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  1. Book: Compte-rendu de la 57e réunion de l'American Society for Therapeutic Radiology and Oncology (ASTRO)

    Chargari, Cyrus / Noel, Georges / Mazeron, Jean-Jacques

    (Cancer radiothérapie ; vol. 20, hors série 1 (janvier 2016))

    2016  

    Author's details rédigé par Cyrus Chargari, Georges Noel, et Jean-Jacques Mazeron
    Series title Cancer radiothérapie ; vol. 20, hors série 1 (janvier 2016)
    Collection
    Language French
    Size S16 Seiten
    Publisher Elsevier Masson
    Publishing place Issy-les-Moulineaux
    Publishing country France
    Document type Book
    HBZ-ID HT018972305
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    Zs A 4832 -20,Hors-sér.1- not available for loan Zeitschriften-Lesesaal

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  2. Article ; Online: Integration of the Molecular Classification of Endometrial Carcinoma to Select Patients for Fertility Sparing Strategies.

    Bani, Mohamed Amine / Maulard, Amandine / Morice, Philippe / Chargari, Cyrus / Genestie, Catherine

    Anticancer research

    2024  Volume 44, Issue 2, Page(s) 445–452

    Abstract: Fertility-sparing treatment (FST) for endometrial carcinoma (EC) is an option for a subgroup of young women with low-risk disease. The low-risk group comprises patients with endometrioid EC stage IA, grade 1, with or without focal lymphovascular invasion. ...

    Abstract Fertility-sparing treatment (FST) for endometrial carcinoma (EC) is an option for a subgroup of young women with low-risk disease. The low-risk group comprises patients with endometrioid EC stage IA, grade 1, with or without focal lymphovascular invasion. In the era of molecular subtyping, treatment de-escalation for some EC subtypes is recommended. Recommendations for fertility-preserving treatments were developed regardless of the molecular classification of EC. However, few studies have focused on this topic. In this review, we summarize the actual data available in the literature and discuss the impact of some molecular subtypes of FST.
    MeSH term(s) Humans ; Female ; Endometrial Neoplasms/genetics ; Endometrial Neoplasms/therapy ; Endometrial Neoplasms/pathology ; Carcinoma, Endometrioid/pathology ; Fertility Preservation ; Fertility ; Risk Factors ; Retrospective Studies
    Language English
    Publishing date 2024-02-02
    Publishing country Greece
    Document type Journal Article ; Review
    ZDB-ID 604549-2
    ISSN 1791-7530 ; 0250-7005
    ISSN (online) 1791-7530
    ISSN 0250-7005
    DOI 10.21873/anticanres.16832
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    Zs.A 1642: Show issues Location:
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  3. Article ; Online: Can we improve survival with less overall morbidity for patients with intermediate-risk cervical cancer without the use of external beam radiotherapy?

    Chargari, Cyrus / Nout, Remi A / Lindegaard, Jacob / Morice, Philippe

    International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

    2023  Volume 33, Issue 5, Page(s) 849–850

    MeSH term(s) Female ; Humans ; Uterine Cervical Neoplasms/pathology ; Brachytherapy ; Carcinoma, Squamous Cell/pathology ; Retrospective Studies ; Hysterectomy ; Neoplasm Staging ; Radiotherapy Dosage ; Radiotherapy, Adjuvant
    Language English
    Publishing date 2023-05-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 1070385-8
    ISSN 1525-1438 ; 1048-891X
    ISSN (online) 1525-1438
    ISSN 1048-891X
    DOI 10.1136/ijgc-2023-004305
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    Zs.A 3198: Show issues Location:
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  4. Article ; Online: Redefining the role of pulsed-dose-rate brachytherapy in cervical cancer treatment using a preplanned approach.

    Annede, Pierre / Robert, Charlotte / Espenel, Sophie / Dumas, Isabelle / Chargari, Cyrus

    Brachytherapy

    2023  Volume 23, Issue 2, Page(s) 107–114

    Abstract: Introduction: This study aims to determine predictive factors for cervical cancer patients who would benefit more from high-dose-rate (HDR) or pulsed-dose-rate (PDR) brachytherapy.: Methods: The sample included 50 patients treated with brachytherapy ... ...

