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Article: Inflammatory breast cancer biomarkers and biology.

van Golen, Kenneth L

International review of cell and molecular biology

2024 Volume 384, Page(s) 63–76

Abstract: Inflammatory breast cancer (IBC) is a unique breast cancer with a highly virulent course and low 5- and 10-year survival rates. Even though it only accounts for 1-5% of breast cancers it is estimated to account for 10% of breast cancer deaths annually in ...

Abstract	Inflammatory breast cancer (IBC) is a unique breast cancer with a highly virulent course and low 5- and 10-year survival rates. Even though it only accounts for 1-5% of breast cancers it is estimated to account for 10% of breast cancer deaths annually in the United States. The accuracy of diagnosis and classification of this unique cancer is a major concern within the medical community. Early molecular and biological studies incidentally included IBC samples with other conventional breast cancers and were not informative as to the unique nature of the disease. Subsequent molecular studies that focused specifically on IBC demonstrated that IBC has a unique biology different from other forms of breast cancer. Additionally, a handful of unique signature genes that are hallmarks of IBC have also been suggested. Further understanding of IBC biology can help with diagnosis and treatment of the disease. The current article reviews the history and highlights of IBC studies.
MeSH term(s)	Humans ; Female ; Inflammatory Breast Neoplasms/genetics ; Breast Neoplasms ; Biomarkers, Tumor ; Biology
Chemical Substances	Biomarkers, Tumor
Language	English
Publishing date	2024-02-05
Publishing country	Netherlands
Document type	Review ; Journal Article
ZDB-ID	2427220-6
ISSN	1937-6448 ; 0074-7696
ISSN	1937-6448 ; 0074-7696
DOI	10.1016/bs.ircmb.2023.11.002
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Article ; Online: Realistic modeling of tumor cells.

van Golen, Kenneth L

Oncotarget

2017 Volume 8, Issue 16, Page(s) 25833–25834

MeSH term(s)	Apoptosis Regulatory Proteins ; Breast Neoplasms ; Humans ; Inflammatory Breast Neoplasms ; Neoplastic Cells, Circulating
Chemical Substances	Apoptosis Regulatory Proteins
Language	English
Publishing date	2017-04-26
Publishing country	United States
Document type	News ; Comment
ZDB-ID	2560162-3
ISSN	1949-2553 ; 1949-2553
ISSN (online)	1949-2553
ISSN	1949-2553
DOI	10.18632/oncotarget.17122
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Article ; Online: Dynamic bioinspired coculture model for probing ER

Pradhan, Lina / Moore, DeVonte / Ovadia, Elisa M / Swedzinski, Samantha L / Cossette, Travis / Sikes, Robert A / van Golen, Kenneth / Kloxin, April M

Science advances

2023 Volume 9, Issue 10, Page(s) eade3186

Abstract: Late recurrences of breast cancer are hypothesized to arise from disseminated tumor cells (DTCs) that reactivate after dormancy and occur most frequently with estrogen receptor-positive ( ... ...

Abstract	Late recurrences of breast cancer are hypothesized to arise from disseminated tumor cells (DTCs) that reactivate after dormancy and occur most frequently with estrogen receptor-positive (ER
MeSH term(s)	Humans ; Female ; Breast Neoplasms/metabolism ; Coculture Techniques ; Bone Marrow/pathology ; Signal Transduction ; Cell Communication ; Tumor Microenvironment
Language	English
Publishing date	2023-03-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	2810933-8
ISSN	2375-2548 ; 2375-2548
ISSN (online)	2375-2548
ISSN	2375-2548
DOI	10.1126/sciadv.ade3186
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Article ; Online: Caveolin-1 Mediates Inflammatory Breast Cancer Cell Invasion via the Akt1 Pathway and RhoC GTPase.

Joglekar, Madhura / Elbazanti, Weam O / Weitzman, Matthew D / Lehman, Heather L / van Golen, Kenneth L

Journal of cellular biochemistry

2017 Volume 118, Issue 5, Page(s) 1273

Language	English
Publishing date	2017-05
Publishing country	United States
Document type	Journal Article ; Published Erratum
ZDB-ID	392402-6
ISSN	1097-4644 ; 0730-2312
ISSN (online)	1097-4644
ISSN	0730-2312
DOI	10.1002/jcb.25876
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Article ; Online: The Third International Inflammatory Breast Cancer Conference.

van Golen, Kenneth L / Cristofanilli, Massimo

Breast cancer research : BCR

2013 Volume 15, Issue 6, Page(s) 318

Abstract: Inflammatory breast cancer (IBC) is the most aggressive and deadly form of breast cancer. Disease-specific research and conferences have been organized since 2008 with the intent to bring together experts in various disciplines. This report focus on the ... ...

