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  1. Article ; Online: Correction: Saadeh et al. Recent Advances in the Synthesis and Biological Activity of 8-Hydroxyquinolines.

    Saadeh, Haythem A / Sweidan, Kamal A / Mubarak, Mohammad S

    Molecules (Basel, Switzerland)

    2022  Volume 27, Issue 13

    Abstract: The author wishes to make the following correction to this paper [ ... ]. ...

    Abstract The author wishes to make the following correction to this paper [...].
    Language English
    Publishing date 2022-07-05
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules27134306
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 81: Show issues

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  2. Article ; Online: Correction

    Haythem A. Saadeh / Kamal A. Sweidan / Mohammad S. Mubarak

    Molecules, Vol 27, Iss 13, p

    Saadeh et al. Recent Advances in the Synthesis and Biological Activity of 8-Hydroxyquinolines. Molecules 2020, 25 , 4321

    2022  Volume 4306

    Abstract: The author wishes to make the following correction to this paper [.] ...

    Abstract The author wishes to make the following correction to this paper [.]
    Keywords n/a ; Organic chemistry ; QD241-441
    Language English
    Publishing date 2022-07-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  3. Article ; Online: Recent Advances in the Synthesis and Biological Activity of 8-Hydroxyquinolines.

    Saadeh, Haythem A / Sweidan, Kamal A / Mubarak, Mohammad S

    Molecules (Basel, Switzerland)

    2020  Volume 25, Issue 18

    Abstract: Compounds containing the 8-hydroxyquinoline (8-HQ) ...

    Abstract Compounds containing the 8-hydroxyquinoline (8-HQ)
    MeSH term(s) Anti-Bacterial Agents/chemical synthesis ; Anti-Bacterial Agents/pharmacology ; Antiviral Agents/chemical synthesis ; Antiviral Agents/pharmacology ; Chemistry Techniques, Synthetic/methods ; Humans ; Oxyquinoline/chemical synthesis ; Oxyquinoline/pharmacology
    Chemical Substances Anti-Bacterial Agents ; Antiviral Agents ; Oxyquinoline (5UTX5635HP)
    Keywords covid19
    Language English
    Publishing date 2020-09-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules25184321
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  4. Article ; Online: Benzimidazole-Piperazine-Coumarin/Cucurbit[7]uril Supramolecular Photoinduced Electron Transfer Fluorochromes for Detection of Carnosol by Stimuli-Responsive Dye Displacement and p

    Bojesomo, Rukayat S / Assaf, Khaleel I / Saadeh, Haythem A / Siddig, Lamia A / Saleh, Na'il

    ACS omega

    2022  Volume 7, Issue 2, Page(s) 2356–2363

    Abstract: A new fluorescent dye (4PBZC) comprising coumarin (C), piperazine (P), and benzimidazole (BZ) was designed, prepared, and complexed to cucurbit[7]uril (CB7) to detect carnosol (CAR), an anti-breast cancer drug, in sub-nanomolar concentrations utilizing ... ...

    Abstract A new fluorescent dye (4PBZC) comprising coumarin (C), piperazine (P), and benzimidazole (BZ) was designed, prepared, and complexed to cucurbit[7]uril (CB7) to detect carnosol (CAR), an anti-breast cancer drug, in sub-nanomolar concentrations utilizing the supramolecular indicator displacement assay strategy, the CB7-assisted p
    Language English
    Publishing date 2022-01-05
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.1c06287
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Highly bioactive novel aryl-, benzyl-, and piperazine-selenoureas: synthesis, structural characterization and in vitro biological evaluation.

    Moussa, Ziad / Kaddoura, Ranem / Saadeh, Haythem A / Abutaha, Nael / Ahmed, Saleh A

    Heliyon

    2022  Volume 8, Issue 9, Page(s) e10709

    Abstract: Selenoureas are widespread as useful elements for constructing important species and biologically active molecules. Finding an efficient and straightforward method to prepare this motif and biologically screen derivatives thereof is crucial. Herein, we ... ...

    Abstract Selenoureas are widespread as useful elements for constructing important species and biologically active molecules. Finding an efficient and straightforward method to prepare this motif and biologically screen derivatives thereof is crucial. Herein, we demonstrate the effectiveness of using ethanol as a solvent in the preparation of various substituted aryl-, benzyl-, and piperazine-selenoureas from isoselenocyanates and amines. The synthetic method includes mild reaction conditions, large substrate scope, and good isolated yields. Biological evaluation of the prepared products on MDA-MB-231 and MCF-7 cancer cell lines revealed several remarkably active compounds (IC
    Language English
    Publishing date 2022-09-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2022.e10709
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: First X-ray Crystal Structure Characterization, Computational Studies, and Improved Synthetic Route to the Bioactive 5-Arylimino-1,3,4-thiadiazole Derivatives.

