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  1. Article ; Online: Reactive lymphocytes in patients with COVID-19.

    Chong, Vanessa C L / Lim, Kian Guan Eric / Fan, Bingwen Eugene / Chan, Stephrene S W / Ong, Kiat H / Kuperan, Ponnudurai

    British journal of haematology

    2020  Volume 189, Issue 5, Page(s) 844

    MeSH term(s) Betacoronavirus/immunology ; COVID-19 ; Cell Nucleus/immunology ; Cell Nucleus/pathology ; Coronavirus Infections/immunology ; Coronavirus Infections/pathology ; Female ; Humans ; Lymphocytes/immunology ; Lymphocytes/pathology ; Male ; Pandemics ; Pneumonia, Viral/immunology ; Pneumonia, Viral/pathology ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-05-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.16690
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  2. Article ; Online: Peripheral lymphocyte subset alterations in COVID-19 patients.

    Chan, Stephrene S W / Christopher, Dheepa / Tan, Guat B / Chong, Vanessa C L / Fan, Bingwen E / Lin, Clement Y / Ong, Kiat H

    International journal of laboratory hematology

    2020  Volume 42, Issue 5, Page(s) e199–e203

    MeSH term(s) Antigens, CD19/immunology ; Asian Continental Ancestry Group ; B-Lymphocytes/immunology ; Blood Cell Count ; CD3 Complex/immunology ; CD4-Positive T-Lymphocytes/immunology ; CD56 Antigen/immunology ; CD8-Positive T-Lymphocytes/immunology ; COVID-19/epidemiology ; COVID-19/immunology ; COVID-19/physiopathology ; Female ; Flow Cytometry ; Fluorescent Dyes/chemistry ; GPI-Linked Proteins/immunology ; Humans ; Killer Cells, Natural/immunology ; Lymphocyte Subsets/immunology ; Male ; Middle Aged ; Pandemics ; Receptors, IgG/immunology
    Chemical Substances Antigens, CD19 ; CD19 molecule, human ; CD3 Complex ; CD56 Antigen ; FCGR3B protein, human ; Fluorescent Dyes ; GPI-Linked Proteins ; NCAM1 protein, human ; Receptors, IgG
    Keywords covid19
    Language English
    Publishing date 2020-07-01
    Publishing country England
    Document type Letter
    ZDB-ID 2268590-X
    ISSN 1751-553X ; 1751-5521 ; 0141-9854
    ISSN (online) 1751-553X
    ISSN 1751-5521 ; 0141-9854
    DOI 10.1111/ijlh.13276
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  3. Article: Peripheral lymphocyte subset alterations in COVID-19 patients

    Chan, Stephrene S W / Christopher, Dheepa / Tan, Guat B / Chong, Vanessa C L / Fan, Bingwen E / Lin, Clement Y / Ong, Kiat H

    Int. j. lab. hematol

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #626836
    Database COVID19

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  5. Article ; Online: Reactive lymphocytes in patients with COVID‐19

    Chong, Vanessa C. L. / Lim, Kian Guan Eric / Fan, Bingwen Eugene / Chan, Stephrene S. W. / Ong, Kiat H. / Kuperan, Ponnudurai

    British Journal of Haematology

    2020  Volume 189, Issue 5, Page(s) 844–844

    Keywords Hematology ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.16690
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  6. Article ; Online: Peripheral lymphocyte subset alterations in COVID‐19 patients

    Chan, Stephrene S. W. / Christopher, Dheepa / Tan, Guat B. / Chong, Vanessa C. L. / Fan, Bingwen E. / Lin, Clement Y. / Ong, Kiat H.

    International Journal of Laboratory Hematology

    2020  Volume 42, Issue 5

    Keywords Clinical Biochemistry ; Hematology ; Biochemistry, medical ; General Medicine ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2268590-X
    ISSN 1751-5521 ; 0141-9854
    ISSN 1751-5521 ; 0141-9854
    DOI 10.1111/ijlh.13276
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  7. Article ; Online: Venetoclax treatment in patients with cancer has limited impact on circulating T and NK cells.

    Teh, Charis E / Peng, Hongke / Luo, Meng-Xiao / Tan, Tania / Trussart, Marie / Howson, Lauren J / Chua, Chong Chyn / Muttiah, Christine / Brown, Fiona / Ritchie, Matthew E / Wei, Andrew H / Roberts, Andrew W / Bryant, Vanessa L / Anderson, Mary Ann / Lindeman, Geoffrey J / Huang, David C S / Thijssen, Rachel / Gray, Daniel H D

    Blood advances

    2022  Volume 7, Issue 12, Page(s) 2733–2745

    Abstract: Venetoclax is an effective treatment for certain blood cancers, such as chronic lymphocytic leukemia (CLL) and acute myeloid leukemia (AML). However, most patients relapse while on venetoclax and further treatment options are limited. Combining ... ...

