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Article ; Online: Avenues for Investigating the Neural Crest and Its Derivatives in Non-model (Unconventional) Vertebrates: A Craniofacial Skeleton Perspective.

Depew, Michael J / Bertocchini, Federica

Methods in molecular biology (Clifton, N.J.)

2019 Volume 1976, Page(s) 207–221

Abstract: One of the early, profound insights regarding the biology of the neural crest was the observation of its contribution to the skeletal structures of the cranium and jaws. The critical nature of these structures made the comparative analysis of the cranial ...

Abstract	One of the early, profound insights regarding the biology of the neural crest was the observation of its contribution to the skeletal structures of the cranium and jaws. The critical nature of these structures made the comparative analysis of the cranial neural crest and its derived structures essential investigative aims toward our understanding of the development and evolution of vertebrates and vertebrate-specific structures. Though classically applied to a relatively wide range of taxa in the nineteenth and early twentieth centuries, the application of traditional methodologies for complex comparative developmental and anatomical analyses subsequently become more limited by their time-consuming nature, resource scarcity, and a greater emphasis on the genetic and molecular regulation of patterning and morphogenesis in a select number of tractable model organisms. Recently, however, this trend has been reversed, and the value of genetic and molecular-based questions applied to non-model (unconventional) vertebrate organisms has been re-appreciated. This is particularly true of comparative investigations of cranial neural crest biology. Herein, we present methodologies for the analysis of the cranial neural crest and its structural derivatives employable in modern investigations of both model and unconventional vertebrate organisms.
MeSH term(s)	Animals ; Gene Expression Regulation, Developmental/physiology ; Microscopy, Electron, Scanning ; Neural Crest/cytology ; Neural Crest/ultrastructure ; Skeleton/cytology ; Skeleton/ultrastructure ; Vertebrates
Language	English
Publishing date	2019-04-11
Publishing country	United States
Document type	Journal Article
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-4939-9412-0_16
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Article: Programmed Cell Death Not as Sledgehammer but as Chisel: Apoptosis in Normal and Abnormal Craniofacial Patterning and Development.

Compagnucci, Claudia / Martinus, Kira / Griffin, John / Depew, Michael J

Frontiers in cell and developmental biology

2021 Volume 9, Page(s) 717404

Abstract: Coordination of craniofacial development involves an complex, intricate, genetically controlled and tightly regulated spatiotemporal series of reciprocal inductive and responsive interactions among the embryonic cephalic epithelia (both endodermal and ... ...

Abstract	Coordination of craniofacial development involves an complex, intricate, genetically controlled and tightly regulated spatiotemporal series of reciprocal inductive and responsive interactions among the embryonic cephalic epithelia (both endodermal and ectodermal) and the cephalic mesenchyme - particularly the cranial neural crest (CNC). The coordinated regulation of these interactions is critical both ontogenetically and evolutionarily, and the clinical importance and mechanistic sensitivity to perturbation of this developmental system is reflected by the fact that one-third of all human congenital malformations affect the head and face. Here, we focus on one element of this elaborate process, apoptotic cell death, and its role in normal and abnormal craniofacial development. We highlight four themes in the temporospatial elaboration of craniofacial apoptosis during development, namely its occurrence at (1) positions of epithelial-epithelial apposition, (2) within intra-epithelial morphogenesis, (3) during epithelial compartmentalization, and (4) with CNC metameric organization. Using the genetic perturbation of
Language	English
Publishing date	2021-10-08
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2737824-X
ISSN	2296-634X
ISSN	2296-634X
DOI	10.3389/fcell.2021.717404
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Article ; Online: Synaptic Development in Diverse Olfactory Neuron Classes Uses Distinct Temporal and Activity-Related Programs.

Aimino, Michael A / DePew, Alison T / Restrepo, Lucas / Mosca, Timothy J

The Journal of neuroscience : the official journal of the Society for Neuroscience

2022 Volume 43, Issue 1, Page(s) 28–55

Abstract: Developing neurons must meet core molecular, cellular, and temporal requirements to ensure the correct formation of synapses, resulting in functional circuits. However, because of the vast diversity in neuronal class and function, it is unclear whether ... ...

