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  1. Article ; Online: T lymphocyte abnormalities in juvenile systemic sclerosis patients.

    Reiff, Andreas / Weinberg, Kenneth I / Triche, Timothy / Masinsin, Bernadette / Mahadeo, Kris M / Lin, Chuan-Hao / Brown, Diane / Parkman, Robertson

    Clinical immunology (Orlando, Fla.)

    2013  Volume 149, Issue 1, Page(s) 146–155

    Abstract: ... Therefore, we undertook to identify abnormalities in the T lymphocytes of jSSc patients and to determine if they differed ... from the abnormalities reported in the T lymphocytes of adult SSc patients. We identified decreases in the frequency ... of resting regulatory T lymphocytes and an increased frequency of CD45RA expressing effector memory (EMRA ...

    Abstract Multi-center evaluations of pediatric patients with juvenile systemic sclerosis (jSSc) have suggested that the pathogenesis of jSSc may differ from that of systemic sclerosis (SSc) in adult patients. Therefore, we undertook to identify abnormalities in the T lymphocytes of jSSc patients and to determine if they differed from the abnormalities reported in the T lymphocytes of adult SSc patients. We identified decreases in the frequency of resting regulatory T lymphocytes and an increased frequency of CD45RA expressing effector memory (EMRA) CD4 T lymphocytes, which were characterized by an increased frequency of CCR7 protein expressing cells. Neither the increases in the EMRA subpopulation nor the increased CCR7 protein expression have been reported in adult SSc patients. The decrease in resting regulatory T lymphocytes in jSSc patients may permit the expansion of the disease initiating CD4 T lymphocytes present in the CCR7 expressing EMRA CD4 T lymphocyte subpopulation.
    MeSH term(s) Adolescent ; Adult ; CD4-Positive T-Lymphocytes/immunology ; Child ; Female ; Gene Expression Profiling ; Humans ; Male ; Oligonucleotide Array Sequence Analysis ; Receptors, CCR7/genetics ; Scleroderma, Systemic/genetics ; Scleroderma, Systemic/immunology ; T-Lymphocyte Subsets/immunology ; Young Adult
    Chemical Substances CCR7 protein, human ; Receptors, CCR7
    Language English
    Publishing date 2013-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1459903-x
    ISSN 1521-7035 ; 1521-6616
    ISSN (online) 1521-7035
    ISSN 1521-6616
    DOI 10.1016/j.clim.2013.07.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book ; Thesis: Auswirkungen der Änderung des § 20 SGB V im Jahr 1996 auf die betriebliche Gesundheitsförderung und Krankheitsprävention

    Reiff, Tilman

    2004  

    Author's details von Tilman Reiff
    Language German
    Size 163 Bl., graph. Darst., 30 cm
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Ulm, Univ., Diss., 2004
    HBZ-ID HT014842989
    Database Catalogue ZB MED Medicine, Health

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  3. Article: DOCK2

    Reiff, Daniel D / Zhang, Mingce / Cron, Randy Q

    Life (Basel, Switzerland)

    2023  Volume 13, Issue 2

    Abstract: ... T cells through a process reliant on perforin and granzyme B to initiate apoptosis. Homozygous genetic ...

    Abstract Hemophagocytic lymphohistiocytosis (HLH) is a syndrome resulting from uncontrolled hyper-inflammation, excessive immune system activation, and elevated levels of inflammatory cytokines. HLH can be caused by the inability to downregulate activated macrophages by natural killer (NK) and CD8 cytotoxic T cells through a process reliant on perforin and granzyme B to initiate apoptosis. Homozygous genetic mutations in this process result in primary HLH (pHLH), a disorder that can lead to multi-system organ failure and death in infancy. Heterozygous, dominant-negative, or monoallelic hypomorphic mutations in these same genes can cause a similar syndrome in the presence of an immune trigger, leading to secondary HLH (sHLH). A genetic mutation in a potential novel HLH-associated gene, dedicator of cytokinesis 2 (
    Language English
    Publishing date 2023-02-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life13020434
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  4. Article ; Online: Two-coordinate, quasi-two-coordinate, and distorted three coordinate, T-shaped chromium(II) amido complexes: unusual effects of coordination geometry on the lowering of ground state magnetic moments.

