticoagulation and those who did not (14% vs 16%, Conclusion and relevance: Therapeutic anticoagulation was not associated with a reduction in the incidence of recurrent VTE or increase the incidence of bleeding in adult cancer patients following a CVC-associated DVT diagnosis.
Language	English
Publishing date	2024-01-02
Publishing country	England
Document type	Journal Article
ZDB-ID	1330764-2
ISSN	1477-092X ; 1078-1552
ISSN (online)	1477-092X
ISSN	1078-1552
DOI	10.1177/10781552231219995
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Zs.A 4488: Show issues

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Article ; Online: Genetic Disruption of System xc-Mediated Glutamate Release from Astrocytes Increases Negative-Outcome Behaviors While Preserving Basic Brain Function in Rat.

Hess, Evan M / Kassel, Sara N / Simandl, Gregory / Raddatz, Nicholas / Maunze, Brian / Hurley, Matthew M / Grzybowski, Michael / Klotz, Jason / Geurts, Aron / Liu, Qing-Song / Choi, SuJean / Twining, Robert C / Baker, David A

The Journal of neuroscience : the official journal of the Society for Neuroscience

2023 Volume 43, Issue 13, Page(s) 2349–2361

Abstract: The importance of neuronal glutamate to synaptic transmission throughout the brain illustrates the immense therapeutic potential and safety risks of targeting this system. Astrocytes also release glutamate, the clinical relevance of which is unknown as ... ...

Abstract	The importance of neuronal glutamate to synaptic transmission throughout the brain illustrates the immense therapeutic potential and safety risks of targeting this system. Astrocytes also release glutamate, the clinical relevance of which is unknown as the range of brain functions reliant on signaling from these cells hasn't been fully established. Here, we investigated system xc- (Sxc), which is a glutamate release mechanism with an
MeSH term(s)	Rats ; Male ; Animals ; Glutamic Acid/metabolism ; Astrocytes/metabolism ; Synaptic Transmission ; Brain/metabolism ; Neurons/metabolism
Chemical Substances	Glutamic Acid (3KX376GY7L)
Language	English
Publishing date	2023-02-14
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	604637-x
ISSN	1529-2401 ; 0270-6474
ISSN (online)	1529-2401
ISSN	0270-6474
DOI	10.1523/JNEUROSCI.1525-22.2023
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Article ; Online: Chronic Exposure to a PFAS Mixture Resembling AFFF-Impacted Surface Water Decreases Body Size in Northern Leopard Frogs (

Hoskins, Tyler D / Flynn, R Wesley / Coogan, Grace S M / Catlin, Ann C / de Perre, Chloe / Modiri Gharehveran, Mahsa / Choi, Youn Jeong / Lee, Linda S / Hoverman, Jason T / Sepúlveda, Maria S

Environmental science & technology

2023 Volume 57, Issue 40, Page(s) 14797–14806

Abstract: Per- and polyfluoroalkyl substances (PFAS) occur in the environment as mixtures, yet mixture toxicity remains poorly understood. Aqueous film-forming foams (AFFFs) are a common source of PFAS. Our objective was to examine chronic effects of a complex ... ...

Abstract	Per- and polyfluoroalkyl substances (PFAS) occur in the environment as mixtures, yet mixture toxicity remains poorly understood. Aqueous film-forming foams (AFFFs) are a common source of PFAS. Our objective was to examine chronic effects of a complex PFAS mixture on amphibian growth and development. We tested toxicity of a five-chemical PFAS mixture summing to 10 μg/L and that accounts for >90% of the PFAS in AFFF-affected surface waters: perfluorooctane sulfonate (PFOS, 40%), perfluorohexane sulfonic acid (PFHxS, 30%), perflurooctanoic acid (PFOA, 12.5%), perfluorohexanoic acid (PFHxA, 12.5%), and perfluoropentanoic acid (PFPeA, 5%). We also included treatments to determine whether PFOS drove mixture toxicity and whether PFOS and mixture components act additively. We exposed Northern leopard frog (
MeSH term(s)	Animals ; Water ; Rana pipiens ; Water Pollutants, Chemical/toxicity ; Water Pollutants, Chemical/analysis ; Alkanesulfonic Acids/toxicity ; Fluorocarbons/toxicity ; Fluorocarbons/analysis ; Larva ; Body Size
Chemical Substances	Water (059QF0KO0R) ; Water Pollutants, Chemical ; Alkanesulfonic Acids ; Fluorocarbons
Language	English
Publishing date	2023-08-23
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ISSN	1520-5851
ISSN (online)	1520-5851
DOI	10.1021/acs.est.3c01118
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Article ; Online: Synthesis and anti-prion aggregation activity of acylthiosemicarbazide analogues.

Kim, Dong Hwan / Kim, Jaehyeon / Lee, Hakmin / Lee, Dongyun / Im, So Myoung / Kim, Ye Eun / Yoo, Miryeong / Cheon, Yong-Pil / Bartz, Jason C / Son, Young-Jin / Choi, Eun-Kyoung / Kim, Yong-Sun / Jeon, Jae-Ho / Kim, Hyo Shin / Lee, Sungeun / Ryou, Chongsuk / Nam, Tae-Gyu

Journal of enzyme inhibition and medicinal chemistry

2023 Volume 38, Issue 1, Page(s) 2191164

Abstract: Prions are infectious protein particles known to cause prion diseases. The biochemical entity of the pathogen is the misfolded prion protein ( ... ...

Abstract	Prions are infectious protein particles known to cause prion diseases. The biochemical entity of the pathogen is the misfolded prion protein (PrP
MeSH term(s)	Humans ; Prions/metabolism ; Prion Proteins/metabolism ; Brain ; Prion Diseases/drug therapy ; Prion Diseases/metabolism ; Prion Diseases/pathology ; Cells, Cultured
Chemical Substances	Prions ; Prion Proteins
Language	English
Publishing date	2023-03-23
Publishing country	England
Document type	Journal Article
ZDB-ID	2082578-X
ISSN	1475-6374 ; 1475-6366
ISSN (online)	1475-6374
ISSN	1475-6366
DOI	10.1080/14756366.2023.2191164
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