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Article: Meatless Monday National School Meal Program Evaluation: Impact on Nutrition, Cost, and Sustainability

Blondin, Stacy A. / Cash, Sean B. / Griffin, Timothy S. / Goldberg, Jeanne P. / Economos, Christina D.

Journal of hunger & environmental nutrition. 2022 Jan. 02, v. 17, no. 1

2022

Abstract: This study evaluated the nutritional, economic, and environmental impacts of a Meatless Monday (MM) National School Lunch Program (NSLP) in a large urban US school district. After averaging the nutrient content of entrees across the week and comparing ... ...

Abstract	This study evaluated the nutritional, economic, and environmental impacts of a Meatless Monday (MM) National School Lunch Program (NSLP) in a large urban US school district. After averaging the nutrient content of entrees across the week and comparing changes relative to recommendations, there were no pre-post differences >15%. Monday entrees offered post-MM required considerably less water to produce (−51%) and were associated with fewer greenhouse gas emissions (−74%). The MM program had little impact on entrée cost (−2.5%). Further research is needed to determine how MM program goals can be achieved within the NSLP context.
Keywords	National School Lunch Program ; greenhouse gases ; hunger ; nutrient content ; program evaluation ; school meals
Language	English
Dates of publication	2022-0102
Size	p. 1-13.
Publishing place	Taylor & Francis
Document type	Article
ZDB-ID	2251933-6
ISSN	1932-0256 ; 1932-0248
ISSN (online)	1932-0256
ISSN	1932-0248
DOI	10.1080/19320248.2020.1842283
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: The efficacy of chemotherapy is limited by intratumoral senescent cells expressing PD-L2.

Chaib, Selim / López-Domínguez, José Alberto / Lalinde-Gutiérrez, Marta / Prats, Neus / Marin, Ines / Boix, Olga / García-Garijo, Andrea / Meyer, Kathleen / Muñoz, María Isabel / Aguilera, Mònica / Mateo, Lidia / Stephan-Otto Attolini, Camille / Llanos, Susana / Pérez-Ramos, Sandra / Escorihuela, Marta / Al-Shahrour, Fatima / Cash, Timothy P / Tchkonia, Tamara / Kirkland, James L /

Abad, María / Gros, Alena / Arribas, Joaquín / Serrano, Manuel

Nature cancer

2024 Volume 5, Issue 3, Page(s) 448–462

Abstract: Chemotherapy often generates intratumoral senescent cancer cells that strongly modify the tumor microenvironment, favoring immunosuppression and tumor growth. We discovered, through an unbiased proteomics screen, that the immune checkpoint inhibitor ... ...

Abstract	Chemotherapy often generates intratumoral senescent cancer cells that strongly modify the tumor microenvironment, favoring immunosuppression and tumor growth. We discovered, through an unbiased proteomics screen, that the immune checkpoint inhibitor programmed cell death 1 ligand 2 (PD-L2) is highly upregulated upon induction of senescence in different types of cancer cells. PD-L2 is not required for cells to undergo senescence, but it is critical for senescent cells to evade the immune system and persist intratumorally. Indeed, after chemotherapy, PD-L2-deficient senescent cancer cells are rapidly eliminated and tumors do not produce the senescence-associated chemokines CXCL1 and CXCL2. Accordingly, PD-L2-deficient pancreatic tumors fail to recruit myeloid-derived suppressor cells and undergo regression driven by CD8 T cells after chemotherapy. Finally, antibody-mediated blockade of PD-L2 strongly synergizes with chemotherapy causing remission of mammary tumors in mice. The combination of chemotherapy with anti-PD-L2 provides a therapeutic strategy that exploits vulnerabilities arising from therapy-induced senescence.
MeSH term(s)	Animals ; Mice ; Pancreatic Neoplasms/metabolism ; CD8-Positive T-Lymphocytes/pathology ; Immune Tolerance ; Immunosuppression Therapy ; Cellular Senescence ; Tumor Microenvironment
Language	English
Publishing date	2024-01-24
Publishing country	England
Document type	Journal Article
ISSN	2662-1347
ISSN (online)	2662-1347
DOI	10.1038/s43018-023-00712-x
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The Blood Neutrophil Count After 1 Month of Treatment Predicts the Radiologic Severity of Lung Disease at Treatment End.