    Abstract Venetoclax is an effective treatment for certain blood cancers, such as chronic lymphocytic leukemia (CLL) and acute myeloid leukemia (AML). However, most patients relapse while on venetoclax and further treatment options are limited. Combining venetoclax with immunotherapies is an attractive approach; however, a detailed understanding of how venetoclax treatment impacts normal immune cells in patients is lacking. In this study, we performed deep profiling of peripheral blood (PB) cells from patients with CLL and AML before and after short-term treatment with venetoclax using mass cytometry (cytometry by time of flight) and found no impact on the concentrations of key T-cell subsets or their expression of checkpoint molecules. We also analyzed PB from patients with breast cancer receiving venetoclax long-term using a single-cell multiomics approach (cellular indexing of transcriptomes and epitopes by sequencing) and functional assays. We found significant depletion of B-cell populations with low expression of MCL-1 relative to other immune cells, attended by extensive transcriptomic changes. By contrast, there was less impact on circulating T cells and natural killer (NK) cells, with no changes in their subset composition, transcriptome, or function following venetoclax treatment. Our data indicate that venetoclax has minimal impact on circulating T or NK cells, supporting the rationale of combining this BH3 mimetic drug with cancer immunotherapies for more durable antitumor responses.
    MeSH term(s) Humans ; Leukemia, Lymphocytic, Chronic, B-Cell/drug therapy ; Killer Cells, Natural ; Leukemia, Myeloid, Acute/drug therapy ; Bridged Bicyclo Compounds, Heterocyclic/pharmacology ; Bridged Bicyclo Compounds, Heterocyclic/therapeutic use
    Chemical Substances venetoclax (N54AIC43PW) ; Bridged Bicyclo Compounds, Heterocyclic
    Language English
    Publishing date 2022-12-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2915908-8
    ISSN 2473-9537 ; 2473-9529
    ISSN (online) 2473-9537
    ISSN 2473-9529
    DOI 10.1182/bloodadvances.2022008221
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  8. Article ; Online: Nicotinamide for Skin-Cancer Chemoprevention in Transplant Recipients.

    Allen, Nicholas C / Martin, Andrew J / Snaidr, Victoria A / Eggins, Renee / Chong, Alvin H / Fernandéz-Peñas, Pablo / Gin, Douglas / Sidhu, Shireen / Paddon, Vanessa L / Banney, Leith A / Lim, Adrian / Upjohn, Edward / Schaider, Helmut / Ganhewa, Aparna D / Nguyen, Jennifer / McKenzie, Catriona A / Prakash, Saurabh / McLean, Catriona / Lochhead, Alistair /
    Ibbetson, Jan / Dettrick, Andrew / Landgren, Anthony / Allnutt, Katherine J / Allison, Clare / Davenport, Rachael B / Mumford, Blake P / Wong, Brittany / Stagg, Brendan / Tedman, Alexander / Gribbin, Hannah / Edwards, Harrison A / De Rosa, Nicholas / Stewart, Thomas / Doolan, Brent J / Kok, Yonatan / Simpson, Kate / Low, Zhi M / Kovitwanichkanont, Tom / Scolyer, Richard A / Dhillon, Haryana M / Vardy, Janette L / Chadban, Steven J / Bowen, David G / Chen, Andrew C / Damian, Diona L

    The New England journal of medicine

    2023  Volume 388, Issue 9, Page(s) 804–812

    Abstract: Background: Immunosuppressed organ-transplant recipients have an increased incidence of, and mortality from, skin cancer. Nicotinamide (vitamin B: Methods: In this phase 3 trial, we randomly assigned, in a 1:1 ratio, organ-transplant recipients who ... ...