    Boynton, Jessica N / Merrill, W Alexander / Reiff, William M / Fettinger, James C / Power, Philip P

    Inorganic chemistry

    2012  Volume 51, Issue 5, Page(s) 3212–3219

    Abstract: ... a distorted T-shaped metal coordination. Desolvation of 3 at about 70 °C gave 4 which has a formally two ...

    Abstract The synthesis and characterization of the mononuclear chromium(II) terphenyl substituted primary amido-complexes Cr{N(H)Ar(Pr(i)(6))}(2) (Ar(Pr(i)(6)) = C(6)H(3)-2,6-(C(6)H(2)-2,4,6-(i)Pr(3))(2) (1), Cr{N(H)Ar(Pr(i)(4))}(2) (Ar(Pr(i)(4)) = C(6)H(3)-2,6-(C(6)H(3)-2,6-(i)Pr(2))(2) (2), Cr{N(H)Ar(Me(6))}(2) (Ar(Me(6)) = C(6)H(3)-2,6-(C(6)H(2)-2,4,6-Me(3))(2) (4), and the Lewis base adduct Cr{N(H)Ar(Me(6))}(2)(THF) (3) are described. Reaction of the terphenyl primary amido lithium derivatives Li{N(H)Ar(Pr(i)(6))} and Li{N(H)Ar(Pr(i)(4))} with CrCl(2)(THF)(2) in a 2:1 ratio afforded complexes 1 and 2, which are extremely rare examples of two coordinate chromium and the first stable chromium amides to have linear coordinated high-spin Cr(2+). The reaction of the less crowded terphenyl primary amido lithium salt Li{N(H)Ar(Me(6))} with CrCl(2)(THF)(2) gave the tetrahydrofuran (THF) complex 3, which has a distorted T-shaped metal coordination. Desolvation of 3 at about 70 °C gave 4 which has a formally two-coordinate chromous ion with a very strongly bent core geometry (N-Cr-N= 121.49(13)°) with secondary Cr--C(aryl ring) interactions of 2.338(4) Å to the ligand. Magnetometry studies showed that the two linear chromium species 1 and 2 have ambient temperature magnetic moments of about 4.20 μ(B) and 4.33 μ(B) which are lower than the spin-only value of 4.90 μ(B) typically observed for six coordinate Cr(2+). The bent complex 4 has a similar room temperature magnetic moment of about 4.36 μ(B). These studies suggest that the two-coordinate chromium complexes have significant spin-orbit coupling effects which lead to moments lower than the spin only value of 4.90 μ(B) because λ (the spin orbit coupling parameter) is positive. The three-coordinated complex 3 had a magnetic moment of 3.79 μ(B).
    Language English
    Publishing date 2012-03-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1484438-2
    ISSN 1520-510X ; 0020-1669
    ISSN (online) 1520-510X
    ISSN 0020-1669
    DOI 10.1021/ic202661n
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  5. Article ; Online: Therapie bei asymptomatischer Stenose der extrakraniellen A. carotis.

    Reiff, Tilman / Ringleb, Peter Arthur

    Deutsche medizinische Wochenschrift (1946)

    2021  Volume 146, Issue 12, Page(s) 793–800

    Abstract: For the asymptomatic carotid stenosis, defined as an atherosclerotic carotid stenosis without neurological symptoms for more than 6 months, there are in contrast to a symptomatic carotid stenosis still no reliable treatment recommendations. Possible ... ...

    Title translation Asymptomatic carotid artery stenosis - treatment recommendations.
    Abstract For the asymptomatic carotid stenosis, defined as an atherosclerotic carotid stenosis without neurological symptoms for more than 6 months, there are in contrast to a symptomatic carotid stenosis still no reliable treatment recommendations. Possible therapy recommendations based on current data are presented below.
    MeSH term(s) Aged ; Asymptomatic Diseases ; Carotid Stenosis/diagnosis ; Carotid Stenosis/drug therapy ; Carotid Stenosis/surgery ; Female ; Germany ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use ; Male ; Middle Aged ; Practice Guidelines as Topic ; Thrombectomy
    Chemical Substances Hydroxymethylglutaryl-CoA Reductase Inhibitors
    Language German
    Publishing date 2021-06-15
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 200446-x
    ISSN 1439-4413 ; 0012-0472
    ISSN (online) 1439-4413
    ISSN 0012-0472
    DOI 10.1055/a-1221-7065
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  6. Article: Observation of a very large internal hyperfine field (62.4 T) in the ferromagnetically ordered state of the S = 1 alpha-iron(II) octaethyltetraazaporphyrin.