Jones, Timothy P W / Dabbaj, Susannah / Mandal, Indrajeet / Cleverley, Joanne / Cash, Charlotte / Lipman, Marc C I / Lowe, David M

Chest

2021 Volume 160, Issue 6, Page(s) 2030–2041

Abstract: ... correlated with sputum smear grade (P = 0.003) and neutrophil count (P < 0.001). At end of treatment, only ... in the multivariate analysis (r = 0.34; P = 0.003) and remained significant after controlling for baseline radiologic scores ...

Abstract	Background: Lung disease after tuberculous confers significant morbidity. However, the determinants of persistent lung damage in TB are not well established. We investigated associations between TB-associated radiologic changes and sociodemographic factors, surrogates of bacillary burden, and blood inflammatory markers at initiation of therapy and after 1 month. Research question: What are the predictors of radiologic severity at the end of TB treatment for TB? Study design and methods: We collected data from patients treated for drug-sensitive pulmonary TB at our center over a 5.5-year period. We recorded age, sex, ethnicity, smoking status, symptom duration, sputum smear grade, time to culture positivity, and blood results (C-reactive protein and neutrophil count) at baseline and after 1 month of treatment. Chest radiographs obtained at baseline, 2 months, and end of treatment were assessed independently by two radiologists and scored using a validated system. Relationships between predictor variables and radiologic outcomes were assessed using linear or binary logistic regression. Results: We assessed 154 individuals with a mean age of 37 years, 63% of whom were men. In a multivariate analysis, baseline radiologic severity correlated with sputum smear grade (P = 0.003) and neutrophil count (P < 0.001). At end of treatment, only the 1-month neutrophil count was associated significantly with overall radiologic severity in the multivariate analysis (r = 0.34; P = 0.003) and remained significant after controlling for baseline radiologic scores. The 1-month neutrophil count also was the only independent correlate of volume loss and pleural thickening at the end of treatment and was significantly higher in patients with persistent cavitation or effusion vs those without. Interpretation: Persistent neutrophilic inflammation after 1 month of TB therapy is associated with poor radiologic outcome, suggesting a target for interventions to minimize lung disease after tuberculous.
MeSH term(s)	Adult ; Antitubercular Agents/therapeutic use ; Biomarkers/blood ; Female ; Humans ; Male ; Neutrophils/pathology ; Radiography, Thoracic ; Severity of Illness Index ; Sputum/microbiology ; Tuberculosis, Pulmonary/diagnostic imaging ; Tuberculosis, Pulmonary/drug therapy ; Tuberculosis, Pulmonary/pathology
Chemical Substances	Antitubercular Agents ; Biomarkers
Language	English
Publishing date	2021-07-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	1032552-9
ISSN	1931-3543 ; 0012-3692
ISSN (online)	1931-3543
ISSN	0012-3692
DOI	10.1016/j.chest.2021.07.041
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Article ; Online: Factors Influencing Fluid Milk Waste in a Breakfast in the Classroom School Breakfast Program.

Blondin, Stacy A / Goldberg, Jeanne P / Cash, Sean B / Griffin, Timothy S / Economos, Christina D

Journal of nutrition education and behavior

2018 Volume 50, Issue 4, Page(s) 349–356.e1

Abstract: ... between predictors and outcomes of interest. P ≤ .05 was considered statistically significant.: Results ...

Abstract	Objective: To determine predictors of fluid milk waste in a Breakfast in the Classroom School Breakfast Program. Design: Cross-sectional with 3 repeated measures/classroom. Setting: Elementary schools in a medium-sized, low-income, urban school district. Participants: Twenty third- through fourth-grade classrooms across 6 schools. Main outcomes: Dependent variables include percentage of total and served milk wasted. Independent variables included observed daily menu offerings, program factors, and teacher and student behavior. Analysis: Descriptive statistics were used to characterize variables across classrooms and schools. Multilevel mixed-effects models were used to test associations between predictors and outcomes of interest. P ≤ .05 was considered statistically significant. Results: Total milk waste increased 12% when juice was offered and 3% for each additional carton of unserved milk. Teacher encouragement to take and/or consume breakfast was associated with a 5% and 9% increase in total and served milk waste, respectively. When students were engaged in other activities in addition to eating breakfast, total milk waste decreased 10%. Conclusions and implications: Beverage offerings were predictive of greater total milk waste. Teacher and student behavior also appeared to influence milk consumption. Findings suggest that specific changes to School Breakfast Program implementation policies and practices could have an important role in waste mitigation.
MeSH term(s)	Animals ; Breakfast ; Child ; Cross-Sectional Studies ; Feeding Behavior/psychology ; Female ; Food Services ; Humans ; Male ; Milk ; Schools ; Students/psychology ; Students/statistics & numerical data ; Urban Population ; Waste Products/statistics & numerical data
Chemical Substances	Waste Products
Language	English
Publishing date	2018-03-16
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Observational Study ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ISSN	1878-2620
ISSN (online)	1878-2620
DOI	10.1016/j.jneb.2017.12.006
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Nutritional, Economic, and Environmental Costs of Milk Waste in a Classroom School Breakfast Program.