    Abstract Introduction: This study aims to determine predictive factors for cervical cancer patients who would benefit more from high-dose-rate (HDR) or pulsed-dose-rate (PDR) brachytherapy.
    Methods: The sample included 50 patients treated with brachytherapy following external radiochemotherapy. PDR plans were compared to HDR preplans, with a focus on patients who may benefit from PDR using preplan metrics and clinical variables. The expected clinical effect was quantified using a tumor control probability model.
    Results: Results showed PDR plans with 60 pulses to be optimal for achieving target clinical goals for D90CTVHR. A CTVHR volume of >67.5cc and/or D90CTVHR dose on the HDR preplan of <31.1 Gy was the strongest indicator for patient selection who would gain >3% increase in TCP with PDR. The process showed 96% accuracy, 88% sensitivity, and 98% specificity. Only 16% of patients showed a relevant benefit from PDR over HDR, with a mean D90CTVHR of 7 Gy higher and a mean TCP at 3 years of 4.8% higher for PDR. The benefit of PDR is highly influenced by the choice of alpha/beta ratio and repair halftime.
    Conclusion: A small subset of cervical cancer patients may gain from PDR over HDR. CTVHR volume and preplan D90CTVHR doses may be useful in selecting patients for PDR brachytherapy.
    MeSH term(s) Female ; Humans ; Uterine Cervical Neoplasms/radiotherapy ; Radiotherapy Dosage ; Brachytherapy/methods ; Models, Theoretical
    Language English
    Publishing date 2023-12-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2098608-7
    ISSN 1873-1449 ; 1538-4721
    ISSN (online) 1873-1449
    ISSN 1538-4721
    DOI 10.1016/j.brachy.2023.10.002
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  5. Article ; Online: Advances in adoptive T-cell therapy for metastatic melanoma.

    Das, Aparimita / Ghose, Aruni / Naicker, Kevin / Sanchez, Elisabet / Chargari, Cyrus / Rassy, Elie / Boussios, Stergios

    Current research in translational medicine

    2023  Volume 71, Issue 3, Page(s) 103404

    Abstract: Adoptive T cell therapy (ACT) is a fast developing, niche area of immunotherapy (IO), which is revolutionising the therapeutic landscape of solid tumour oncology, especially metastatic melanoma (MM). Identifying tumour antigens (TAs) as potential targets, ...

    Abstract Adoptive T cell therapy (ACT) is a fast developing, niche area of immunotherapy (IO), which is revolutionising the therapeutic landscape of solid tumour oncology, especially metastatic melanoma (MM). Identifying tumour antigens (TAs) as potential targets, the ACT response is mediated by either Tumour Infiltrating Lymphocytes (TILs) or genetically modified T cells with specific receptors - T cell receptors (TCRs) or chimeric antigen receptors (CARs) or more prospectively, natural killer (NK) cells. Clinical trials involving ACT in MM from 2006 to present have shown promising results. Yet it is not without its drawbacks which include significant auto-immune toxicity and need for pre-conditioning lymphodepletion. Although immune-modulation is underway using various combination therapies in the hope of enhancing efficacy and reducing toxicity. Our review article explores the role of ACT in MM, including the various modalities - their safety, efficacy, risks and their development in the trial and the real world setting.
    Language English
    Publishing date 2023-07-07
    Publishing country France
    Document type Journal Article ; Review
    ISSN 2452-3186
    ISSN (online) 2452-3186
    DOI 10.1016/j.retram.2023.103404
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  6. Article ; Online: Vulvar Carcinoma: Standard of Care and Perspectives.

    Chargari, Cyrus / Wasserman, Johanna / Gabro, Alexandra / Canlobre, Geoffroy / Spano, Jean-Philippe / Uzan, Catherine / Maingon, Philippe

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2024  Volume 42, Issue 8, Page(s) 961–972

    Abstract: Purpose: Treatment of vulvar carcinoma (VC) is challenging. The objectives of this review were to describe for clinicians the epidemiologic and clinical aspects of VC, the standard of care in terms of primary local treatment and systemic therapies, and ... ...