Abstract	Inflammatory breast cancer (IBC) is the most aggressive and deadly form of breast cancer. Disease-specific research and conferences have been organized since 2008 with the intent to bring together experts in various disciplines. This report focus on the Third International IBC Conference held in Philadelphia on December 2012.
MeSH term(s)	Biomedical Research ; Female ; Humans ; Inflammatory Breast Neoplasms/diagnosis ; Inflammatory Breast Neoplasms/genetics ; Inflammatory Breast Neoplasms/metabolism ; Inflammatory Breast Neoplasms/therapy ; Inflammatory Breast Neoplasms/virology ; Molecular Targeted Therapy
Language	English
Publishing date	2013-11-05
Publishing country	England
Document type	Congress
ZDB-ID	2015059-3
ISSN	1465-542X ; 1465-5411
ISSN (online)	1465-542X
ISSN	1465-5411
DOI	10.1186/bcr3571
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Zs.A 5494: Show issues

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Article ; Online: A Physiologically-Based Pharmacokinetic Model for Targeting Calcitriol-Conjugated Quantum Dots to Inflammatory Breast Cancer Cells.

Forder, James / Smith, Mallory / Wagner, Margot / Schaefer, Rachel J / Gorky, Jonathon / van Golen, Kenneth L / Nohe, Anja / Dhurjati, Prasad

Clinical and translational science

2019 Volume 12, Issue 6, Page(s) 617–624

Abstract: Quantum dots (QDs) conjugated with 1,25 dihydroxyvitamin D3 (calcitriol) and Mucin-1 (MUC-1) antibodies (SM3) have been found to target inflammatory breast cancer (IBC) tumors and reduce proliferation, migration, and differentiation of these tumors in ... ...

Abstract	Quantum dots (QDs) conjugated with 1,25 dihydroxyvitamin D3 (calcitriol) and Mucin-1 (MUC-1) antibodies (SM3) have been found to target inflammatory breast cancer (IBC) tumors and reduce proliferation, migration, and differentiation of these tumors in mice. A physiologically-based pharmacokinetic model has been constructed and optimized to match experimental data for multiple QDs: control QDs, QDs conjugated with calcitriol, and QDs conjugated with both calcitriol and SM3 MUC1 antibodies. The model predicts continuous QD concentration for key tissues in mice distinguished by IBC stage (healthy, early-stage, and late-stage). Experimental and clinical efforts in QD treatment of IBC can be augmented by in silico simulations that predict the short-term and long-term behavior of QD treatment regimens.
MeSH term(s)	Animals ; Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/pharmacokinetics ; Breast Neoplasms/drug therapy ; Breast Neoplasms/immunology ; Calcitriol/administration & dosage ; Calcitriol/pharmacokinetics ; Cell Line, Tumor ; Drug Delivery Systems/methods ; Female ; Humans ; Immunoconjugates/administration & dosage ; Immunoconjugates/pharmacokinetics ; Mice ; Models, Biological ; Mucin-1/immunology ; Quantum Dots/administration & dosage ; Xenograft Model Antitumor Assays
Chemical Substances	Antineoplastic Agents ; Immunoconjugates ; MUC1 protein, human ; Mucin-1 ; Calcitriol (FXC9231JVH)
Language	English
Publishing date	2019-07-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2433157-0
ISSN	1752-8062 ; 1752-8054
ISSN (online)	1752-8062
ISSN	1752-8054
DOI	10.1111/cts.12664
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Article: Immunohistochemical Staining for Uroguanylin, a Satiety Hormone, is Decreased in Intestinal Tissue Specimens From Female Adolescents With Obesity.

Di Guglielmo, Matthew D / Perdue, Lacey / Adeyemi, Adebowale / van Golen, Kenneth L / Corao, Diana U

Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society

2017 Volume 21, Issue 3, Page(s) 285–295

Abstract: Gastrointestinal tract-secreted satiety hormones play a significant role in one of the largest health-care challenges for children and adults, obesity. Recent studies in mice identified a novel role for uroguanylin, the endogenous intestinal hormone that ...

