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  1. Article ; Online: Structural characterization and calcium absorption-promoting effect of sucrose-calcium chelate in Caco-2 monolayer cells and mice.

    Du, Qian / Wang, Ruiyan / Deng, Zeyuan / Zhou, Jianqun / Li, Nan / Li, Wenwen / Zheng, Liufeng

    Journal of food science

    2024  Volume 89, Issue 3, Page(s) 1773–1790

    Abstract: Sucrose emerges as a chelating agent to form a stable sucrose-metal-ion chelate that can potentially improve metal-ion absorption. This study aimed to analyze the structure of sucrose-calcium chelate and its potential to promote calcium absorption in ... ...

    Abstract Sucrose emerges as a chelating agent to form a stable sucrose-metal-ion chelate that can potentially improve metal-ion absorption. This study aimed to analyze the structure of sucrose-calcium chelate and its potential to promote calcium absorption in both Caco-2 monolayer cells and mice. The characterization results showed that calcium ions mainly chelated with hydroxyl groups in sucrose to produce sucrose-calcium chelate, altering the crystal structure of sucrose (forming polymer particles) and improving its thermal stability. Sucrose-calcium chelate dose dependently increased the amount of calcium uptake, retention, and transport in the Caco-2 monolayer cell model. Compared to CaCl
    MeSH term(s) Humans ; Mice ; Animals ; Calcium/metabolism ; Caco-2 Cells ; Calcium Chloride ; Calcium, Dietary ; Chemical Phenomena
    Chemical Substances Calcium (SY7Q814VUP) ; Calcium Chloride (M4I0D6VV5M) ; Calcium, Dietary
    Language English
    Publishing date 2024-02-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 241615-3
    ISSN 1750-3841 ; 0022-1147
    ISSN (online) 1750-3841
    ISSN 0022-1147
    DOI 10.1111/1750-3841.16960
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Protective Effect of Vitexin Against IL-17-Induced Vascular Endothelial Inflammation Through Keap1/Nrf2-Dependent Signaling Pathway.

    Gan, Ting / Xing, Qian / Li, Nan / Deng, Zeyuan / Pan, Changxuan / Liu, Xiaoru / Zheng, Liufeng

    Molecular nutrition & food research

    2024  Volume 68, Issue 5, Page(s) e2300331

    Abstract: Scope: Vitexin, a C-glycosylated flavonoid, is abundant in food sources and has potential health-beneficial properties. However, the targets for its beneficial effects remain largely unknown. This study aims to establish an in vitro cell model of ... ...

    Abstract Scope: Vitexin, a C-glycosylated flavonoid, is abundant in food sources and has potential health-beneficial properties. However, the targets for its beneficial effects remain largely unknown. This study aims to establish an in vitro cell model of vascular low-grade inflammation and explore the antiinflammatory mechanism of vitexin.
    Methods and results: Low-dose TNFα and IL-17 are combined to establish a cell model of vascular low-grade inflammation. Cell-based studies show that low-dose TNFα (1 ng mL
    Conclusion: The findings provide a reliable cell model of vascular low-grade inflammation and indicate Nrf2 protein as the potential target of vitexin to inhibit vascular inflammation.
    MeSH term(s) Humans ; Animals ; Mice ; Kelch-Like ECH-Associated Protein 1/metabolism ; NF-E2-Related Factor 2/metabolism ; Tumor Necrosis Factor-alpha/metabolism ; Interleukin-17/metabolism ; Molecular Docking Simulation ; Oxidative Stress ; Signal Transduction ; Inflammation/drug therapy ; Body Weight ; Apigenin
    Chemical Substances Kelch-Like ECH-Associated Protein 1 ; NF-E2-Related Factor 2 ; vitexin (9VP70K75OK) ; Tumor Necrosis Factor-alpha ; Interleukin-17 ; Keap1 protein, mouse ; Apigenin (7V515PI7F6)
    Language English
    Publishing date 2024-02-01
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2160372-8
    ISSN 1613-4133 ; 1613-4125
    ISSN (online) 1613-4133
    ISSN 1613-4125
    DOI 10.1002/mnfr.202300331
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Non-oxidized and oxidized flaxseed orbitides differently induce HepG2 cell apoptosis: involvement of cellular uptake and membrane death receptor DR4.

