Article ; Online: Assessing the role of Chemokine (C-C motif) ligand 14 in AKI: a European consensus meeting.
2024 Volume 46, Issue 1, Page(s) 2345747
Abstract: Background: Urinary Chemokine (C-C motif) ligand 14 (CCL14) is a biomarker associated ...
Abstract | Background: Urinary Chemokine (C-C motif) ligand 14 (CCL14) is a biomarker associated with persistent severe acute kidney injury (AKI). There is limited data to support the implementation of this AKI biomarker to guide therapeutic actions. Methods: Sixteen AKI experts with clinical CCL14 experience participated in a Delphi-based method to reach consensus on when and how to potentially use CCL14. Consensus was defined as ≥ 80% agreement (participants answered with 'Yes', or three to four points on a five-point Likert Scale). Results: Key consensus areas for CCL14 test implementation were: identifying challenges and mitigations, developing a comprehensive protocol and pairing it with a treatment plan, and defining the target population. The majority agreed that CCL14 results can help to prioritize AKI management decisions. CCL14 levels above the high cutoff (> 13 ng/mL) significantly changed the level of concern for modifying the AKI treatment plan ( Conclusion: Real world urinary CCL14 use appears to provide improved care options to patients at risk for persistent severe AKI. Experts believe there is a role for CCL14 in AKI management and it may potentially reduce AKI-disease burden. There is, however, an urgent need for evidence on treatment decisions and adjustments based on CCL14 results. |
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MeSH term(s) | Acute Kidney Injury/urine ; Acute Kidney Injury/therapy ; Acute Kidney Injury/diagnosis ; Humans ; Biomarkers/urine ; Delphi Technique ; Renal Replacement Therapy ; Consensus ; Chemokines, CC/urine ; Europe |
Chemical Substances | Biomarkers ; Chemokines, CC |
Language | English |
Publishing date | 2024-04-26 |
Publishing country | England |
Document type | Journal Article ; Consensus Development Conference |
ZDB-ID | 632949-4 |
ISSN | 1525-6049 ; 0886-022X |
ISSN (online) | 1525-6049 |
ISSN | 0886-022X |
DOI | 10.1080/0886022X.2024.2345747 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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