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  1. Article ; Online: Slam-associated protein plays a key role in development of autoimmunity.

    Sawada, Shigemasa

    Autoimmunity reviews

    2012  Volume 11, Issue 11, Page(s) 804–805

    Abstract: In 1995, the SLAM-associated protein (SAP) gene was cloned in our laboratory, and patents were subsequently filed in the USA, EU and Canada. In 1998, the SAP gene was shown to be defective in patients with X-linked lymphoproliferative disease. Since this ...

    Abstract In 1995, the SLAM-associated protein (SAP) gene was cloned in our laboratory, and patents were subsequently filed in the USA, EU and Canada. In 1998, the SAP gene was shown to be defective in patients with X-linked lymphoproliferative disease. Since this discovery, the gene has been demonstrated to play a significant role in viral protection, cytokine production and life-long immune memory (vaccination). This article reviews the crucial role of SAP in the development of autoimmunity.
    MeSH term(s) Animals ; Arthritis, Rheumatoid/immunology ; Arthritis, Rheumatoid/virology ; Autoantibodies/immunology ; Autoantibodies/metabolism ; Autoimmunity/genetics ; Autoimmunity/immunology ; Herpesvirus 4, Human/immunology ; Humans ; Intracellular Signaling Peptides and Proteins/genetics ; Intracellular Signaling Peptides and Proteins/metabolism ; Intracellular Signaling Peptides and Proteins/physiology ; Signaling Lymphocytic Activation Molecule Associated Protein ; Synovial Fluid/virology
    Chemical Substances Autoantibodies ; Intracellular Signaling Peptides and Proteins ; SH2D1A protein, human ; Signaling Lymphocytic Activation Molecule Associated Protein
    Language English
    Publishing date 2012-09
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2144145-5
    ISSN 1873-0183 ; 1568-9972
    ISSN (online) 1873-0183
    ISSN 1568-9972
    DOI 10.1016/j.autrev.2012.02.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5913: Show issues Location:
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  2. Article: Regulation of various genes in human leukocytes acutely exposed to morphine: expression microarray analysis.

    Sawada, Shigemasa

    Medical science monitor : international medical journal of experimental and clinical research

    2005  Volume 11, Issue 11, Page(s) LE19–20

    MeSH term(s) Gene Expression Regulation ; Humans ; Leukocytes/drug effects ; Leukocytes/metabolism ; Morphine/pharmacology ; Oligonucleotide Array Sequence Analysis
    Chemical Substances Morphine (76I7G6D29C)
    Language English
    Publishing date 2005-11
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 1439041-3
    ISSN 1643-3750 ; 1234-1010
    ISSN (online) 1643-3750
    ISSN 1234-1010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: 'Hydrolysis of myelin basic protein by IgM and IgA antibodies from the sera of patients with multiple sclerosis'--in reply.

    Sawada, Shigemasa

    Medical science monitor : international medical journal of experimental and clinical research

    2005  Volume 11, Issue 10, Page(s) LE16

    MeSH term(s) Catalysis ; Chromatography, Gel ; Humans ; Hydrolysis ; Immunoglobulin A/blood ; Immunoglobulin M/blood ; Multiple Sclerosis/blood ; Myelin Basic Protein/blood
    Chemical Substances Immunoglobulin A ; Immunoglobulin M ; Myelin Basic Protein
    Language English
    Publishing date 2005-10
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 1439041-3
    ISSN 1643-3750 ; 1234-1010
    ISSN (online) 1643-3750
    ISSN 1234-1010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Hepatitis C virus associated arthritis in absence of clinical, biochemical and histological evidence of liver disease--responding to interferon therapy.

    Sawada, Shigemasa

    Medical science monitor : international medical journal of experimental and clinical research

    2005  Volume 11, Issue 9, Page(s) LE10–10

    MeSH term(s) Antiviral Agents/therapeutic use ; Arthritis, Infectious/drug therapy ; Arthritis, Infectious/etiology ; Hepatitis C/complications ; Hepatitis C/drug therapy ; Humans ; Interferon Type I/therapeutic use ; RNA, Viral/isolation & purification ; Recombinant Proteins
    Chemical Substances Antiviral Agents ; Interferon Type I ; RNA, Viral ; Recombinant Proteins
    Language English
    Publishing date 2005-09
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 1439041-3
    ISSN 1643-3750 ; 1234-1010
    ISSN (online) 1643-3750
    ISSN 1234-1010
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    Zs.A 4924: Show issues Location:
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  5. Article ; Online: Comparison of anti-inflammatory effects of rivaroxaban vs. dabigatran in patients with non-valvular atrial fibrillation (RIVAL-AF study): multicenter randomized study.