    Abstract Purpose: Treatment of vulvar carcinoma (VC) is challenging. The objectives of this review were to describe for clinicians the epidemiologic and clinical aspects of VC, the standard of care in terms of primary local treatment and systemic therapies, and the recent innovations and perspectives emerging from translational research in immuno-oncology.
    Design: We conducted a comprehensive review outlying the clinical aspects and biologic background of vulvar cancer, highlighting modern treatment strategies on the basis of a personalized approach.
    Results: Epidemiologic data showed a recent rise in incidence of VC, attributed to human papillomavirus. Surgery is the mainstay of primary treatment, but multimodal approaches are frequently required in the presence of adverse prognosis histopathologic factors. Chemoradiation is indicated when organ-sparing surgery is not feasible. However, inability to achieve high locoregional control rates in advanced cases and the morbidity associated with local treatments are still key issues. Recent clinical data showed the benefit of individualized strategies combining organ-sparing surgical strategies, less invasive lymph node staging procedures, and refinement in radiotherapy modalities. Among the most important research area, there is a sound rationale for testing modern systemic approaches such as immune checkpoint inhibitors in selected patients with recurrent and/or metastatic tumors. Although no specific data exist for VC, the role of supportive care and post-treatment rehabilitation strategies is also crucial.
    Conclusion: There are still insufficient studies dedicated to patients with VC. Public health programs for prevention, screening, and early diagnosis are required, and clinical research should be strengthened to provide high-quality clinical evidence and improve patients' oncologic and functional outcomes.
    MeSH term(s) Female ; Humans ; Vulvar Neoplasms/therapy ; Vulvar Neoplasms/pathology ; Standard of Care ; Lymph Nodes/pathology ; Chemoradiotherapy ; Carcinoma/surgery
    Language English
    Publishing date 2024-02-05
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.23.01187
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    Zs.A 1847: Show issues Location:
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    Zs.MO 650: Show issues

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  7. Article ; Online: From polychemotherapy regimens to molecular targeting strategies.

    Chargari, Cyrus

    Biomedical journal

    2013  Volume 36, Issue 5, Page(s) 257–258

    MeSH term(s) Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Carcinoma ; Female ; Humans ; Male ; Nasopharyngeal Carcinoma ; Nasopharyngeal Neoplasms/drug therapy
    Language English
    Publishing date 2013-11-01
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2698541-X
    ISSN 2320-2890 ; 2319-4170
    ISSN (online) 2320-2890
    ISSN 2319-4170
    DOI 10.4103/2319-4170.119702
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  8. Article ; Online: Revolutionizing Radiotoxicity Management with Mesenchymal Stem Cells and Their Derivatives: A Focus on Radiation-Induced Cystitis.

    Helissey, Carole / Cavallero, Sophie / Guitard, Nathalie / Théry, Hélène / Chargari, Cyrus / François, Sabine

    International journal of molecular sciences

    2023  Volume 24, Issue 10

    Abstract: Although radiation therapy plays a crucial role in cancer treatment, and techniques have improved continuously, irradiation induces side effects in healthy tissue. Radiation cystitis is a potential complication following the therapeutic irradiation of ... ...