Abstract	Developing neurons must meet core molecular, cellular, and temporal requirements to ensure the correct formation of synapses, resulting in functional circuits. However, because of the vast diversity in neuronal class and function, it is unclear whether or not all neurons use the same organizational mechanisms to form synaptic connections and achieve functional and morphologic maturation. Moreover, it remains unknown whether neurons united in a common goal and comprising the same sensory circuit develop on similar timescales and use identical molecular approaches to ensure the formation of the correct number of synapses. To begin to answer these questions, we took advantage of the
MeSH term(s)	Animals ; Female ; Male ; Glycogen Synthase Kinase 3 beta/metabolism ; Olfactory Receptor Neurons/physiology ; Drosophila/physiology ; Smell/physiology ; Synapses/physiology ; Olfactory Pathways/physiology
Chemical Substances	Glycogen Synthase Kinase 3 beta (EC 2.7.11.1)
Language	English
Publishing date	2022-11-29
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	604637-x
ISSN	1529-2401 ; 0270-6474
ISSN (online)	1529-2401
ISSN	0270-6474
DOI	10.1523/JNEUROSCI.0884-22.2022
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Article ; Online: Programmed Cell Death Not as Sledgehammer but as Chisel

Claudia Compagnucci / Kira Martinus / John Griffin / Michael J. Depew

Frontiers in Cell and Developmental Biology, Vol

Apoptosis in Normal and Abnormal Craniofacial Patterning and Development

2021 Volume 9

Abstract	Coordination of craniofacial development involves an complex, intricate, genetically controlled and tightly regulated spatiotemporal series of reciprocal inductive and responsive interactions among the embryonic cephalic epithelia (both endodermal and ectodermal) and the cephalic mesenchyme — particularly the cranial neural crest (CNC). The coordinated regulation of these interactions is critical both ontogenetically and evolutionarily, and the clinical importance and mechanistic sensitivity to perturbation of this developmental system is reflected by the fact that one-third of all human congenital malformations affect the head and face. Here, we focus on one element of this elaborate process, apoptotic cell death, and its role in normal and abnormal craniofacial development. We highlight four themes in the temporospatial elaboration of craniofacial apoptosis during development, namely its occurrence at (1) positions of epithelial-epithelial apposition, (2) within intra-epithelial morphogenesis, (3) during epithelial compartmentalization, and (4) with CNC metameric organization. Using the genetic perturbation of Satb2, Pbx1/2, Fgf8, and Foxg1 as exemplars, we examine the role of apoptosis in the elaboration of jaw modules, the evolution and elaboration of the lambdoidal junction, the developmental integration at the mandibular arch hinge, and the control of upper jaw identity, patterning and development. Lastly, we posit that apoptosis uniquely acts during craniofacial development to control patterning cues emanating from core organizing centres.
Keywords	craniofacial ; hinge and caps ; Satb2 ; Fgf8 ; Foxg1 ; Pbx ; Biology (General) ; QH301-705.5
Language	English
Publishing date	2021-10-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
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Article: The Tenets of Teneurin: Conserved Mechanisms Regulate Diverse Developmental Processes in the

DePew, Alison T / Aimino, Michael A / Mosca, Timothy J

Frontiers in neuroscience

2019 Volume 13, Page(s) 27

Abstract: To successfully integrate a neuron into a circuit, a myriad of developmental events must occur correctly and in the correct order. Neurons must be born and grow out toward a destination, responding to guidance cues to direct their path. Once arrived, ... ...

Abstract	To successfully integrate a neuron into a circuit, a myriad of developmental events must occur correctly and in the correct order. Neurons must be born and grow out toward a destination, responding to guidance cues to direct their path. Once arrived, each neuron must segregate to the correct sub-region before sorting through a milieu of incorrect partners to identify the correct partner with which they can connect. Finally, the neuron must make a synaptic connection with their correct partner; a connection that needs to be broadly maintained throughout the life of the animal while remaining responsive to modes of plasticity and pruning. Though many intricate molecular mechanisms have been discovered to regulate each step, recent work showed that a single family of proteins, the Teneurins, regulates a host of these developmental steps in
Language	English
Publishing date	2019-01-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2411902-7
ISSN	1662-453X ; 1662-4548
ISSN (online)	1662-453X
ISSN	1662-4548
DOI	10.3389/fnins.2019.00027
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Article: Analysis of skeletal ontogenesis through differential staining of bone and cartilage.

Depew, Michael J

Methods in molecular biology (Clifton, N.J.)

