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  1. Article ; Online: Twelfth ISABS Conference on Forensic and Anthropologic Genetics and Mayo Clinic Lectures in Individualized Medicine, Dubrovnik, Croatia, June 22-27, 2022.

    Vuk-Pavlović, Stanimir / Primorac, Dragan

    Croatian medical journal

    2022  Volume 63, Issue 3, Page(s) 211–212

    MeSH term(s) Croatia ; Humans ; Multiple Sclerosis ; Precision Medicine
    Language English
    Publishing date 2022-02-27
    Publishing country Croatia
    Document type Editorial
    ZDB-ID 1157623-6
    ISSN 1332-8166 ; 0353-9504
    ISSN (online) 1332-8166
    ISSN 0353-9504
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 187: Show issues Location:
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  2. Article ; Online: A Tribute to Dragan Primorac on the Twentieth Anniversary of The International Society of Applied Biological Sciences and Its Tenth Biennial Conference.

    Vuk-Pavlović, Stanimir / Schanfield, Moses

    Croatian medical journal

    2017  Volume 58, Issue 3, Page(s) 201–202

    Language English
    Publishing date 2017-04-19
    Publishing country Croatia
    Document type Editorial
    ZDB-ID 1157623-6
    ISSN 1332-8166 ; 0353-9504
    ISSN (online) 1332-8166
    ISSN 0353-9504
    DOI 10.3325/cmj.2017.58.201
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Into the third decade: eleventh ISABS Conference on Forensic and Anthropological Genetics and Mayo Clinic Lectures in Individualized Medicine.

    Vuk-Pavlović, Stanimir / Schanfield, Moses / Primorac, Dragan

    Croatian medical journal

    2019  Volume 60, Issue 3, Page(s) 189–190

    Language English
    Publishing date 2019-06-12
    Publishing country Croatia
    Document type Editorial
    ZDB-ID 1157623-6
    ISSN 1332-8166 ; 0353-9504
    ISSN (online) 1332-8166
    ISSN 0353-9504
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  4. Article ; Online: Paying the price for standing tall: Fluid mechanics of prostate pathology.

    Gat, Yigal / Joshua, Sharon / Vuk-Pavlović, Stanimir / Goren, Menachem

    The Prostate

    2020  Volume 80, Issue 15, Page(s) 1297–1303

    Abstract: Background: Age-dependent increase in the incidence of benign prostatic hyperplasia (BPH) and prostate cancer (PCa) are both related to cell proliferation and survival controlled by intraprostatic free testosterone (FT) concentration. Paradoxically, BPH ...

    Abstract Background: Age-dependent increase in the incidence of benign prostatic hyperplasia (BPH) and prostate cancer (PCa) are both related to cell proliferation and survival controlled by intraprostatic free testosterone (FT) concentration. Paradoxically, BPH and PCa occur as circulating testosterone levels decrease, so any possible relationship between testosterone levels and development of BPH and PCa remains obscure.
    Results: In BPH the enlarging prostate is exposed to high testosterone levels arriving directly from the testes at concentrations about hundredfold higher than systemic FT. This occurs because venous blood from the testes is diverted into the prostate due to the elevated hydrostatic pressure of blood in the internal spermatic veins (ISVs). Elevated pressure is caused by the destruction of one-way valves (clinically detected as varicocele), a unique phenomenon related to human erect posture. While standing, human males are ISVs vertically oriented, resulting in high intraluminal hydrostatic pressures-a phenomenon not found in quadrupeds. In this communication, we demonstrate the fluid mechanics' phenomena at the basis of varicocele leading to prostate pathology.
    Conclusions: So far, varicocele has been studied mostly for its etiologic role in male infertility and, thus, for its effects on the testes. It is becoming clear that varicocele is a major etiologic factor in BPH and likely also in PCa. Restoring normal testicular venous pressure by treatment of the abnormal ISV's in varicocele has been shown to avert the flow from the prostate with the effect of reducing prostate volume, alleviating symptoms of BPH, and increasing concentrations of circulating FT.
    MeSH term(s) Humans ; Hydrodynamics ; Hydrostatic Pressure ; Male ; Posture/physiology ; Prostate/pathology ; Prostate/physiopathology ; Prostatic Hyperplasia/blood ; Prostatic Hyperplasia/pathology ; Prostatic Hyperplasia/physiopathology ; Testis/blood supply ; Testis/pathology ; Testosterone/blood ; Varicocele/blood ; Varicocele/pathology ; Varicocele/physiopathology
    Chemical Substances Testosterone (3XMK78S47O)
    Language English
    Publishing date 2020-08-24
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 604707-5
    ISSN 1097-0045 ; 0270-4137
    ISSN (online) 1097-0045
    ISSN 0270-4137
    DOI 10.1002/pros.24051
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    Zs.A 1608: Show issues Location:
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  5. Article ; Online ; Conference proceedings: Biomathematical modeling and cancer immunotherapy: report of the workshop held at Bol, Island of Brač, Croatia, 20-21 June 2011.

