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  1. Article ; Online: Hide and seek with SARS-CoV-2: spike receptor-binding domain-specific memory B cells still recognize Omicron variant.

    Odak, Ivan / Förster, Reinhold / Bošnjak, Berislav

    Signal transduction and targeted therapy

    2022  Volume 7, Issue 1, Page(s) 343

    MeSH term(s) COVID-19 ; Humans ; Memory B Cells ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus/genetics
    Chemical Substances Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2
    Language English
    Publishing date 2022-10-02
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2886872-9
    ISSN 2059-3635 ; 2095-9907
    ISSN (online) 2059-3635
    ISSN 2095-9907
    DOI 10.1038/s41392-022-01192-8
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  2. Article ; Online: Brief research report: in-depth immunophenotyping reveals stability of CD19 CAR T-cells over time.

    Odak, Ivan / Bayir, Lâle M / Riemann, Lennart / Sikora, Ruth / Schneider, Jessica / Xiao, Yankai / Möhn, Nora / Skripuletz, Thomas / Beutel, Gernot / Eder, Matthias / Ganser, Arnold / Förster, Reinhold / Schultze-Florey, Christian R / Koenecke, Christian

    Frontiers in immunology

    2024  Volume 15, Page(s) 1298598

    Abstract: Variability or stability might have an impact on treatment success and toxicity of CD19 CAR T-cells. We conducted a prospective observational study of 12 patients treated with Tisagenlecleucel for ... ...

    Abstract Variability or stability might have an impact on treatment success and toxicity of CD19 CAR T-cells. We conducted a prospective observational study of 12 patients treated with Tisagenlecleucel for CD19
    MeSH term(s) Humans ; Adaptor Proteins, Signal Transducing ; Antigens, CD19 ; Immunophenotyping ; T-Lymphocytes ; Prospective Studies
    Chemical Substances Adaptor Proteins, Signal Transducing ; Antigens, CD19
    Language English
    Publishing date 2024-01-22
    Publishing country Switzerland
    Document type Observational Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2024.1298598
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  3. Article ; Online: Cholinesterase Inhibitory and Anti-Inflammatory Activity of the Naphtho- and Thienobenzo-Triazole Photoproducts: Experimental and Computational Study.

    Mlakić, Milena / Faraho, Ivan / Odak, Ilijana / Kovačević, Borislav / Raspudić, Anamarija / Šagud, Ivana / Bosnar, Martina / Škorić, Irena / Barić, Danijela

    International journal of molecular sciences

    2023  Volume 24, Issue 19

    Abstract: New 1,2,3-triazolo(thieno)stilbenes were synthesized as mixtures of isomers and efficiently photochemically transformed to their corresponding substituted thienobenzo/naphtho-triazoles in high isolated yields. The resulting photoproducts were studied as ... ...

    Abstract New 1,2,3-triazolo(thieno)stilbenes were synthesized as mixtures of isomers and efficiently photochemically transformed to their corresponding substituted thienobenzo/naphtho-triazoles in high isolated yields. The resulting photoproducts were studied as acetyl- (AChE) and butyrylcholinesterase (BChE) inhibitors without or with interconnected inhibition potential of TNF-α cytokine production. The most promising anti-inflammatory activity was shown again by naphtho-triazoles, with a derivative featuring 4-pentenyl substituents exhibiting notable potential as a cholinesterase inhibitor. To identify interactions between ligands and the active site of cholinesterases, molecular docking was performed for the best potential inhibitors. Additionally, molecular dynamics simulations were employed to assess and validate the stability and flexibility of the protein-ligand complexes generated through docking.
    MeSH term(s) Butyrylcholinesterase/metabolism ; Acetylcholinesterase/metabolism ; Triazoles/pharmacology ; Triazoles/chemistry ; Molecular Docking Simulation ; Structure-Activity Relationship ; Cholinesterase Inhibitors/pharmacology ; Cholinesterase Inhibitors/chemistry ; Ligands
    Chemical Substances Butyrylcholinesterase (EC 3.1.1.8) ; Acetylcholinesterase (EC 3.1.1.7) ; Triazoles ; Cholinesterase Inhibitors ; Ligands
    Language English
    Publishing date 2023-09-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241914676
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  4. Article ; Online: Cholinesterase Inhibitory and Anti-Inflammatory Activity of the Naphtho- and Thienobenzo-Triazole Photoproducts

    Milena Mlakić / Ivan Faraho / Ilijana Odak / Borislav Kovačević / Anamarija Raspudić / Ivana Šagud / Martina Bosnar / Irena Škorić / Danijela Barić

    International Journal of Molecular Sciences, Vol 24, Iss 14676, p

    Experimental and Computational Study

    2023  Volume 14676

    Abstract: New 1,2,3-triazolo(thieno)stilbenes were synthesized as mixtures of isomers and efficiently photochemically transformed to their corresponding substituted thienobenzo/naphtho-triazoles in high isolated yields. The resulting photoproducts were studied as ... ...