2008 Volume 461, Page(s) 37–45

MeSH term(s)	Alcian Blue/pharmacology ; Animals ; Anthraquinones/pharmacology ; Bone and Bones/embryology ; Cartilage/embryology ; Ethanol/pharmacology ; Formaldehyde/pharmacology ; Glycerol/pharmacology ; Hydroxides/pharmacology ; Morphogenesis/physiology ; Potassium Compounds/pharmacology ; Staining and Labeling/methods ; Tissue Fixation/methods
Chemical Substances	Anthraquinones ; Hydroxides ; Potassium Compounds ; Formaldehyde (1HG84L3525) ; Ethanol (3K9958V90M) ; alizarin (60MEW57T9G) ; Alcian Blue (P4448TJR7J) ; Glycerol (PDC6A3C0OX) ; potassium hydroxide (WZH3C48M4T)
Language	English
Publishing date	2008
Publishing country	United States
Document type	Journal Article ; Review
ISSN	1064-3745
ISSN	1064-3745
DOI	10.1007/978-1-60327-483-8_5
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Article ; Online: γ-secretase promotes Drosophila postsynaptic development through the cleavage of a Wnt receptor.

Restrepo, Lucas J / DePew, Alison T / Moese, Elizabeth R / Tymanskyj, Stephen R / Parisi, Michael J / Aimino, Michael A / Duhart, Juan Carlos / Fei, Hong / Mosca, Timothy J

Developmental cell

2022 Volume 57, Issue 13, Page(s) 1643–1660.e7

Abstract: Developing synapses mature through the recruitment of specific proteins that stabilize presynaptic and postsynaptic structure and function. Wnt ligands signaling via Frizzled (Fz) receptors play many crucial roles in neuronal and synaptic development, ... ...

Abstract	Developing synapses mature through the recruitment of specific proteins that stabilize presynaptic and postsynaptic structure and function. Wnt ligands signaling via Frizzled (Fz) receptors play many crucial roles in neuronal and synaptic development, but whether and how Wnt and Fz influence synaptic maturation is incompletely understood. Here, we show that Fz2 receptor cleavage via the γ-secretase complex is required for postsynaptic development and maturation. In the absence of γ-secretase, Drosophila neuromuscular synapses fail to recruit postsynaptic scaffolding and cytoskeletal proteins, leading to behavioral deficits. Introducing presenilin mutations linked to familial early-onset Alzheimer's disease into flies leads to synaptic maturation phenotypes that are identical to those seen in null alleles. This conserved role for γ-secretase in synaptic maturation and postsynaptic development highlights the importance of Fz2 cleavage and suggests that receptor processing by proteins linked to neurodegeneration may be a shared mechanism with aspects of synaptic development.
MeSH term(s)	Amyloid Precursor Protein Secretases/genetics ; Amyloid Precursor Protein Secretases/metabolism ; Animals ; Drosophila/metabolism ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism ; Frizzled Receptors/metabolism ; Receptors, Wnt/metabolism ; Synapses/metabolism
Chemical Substances	Drosophila Proteins ; Frizzled Receptors ; Receptors, Wnt ; fz2 protein, Drosophila ; Amyloid Precursor Protein Secretases (EC 3.4.-)
Language	English
Publishing date	2022-06-01
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2054967-2
ISSN	1878-1551 ; 1534-5807
ISSN (online)	1878-1551
ISSN	1534-5807
DOI	10.1016/j.devcel.2022.05.006
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Zs.A 5742: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 76: Show issues

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Article ; Online: Left-right asymmetry of the gnathostome skull: its evolutionary, developmental, and functional aspects.

Compagnucci, Claudia / Fish, Jennifer / Depew, Michael J

Genesis (New York, N.Y. : 2000)

2014 Volume 52, Issue 6, Page(s) 515–527

Abstract: Much of the gnathostome (jawed vertebrate) evolutionary radiation was dependent on the ability to sense and interpret the environment and subsequently act upon this information through utilization of a specialized mode of feeding involving the jaws. ... ...

