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Article ; Online: A prospective review of the health-promoting potential of Jing Si Herbal Tea.

Ho, Tsung-Jung / Ahmed, Tanvir / Shibu, Marthandam Asokan / Lin, Yu-Jung / Shih, Cheng Yen / Lin, Pi-Yu / Ling, Shinn-Zong / Chiang, Chien-Yi / Kuo, Wei-Wen / Huang, Chih-Yang

Tzu chi medical journal

2024 Volume 36, Issue 1, Page(s) 1–22

Abstract: ... Jing Si Herbal Tea (JSHT)," has been reported recently for their health-promoting effects in improving ...

Abstract	Traditional Chinese medicine (TCM) has gained considerable attention over the past few years for its multicomponent, multitarget, and multi-pathway approach to treating different diseases. Studies have shown that TCMs as adjuvant therapy along with conventional treatment may benefit in safely treating various disorders. However, investigations on finding effective herbal combinations are ongoing. A novel TCM formula, "Jing Si Herbal Tea (JSHT)," has been reported recently for their health-promoting effects in improving overall body and mental health. JSHT is a combination of eight herbs recognized in Chinese herbal pharmacopoeia for their anti-viral, anti-aging, and anti-cancer properties as well as protective effects against cardiovascular, metabolic, neural, digestive, and genitourinary diseases. Thus, to better understand the beneficial effects of the ingredients of JSHT on health, this review intends to summarize the preclinical and clinical studies of the ingredients of JSHT on human health and diseases, and possible therapeutic effects with the related mode of actions and future prospects for their application in complementary therapies.
Language	English
Publishing date	2024-01-12
Publishing country	India
Document type	Journal Article ; Review
ZDB-ID	2452925-4
ISSN	2223-8956 ; 2223-8956
ISSN (online)	2223-8956
ISSN	2223-8956
DOI	10.4103/tcmj.tcmj_194_23
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Recuperative herbal formula Jing Si maintains vasculature permeability balance, regulates inflammation and assuages concomitants of "Long-Covid".

Chiang, Chien-Yi / Lin, Yu-Jung / Weng, Wen-Tsan / Lin, Heng-Dao / Lu, Cheng-You / Chen, Wan-Jing / Shih, Cheng Yen / Lin, Pi-Yu / Lin, Shinn-Zong / Ho, Tsung-Jung / Shibu, Marthandam Asokan / Huang, Chih-Yang

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2023 Volume 163, Page(s) 114752

Abstract: ... the therapeutic effects of Jing Si herbal tea (JSHT) against COVID-19 infection and associated long-term effects ...

Abstract	Coronavirus disease 2019 (COVID-19) is a worldwide health threat that has long-term effects on the patients and there is currently no efficient cure prescribed for the treatment and the prolonging effects. Traditional Chinese medicines (TCMs) have been reported to exert therapeutic effect against COVID-19. In this study, the therapeutic effects of Jing Si herbal tea (JSHT) against COVID-19 infection and associated long-term effects were evaluated in different in vitro and in vivo models. The anti-inflammatory effects of JSHT were studied in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells and in Omicron pseudotyped virus-induced acute lung injury model. The effect of JSHT on cellular stress was determined in HK-2 proximal tubular cells and H9c2 cardiomyoblasts. The therapeutic benefits of JSHT on anhedonia and depression symptoms associated with long COVID were evaluated in mice models for unpredictable chronic mild stress (UCMS). JSHT inhibited the NF-ƙB activities, and significantly reduced LPS-induced expression of TNFα, COX-2, NLRP3 inflammasome, and HMGB1. JSHT was also found to significantly suppress the production of NO by reducing iNOS expression in LPS-stimulated RAW 264.7 cells. Further, the protective effects of JSHT on lung tissue were confirmed based on mitigation of lung injury, repression in TMRRSS2 and HMGB-1 expression and reduction of cytokine storm in the Omicron pseudotyped virus-induced acute lung injury model. JSHT treatment in UCMS models also relieved chronic stress and combated depression symptoms. The results therefore show that JSHT attenuates the cytokine storm by repressing NF-κB cascades and provides the protective functions against symptoms associated with long COVID-19 infection.
MeSH term(s)	Mice ; Humans ; Animals ; Post-Acute COVID-19 Syndrome ; Lipopolysaccharides/adverse effects ; Cytokine Release Syndrome ; Cytokines/metabolism ; COVID-19 ; Inflammation/drug therapy ; Inflammation/metabolism ; Acute Lung Injury/metabolism ; NF-kappa B/metabolism
Chemical Substances	Lipopolysaccharides ; Cytokines ; NF-kappa B
Language	English
Publishing date	2023-04-26
Publishing country	France
Document type	Journal Article
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2023.114752
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Article ; Online: Jing Si Herbal Drink as a prospective adjunctive therapy for COVID-19 treatment