    Abstract Background: Immunosuppressed organ-transplant recipients have an increased incidence of, and mortality from, skin cancer. Nicotinamide (vitamin B
    Methods: In this phase 3 trial, we randomly assigned, in a 1:1 ratio, organ-transplant recipients who had had at least two keratinocyte cancers in the past 5 years to receive 500 mg of nicotinamide or placebo twice daily for 12 months. Participants were examined for skin lesions by dermatologists at 3-month intervals for 12 months. The primary end point was the number of new keratinocyte cancers during the 12-month intervention period. Secondary end points included the numbers of squamous-cell and basal-cell carcinomas during the 12-month intervention period, the number of actinic keratoses until 6 months after randomization, safety, and quality of life.
    Results: A total of 158 participants were enrolled, with 79 assigned to the nicotinamide group and 79 to the placebo group. The trial was stopped early owing to poor recruitment. At 12 months, there were 207 new keratinocyte cancers in the nicotinamide group and 210 in the placebo group (rate ratio, 1.0; 95% confidence interval, 0.8 to 1.3; P = 0.96). No significant between-group differences in squamous-cell and basal-cell carcinoma counts, actinic keratosis counts, or quality-of-life scores were observed. Adverse events and changes in blood or urine laboratory variables were similar in the two groups.
    Conclusions: In this 12-month, placebo-controlled trial, oral nicotinamide therapy did not lead to lower numbers of keratinocyte cancers or actinic keratoses in immunosuppressed solid-organ transplant recipients. (Funded by the National Health and Medical Research Council; ONTRANS Australian New Zealand Clinical Trials Registry number, ACTRN12617000599370.).
    MeSH term(s) Humans ; Australia ; Carcinoma, Basal Cell/etiology ; Carcinoma, Basal Cell/prevention & control ; Carcinoma, Squamous Cell/etiology ; Carcinoma, Squamous Cell/prevention & control ; Chemoprevention ; Keratosis, Actinic/etiology ; Keratosis, Actinic/prevention & control ; Niacinamide/administration & dosage ; Niacinamide/therapeutic use ; Quality of Life ; Skin Neoplasms/etiology ; Skin Neoplasms/prevention & control ; Transplant Recipients ; Immunocompromised Host ; Organ Transplantation/adverse effects ; Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/therapeutic use ; Ultraviolet Rays/adverse effects
    Chemical Substances Niacinamide (25X51I8RD4) ; Antineoplastic Agents
    Language English
    Publishing date 2023-03-01
    Publishing country United States
    Document type Clinical Trial, Phase III ; Journal Article ; Randomized Controlled Trial
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMoa2203086
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  9. Article ; Online: Male germ cells support long-term propagation of Zika virus

    Christopher L. Robinson / Angie C. N. Chong / Alison W. Ashbrook / Ginnie Jeng / Julia Jin / Haiqi Chen / Elizabeth I. Tang / Laura A. Martin / Rosa S. Kim / Reyn M. Kenyon / Eileen Do / Joseph M. Luna / Mohsan Saeed / Lori Zeltser / Harold Ralph / Vanessa L. Dudley / Marc Goldstein / Charles M. Rice / C. Yan Cheng /
    Marco Seandel / Shuibing Chen

    Nature Communications, Vol 9, Iss 1, Pp 1-

    2018  Volume 11

    Abstract: Zika virus (ZIKV) can persist for months in semen and sperm. Here, the authors show that germ cells, compared to other cell types in the reproductive tract, are most susceptible to ZIKV and produce high levels of progeny virus, which coincides with ... ...

    Abstract Zika virus (ZIKV) can persist for months in semen and sperm. Here, the authors show that germ cells, compared to other cell types in the reproductive tract, are most susceptible to ZIKV and produce high levels of progeny virus, which coincides with decreased expression of the interferon-stimulated gene Ifi44l.
    Keywords Science ; Q
    Language English
    Publishing date 2018-05-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
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  10. Article ; Online: Male germ cells support long-term propagation of Zika virus

    Christopher L. Robinson / Angie C. N. Chong / Alison W. Ashbrook / Ginnie Jeng / Julia Jin / Haiqi Chen / Elizabeth I. Tang / Laura A. Martin / Rosa S. Kim / Reyn M. Kenyon / Eileen Do / Joseph M. Luna / Mohsan Saeed / Lori Zeltser / Harold Ralph / Vanessa L. Dudley / Marc Goldstein / Charles M. Rice / C. Yan Cheng /
    Marco Seandel / Shuibing Chen

    Nature Communications, Vol 9, Iss 1, Pp 1-

    2018  Volume 11

    Abstract: Zika virus (ZIKV) can persist for months in semen and sperm. Here, the authors show that germ cells, compared to other cell types in the reproductive tract, are most susceptible to ZIKV and produce high levels of progeny virus, which coincides with ... ...

    Abstract Zika virus (ZIKV) can persist for months in semen and sperm. Here, the authors show that germ cells, compared to other cell types in the reproductive tract, are most susceptible to ZIKV and produce high levels of progeny virus, which coincides with decreased expression of the interferon-stimulated gene Ifi44l.
    Keywords Science ; Q
    Language English
    Publishing date 2018-05-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
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