Blondin, Stacy A / Cash, Sean B / Goldberg, Jeanne P / Griffin, Timothy S / Economos, Christina D

American journal of public health

2017 Volume 107, Issue 4, Page(s) 590–592

Abstract: Objectives: To measure fluid milk waste in a US School Breakfast in the Classroom Program and estimate its nutritional, economic, and environmental effects.: Methods: Fluid milk waste was directly measured on 60 elementary school classroom days in a ... ...

Abstract	Objectives: To measure fluid milk waste in a US School Breakfast in the Classroom Program and estimate its nutritional, economic, and environmental effects. Methods: Fluid milk waste was directly measured on 60 elementary school classroom days in a medium-sized, urban district. The US Department of Agriculture nutrition database, district cost data, and carbon dioxide equivalent (CO Results: Of the total milk offered to School Breakfast Program participants, 45% was wasted. A considerably smaller portion of served milk was wasted (26%). The amount of milk wasted translated into 27% of vitamin D and 41% of calcium required of School Breakfast Program meals. The economic and environmental costs amounted to an estimated $274 782 (16% of the district's total annual School Breakfast Program food expenditures), 644 893 kilograms of CO Conclusions: These substantial effects of milk waste undermine the School Breakfast Program's capacity to ensure short- and long-term food security and federal food waste reduction targets. Interventions that reduce waste are urgently needed.
MeSH term(s)	Animals ; Breakfast ; Carbon Dioxide/analysis ; Child ; Female ; Food Services/economics ; Humans ; Male ; Milk/economics ; Nutritional Status ; Schools ; United States ; United States Department of Agriculture ; Waste Disposal, Fluid/economics
Chemical Substances	Carbon Dioxide (142M471B3J)
Language	English
Publishing date	2017-02-16
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	121100-6
ISSN	1541-0048 ; 0090-0036 ; 0002-9572
ISSN (online)	1541-0048
ISSN	0090-0036 ; 0002-9572
DOI	10.2105/AJPH.2016.303647
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bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

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Article: Qualitative Exploration of Farm to School Program Adoption and Expansion in Massachusetts Schools

Lehnerd, Megan E / Goldberg, Jeanne P / Folta, Sara C / Cash, Sean B / Griffin, Timothy S / Lucas, Rebecca / Sacheck, Jennifer M

Journal of hunger & environmental nutrition. 2020 Mar. 3, v. 15, no. 2

2020

Abstract: Limited research has examined the rapid growth of farm to school (FTS) programs in the US. Qualitative interviews (n = 24) framed by Diffusion of Innovations theory were used to explore FTS program adoption and expansion in Massachusetts. Program ... ...

Abstract	Limited research has examined the rapid growth of farm to school (FTS) programs in the US. Qualitative interviews (n = 24) framed by Diffusion of Innovations theory were used to explore FTS program adoption and expansion in Massachusetts. Program compatibility and relative advantages related to academics, school meal participation, and child health motivated initial engagement. Active classroom integration, implementation simplification, and strong support networks aided program expansion. Leadership and sustainability plans, garden maintenance partnerships, and Community Eligibility Provision participation hold promise to help further program diffusion. Future research should focus on providing additional evidence for FTS aspects salient to adoption and expansion.
Keywords	child health ; farm to school ; gardens ; interviews ; leadership ; school meals ; schools ; Massachusetts
Language	English
Dates of publication	2020-0303
Size	p. 230-250.
Publishing place	Taylor & Francis
Document type	Article
ZDB-ID	2251933-6
ISSN	1932-0256 ; 1932-0248
ISSN (online)	1932-0256
ISSN	1932-0248
DOI	10.1080/19320248.2019.1610539
Database	NAL-Catalogue (AGRICOLA)

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Article: Induction of Lysosome Membrane Permeabilization as a Therapeutic Strategy to Target Pancreatic Cancer Stem Cells.