    Kikuchi, Shinnosuke / Tsukahara, Kengo / Sakamaki, Kentaro / Morita, Yukiko / Takamura, Takeshi / Fukui, Kazuki / Endo, Tsutomu / Shimizu, Makoto / Sawada, Reimin / Sugano, Teruyasu / Himeno, Hideo / Kobayashi, Syunichi / Arakawa, Kentaro / Mochida, Yasuyuki / Tsunematsu, Takashi / Shigemasa, Tomohiko / Okuda, Jun / Ishikawa, Toshiyuki / Kimura, Kazuo /
    Tamura, Kouichi

    Heart and vessels

    2019  Volume 34, Issue 6, Page(s) 1002–1013

    Abstract: Some experimental studies have shown that direct oral anticoagulants (DOACs) have anti-inflammatory effects. However, the interval changes in inflammatory markers in patients with non-valvular atrial fibrillation (AF) who receive DOACs remain unknown. ... ...

    Abstract Some experimental studies have shown that direct oral anticoagulants (DOACs) have anti-inflammatory effects. However, the interval changes in inflammatory markers in patients with non-valvular atrial fibrillation (AF) who receive DOACs remain unknown. Between July 2013 and April 2014, a total of 187 AF patients randomly assigned to receive rivaroxaban (n = 91) or dabigatran (n = 96) were assessed for eligibility. The levels of the following inflammatory markers were serially evaluated: high-sensitivity C-reactive protein, pentraxin-3, interleukin (IL)-1β, IL-6, IL-18, tumor necrosis factor-α, monocyte chemotactic protein-1, growth and differentiation factor-15, and soluble thrombomodulin (sTM). The aim in this study was to evaluate the anti-inflammatory effects of rivaroxaban and dabigatran in patients with AF, in addition to the impact of markers on bleeding events. Finally, 117 patients (rivaroxaban: n = 55, dabigatran: n = 62) were included in the analysis at 12 months. Although the interval changes in sTM levels tended to be greater in the dabigatran group [0.3 (0-0.7) vs. 0.5 (0-1.0) FU/ml, p = 0.061], there were no significant differences in the interval changes in any inflammatory marker between 2 groups. There were no significant differences in bleeding events between 2 groups. The interval changes in sTM levels were significantly greater in patients with bleeding compared with those without [0.8 (0.5-1.3) vs. 0.4 (- 0.1-0.8) FU/ml, p = 0.017]. There were no significant differences in the interval changes in any inflammatory marker between rivaroxaban and dabigatran treatments in patients with AF. The increased levels of sTM after DOACs treatment might be related to bleeding events.
    MeSH term(s) Aged ; Anticoagulants/adverse effects ; Anticoagulants/therapeutic use ; Atrial Fibrillation/complications ; Atrial Fibrillation/drug therapy ; Dabigatran/adverse effects ; Dabigatran/therapeutic use ; Female ; Hemorrhage/chemically induced ; Hemorrhage/epidemiology ; Humans ; Japan ; Male ; Middle Aged ; Multivariate Analysis ; Prospective Studies ; Regression Analysis ; Rivaroxaban/adverse effects ; Rivaroxaban/therapeutic use ; Severity of Illness Index ; Stroke/etiology ; Stroke/prevention & control
    Chemical Substances Anticoagulants ; Rivaroxaban (9NDF7JZ4M3) ; Dabigatran (I0VM4M70GC)
    Language English
    Publishing date 2019-01-01
    Publishing country Japan
    Document type Comparative Study ; Journal Article ; Multicenter Study ; Randomized Controlled Trial
    ZDB-ID 89678-0
    ISSN 1615-2573 ; 0910-8327 ; 0935-736X
    ISSN (online) 1615-2573
    ISSN 0910-8327 ; 0935-736X
    DOI 10.1007/s00380-018-01324-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2049: Show issues Location:
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  6. Article: Possible involvement of Epstein-Barr virus and its regulatory gene in rheumatoid synovitis.

    Sawada, Shigemasa / Takei, Masami

    Autoimmunity reviews

    2004  Volume 3 Suppl 1, Page(s) S69–71

    MeSH term(s) Genes, Regulator ; Herpesvirus 4, Human/immunology ; Synovitis/immunology ; Synovitis/virology
    Language English
    Publishing date 2004-06
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2144145-5
    ISSN 1568-9972
    ISSN 1568-9972
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Professor Norman Talal 1934-2015.

    Moutsopoulos, Haralampos M / Sugai, Susumu / Sawada, Shigemasa / Koike, Takao / Miyasaka, Nobuyuki / Kobayashi, Seiichi / Takei, Masami / Ogawa, Noriyoshi

    Modern rheumatology

    2015  Volume 25, Issue 4, Page(s) 664

    MeSH term(s) Allergy and Immunology/history ; Autoimmune Diseases/history ; Biomedical Research/history ; History, 20th Century ; History, 21st Century ; Humans ; United States
    Language English
    Publishing date 2015-06-12
    Publishing country United States
    Document type Biography ; Historical Article ; Portrait
    ZDB-ID 2078157-X
    ISSN 1439-7609 ; 1439-7595
    ISSN (online) 1439-7609
    ISSN 1439-7595
    DOI 10.3109/14397595.2015.1052683
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 2982: Show issues Location:
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  8. Article: Improvement of anemia by H. pylori eradication in a patient with myelodysplastic syndrome.