    Vuk-Pavlović, Stanimir

    Cytotherapy

    2012  Volume 14, Issue 2, Page(s) 144–146

    Abstract: At the end of June 2011, mathematicians, physicians and biomedical scientists met for a 2-day workshop at Bol, Island of Brač, Croatia. The purpose of the event was to evaluate the role of mathematical models as practical tools for optimizing cancer ... ...

    Abstract At the end of June 2011, mathematicians, physicians and biomedical scientists met for a 2-day workshop at Bol, Island of Brač, Croatia. The purpose of the event was to evaluate the role of mathematical models as practical tools for optimizing cancer immunotherapy. Participants reviewed recent advances in the field and addressed potential causes of the lack of predictable clinical outcomes. They agreed that there is a need for treatments tailored to the individual patient based on the patient's ability to respond. Dynamic mathematical models based on the available understanding of interactions between the tumor, immunity and therapeutic intervention and 'trained' on the actual clinical data could help stratify patients before treatment and predict individual responses to ongoing treatment. In addition, mathematical models could assist in selecting the most beneficial individualized treatment modifications. Participants established a collaborative network to test some of the ideas discussed at the workshop and decided to review progress at the next meeting in Croatia in 2012.
    MeSH term(s) Croatia ; Humans ; Immunotherapy/methods ; Models, Theoretical ; Neoplasms/immunology ; Neoplasms/therapy ; Precision Medicine ; Treatment Outcome
    Language English
    Publishing date 2012-02
    Publishing country England
    Document type Congresses
    ZDB-ID 2039821-9
    ISSN 1477-2566 ; 1465-3249
    ISSN (online) 1477-2566
    ISSN 1465-3249
    DOI 10.3109/14653249.2011.623694
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5601: Show issues Location:
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  6. Article ; Online: Mathematical modeling in immunotherapy of cancer: personalizing clinical trials.

    Agur, Zvia / Vuk-Pavlović, Stanimir

    Molecular therapy : the journal of the American Society of Gene Therapy

    2012  Volume 20, Issue 1, Page(s) 1–2

    MeSH term(s) Humans ; Immunotherapy ; Models, Biological ; Neoplasms/therapy ; Precision Medicine
    Language English
    Publishing date 2012-01-04
    Publishing country United States
    Document type Editorial
    ZDB-ID 2010592-7
    ISSN 1525-0024 ; 1525-0016
    ISSN (online) 1525-0024
    ISSN 1525-0016
    DOI 10.1038/mt.2011.272
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    Zs.A 5640: Show issues Location:
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  7. Article: Personalizing immunotherapy: Balancing predictability and precision.

    Agur, Zvia / Vuk-Pavlović, Stanimir

    Oncoimmunology

    2012  Volume 1, Issue 7, Page(s) 1169–1171

    Abstract: Despite great expectations and research efforts, anticancer immunotherapy has not yet become a definitive cure. Perhaps, this is because past reductionist approaches were too simplistic for the patient-specific complex system of co-evolving tumor cells ... ...

    Abstract Despite great expectations and research efforts, anticancer immunotherapy has not yet become a definitive cure. Perhaps, this is because past reductionist approaches were too simplistic for the patient-specific complex system of co-evolving tumor cells and host immunity. Recent efforts based on a systems-based approach promise improved clinical outcomes engendered by a dynamic modification of personalized therapeutic regimens.
    Language English
    Publishing date 2012-10-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2645309-5
    ISSN 2162-402X ; 2162-4011
    ISSN (online) 2162-402X
    ISSN 2162-4011
    DOI 10.4161/onci.20955
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Rebuilding immunity in cancer patients.

    Vuk-Pavlovic, Stanimir

    Blood cells, molecules & diseases

    2008  Volume 40, Issue 1, Page(s) 94–100

    Abstract: Rebuilding and maintaining immunity are paramount to the success of cancer immunotherapy and hematopoietic stem cell transplantation. If immune surveillance indeed can protect from cancer, the very manifestation of malignancy means that the disease has ... ...