Cash, Timothy P / Alcalá, Sonia / Rico-Ferreira, María Del Rosario / Hernández-Encinas, Elena / García, Jennifer / Albarrán, María Isabel / Valle, Sandra / Muñoz, Javier / Martínez-González, Sonia / Blanco-Aparicio, Carmen / Pastor, Joaquín / Serrano, Manuel / Sainz, Bruno

Cancers

2020 Volume 12, Issue 7

Abstract: Despite significant efforts to improve pancreatic ductal adenocarcinoma (PDAC) clinical outcomes, overall survival remains dismal. The poor response to current therapies is partly due to the existence of pancreatic cancer stem cells (PaCSCs), which are ... ...

Abstract	Despite significant efforts to improve pancreatic ductal adenocarcinoma (PDAC) clinical outcomes, overall survival remains dismal. The poor response to current therapies is partly due to the existence of pancreatic cancer stem cells (PaCSCs), which are efficient drivers of PDAC tumorigenesis, metastasis and relapse. To find new therapeutic agents that could efficiently kill PaCSCs, we screened a chemical library of 680 compounds for candidate small molecules with anti-CSC activity, and identified two compounds of a specific chemical series with potent activity in vitro and in vivo against patient-derived xenograft (PDX) cultures. The anti-CSC mechanism of action of this specific chemical series was found to rely on induction of lysosomal membrane permeabilization (LMP), which is likely associated with the increased lysosomal mass observed in PaCSCs. Using the well characterized LMP-inducer siramesine as a tool molecule, we show elimination of the PaCSC population in mice implanted with tumors from two PDX models. Collectively, our approach identified lysosomal disruption as a promising anti-CSC therapeutic strategy for PDAC.
Language	English
Publishing date	2020-07-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers12071790
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Article: Factors Influencing Fluid Milk Waste in a Breakfast in the Classroom School Breakfast Program

Blondin, Stacy A / Cash, Sean B / Economos, Christina D / Goldberg, Jeanne P / Griffin, Timothy S

Society for Nutrition Education and Behavior Journal of nutrition education and behavior. 2018 Apr., v. 50, no. 4

2018

Abstract: ... associations between predictors and outcomes of interest. P ≤ .05 was considered statistically significant ...

Abstract	To determine predictors of fluid milk waste in a Breakfast in the Classroom School Breakfast Program.Cross-sectional with 3 repeated measures/classroom.Elementary schools in a medium-sized, low-income, urban school district.Twenty third- through fourth-grade classrooms across 6 schools.Dependent variables include percentage of total and served milk wasted. Independent variables included observed daily menu offerings, program factors, and teacher and student behavior.Descriptive statistics were used to characterize variables across classrooms and schools. Multilevel mixed-effects models were used to test associations between predictors and outcomes of interest. P ≤ .05 was considered statistically significant.Total milk waste increased 12% when juice was offered and 3% for each additional carton of unserved milk. Teacher encouragement to take and/or consume breakfast was associated with a 5% and 9% increase in total and served milk waste, respectively. When students were engaged in other activities in addition to eating breakfast, total milk waste decreased 10%.Beverage offerings were predictive of greater total milk waste. Teacher and student behavior also appeared to influence milk consumption. Findings suggest that specific changes to School Breakfast Program implementation policies and practices could have an important role in waste mitigation.
Keywords	breakfast ; fluid milk ; fruit juices ; issues and policy ; milk ; milk consumption ; models ; National School Breakfast Program ; school breakfast ; schools ; statistics ; students ; teachers ; wastes
Language	English
Dates of publication	2018-04
Size	p. 349-356.e1.
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	2080501-9
ISSN	1708-8259 ; 1499-4046
ISSN (online)	1708-8259
ISSN	1499-4046
DOI	10.1016/j.jneb.2017.12.006
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Farmers' Perspectives on the Adoption and Impacts of Nutrition Incentive and Farm to School Programs

Megan E. Lehnerd / Jennifer M. Sacheck / Timothy S. Griffin / Jeanne P. Goldberg / Sean B. Cash

Journal of Agriculture, Food Systems, and Community Development, Vol 8, Iss

2018 Volume 1

Abstract: Recent increases in consumer demand for local food have resulted in more opportunities for food to be purchased in close proximity to where it is produced. However, local markets can be challenging retail outlets for farmers and not uniformly affordable ...