    Abstract New 1,2,3-triazolo(thieno)stilbenes were synthesized as mixtures of isomers and efficiently photochemically transformed to their corresponding substituted thienobenzo/naphtho-triazoles in high isolated yields. The resulting photoproducts were studied as acetyl- (AChE) and butyrylcholinesterase (BChE) inhibitors without or with interconnected inhibition potential of TNF-α cytokine production. The most promising anti-inflammatory activity was shown again by naphtho-triazoles, with a derivative featuring 4-pentenyl substituents exhibiting notable potential as a cholinesterase inhibitor. To identify interactions between ligands and the active site of cholinesterases, molecular docking was performed for the best potential inhibitors. Additionally, molecular dynamics simulations were employed to assess and validate the stability and flexibility of the protein–ligand complexes generated through docking.
    Keywords anti-inflammatory activity ; cholinesterase inhibition ; molecular docking ; molecular dynamics ; naphtho/thienobenzo-triazoles ; photochemical synthesis ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 540
    Language English
    Publishing date 2023-09-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: New naphtho/thienobenzo-triazoles with interconnected anti-inflammatory and cholinesterase inhibitory activity.

    Mlakić, Milena / Odak, Ilijana / Faraho, Ivan / Talić, Stanislava / Bosnar, Martina / Lasić, Kornelija / Barić, Danijela / Škorić, Irena

    European journal of medicinal chemistry

    2022  Volume 241, Page(s) 114616

    Abstract: New 1,2,3-triazolo(thieno)stilbenes were synthesized by Wittig reaction and photochemically transformed to corresponding substituted thienobenzo/naphtho-triazoles in high isolated yields. They were prepared to study the acetyl- and butyrylcholinesterase ... ...

    Abstract New 1,2,3-triazolo(thieno)stilbenes were synthesized by Wittig reaction and photochemically transformed to corresponding substituted thienobenzo/naphtho-triazoles in high isolated yields. They were prepared to study the acetyl- and butyrylcholinesterase inhibition associated with the inhibition of TNFα cytokine production and anti-inflammatory activity. The best experimental results were achieved with the allyl-thienobenzotriazole and isopropyl, p-methoxybenzyl, and hydroxybutyl substituted naphthotriazoles bearing additional chloro or methoxy groups. The allyl-thienobenzotriazole photoproduct is twice as potent an inhibitor of eqBChE compared to the standard galantamine. At the same time, this compound strongly inhibited TNFα production in PBMCs in response to the LPS stimulus. The complexes between selected compounds with the active site of BChE and AChE are assessed by docking, providing insight into the stabilizing interactions between the potential inhibitor and the active site.
    MeSH term(s) Acetylcholinesterase/metabolism ; Anti-Inflammatory Agents/pharmacology ; Butyrylcholinesterase/metabolism ; Cholinesterase Inhibitors/chemistry ; Cholinesterase Inhibitors/pharmacology ; Molecular Docking Simulation ; Structure-Activity Relationship ; Triazoles/chemistry ; Triazoles/pharmacology ; Tumor Necrosis Factor-alpha
    Chemical Substances Anti-Inflammatory Agents ; Cholinesterase Inhibitors ; Triazoles ; Tumor Necrosis Factor-alpha ; Acetylcholinesterase (EC 3.1.1.7) ; Butyrylcholinesterase (EC 3.1.1.8)
    Language English
    Publishing date 2022-07-19
    Publishing country France
    Document type Journal Article
    ZDB-ID 188597-2
    ISSN 1768-3254 ; 0009-4374 ; 0223-5234
    ISSN (online) 1768-3254
    ISSN 0009-4374 ; 0223-5234
    DOI 10.1016/j.ejmech.2022.114616
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 784: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: New Charged Cholinesterase Inhibitors: Design, Synthesis, and Characterization.

    Mlakić, Milena / Barić, Danijela / Ratković, Ana / Šagud, Ivana / Čipor, Ivona / Piantanida, Ivo / Odak, Ilijana / Škorić, Irena

    Molecules (Basel, Switzerland)

    2024  Volume 29, Issue 7

    Abstract: Triazoles and triazolium salts are very common subunits in the structures of various drugs. Medicaments with a characteristic 1,2,3-triazole core are also being developed to treat neurodegenerative disorders associated with cholinesterase enzyme activity. ...

    Abstract Triazoles and triazolium salts are very common subunits in the structures of various drugs. Medicaments with a characteristic 1,2,3-triazole core are also being developed to treat neurodegenerative disorders associated with cholinesterase enzyme activity. Several naphtho- and thienobenzo-triazoles from our previous research emerged as being particularly promising in that sense. For this reason, in this research, new naphtho- and thienobenzo-triazoles
    MeSH term(s) Cholinesterase Inhibitors/pharmacology ; Butyrylcholinesterase ; Acetylcholinesterase ; Molecular Docking Simulation ; Salts ; Multienzyme Complexes ; Triazoles/pharmacology
    Chemical Substances Cholinesterase Inhibitors ; Butyrylcholinesterase (EC 3.1.1.8) ; Acetylcholinesterase (EC 3.1.1.7) ; Salts ; Multienzyme Complexes ; Triazoles
    Language English
    Publishing date 2024-04-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules29071622
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    Zs.MO 81: Show issues

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  7. Article: Lyz2

    Menon, Manoj B / Yakovleva, Tatiana / Ronkina, Natalia / Suwandi, Abdulhadi / Odak, Ivan / Dhamija, Sonam / Sandrock, Inga / Hansmann, Florian / Baumgärtner, Wolfgang / Förster, Reinhold / Kotlyarov, Alexey / Gaestel, Matthias

    Frontiers in cell and developmental biology

    2022  Volume 9, Page(s) 795798

    Abstract: ... By ... ...