Abstract	Gastrointestinal tract-secreted satiety hormones play a significant role in one of the largest health-care challenges for children and adults, obesity. Recent studies in mice identified a novel role for uroguanylin, the endogenous intestinal hormone that binds guanylyl cyclase C (GUCY2C), in regulating satiety via a gut-brain signaling pathway. Mice bred without GUCY2C receptors over-ate and developed obesity. We hypothesized that intestinal uroguanylin expression in pediatric patients with obesity would be lower than patients without obesity, and we attempted to examine the difference with immunohistochemistry. Retrospective chart review of gastrointestinal endoscopic procedures at an academic children's hospital identified patients with normal pathology findings on biopsy. Children aged 8-17 were included in the review; we analyzed biopsy samples from 20 matched pairs that differed only by body mass index (BMI)-for-age (average: 25%-75% vs. high: >95%). Biopsies of the duodenum, terminal ileum, ascending colon, and descending colon were subjected to immunohistochemistry for GUCY2C, uroguanylin, and the endogenous colonic hormone, guanylin. Intensity staining of all specimens was scored by a blinded pathologist. The overall staining intensity for females with high BMI-for-age was less for uroguanylin and guanylin as compared to average BMI-for-age females while GUCY2C staining was equal. Males did not exhibit different staining intensities for uroguanylin or guanylin. More matched female pairs had greater uroguanylin and guanylin staining in the average BMI-for-age cohort. The intestinal expression of uroguanylin, a key satiety hormone, appears to be diminished in female pediatric patients in the setting of obesity.
MeSH term(s)	Adolescent ; Biomarkers/metabolism ; Biopsy ; Case-Control Studies ; Child ; Endoscopy, Gastrointestinal ; Female ; Humans ; Immunohistochemistry ; Intestinal Mucosa/metabolism ; Intestinal Mucosa/pathology ; Male ; Natriuretic Peptides/metabolism ; Pediatric Obesity/diagnostic imaging ; Pediatric Obesity/metabolism ; Pediatric Obesity/pathology ; Retrospective Studies ; Sex Factors ; Single-Blind Method
Chemical Substances	Biomarkers ; Natriuretic Peptides ; uroguanylin (152175-68-3)
Language	English
Publishing date	2017-08-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	1463498-3
ISSN	1615-5742 ; 1093-5266
ISSN (online)	1615-5742
ISSN	1093-5266
DOI	10.1177/1093526617722912
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Zs.A 5063: Show issues

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Article ; Online: Is caveolin-1 a viable therapeutic target to reduce cancer metastasis?

van Golen, Kenneth L

Expert opinion on therapeutic targets

2006 Volume 10, Issue 5, Page(s) 709–721

Abstract: Caveolin-1 is the major structural protein in caveolae; small Omega-shaped invaginations within the plasma membrane. Caveolae are involved in signal transduction, wherein caveolin-1 acts as a scaffold to organise multiple molecular complexes regulating a ...

Abstract	Caveolin-1 is the major structural protein in caveolae; small Omega-shaped invaginations within the plasma membrane. Caveolae are involved in signal transduction, wherein caveolin-1 acts as a scaffold to organise multiple molecular complexes regulating a variety of cellular events. Caveolin-1 has both tumour suppressor and oncogenic activities. However, recent evidence suggests a role for caveolin-1 in promoting cancer cell migration and metastasis with both loss and overexpression of caveolin-1 being described as a marker for progression in a variety of tumour types. Further studies are beginning to determine the molecular mechanisms by which caveolin-1 acts in promoting a metastatic phenotype. Targeting caveolin-1 expression may present a novel means of preventing metastasis. The purpose of this review is twofold: firstly, to survey the current knowledge of the contribution of caveolin-1 in promoting a metastasis, and secondly, to explore the viability of targeting caveolin-1 with novel therapeutics.
MeSH term(s)	Animals ; Antineoplastic Agents/administration & dosage ; Caveolin 1/metabolism ; Drug Delivery Systems/methods ; Humans ; Neoplasm Metastasis/drug therapy ; Neoplasm Metastasis/prevention & control ; Neoplasms/drug therapy ; Neoplasms/metabolism
Chemical Substances	Antineoplastic Agents ; Caveolin 1
Language	English
Publishing date	2006-08-29
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
ZDB-ID	2055208-7
ISSN	1744-7631 ; 1472-8222
ISSN (online)	1744-7631
ISSN	1472-8222
DOI	10.1517/14728222.10.5.709
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Zs.A 5244: Show issues

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Article ; Online: Pilot Study Measuring the Novel Satiety Hormone, Pro-Uroguanylin, in Adolescents With and Without Obesity.

Di Guglielmo, Matthew D / Tonb, Dalal / He, Zhaoping / Adeyemi, Adebowale / van Golen, Kenneth L

Journal of pediatric gastroenterology and nutrition

2017 Volume 66, Issue 3, Page(s) 489–495

Abstract: Objective: Disruption of satiety signaling may lead to increased caloric intake and obesity. Uroguanylin, the intestinal hormone, travels as a precursor to the central nervous system where it activates guanylyl cyclase C and stimulates pro-satiety ... ...