    Peng, Changmei / Li, Jing / Zhao, Aixiu / Yu, Shaoqing / Zheng, Liufeng / Deng, Ze-Yuan

    Journal of the science of food and agriculture

    2024  Volume 104, Issue 7, Page(s) 4296–4308

    Abstract: Background: Flaxseed orbitides have health-promoting properties, particularly potent anti-cancer activity. However, flaxseed orbitides containing a methionine structure, such as [1-9-NαC]-linusorb B2 (CLB), are easily oxidized to sulfoxide ([1-9-NαC],[1- ...

    Abstract Background: Flaxseed orbitides have health-promoting properties, particularly potent anti-cancer activity. However, flaxseed orbitides containing a methionine structure, such as [1-9-NαC]-linusorb B2 (CLB), are easily oxidized to sulfoxide ([1-9-NαC],[1-Rs,Ss-MetO]-linusorb-B2 (CLC)) and sulfone ([1-9-NαC], [1-MetO]-linusorb B2 (CLK)), with CLC having less anti-cancer ability than CLB. It is unclear why oxidized flaxseed orbitides are less effective against cancer than non-oxidized flaxseed orbitide.
    Results: Non-oxidized ([1-9-NαC]-linusorb-B3 (CLA) and CLB) and oxidized (CLC and CLK) flaxseed orbitides were found to significantly upregulate the levels of pro-apoptotic proteins, including Bax/Bcl-2, CytoC, caspase-3, and caspase-8, in a dose-dependent manner, with non-oxidized flaxseed orbitides being more effective than oxidized flaxseed orbitides. Mechanically, the cellular absorption of non-oxidized flaxseed orbitides was higher than that of oxidized flaxseed orbitides. Moreover, the significant fluorescence quenching of DR4 protein by flaxseed orbitides (especially non-oxidized orbitides) indicated the formation of a DR4-orbitide complex. Molecular docking demonstrated that non-oxidized orbitides could easily dock into the active cavity of DR4 protein. Further blocking DR4 significantly reduced the ability of non-oxidized flaxseed orbitides to stimulate caspase-3 expression, whereas oxidized flaxseed orbitides retained this ability.
    Conclusion: Non-oxidized flaxseed orbitides are more effective against cancer than oxidized flaxseed orbitides due to higher cellular uptake and activation of the DR4-mediated death receptor signaling pathway. © 2024 Society of Chemical Industry.
    MeSH term(s) Humans ; Flax/chemistry ; Peptides, Cyclic/chemistry ; Caspase 3 ; Hep G2 Cells ; Molecular Docking Simulation ; Apoptosis ; Receptors, Death Domain ; Cell Line, Tumor
    Chemical Substances Peptides, Cyclic ; Caspase 3 (EC 3.4.22.-) ; Receptors, Death Domain
    Language English
    Publishing date 2024-03-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 184116-6
    ISSN 1097-0010 ; 0022-5142
    ISSN (online) 1097-0010
    ISSN 0022-5142
    DOI 10.1002/jsfa.13315
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Construction and application of a multilevel geohazard domain ontology

    Min Wen / Qinjun Qiu / Shiyu Zheng / Kai Ma / Shuai Zheng / Zhong Xie / Liufeng Tao

    Applied Computing and Geosciences, Vol 20, Iss , Pp 100134- (2023)

    A case study of landslide geohazards

    2023  

    Abstract: The occurrence of geohazards entails sudden, unpredictable, and cascading effects, with numerous conceptual frameworks and intricate spatiotemporal relationships existing between hazard events. Presently, the absence of a unified mechanism for describing ...