    Abstract By crossing
    Language English
    Publishing date 2022-01-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2021.795798
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  8. Article ; Online: Distribution of major lymphocyte subsets and memory T-cell subpopulations in healthy adults employing GLP-conforming multicolor flow cytometry.

    Schultze-Florey, Christian R / Chukhno, Ekaterina / Goudeva, Lilia / Blasczyk, Rainer / Ganser, Arnold / Prinz, Immo / Förster, Reinhold / Koenecke, Christian / Odak, Ivan

    Leukemia

    2021  Volume 35, Issue 10, Page(s) 3021–3025

    MeSH term(s) Adolescent ; Adult ; Aged ; Female ; Flow Cytometry/methods ; Healthy Volunteers ; Humans ; Immunophenotyping/methods ; Laboratories/standards ; Lymphocyte Subsets/classification ; Lymphocyte Subsets/immunology ; Male ; Memory T Cells/immunology ; Middle Aged ; Young Adult
    Language English
    Publishing date 2021-07-21
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 807030-1
    ISSN 1476-5551 ; 0887-6924
    ISSN (online) 1476-5551
    ISSN 0887-6924
    DOI 10.1038/s41375-021-01348-5
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2295: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Synthesis, Photochemistry, Computational Study and Potential Application of New Styryl-Thiophene and Naphtho-Thiophene Benzylamines

    Milena Mlakić / Ilijana Odak / Ivan Faraho / Martina Bosnar / Mihailo Banjanac / Zlata Lasić / Željko Marinić / Danijela Barić / Irena Škorić

    International Journal of Molecular Sciences, Vol 24, Iss 1, p

    2022  Volume 610

    Abstract: In this research, the synthesis, photochemistry, and computational study of new cis - and trans -isomers of amino-thienostilbenes is performed to test the efficiency of their production and acid resistance, and to investigate their electronic structure, ... ...

    Abstract In this research, the synthesis, photochemistry, and computational study of new cis - and trans -isomers of amino-thienostilbenes is performed to test the efficiency of their production and acid resistance, and to investigate their electronic structure, photoreactivity, photophysical characteristics, and potential biological activity. The electronic structure and conformations of synthesized thienostilbene amines and their photocyclization products are examined computationally, along with molecular modeling of amines possessing two thiophene rings that showed inhibitory potential toward cholinesterases. New amino-styryl thiophenes, with favorable photophysical properties and proven acid resistance, represent model compounds for their water-soluble ammonium salts as potential styryl optical dyes. The comparison with organic dyes possessing a trans -aminostilbene subunit as the scaffold shows that the newly synthesized trans -aminostilbenes have very similar absorbance wavelengths. Furthermore, their functionalized cis -isomers and photocyclization products are good candidates for cholinesterase inhibitors because of the structural similarity of the molecular skeleton to some already proven bioactive derivatives.
    Keywords acid resistance ; benzylamines ; DFT ; heterostilbenes ; molecular docking ; photocyclization ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 540
    Language English
    Publishing date 2022-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Upregulation of antimicrobial peptide expression in slc26a3-/- mice with colonic dysbiosis and barrier defect.

    Kini, Archana / Zhao, Bei / Basic, Marijana / Roy, Urmi / Iljazovic, Aida / Odak, Ivan / Ye, Zhenghao / Riederer, Brigitte / Di Stefano, Gabriella / Römermann, Dorothee / Koenecke, Christian / Bleich, André / Strowig, Till / Seidler, Ursula

    Gut microbes

    2022  Volume 14, Issue 1, Page(s) 2041943

    Abstract: Genetic defects in SLC26A3 (DRA), an intestinal ... ...

    Abstract Genetic defects in SLC26A3 (DRA), an intestinal Cl
    MeSH term(s) Animals ; Antimicrobial Peptides ; Antiporters/genetics ; Colon/metabolism ; Dysbiosis/genetics ; Dysbiosis/metabolism ; Gastrointestinal Microbiome ; Intestinal Mucosa/metabolism ; Mice ; RNA, Ribosomal, 16S/genetics ; Sulfate Transporters/genetics ; Sulfate Transporters/metabolism ; Up-Regulation
    Chemical Substances Antimicrobial Peptides ; Antiporters ; RNA, Ribosomal, 16S ; Slc26a3 protein, mouse ; Sulfate Transporters
    Language English
    Publishing date 2022-02-26
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1949-0984
    ISSN (online) 1949-0984
    DOI 10.1080/19490976.2022.2041943
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