Ping-Hsun Lu / Chien-Wei Tseng / Jing-Ling Lee / En-Yu Lee / Yu-Ping Lin / I-Hsin Lin / Min-Chien Yu / Kuo-Cheng Lu / Ko-Lin Kuo

Pharmacological Research - Modern Chinese Medicine, Vol 2, Iss , Pp 100024- (2022)

Molecular evidence and mechanisms

2022

Abstract: ... the symptoms of COVID-19 infection, and TCMs can affect the pathogenesis of SARS-CoV-2 infection in vitro. Jing ...

Abstract	Background: SARS-CoV-2 has led to a sharp increase in the number of hospitalizations and deaths from pneumonia and multiorgan disease worldwide; therefore, SARS-CoV-2 has become a global health problem. Supportive therapies remain the mainstay treatments against COVID-19, such as oxygen inhalation, antiviral drugs, and antibiotics. Traditional Chinese medicine (TCM) has been shown clinically to relieve the symptoms of COVID-19 infection, and TCMs can affect the pathogenesis of SARS-CoV-2 infection in vitro. Jing Si Herbal Drink (JSHD), an eight herb formula jointly developed by Tzu Chi University and Tzu Chi Hospital, has shown potential as an adjuvant treatment for COVID-19 infection. A randomized controlled trial (RCT) of JSHD as an adjuvant treatment in patients with COVID-19 infection is underway Objectives: This article aims to explore the efficacy of the herbs in JSHD against COVID-19 infection from a mechanistic standpoint and provide a reference for the rational utilization of JSHD in the treatment of COVID-19. Method: We compiled evidence of the herbs in JSHD to treat COVID-19 in vivo and in vitro. Results: We described the efficacy and mechanism of action of the active ingredients in JSHD to treat COVID-19 based on experimental evidence. JSHD includes 5 antiviral herbs, 7 antioxidant herbs, and 7 anti-inflammatory herbs. In addition, 2 herbs inhibit the overactive immune system, 1 herb reduces cell apoptosis, and 1 herb possesses antithrombotic ability. Conclusion: Although experimental data have confirmed that the ingredients in JSHD are effective against COVID-19, more rigorously designed studies are required to confirm the efficacy and safety of JSHD as a COVID-19 treatment.
Keywords	COVID-19 ; Jing Si Herbal Drink ; Herbs ; Mechanism ; Antivirus ; Anti-inflammation ; Other systems of medicine ; RZ201-999 ; Therapeutics. Pharmacology ; RM1-950
Subject code	610
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Human adipose-derived stem cells preconditioned with a novel herbal formulation Jing Shi attenuate doxorubicin-induced cardiac damage.

Hsieh, Dennis Jine-Yuan / Tsai, Bruce Chi-Kang / Barik, Parthasarathi / Shibu, Marthandam Asokan / Kuo, Chia-Hua / Kuo, Wei-Wen / Lin, Pi-Yu / Shih, Cheng-Yen / Lin, Shinn-Zong / Ho, Tsung-Jung / Huang, Chih-Yang

Aging

2023 Volume 15, Issue 17, Page(s) 9167–9181

Abstract: ... with novel herbal formulation Jing Si (JS) improved protective ability of stem cells against doxorubicin ...

