Article ; Online: Association of Prenatally Diagnosed Isolated Single Left Superior Vena Cava and Postnatal Development of Coarctation of the Aorta.
2024 Volume 45, Issue 4, Page(s) 749–758
Abstract: To report the prevalence of coarctation of the aorta (CoA) in fetuses with single left superior vena cava (SL-SVC) and to evaluate changes in echocardiographic measurements. Additionally, to report the prevalence of associated malformations. ... ...
| Abstract | To report the prevalence of coarctation of the aorta (CoA) in fetuses with single left superior vena cava (SL-SVC) and to evaluate changes in echocardiographic measurements. Additionally, to report the prevalence of associated malformations. Retrospective observational study of fetuses diagnosed with SL-SVC between 2012 and 2021 at a tertiary fetal cardiology unit. In fetuses without intracardiac abnormalities, Z-scores of the ventricles, great arteries, and Doppler flow patterns are reported. We identified 47 fetuses with SL-SVC of which 8/47 (17%) had abnormal intracardiac anatomy. One fetus was lost to follow-up. Of those with normal intracardiac anatomy and postnatal follow-up (38), karyotype abnormalities were confirmed in 2/38 (5%) and ECA in 8/38 (21%). 33/38 were live-born. None developed CoA postnatally. Paired analysis of Z-scores between early and late scans of 24 fetuses showed that diameters of the right heart structures and Doppler flows of tricuspid valve increased significantly during pregnancy, while the left heart structures and flow patterns did not change. The median risk of CoA did not change between the early and the late scan. We did not observe CoA in this cohort. A degree of ventricular asymmetry was present, but this was due to right heart dominance rather than hypoplasia of left heart structures. This likely reflects redistribution of blood and does not appear to confer increased risk of CoA. Predictive models of the postnatal development of CoA which set the dimensions of right and left heart structures in relation might not be applicable in this situation. |
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| MeSH term(s) | Pregnancy ; Female ; Humans ; Aortic Coarctation/diagnostic imaging ; Vena Cava, Superior/diagnostic imaging ; Ultrasonography, Prenatal/methods ; Aorta/diagnostic imaging ; Heart ; Retrospective Studies ; Heart Defects, Congenital ; Gestational Age |
| Language | English |
| Publishing date | 2024-02-21 |
| Publishing country | United States |
| Document type | Observational Study ; Journal Article |
| ZDB-ID | 800857-7 |
| ISSN | 1432-1971 ; 0172-0643 |
| ISSN (online) | 1432-1971 |
| ISSN | 0172-0643 |
| DOI | 10.1007/s00246-024-03407-x |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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