Abstract	Objective: Disruption of satiety signaling may lead to increased caloric intake and obesity. Uroguanylin, the intestinal hormone, travels as a precursor to the central nervous system where it activates guanylyl cyclase C and stimulates pro-satiety neurons. Rodent studies have demonstrated that guanylyl cyclase C-knockout mice overeat and have increased weight gain versus wild-type mice and hyper-caloric obesity diminishes uroguanylin expression. We measured circulating plasma pro-uroguanylin, along with other gastrointestinal peptides and inflammatory markers, in human adolescents with and without obesity, as a pilot study. We hypothesized that adolescents with obesity would have less circulating pro-uroguanylin than adolescents without obesity have. Methods: We recruited 24 adolescents (age 14-17 years) with and without obesity (body mass index >95% or body mass index <95%) and measured plasma pro-uroguanylin at fasting and successive time points after a meal. We measured 3 other satiety hormones and 2 inflammatory markers to characterize overall satiety signaling and highlight any link between uroguanylin and inflammation. Results: Female adolescents with obesity had lower circulating pro-uroguanylin levels than female adolescents without obesity; we observed no difference in males. Other measured gastrointestinal peptides varied in their differences between cohorts. Inflammatory markers were higher in female participants with obesity. Conclusions: In adolescents with and without obesity, we can measure circulating pro-uroguanylin levels. In female adolescents without obesity, levels are particularly higher. Pro-uroguanylin secretion patterns differ from other circulating gastrointestinal peptides. In female adolescents with obesity, inflammation correlates with decreased pro-uroguanylin levels.
MeSH term(s)	Adolescent ; Biomarkers/blood ; Case-Control Studies ; Female ; Humans ; Male ; Natriuretic Peptides/blood ; Pediatric Obesity/blood ; Pediatric Obesity/etiology ; Pediatric Obesity/physiopathology ; Pilot Projects ; Satiation/physiology
Chemical Substances	Biomarkers ; Natriuretic Peptides ; uroguanylin (152175-68-3)
Language	English
Publishing date	2017-11-09
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	603201-1
ISSN	1536-4801 ; 0277-2116
ISSN (online)	1536-4801
ISSN	0277-2116
DOI	10.1097/MPG.0000000000001796
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Article: Understanding ER+ Breast Cancer Dormancy Using Bioinspired Synthetic Matrices for Long-Term 3D Culture and Insights into Late Recurrence.

Ovadia, Elisa M / Pradhan, Lina / Sawicki, Lisa A / Cowart, Julie E / Huber, Rebecca E / Polson, Shawn W / Chen, Chuming / van Golen, Kenneth L / Ross, Karen E / Wu, Cathy H / Kloxin, April M

Advanced biosystems

2020 Volume 4, Issue 9, Page(s) e2000119

Abstract: Late recurrences of breast cancer are hypothesized to originate from disseminated tumor cells that re-activate after a long period of dormancy, ≥5 years for estrogen-receptor positive (ER+) tumors. An outstanding question remains as to what the key ... ...

Abstract	Late recurrences of breast cancer are hypothesized to originate from disseminated tumor cells that re-activate after a long period of dormancy, ≥5 years for estrogen-receptor positive (ER+) tumors. An outstanding question remains as to what the key microenvironment interactions are that regulate this complex process, and well-defined human model systems are needed for probing this. Here, a robust, bioinspired 3D ER+ dormancy culture model is established and utilized to probe the effects of matrix properties for common sites of late recurrence on breast cancer cell dormancy. Formation of dormant micrometastases over several weeks is examined for ER+ cells (T47D, BT474), where the timing of entry into dormancy versus persistent growth depends on matrix composition and cell type. In contrast, triple negative cells (MDA-MB-231), associated with early recurrence, are not observed to undergo long-term dormancy. Bioinformatic analyses quantitatively support an increased "dormancy score" gene signature for ER+ cells (T47D) and reveal differential expression of genes associated with different biological processes based on matrix composition. Further, these analyses support a link between dormancy and autophagy, a potential survival mechanism. This robust model system will allow systematic investigations of other cell-microenvironment interactions in dormancy and evaluation of therapeutics for preventing late recurrence.
MeSH term(s)	Autophagy ; Breast Neoplasms/chemistry ; Breast Neoplasms/metabolism ; Breast Neoplasms/physiopathology ; Cell Culture Techniques/methods ; Cell Line, Tumor ; Extracellular Matrix/metabolism ; Female ; Humans ; Models, Biological ; Receptors, Estrogen/metabolism ; Synthetic Biology ; Tumor Microenvironment/physiology
Chemical Substances	Receptors, Estrogen
Language	English
Publishing date	2020-06-30
Publishing country	Germany
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ISSN	2366-7478
ISSN	2366-7478
DOI	10.1002/adbi.202000119
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