    Abstract The occurrence of geohazards entails sudden, unpredictable, and cascading effects, with numerous conceptual frameworks and intricate spatiotemporal relationships existing between hazard events. Presently, the absence of a unified mechanism for describing and expressing geohazard knowledge poses substantial challenges in terms of sharing and reusing domain-specific knowledge pertaining to geohazards. Therefore, it is imperative to address the issue of constructing a cohesive descriptive model that facilitates the sharing and reuse of geohazard knowledge. In this study, we propose a multilayered ontology construction method tailored specifically for the domain of landslide geological hazards. By comparing existing methods, we establish a hierarchical structure and expression framework for the geological hazard ontology. Notably, our approach seamlessly integrates the conceptual and semantic layers in the relationship description at each level, enabling association representation of hazard data across multiple tiers. We define essential concepts and attributes related to landslide geological hazards, along with their respective interrelationships. To achieve effective knowledge sharing and reuse, we model the ontology of the landslide geological disaster domain using the Web Ontology Language (OWL). This modeling approach serves as a powerful tool that facilitates the sharing and reuse of disaster-related knowledge. Finally, we verify the method's validity and reliability by employing illustrative case studies. The results demonstrate that the proposed approach imposes an affordable workload on human resources. Additionally, the foundational domain ontology significantly enhances information retrieval performance, thereby yielding satisfactory outcomes.
    Keywords Geological hazard ontology ; Landslide geohazard ; Unified description model ; Information retrieval ; Geography. Anthropology. Recreation ; G ; Geology ; QE1-996.5 ; Electronic computers. Computer science ; QA75.5-76.95
    Subject code 690
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Synergistic protection of quercetin and lycopene against oxidative stress via SIRT1-Nox4-ROS axis in HUVEC cells.

    Chen, Xuan / Zheng, Liufeng / Zhang, Bing / Deng, Zeyuan / Li, Hongyan

    Current research in food science

    2022  Volume 5, Page(s) 1985–1993

    Abstract: Oxidative stress is a potential factor in the promotion of endothelial dysfunction. In this research, flavonoids (quercetin, luteolin) combined with carotenoids (lycopene, lutein), especially quercetin-lycopene combination (molar ratio 5:1), prevented ... ...

    Abstract Oxidative stress is a potential factor in the promotion of endothelial dysfunction. In this research, flavonoids (quercetin, luteolin) combined with carotenoids (lycopene, lutein), especially quercetin-lycopene combination (molar ratio 5:1), prevented the oxidative stress in HUVEC cells by reducing the reactive oxygen species (ROS) and suppressing the expression of NADPH oxidase 4 (Nox4), a major source of ROS production. RNA-seq analysis indicated quercetin-lycopene combination downregulated inflammatory genes induced by H
    Language English
    Publishing date 2022-10-18
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2665-9271
    ISSN (online) 2665-9271
    DOI 10.1016/j.crfs.2022.10.018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: 1,3-Dioleoyl-2-palmitoyl-glycerol and 1-oleoyl-2-palmitoyl-3-linoleoyl-glycerol: Structure-function relationship, triacylglycerols preparation, nutrition value.

    Wei, Teng / Mueed, Abdul / Luo, Ting / Sun, Yong / Zhang, Bing / Zheng, Liufeng / Deng, Zeyuan / Li, Jing

    Food chemistry

    2024  Volume 443, Page(s) 138560

    Abstract: Based on multivariate statistics, this review compared major triacylglycerols (TAGs) in animal milk and human milk fat from China and other countries. Human milk fat differs from animal milk fat in that it has longer acyl chains and higher concentrations ...

    Abstract Based on multivariate statistics, this review compared major triacylglycerols (TAGs) in animal milk and human milk fat from China and other countries. Human milk fat differs from animal milk fat in that it has longer acyl chains and higher concentrations of 1,3-dioleoyl-2-palmitoyl-glycerol (O-P-O) and 1-oleoyl-2-palmitoyl-3-linoleoylglycerol (O-P-L). O-P-L is a significant and distinct TAG in human milk fat, particularly in China. 1-oleoyl-2-palmitoyl-3-linoleoylglycerol (OPL) is human milk's major triglyceride molecule of O-P-L, accounting for more than 70%. As a result, OPL has piqued the interest of Chinese academics. The synthesis process and nutritional outcomes of OPL have been studied, including changes in gut microbiota, serum lipid composition, improved fatty acid and calcium absorption, and increased total bile acid levels. However, current OPL research is limited. Therefore, this review discussed enzymatic preparation of 1,3-dioleoyl-2-palmitoyl-glycerol (OPO) and OPL and their nutritional and physiological activity to direct future research direction for sn-2 palmitate and OPL.
    MeSH term(s) Animals ; Humans ; Triglycerides/analysis ; Glycerol ; Milk, Human/chemistry ; Nutritive Value ; Structure-Activity Relationship ; Glycerides
    Chemical Substances Triglycerides ; 2-palmitoylglycerol (21I29V2935) ; Glycerol (PDC6A3C0OX) ; Glycerides
    Language English
    Publishing date 2024-01-26
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 243123-3
    ISSN 1873-7072 ; 0308-8146
    ISSN (online) 1873-7072
    ISSN 0308-8146
    DOI 10.1016/j.foodchem.2024.138560
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Combining