Abstract	Pathological cardiac hypertrophy is a considerable contributor to global disease burden. Chinese herbal medicine (CHM) has been used to treat cardiovascular diseases since antiquity. Enhancing stem cell-mediated recovery through CHM represents a promising approach for protection against doxorubicin (Dox)-induced cardiac hypertrophy. Herein, we investigated whether human adipose-derived stem cells (hADSCs) preconditioned with novel herbal formulation Jing Si (JS) improved protective ability of stem cells against doxorubicin-induced cardiac damage. The effect of JS on hADSC viability and migration capacity was determined via MTT and migration assays, respectively. Co-culture of hADSC or JS-preconditioned hADSCs with H9c2 cells was analyzed with immunoblot, flow cytometry, TUNEL staining, LC3B staining, F-actin staining, and MitoSOX staining. The
MeSH term(s)	Humans ; Animals ; Rats ; Rats, Sprague-Dawley ; Heart ; Stem Cells ; Doxorubicin/toxicity ; Cardiomegaly
Chemical Substances	Doxorubicin (80168379AG)
Language	English
Publishing date	2023-09-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1945-4589
ISSN (online)	1945-4589
DOI	10.18632/aging.205026
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Article ; Online: Egg residue and depletion of meloxicam in Jing Hong laying hens following multiple oral doses.

Shao, Hao-Tian / Gao, Liang / Li, Hao-Tian / Zhang, Mei / Chen, Jun-Cheng / Duan, Ming-Hui / Li, Ze-En / Dai, Yan / Li, Xing-Ping / Yang, Fan

Poultry science

2023 Volume 102, Issue 8, Page(s) 102761

Abstract: ... enriched the study on the residue of meloxicam in domestic Jing Hong laying hens and provided WDIs to help ...

Abstract	Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID) commonly used in an extra-label manner in commercial laying hens for the treatment of foot lesions, which are a common issue in this species. The present study aimed to determine the depletion profiles of meloxicam in eggs with multiple oral administration under 2 different dosing regimens and to further recommend reasonable withdrawal intervals (WDIs). Meloxicam (1 mg/kg) was administered orally to laying hens under 2 dosing schedules: 10 doses at 24-h intervals and 15 doses at 12-h intervals. Eggs were collected daily after the first dosing, and meloxicam concentrations in both yolk and white were determined by a high-performance liquid chromatography (HPLC) method. The weight ratio of white to yolk in the whole egg was 1.54 (the mean of 20 eggs with repeated tests), and this value combined with the meloxicam concentrations in white and yolk were used to calculate the drug concentrations in whole eggs. Meloxicam was quickly eliminated from egg white, and its concentrations could only be quantified at 2 time points during the elimination phase. The elimination half-lives in yolk and whole egg were 3.07 ± 1.00 and 2.98 ± 0.88 d, respectively, after 10 repeated doses. And the corresponding elimination half-lives were 2.30 ± 0.83 and 2.18 ± 0.67 d, respectively, after repeated 15 doses. Considering the time when meloxicam was not detectable in eggs with the time of ovum development and maturation, a withdrawal interval (WDI) was suggested as 17 d for both dosing schedules. The current results enriched the study on the residue of meloxicam in domestic Jing Hong laying hens and provided WDIs to help ensure animal-derived food safety.
MeSH term(s)	Animals ; Female ; Meloxicam/analysis ; Egg Yolk/chemistry ; Chickens ; Drug Residues/analysis ; Ovum/chemistry ; Administration, Oral ; Eggs/analysis
Chemical Substances	Meloxicam (VG2QF83CGL)
Language	English
Publishing date	2023-04-27
Publishing country	England
Document type	Journal Article
ZDB-ID	242586-5
ISSN	1525-3171 ; 0032-5791
ISSN (online)	1525-3171
ISSN	0032-5791
DOI	10.1016/j.psj.2023.102761
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Article: Combined effect of traditional Chinese herbal-based formulations Jing Si herbal tea and Jing Si nasal drop inhibits adhesion and transmission of SARS-CoV2 in diabetic SKH-1 mice.