    Abstract Although radiation therapy plays a crucial role in cancer treatment, and techniques have improved continuously, irradiation induces side effects in healthy tissue. Radiation cystitis is a potential complication following the therapeutic irradiation of pelvic cancers and negatively impacts patients' quality of life (QoL). To date, no effective treatment is available, and this toxicity remains a therapeutic challenge. In recent times, stem cell-based therapy, particularly the use of mesenchymal stem cells (MSC), has gained attention in tissue repair and regeneration due to their easy accessibility and their ability to differentiate into several tissue types, modulate the immune system and secrete substances that help nearby cells grow and heal. In this review, we will summarize the pathophysiological mechanisms of radiation-induced injury to normal tissues, including radiation cystitis (RC). We will then discuss the therapeutic potential and limitations of MSCs and their derivatives, including packaged conditioned media and extracellular vesicles, in the management of radiotoxicity and RC.
    MeSH term(s) Humans ; Quality of Life ; Mesenchymal Stem Cell Transplantation ; Radiation Injuries/etiology ; Radiation Injuries/therapy ; Extracellular Vesicles/physiology ; Cystitis/etiology ; Cystitis/therapy ; Mesenchymal Stem Cells/physiology
    Language English
    Publishing date 2023-05-22
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24109068
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  9. Article ; Online: Stereotactic ablative radiotherapy for unresectable inferior vena cava tumor thrombus in a patient with renal cell carcinoma: a case report.

    Castelnau-Marchand, Pauline / Scher, Nathaniel / Bollet, Marc / Chargari, Cyrus / Toledano, Alain

    Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al

    2023  Volume 199, Issue 4, Page(s) 420–424

    Abstract: Purpose: Treatment options for renal cell carcinoma (RCC) with inferior vena cava tumor thrombus (IVC-TT) are limited and carry substantial risks. Currently, there are no standard treatment options in the setting of recurrent or unresectable RCC with ... ...

    Abstract Purpose: Treatment options for renal cell carcinoma (RCC) with inferior vena cava tumor thrombus (IVC-TT) are limited and carry substantial risks. Currently, there are no standard treatment options in the setting of recurrent or unresectable RCC with IVC-TT.
    Methods: We report our experience of treating an IVC-TT RCC patient with stereotactic body radiation therapy (SBRT).
    Results: This 62-year-old gentleman presented renal cell carcinoma with IVC-TT and liver metastases. Initial treatment consisted of radical nephrectomy and thrombectomy followed by continuous sunitinib. At 3 months, he developed an unresectable IVC-TT recurrence. A fiducial marker was implanted into the IVC-TT by catheterization. New biopsies were performed at the same time, demonstrating a recurrence of the RCC. SBRT consisted of 5 fractions of 7 Gy to the IVC-TT with excellent initial tolerance. He subsequently received anti-PD1 therapy (nivolumab). At 4 years follow-up, he is doing well with no IVC-TT recurrence and no late toxicity.
    Conclusion: SBRT appears to be a feasible and safe treatment for IVC-TT secondary to RCC in patients who are not candidates for surgery.
    MeSH term(s) Male ; Humans ; Middle Aged ; Carcinoma, Renal Cell/radiotherapy ; Carcinoma, Renal Cell/pathology ; Kidney Neoplasms/radiotherapy ; Kidney Neoplasms/pathology ; Vena Cava, Inferior/pathology ; Vena Cava, Inferior/surgery ; Radiosurgery/adverse effects ; Venous Thrombosis/radiotherapy ; Venous Thrombosis/complications ; Nephrectomy/adverse effects ; Retrospective Studies
    Language English
    Publishing date 2023-03-02
    Publishing country Germany
    Document type Case Reports ; Journal Article
    ZDB-ID 84983-2
    ISSN 1439-099X ; 0179-7158 ; 0039-2073
    ISSN (online) 1439-099X
    ISSN 0179-7158 ; 0039-2073
    DOI 10.1007/s00066-023-02054-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ue I Zs.40: Show issues Location:
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  10. Article ; Online: The issue of radiation-induced cardiovascular toxicity: preclinical highlights and perspectives on preventive strategies.

    Chargari, Cyrus

    Biomedical journal

    2013  Volume 36, Issue 3, Page(s) 150–151

    MeSH term(s) Breast Neoplasms/radiotherapy ; Female ; Heart/radiation effects ; Humans ; Myocardial Ischemia/etiology ; Radiotherapy, Adjuvant/adverse effects
    Language English
    Publishing date 2013-05
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 2698541-X
    ISSN 2320-2890 ; 2319-4170
    ISSN (online) 2320-2890
    ISSN 2319-4170
    DOI 10.4103/2319-4170.113235
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