    Abstract Rebuilding and maintaining immunity are paramount to the success of cancer immunotherapy and hematopoietic stem cell transplantation. If immune surveillance indeed can protect from cancer, the very manifestation of malignancy means that the disease has prevailed over immunity. Yet, often, tumor-specific T cells can be found in cancer patients irrespective of vaccination. Interestingly, patients suffering from malignancy often harbor unexpectedly high levels of immature CD14(+)HLA-DR(-) monocytes, although the abundance of CD4(+) cells, CD8(+) cells and CD4(+)CD25(high) cells may be normal. It is plausible that in cancer such cells suppress T cell function, analogous to CD14(+)HLA-DR(-) cells in sepsis and major trauma, in addition to their likely failure to re-present tumor-associated antigens once dendritic cells have initiated the T cell response. Recent evidence indicates that tumor-borne adenosine, lactate and hypoxia in the tumor environment may modulate tumor-specific immunity to a significant extent, but their effects on myeloid cell function are unclear. Thus, understanding and controlling these factors may appreciably impact the success of rebuilding and maintaining immunity in cancer patients.
    MeSH term(s) Antigens, Neoplasm/immunology ; HLA Antigens/immunology ; Humans ; Immunity/physiology ; Immunologic Factors ; Neoplasms/immunology ; T-Cell Antigen Receptor Specificity
    Chemical Substances Antigens, Neoplasm ; HLA Antigens ; Immunologic Factors
    Language English
    Publishing date 2008-01
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 1237083-6
    ISSN 1096-0961 ; 1079-9796
    ISSN (online) 1096-0961
    ISSN 1079-9796
    DOI 10.1016/j.bcmd.2007.06.025
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    Zs.A 1138: Show issues Location:
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  9. Article ; Online: Eighth ISABS conference on forensic, anthropologic and medical genetics and Mayo Clinic lectures on translational medicine, Split, Croatia, June 24-28, 2013.

    Primorac, Dragan / Schanfield, Moses / Vuk-Pavlovic, Stanimir

    Croatian medical journal

    2013  Volume 54, Issue 3, Page(s) 217–218

    MeSH term(s) Croatia ; Forensic Anthropology ; Genetics, Medical ; Humans ; Schools, Medical ; Translational Medical Research
    Language English
    Publishing date 2013-06-15
    Publishing country Croatia
    Document type Editorial
    ZDB-ID 1157623-6
    ISSN 1332-8166 ; 0353-9504
    ISSN (online) 1332-8166
    ISSN 0353-9504
    DOI 10.3325/cmj.2013.54.217
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  10. Article: Modeling positive regulatory feedbacks in cell-cell interactions.

    Bajzer, Zeljko / Vuk-Pavlović, Stanimir

    Bio Systems

    2005  Volume 80, Issue 1, Page(s) 1–10

    Abstract: Our current understanding of molecular mechanisms of cellular regulation still does not support quantitative predictions of the overall growth kinetics of normal or malignant tissues. However, discernment of the role of growth-factor mediated cell-cell ... ...

    Abstract Our current understanding of molecular mechanisms of cellular regulation still does not support quantitative predictions of the overall growth kinetics of normal or malignant tissues. However, discernment of the role of growth-factor mediated cell-cell communication in tissue kinetics is possible by the use of simple mathematical models. Here we discuss the design and use of mathematical models in quantifying the contribution of autocrine and paracrine (i.e., humoral) interactions to the kinetics of tissue growth. We present models that include a humorally mediated regulatory feedback among cells built into phenomenological mathematical models of growth. Application of these models to data exemplifies the finite contributions of positive feedback in cell-cell interactions to the overall tissue growth. In addition, we propose a perturbation approach to allow separation of cell-cell interactions dependent on the perturbing agent (such as hormone antagonists in hormone-dependent tissues) from cell-cell interactions independent of it.
    MeSH term(s) Animals ; Autocrine Communication/physiology ; Cell Proliferation ; Computer Simulation ; Feedback/physiology ; Humans ; Models, Biological ; Neoplasms/physiopathology ; Paracrine Communication/physiology ; Spheroids, Cellular/physiology ; Tumor Cells, Cultured
    Language English
    Publishing date 2005-04
    Publishing country Ireland
    Document type Evaluation Studies ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, P.H.S. ; Validation Studies
    ZDB-ID 186234-0
    ISSN 0303-2647
    ISSN 0303-2647
    DOI 10.1016/j.biosystems.2004.09.025
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