Chiang, Chien-Yi / Kuo, Wei-Wen / Lin, Yu-Jung / Kuo, Chia-Hua / Shih, Cheng-Yen / Lin, Pi-Yu / Lin, Shinn-Zong / Ho, Tsung-Jung / Huang, Chih-Yang / Shibu, Marthandam Asokan

Frontiers in pharmacology

2022 Volume 13, Page(s) 953438

Abstract: Multiple studies show increased severity of SARS-CoV2-infection in patients with comorbidities such as hypertension and diabetes. In this study, we have prepared two herbal-based formulations, a pleiotropic herbal drink (Jin Si Herbal Tea, JHT) and a ... ...

Abstract	Multiple studies show increased severity of SARS-CoV2-infection in patients with comorbidities such as hypertension and diabetes. In this study, we have prepared two herbal-based formulations, a pleiotropic herbal drink (Jin Si Herbal Tea, JHT) and a nasal drop (Jin Si nasal drop, JND), to provide preventive care against SARS-CoV2 infection. The effect of JHT and JND was determined in SARS-CoV2-S-pseudotyped lentivirus-infected bronchial and colorectal cell lines and in SKH-1 mouse models. For preliminary studies, ACE2 receptor abundant bronchial (Calu-3) and colorectal cells (Caco-2) were used to determine the effect of JHT and JND on the host entry of various variants of SARS-CoV2-S-pseudotyped lentivirus. A series of experiments were performed to understand the infection rate in SKH-1 mice (6 weeks old, n = 9), find the effective dosage of JHT and JND, and determine the combination effect of JHT and JND on the entry and adhesion of various variant SARS-CoV2-S-pseudotyped lentiviruses, which included highly transmissible delta and gamma mutants. Furthermore, the effect of combined JHT and JND was determined on diabetes-induced SKH-1 mice against the comorbidity-associated intense viral entry and accumulation. In addition, the effect of combined JHT and JND administration on viral transmission from infected SKH-1 mice to uninfected cage mate mice was determined. The results showed that both JHT and JND were effective in alleviating the viral entry and accumulation in the thorax and the abdominal area. While JHT showed a dose-dependent decrease in the viral load, JND showed early inhibition of viral entry from day 1 of the infection. Combined administration of 48.66 mg of JHT and 20 µL of JND showed rapid reduction in the viral entry and reduced the viral load (97-99%) in the infected mice within 3 days of treatment. Moreover, 16.22 mg of JHT and 20 µL JND reduced the viral infection in STZ-induced diabetic SKH-1 mice. Interestingly, combined JHT and JND also inhibited viral transmission among cage mates. The results, therefore, showed that combined administration of JHT and JND is a novel and an efficient strategy to potentially prevent SARS-CoV2 infection.
Language	English
Publishing date	2022-11-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2022.953438
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Article ; Online: Novel anti-aging herbal formulation Jing Si displays pleiotropic effects against aging associated disorders.

Shibu, Marthandam Asokan / Lin, Yu-Jung / Chiang, Chien-Yi / Lu, Cheng-You / Goswami, Debakshee / Sundhar, Navaneethan / Agarwal, Surbhi / Islam, Md Nazmul / Lin, Pi-Yu / Lin, Shinn-Zong / Ho, Tsung-Jung / Tsai, Wan-Ting / Kuo, Wei-Wen / Huang, Chih-Yang

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2022 Volume 146, Page(s) 112427

Abstract: ... effects of a decoction Jing Si herbal drink (JS) containing eight Traditional Chinese Medicine based herbs ...