    Reiff, W M / Frommen, C M / Yee, G T / Sellers, S P

    Inorganic chemistry

    2000  Volume 39, Issue 10, Page(s) 2076–2079

    Abstract: The origins of the extraordinarily large internal hyperfine field (62.4 T) for the three ...

    Abstract The origins of the extraordinarily large internal hyperfine field (62.4 T) for the three-dimensional (weak) ferromagnetically ordered ground state of alpha-Fe(OETAP) are discussed semiquantitatively in terms of existing physical theory. In particular, the classical Fermi-contact contribution to the internal field is found to be highly enhanced by a very large orbital contribution and a significant dipolar term of the same sign. A rationale for the unexpected ordering of this S = 1 non-Kramers system is also presented.
    Language English
    Publishing date 2000-05-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1484438-2
    ISSN 1520-510X ; 0020-1669
    ISSN (online) 1520-510X
    ISSN 0020-1669
    DOI 10.1021/ic990910l
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  7. Book ; Thesis: Nachweis der Kontrastmittelinduzierten Vasodilatation und Bestimmung der Koronarreserve mittels Videodensitometrie

    Reiff, Thomas

    1995  

    Author's details vorgelegt von Thomas Reiff
    Language German
    Size 65 S. : Ill., graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Bonn, Univ., Diss., 1995
    HBZ-ID HT006715332
    Database Catalogue ZB MED Medicine, Health

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  8. Article ; Online: Consequences of a linear two-coordinate geometry for the orbital magnetism and Jahn-Teller distortion behavior of the high spin iron(II) complex Fe[N(t-Bu)2]2.

    Reiff, William M / Schulz, Charles E / Whangbo, Myung-Hwan / Seo, Jung In / Lee, Yoon Sup / Potratz, Gregory R / Spicer, Charles W / Girolami, Gregory S

    Journal of the American Chemical Society

    2009  Volume 131, Issue 2, Page(s) 404–405

    Abstract: ... amide Fe[N(t-Bu)(2)](2) show that it retains a linear N-Fe-N framework due to the nonbonding delta ...

    Abstract Mossbauer, EPR, magnetic susceptibility, and DFT studies of the unusual two-coordinate iron(II) amide Fe[N(t-Bu)(2)](2) show that it retains a linear N-Fe-N framework due to the nonbonding delta nature of the (xy, x(2)-y(2)) orbitals. The resulting near-degenerate ground state gives rise to a large magnetic moment and a remarkably large internal hyperfine field. The results confirm that extraordinary orbital magnetic effects can arise in linear transition metal complexes in which orbital degeneracies are not broken by Jahn-Teller or Renner-Teller distortions.
    Language English
    Publishing date 2009-01-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/ja806660f
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  9. Article ; Online: Treatment of asymptomatic carotid stenosis in SPACE-2 - Authors' reply.

    Reiff, Tilman / Eckstein, Hans-Henning / Mansmann, Ulrich / Hacke, Werner / Ringleb, Peter Arthur

    The Lancet. Neurology

    2023  Volume 22, Issue 3, Page(s) 198–199

    MeSH term(s) Humans ; Carotid Stenosis/complications ; Endarterectomy, Carotid ; Stents ; Asymptomatic Diseases ; Stroke
    Language English
    Publishing date 2023-02-17
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2081241-3
    ISSN 1474-4465 ; 1474-4422
    ISSN (online) 1474-4465
    ISSN 1474-4422
    DOI 10.1016/S1474-4422(23)00030-3
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  10. Article: Therapie bei asymptomatischer Stenose der extrakraniellen A. carotis

    Reiff, Tilman / Ringleb, Peter Arthur

    DMW - Deutsche Medizinische Wochenschrift

    2021  Volume 146, Issue 12, Page(s) 793–800

    Keywords asymptomatische Karotisstenose ; Karotis-Thrombendarterektomie ; Karotisstenting ; konservative Therapie ; Schlaganfall-Primärprophylaxe ; asymptomatic carotid stenosis ; carotid endarterectomy ; carotid artery stenting ; best medical therapy ; stroke prevention
    Language German
    Publishing date 2021-06-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 200446-x
    ISSN 1439-4413 ; 0012-0472
    ISSN (online) 1439-4413
    ISSN 0012-0472
    DOI 10.1055/a-1221-7065
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