    Xiao, Ting / Zeng, Junpeng / Qiu, Leyun / Wang, Ruiyan / Li, Nan / Deng, Zeyuan / Zheng, Liufeng

    Food & function

    2022  Volume 13, Issue 5, Page(s) 2899–2912

    Abstract: Potential endogenous hypoglycemic peptides derived from breast milk were screened ... ...

    Abstract Potential endogenous hypoglycemic peptides derived from breast milk were screened by
    MeSH term(s) Caco-2 Cells/drug effects ; Diabetes Mellitus, Type 2/prevention & control ; Glucose/metabolism ; Humans ; Hypoglycemic Agents/chemistry ; Hypoglycemic Agents/pharmacology ; Milk, Human ; Molecular Docking Simulation ; Peptides/chemistry ; Peptides/pharmacology ; Tandem Mass Spectrometry
    Chemical Substances Hypoglycemic Agents ; Peptides ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2022-03-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2612033-1
    ISSN 2042-650X ; 2042-6496
    ISSN (online) 2042-650X
    ISSN 2042-6496
    DOI 10.1039/d1fo03537a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Structural Characterization of Zinc-Sucrose Complex and Its Ability to Promote Zinc Absorption in Caco-2 Monolayer Cells and Mice.

    Li, Nan / Wang, Ruiyan / Deng, Zeyuan / Zhou, Jianqun / Li, Wenwen / Du, Qian / Zheng, Liufeng

    Journal of agricultural and food chemistry

    2023  Volume 71, Issue 31, Page(s) 12094–12104

    Abstract: Sucrose emerges as a metal-ion chelating agent with excellent stability that may increase metal-ion absorption. This study aimed to characterize the structure of zinc-sucrose complex and investigate its ability to promote zinc absorption in Caco-2 ... ...

    Abstract Sucrose emerges as a metal-ion chelating agent with excellent stability that may increase metal-ion absorption. This study aimed to characterize the structure of zinc-sucrose complex and investigate its ability to promote zinc absorption in Caco-2 monolayer cells and mice. Based on the results of the inductively coupled plasma emission spectrometer (ICP-ES), scanning electron microscopy-energy-dispersive X-ray spectroscopy (SEM-EDX), and Fourier transform infrared spectroscopy (FT-IR), it can be inferred that zinc and sucrose were chelated at a 1:1 ratio, with the hydroxyl groups playing a significant role. The Caco-2 monolayer cell model revealed that zinc-sucrose complex increased the amount of zinc uptake, retention, and transport in a dose- and time-dependent manner. Through the upregulation of genes and proteins for ZIP4, MT1, and DMT1, treatment with zinc-sucrose complex improved the proportion of absorbed zinc utilized for transport compared to ZnCl
    MeSH term(s) Humans ; Mice ; Animals ; Zinc/metabolism ; Caco-2 Cells ; Spectroscopy, Fourier Transform Infrared ; Up-Regulation ; Chelating Agents/pharmacology
    Chemical Substances Zinc (J41CSQ7QDS) ; Chelating Agents
    Language English
    Publishing date 2023-07-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 241619-0
    ISSN 1520-5118 ; 0021-8561
    ISSN (online) 1520-5118
    ISSN 0021-8561
    DOI 10.1021/acs.jafc.3c02806
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Human Milk Oligosaccharides: A Critical Review on Structure, Preparation, Their Potential as a Food Bioactive Component, and Future Perspectives.