Abstract	Recent increases in consumer demand for local food have resulted in more opportunities for food to be purchased in close proximity to where it is produced. However, local markets can be challenging retail outlets for farmers and not uniformly affordable and accessible to all consumers. Farmers market nutrition incentive (FMNI) and farm to school (F2S) programs are two community-based initiatives that support farmers while simultaneously lessening the burden of local food access for lower income populations. In this study, we explore farmer perceptions, barriers to adoption, and impacts of FMNI and F2S programs. A survey was developed based on the Diffusion of Innovations theory to assess (1) the key factors that influence adoption of FMNI and F2S programs; (2) farmer perceptions of the most significant barriers to program adoption; and (3) the influence of non-economic impacts on farmers’ motivation to participate in those programs. A total of 155 Mid-Atlantic fruit and vegetable farmers completed the survey. Participating farmers perceived FMNI and F2S as providing advantageous social impact and various economic opportunities. However, participants and non-participants had differing perspectives on program complexity, compatibility with their business model, and the degree to which others have succeeded when participating. The most significant barriers relate to issues with product pricing, customer engagement, and logistics. Three-quarters of farmers ranked social/community impacts as most important to them. A deeper understanding of farmers’ involvement in FMNI and F2S programs will help address barriers and modify program components to increase economic, social/community, and environmental impacts.
Keywords	Farmers Markets ; Farm to School ; Mid-Atlantic Farmer ; Fruit and Vegetable Farmer ; Survey Design ; Motivation ; Agriculture ; S ; Technology ; T ; Home economics ; TX1-1110 ; Nutrition. Foods and food supply ; TX341-641 ; Geography. Anthropology. Recreation ; G ; Recreation. Leisure ; GV1-1860 ; Human ecology. Anthropogeography ; GF1-900 ; Environmental sciences ; GE1-350 ; Social Sciences ; H ; Communities. Classes. Races ; HT51-1595 ; Urban groups. The city. Urban sociology ; HT101-395 ; Regional planning ; HT390-395
Subject code	910
Language	English
Publishing date	2018-03-01T00:00:00Z
Publisher	Thomas A. Lyson Center for Civic Agriculture and Food Systems
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Farmers' Perspectives on the Adoption and Impacts of Nutrition Incentive and Farm to School Programs

Lehnerd, Megan E / Jeanne P. Goldberg / Jennifer M. Sacheck / Sean B. Cash / Timothy S. Griffin

Journal of agriculture, food systems, and community development. 2018, v. 8, no. 1

2018

Abstract	Recent increases in consumer demand for local food have resulted in more opportunities for food to be purchased in close proximity to where it is produced. However, local markets can be challenging retail outlets for farmers and not uniformly affordable and accessible to all consumers. Farmers market nutrition incentive (FMNI) and farm to school (F2S) programs are two community-based initiatives that support farmers while simultaneously lessening the burden of local food access for lower income populations. In this study, we explore farmer perceptions, barriers to adoption, and impacts of FMNI and F2S programs. A survey was developed based on the Diffusion of Innovations theory to assess (1) the key factors that influence adoption of FMNI and F2S programs; (2) farmer perceptions of the most significant barriers to program adoption; and (3) the influence of non-economic impacts on farmers’ motivation to participate in those programs. A total of 155 Mid-Atlantic fruit and vegetable farmers completed the survey. Participating farmers perceived FMNI and F2S as providing advantageous social impact and various economic opportunities. However, participants and non-participants had differing perspectives on program complexity, compatibility with their business model, and the degree to which others have succeeded when participating. The most significant barriers relate to issues with product pricing, customer engagement, and logistics. Three-quarters of farmers ranked social/community impacts as most important to them. A deeper understanding of farmers’ involvement in FMNI and F2S programs will help address barriers and modify program components to increase economic, social/community, and environmental impacts.
Keywords	consumer demand ; econometric models ; environmental impact ; farm to school ; farmers ; farmers' attitudes ; farmers' markets ; fruits ; nutrition ; prices ; retail marketing ; social impact ; surveys ; vegetables
Language	English
Size	p. 147-165.
Publishing place	New Leaf Associates, Inc.
Document type	Article
ISSN	2152-0801
DOI	10.5304/jafscd.2018.081.012
Database	NAL-Catalogue (AGRICOLA)

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