Abstract	Much of the gnathostome (jawed vertebrate) evolutionary radiation was dependent on the ability to sense and interpret the environment and subsequently act upon this information through utilization of a specialized mode of feeding involving the jaws. While the gnathostome skull, reflective of the vertebrate baüplan, typically is bilaterally symmetric with right (dextral) and left (sinistral) halves essentially representing mirror images along the midline, both adaptive and abnormal asymmetries have appeared. Herein we provide a basic primer on studies of the asymmetric development of the gnathostome skull, touching briefly on asymmetry as a field of study, then describing the nature of cranial development and finally underscoring evolutionary and functional aspects of left-right asymmetric cephalic development.
MeSH term(s)	Adaptation, Biological ; Animals ; Biological Evolution ; Body Patterning/physiology ; Embryonic Development ; Selection, Genetic ; Skull/embryology ; Vertebrates/embryology
Language	English
Publishing date	2014-05-08
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2004544-X
ISSN	1526-968X ; 1526-954X
ISSN (online)	1526-968X
ISSN	1526-954X
DOI	10.1002/dvg.22786
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Zs.A 2772: Show issues

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Article ; Online: Tweaking the hinge and caps: testing a model of the organization of jaws.

Depew, Michael J / Compagnucci, Claudia

Journal of experimental zoology. Part B, Molecular and developmental evolution

2008 Volume 310, Issue 4, Page(s) 315–335

Abstract: Historically, examinations of gnathostome skulls have indicated that for essentially the entirety of their existence, jaws have been characterized by a high degree of fidelity to an initial basic structural design that will then go on to manifest an ... ...

Abstract	Historically, examinations of gnathostome skulls have indicated that for essentially the entirety of their existence, jaws have been characterized by a high degree of fidelity to an initial basic structural design that will then go on to manifest an amazing array of end-point phenotypes. These two traits-bauplan fidelity and elaboration of design-are inter-connected and striking, and beg a number of questions, including: Are all jaws made in the same manner and if not how not? To begin to tackle such questions, we herein operationally define jaws as two appositional, hinged cranial units for which polarity and potential modularity are characteristics, and then address what is necessary for them to form, including delineating both the sources of cells and tissues that will formally yield the jaws as well as what informs their ontogeny (e.g., sources of positional information and factors directing the interpretation of developmental cues). Following on this, we briefly describe a predictive, testable model of jaw development (the "Hinge and Caps" model) and present evidence that the Satb2+cell population in the developing jaw primordia of mice defines a developmentally and evolutionarily significant jaw module such as would be predicted by the model.
MeSH term(s)	Animals ; Biological Evolution ; Jaw/anatomy & histology ; Jaw/embryology ; Models, Biological ; Morphogenesis/physiology ; Species Specificity ; Vertebrates/embryology
Language	English
Publishing date	2008-06-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2103823-5
ISSN	1552-5015 ; 0022-104X ; 1552-5007
ISSN (online)	1552-5015
ISSN	0022-104X ; 1552-5007
DOI	10.1002/jez.b.21205
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Article ; Online: Symposium on the evolution and development of the vertebrate head.

Depew, Michael J / Olsson, Lennart

Journal of experimental zoology. Part B, Molecular and developmental evolution

2008 Volume 310, Issue 4, Page(s) 287–293

Abstract: Among the symposia held at the seminal meeting of the European Society for Evolutionary Developmental Biology was one centered on the development and evolution of the vertebrate head, an exquisitely complex anatomical system. The articles presented at ... ...

Abstract	Among the symposia held at the seminal meeting of the European Society for Evolutionary Developmental Biology was one centered on the development and evolution of the vertebrate head, an exquisitely complex anatomical system. The articles presented at this meeting have been gathered in a special issue of the Journal of Experimental Zoology, and are here reviewed by the organizers of the symposia. These articles cover a breadth of subjects, including interactions between cells derived from the different germ layers, such as those underlying neural crest cell migration and fate and cranial muscle specification, as well as placode development and the origin, development, and evolution of important evolutionary innovations such as jaws and the trabecula cranii. In this introduction, we provide a short historical overview of themes of research into the fundamental organization, structure, and development of the vertebrate head, including the search for head segmentation and the relevance of the New Head Hypothesis, and subsequently present the topics discussed in each of the articles. This overview of the past and the present of head evo-devo is then followed by a glimpse at its possible future and a brief examination of the utility of the notions of heterochrony, heterotopy, and heterofacience in describing evolutionarily important changes in developmental events.
MeSH term(s)	Animals ; Biological Evolution ; Developmental Biology/trends ; Head/anatomy & histology ; Head/embryology ; Species Specificity ; Vertebrates
Language	English
Publishing date	2008-06-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2103823-5
ISSN	1552-5015 ; 0022-104X ; 1552-5007
ISSN (online)	1552-5015
ISSN	0022-104X ; 1552-5007
DOI	10.1002/jez.b.21219
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