    Zhu, Liuying / Li, Hongyan / Luo, Ting / Deng, Zeyuan / Li, Jing / Zheng, Liufeng / Zhang, Bing

    Journal of agricultural and food chemistry

    2023  Volume 71, Issue 43, Page(s) 15908–15925

    Abstract: Human milk is the gold standard for infant feeding. Human milk oligosaccharides (HMOs) are a unique group of oligosaccharides in human milk. Great interest in HMOs has grown in recent years due to their positive effects on various aspects of infant ... ...

    Abstract Human milk is the gold standard for infant feeding. Human milk oligosaccharides (HMOs) are a unique group of oligosaccharides in human milk. Great interest in HMOs has grown in recent years due to their positive effects on various aspects of infant health. HMOs provide various physiologic functions, including establishing a balanced infant's gut microbiota, strengthening the gastrointestinal barrier, preventing infections, and potential support to the immune system. However, the clinical application of HMOs is challenging due to their specificity to human milk and the difficulties and high costs associated with their isolation and synthesis. Here, the differences in oligosaccharides in human and other mammalian milk are compared, and the synthetic strategies to access HMOs are summarized. Additionally, the potential use and molecular mechanisms of HMOs as a new food bioactive component in different diseases, such as infection, necrotizing enterocolitis, diabetes, and allergy, are critically reviewed. Finally, the current challenges and prospects of HMOs in basic research and application are discussed.
    MeSH term(s) Infant ; Female ; Animals ; Infant, Newborn ; Humans ; Milk, Human/chemistry ; Breast Feeding ; Oligosaccharides/chemistry ; Gastrointestinal Microbiome/physiology ; Immune System ; Mammals
    Chemical Substances Oligosaccharides
    Language English
    Publishing date 2023-10-18
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 241619-0
    ISSN 1520-5118 ; 0021-8561
    ISSN (online) 1520-5118
    ISSN 0021-8561
    DOI 10.1021/acs.jafc.3c04412
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Comparative Analysis of Protein Digestion Characteristics in Human, Cow, Goat, Sheep, Mare, and Camel Milk under Simulated Infant Condition.

    Xiao, Ting / Zeng, Junpeng / Zhao, Caidong / Hou, Yanmei / Wu, Tong / Deng, Zeyuan / Zheng, Liufeng

    Journal of agricultural and food chemistry

    2023  Volume 71, Issue 41, Page(s) 15035–15047

    Abstract: An infant in vitro digestion model was utilized to investigate protein digestion characteristics in human and diverse mammalian milk (i.e., cow, goat, sheep, mare, and camel milk) using electrophoresis and chromatography. Digestive differences among ... ...

    Abstract An infant in vitro digestion model was utilized to investigate protein digestion characteristics in human and diverse mammalian milk (i.e., cow, goat, sheep, mare, and camel milk) using electrophoresis and chromatography. Digestive differences among milks were mainly manifested in the infant gastric phase, as evidenced by varying degrees of protein digestion. Notably, proteins (i.e., lactoferrin, serum albumin, and immunoglobulin G-heavy chain) remained partially intact in human milk, whereas these proteins in animal milk were exclusively degraded after gastrointestinal digestion. The peptide spectra of human, mare, and camel milk were highly similar, with a predominant formation of low-intensity small peptides, whereas the other three milk showed the opposite phenomenon. Heatmap cluster analysis indicated that camel milk was the most comparable to human milk before digestion, yet sheep milk was the most similar to human milk regarding protein digestion behaviors following infant gastric digestion.
    MeSH term(s) Humans ; Infant ; Animals ; Horses ; Female ; Cattle ; Sheep ; Milk/chemistry ; Camelus ; Goats/metabolism ; Proteolysis ; Milk, Human/metabolism ; Stomach ; Peptides/metabolism ; Digestion
    Chemical Substances Peptides
    Language English
    Publishing date 2023-10-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 241619-0
    ISSN 1520-5118 ; 0021-8561
    ISSN (online) 1520-5118
    ISSN 0021-8561
    DOI 10.1021/acs.jafc.3c03123
    Database MEDical Literature Analysis and Retrieval System OnLINE

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