Abstract	Common characteristics of aging include reduced somatic stem cell number, susceptibility to cardiac injuries, metabolic imbalances and increased risk for oncogenesis. In this study, Pleiotropic anti-aging effects of a decoction Jing Si herbal drink (JS) containing eight Traditional Chinese Medicine based herbs, with known effects against aging related disorders was evaluated. Adipose derived mesenchymal stem cells (ADMSCs) from 16 week old adult and 24 month old aging WKY rats were evaluated for the age-related changes in stem cell homeostasis. Effects of JS on self-renewal, klotho and Telomerase Reverse Transcriptase expression DNA damage response were determined by immunofluorescence staining. The effects were confirmed in senescence induced human ADMSCs and in addition, the potential of JS to maintain telomere length was evaluated by qPCR analysis in ADMSCs challenged for long term with doxorubicin. Further, the effects of JS on doxorubicin-induced hypertrophic effect and DNA damage in H9c2 cardiac cells; MPP+-induced damages in SH-SY5Y neuron cells were investigated. In addition, effects of JS in maintaining metabolic regulation, in terms of blood glucose regulation in type-II diabetes mice model, and their potential to suppress malignancy in different cancer cells were ascertained. The results show that JS maintains stem cell homeostasis and provides cytoprotection. In addition JS regulates blood glucose metabolism, enhances autophagic clearances in neurons and suppresses cancer growth and migration. The results show that JS acts on multiple targets and provides a cumulative protective effect against various age-associated disorders and therefore it is a candidate pleiotropic agent for healthy aging.
MeSH term(s)	Aging/drug effects ; Animals ; Cytoprotection/drug effects ; Drugs, Chinese Herbal/administration & dosage ; Drugs, Chinese Herbal/pharmacology ; Glycemic Control/methods ; Humans ; Mesenchymal Stem Cells/drug effects ; Mice ; Rats ; Rats, Inbred WKY ; Regenerative Medicine/methods ; Telomere Homeostasis/drug effects
Chemical Substances	Drugs, Chinese Herbal
Language	English
Publishing date	2022-01-05
Publishing country	France
Document type	Journal Article
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2021.112427
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Article ; Online: Egg residue and depletion of meloxicam in Jing Hong laying hens following multiple oral doses

Shao, Hao-Tian / Gao, Liang / Li, Hao-tian / Zhang, Mei / Chen, Jun-Cheng / Duan, Ming-Hui / Li, Ze'en / Dai, Yan / Li, Xing-Ping / Yang, Fan

Poultry Science. 2023 Apr. 27, p.102761-

2023 , Page(s) 102761–

Abstract: ... results enriched the study on the residue of meloxicam in domestic Jing Hong laying hens and provided WDIs ...

Abstract	Meloxicam is a non-steroidal anti-inflammatory drug (NSAID) commonly used in an extra-label manner in commercial laying hens for the treatment of foot lesions, which are a common issue in this species. The present study aimed to determine the depletion profiles of meloxicam in eggs with multiple oral administration under two different dosing regimens and to further recommend reasonable withdrawal intervals (WDIs). Meloxicam (1 mg/kg) was administered orally to laying hens under two dosing schedules: 10 doses at 24-hour intervals and 15 doses at 12-hour intervals. Eggs were collected daily after the first dosing, and meloxicam concentrations in both yolk and white were determined by a high-performance liquid chromatography (HPLC) method. The weight ratio of white to yolk in the whole egg was 1.54 (the mean of 20 eggs with repeated tests), and this value combined with the meloxicam concentrations in white and yolk were used to calculate the drug concentrations in whole eggs. Meloxicam was quickly eliminated from egg white, and its concentrations could only be quantified at two time points during the elimination phase. The elimination half-lives in yolk and whole egg were 3.07 ± 1.00 and 2.98 ± 0.88 d, respectively, after 10 repeated doses. And the corresponding elimination half-lives were 2.30 ± 0.83 and 2.18 ± 0.67 d, respectively, after repeated 15 doses. Considering the time when meloxicam was not detectable in eggs with the time of ovum development and maturation, a withdrawal interval (WDI) was suggested as 17 days for both dosing schedules. The current results enriched the study on the residue of meloxicam in domestic Jing Hong laying hens and provided WDIs to help ensure animal-derived food safety.
Keywords	animal-based foods ; egg albumen ; eggs ; food safety ; half life ; high performance liquid chromatography ; meloxicam ; nonsteroidal anti-inflammatory agents ; oral administration ; ova ; poultry science ; withdrawal interval ; Jing Hong laying hens ; HPLC ; the weight ratio of white to yolk
Language	English
Dates of publication	2023-0427
Size	p. 102761
Publishing place	Elsevier Inc.
Document type	Article ; Online
Note	Pre-press version ; Use and reproduction
ZDB-ID	242586-5
ISSN	1525-3171 ; 0032-5791
ISSN (online)	1525-3171
ISSN	0032-5791
DOI	10.1016/j.psj.2023.102761
Database	NAL-Catalogue (AGRICOLA)