    Matsukawa, Yoshihiro / Sawada, Shigemasa / Sawada, Umihiko

    Medical hypotheses

    2006  Volume 67, Issue 2, Page(s) 423

    MeSH term(s) Anemia/diet therapy ; Anemia/microbiology ; Helicobacter Infections/drug therapy ; Helicobacter pylori/drug effects ; Humans ; Male ; Middle Aged ; Myelodysplastic Syndromes/drug therapy ; Myelodysplastic Syndromes/microbiology ; Treatment Outcome
    Language English
    Publishing date 2006
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 193145-3
    ISSN 1532-2777 ; 0306-9877
    ISSN (online) 1532-2777
    ISSN 0306-9877
    DOI 10.1016/j.mehy.2006.03.032
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    Zs.A 1132: Show issues Location:
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  9. Article: Reproductive interference between two serious pests, oriental fruit flies Bactrocera carambolae and B. dorsalis (Diptera: Tephritidae), with very wide but partially overlapping host ranges

    Kitano, Daisuque / Fujii, Nobuyuki / Honma, Atsushi / Kitamura, Tasuku / Nishida, Takayoshi / Sawada, Hiroichi / Sujiono / Takakura, Koh-Ichi / Tsukada, Morio / Yamaue, Shigemasa

    Applied entomology and zoology. 2018 Nov., v. 53, no. 4

    2018  

    Abstract: Bactrocera carambolae and B. dorsalis (Diptera: Tephritidae) are extremely destructive pests of fruits and vegetables in the Asia-Pacific region. Earlier reports have described that B. carambolae and B. dorsalis, respectively, use mainly star fruit and ... ...

    Abstract Bactrocera carambolae and B. dorsalis (Diptera: Tephritidae) are extremely destructive pests of fruits and vegetables in the Asia-Pacific region. Earlier reports have described that B. carambolae and B. dorsalis, respectively, use mainly star fruit and mango, suggesting a certain level of host partitioning which can be ascribed neither to differences in larval food qualities nor host-specific parasitoid mortality. This study specifically examined reproductive interference (antagonistic sexual interaction) between B. carambolae and B. dorsalis as a potential factor strongly affecting their host partitioning. We observed mating behaviors, especially interspecific courtships and mating, by cohabiting the conspecific and heterospecific pairs together. Consequently, we quantified their effects on the reproductive success of females. Males of both species frequently courted their own females, but they also courted females of other species. Courtship refusal by females was not selective in males of either species. This incomplete discrimination of both sexes led to frequent occurrences of interspecific sexual interactions in both species, but only B. carambolae females showed reduced reproductive success. These results suggest that B. dorsalis, superior in reproductive interference, can occupy high-quality mango, whereas B. carambolae, inferior in reproductive interference, must use low-quality star fruit.
    Keywords Averrhoa carambola ; Bactrocera carambolae ; Bactrocera dorsalis ; courtship ; females ; fruit flies ; fruits ; host range ; host specificity ; larvae ; males ; mangoes ; mortality ; parasitoids ; reproductive success ; vegetables
    Language English
    Dates of publication 2018-11
    Size p. 525-533.
    Publishing place Springer Japan
    Document type Article
    ZDB-ID 820195-x
    ISSN 1347-605X ; 0003-6862
    ISSN (online) 1347-605X
    ISSN 0003-6862
    DOI 10.1007/s13355-018-0584-6
    Database NAL-Catalogue (AGRICOLA)

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    Z 2866: Show issues

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  10. Article: Reactivation of immanent herpes group virus.

    Sawada, Shigemasa / Takei, Masami

    Internal medicine (Tokyo, Japan)

    2003  Volume 42, Issue 2, Page(s) 140–141

    MeSH term(s) Adult ; Antibodies, Viral/analysis ; Colitis, Ulcerative/drug therapy ; Drug Hypersensitivity/diagnosis ; Drug Hypersensitivity/etiology ; Female ; Herpesvirus 6, Human/immunology ; Herpesvirus 6, Human/physiology ; Humans ; Prognosis ; Risk Assessment ; Sulfasalazine/adverse effects ; Sulfasalazine/therapeutic use ; Virus Activation/drug effects ; Virus Latency/drug effects ; Virus Latency/physiology
    Chemical Substances Antibodies, Viral ; Sulfasalazine (3XC8GUZ6CB)
    Language English
    Publishing date 2003-03-09
    Publishing country Japan
    Document type Case Reports ; Comment ; Editorial
    ZDB-ID 32371-8
    ISSN 0918-2918 ; 0021-5120
    ISSN 0918-2918 ; 0021-5120
    DOI 10.2169/internalmedicine.42.140
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 240: Show issues Location:
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