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Article: Liver and gall bladder channel parallels in the Hippocratic Corpus and Huang Di Nei Jing with theoretical considerations.

Paulo, Roger F / Zhang, Qi Cheng

Journal of traditional and complementary medicine

2021 Volume 12, Issue 4, Page(s) 384–390

Abstract: Chinese history contains an abundance of records discussing contact with the outside world. In the ever elusive search for the origin of the meridian theory, an extended investigation into the Hippocratic Corpus reveals parallels with ... ...

Abstract	Chinese history contains an abundance of records discussing contact with the outside world. In the ever elusive search for the origin of the meridian theory, an extended investigation into the Hippocratic Corpus reveals parallels with the
Language	English
Publishing date	2021-12-22
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2709698-1
ISSN	2225-4110
ISSN	2225-4110
DOI	10.1016/j.jtcme.2021.11.005
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Article: Efficacy and Safety of Complementary Therapy With Jing Si Herbal Tea in Patients With Mild-To-Moderate COVID-19: A Prospective Cohort Study.

Hsieh, Po-Chun / Chao, You-Chen / Tsai, Kuo-Wang / Li, Chung-Hsien / Tzeng, I-Shiang / Wu, Yao-Kuang / Shih, Cheng Yen

Frontiers in nutrition

2022 Volume 9, Page(s) 832321

Abstract: ... essential. Jing-Si Herbal Tea (JSHT), a novel traditional Chinese medicine formula was developed to treat ...

Abstract	Background: Since late 2019, there has been a global COVID-19 pandemic. To preserve medical capacity and decrease adverse health effects, preventing the progression of COVID-19 to severe status is essential. Jing-Si Herbal Tea (JSHT), a novel traditional Chinese medicine formula was developed to treat COVID-19. This study examined the clinical efficacy and safety of JSHT in patients with mild-to-moderate COVID-19. Methods: In this prospective cohort study, we enrolled 260 patients with mild-to-moderate COVID-19. The enrolled patients were divided into the JSHT ( Results: Compared with standard management alone, JSHT combined with standard management more effectively improved the reverse transcription-polymerase chain reaction cycle threshold value, C-reactive protein level, and Brixia score in the adult patients with mild-to-moderate COVID-19, especially in the male and older patients (those aged ≥60 years). The results revealed that the patients treated with JSHT combined with standard management had 51, 70, and 100% lower risks of intubation, Medisave Care Unit admission, and mortality compared with those receiving standard management only. Conclusions: JSHT combined with standard management more effectively reduced the SARS-CoV-2 viral load and systemic inflammation and alleviated lung infiltrates in the patients with mild-to-moderate COVID-19, especially in the male and older patients (those aged ≥60 years). JSHT combined with standard management may prevent critical status and mortality in patients with mild-to-moderate COVID-19. JSHT is a promising complementary therapy for patients with mild-to-moderate COVID-19.
Language	English
Publishing date	2022-03-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2776676-7
ISSN	2296-861X
ISSN	2296-861X
DOI	10.3389/fnut.2022.832321
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