    Moussa, Ziad / Paz, Alejandro Perez / Judeh, Zaher M A / Alzamly, Ahmed / Saadeh, Haythem A / Asghar, Basim H / Alsaedi, Sara / Masoud, Bayan / Almeqbaali, Salama / Estwani, Saeda / Aljaberi, Amna / Al-Rooqi, Munirah M / Ahmed, Saleh A

    International journal of molecular sciences

    2023  Volume 24, Issue 4

    Abstract: ... ...

    Abstract N
    MeSH term(s) X-Rays ; Thiadiazoles/chemistry ; Chlorides ; Molecular Structure ; Heterocyclic Compounds/chemistry
    Chemical Substances Thiadiazoles ; Chlorides ; Heterocyclic Compounds
    Language English
    Publishing date 2023-02-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24043759
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Hybrid Drugs as Potential Combatants Against Drug-Resistant Microbes: A Review.

    Saadeh, Haythem A / Mubarak, Mohammad S

    Current topics in medicinal chemistry

    2017  Volume 17, Issue 8, Page(s) 895–906

    Abstract: Antimicrobial resistance to drugs is a serious threat to public health. Different strategies have been adopted to deal with antimicrobial resistance to known drugs, one such strategy is the use of drug hybrids; this is a promising strategy to address the ...

    Abstract Antimicrobial resistance to drugs is a serious threat to public health. Different strategies have been adopted to deal with antimicrobial resistance to known drugs, one such strategy is the use of drug hybrids; this is a promising strategy to address the growing problem of drug resistance. The present review covers the very recent examples of combining (hybrid) two standard drugs in a single molecule for combating antibiotic-resistant microorganisms, and to present evidence supporting that drug hybrids are the urgent and practical solution to stop or slow down the spread of drug resistance. In addition, this review provides a literature overview of antimicrobial hybrids of standard drugs and their impact on antimicrobial resistance, covering publications between 2015 and 2016.
    MeSH term(s) Anti-Bacterial Agents/chemical synthesis ; Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Bacteria/drug effects ; Drug Resistance, Multiple, Bacterial/drug effects ; Humans ; Microbial Sensitivity Tests ; Molecular Structure
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2017
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2064823-6
    ISSN 1873-4294 ; 1568-0266
    ISSN (online) 1873-4294
    ISSN 1568-0266
    DOI 10.2174/1568026616666160927155251
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5572: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Benzimidazole–Piperazine–Coumarin/Cucurbit[7]uril Supramolecular Photoinduced Electron Transfer Fluorochromes for Detection of Carnosol by Stimuli-Responsive Dye Displacement and pKa Tuning

    Rukayat S. Bojesomo / Khaleel I. Assaf / Haythem A. Saadeh / Lamia A. Siddig / Na’il Saleh

    ACS Omega, Vol 7, Iss 2, Pp 2356-

    2022  Volume 2363

    Keywords Chemistry ; QD1-999
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher American Chemical Society
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  9. Article ; Online: Highly bioactive novel aryl-, benzyl-, and piperazine-selenoureas: synthesis, structural characterization and in vitro biological evaluation

    Moussa, Ziad / Kaddoura, Ranem / Saadeh, Haythem A. / Abutaha, Nael / Ahmed, Saleh A.

    Heliyon. 2022 Sept., v. 8, no. 9 p.e10709-

    2022  

    Abstract: Selenoureas are widespread as useful elements for constructing important species and biologically active molecules. Finding an efficient and straightforward method to prepare this motif and biologically screen derivatives thereof is crucial. Herein, we ... ...

    Abstract Selenoureas are widespread as useful elements for constructing important species and biologically active molecules. Finding an efficient and straightforward method to prepare this motif and biologically screen derivatives thereof is crucial. Herein, we demonstrate the effectiveness of using ethanol as a solvent in the preparation of various substituted aryl-, benzyl-, and piperazine-selenoureas from isoselenocyanates and amines. The synthetic method includes mild reaction conditions, large substrate scope, and good isolated yields. Biological evaluation of the prepared products on MDA-MB-231 and MCF-7 cancer cell lines revealed several remarkably active compounds (IC₅₀ < 10 μΜ) with the best one exhibiting IC₅₀ values of 1.8 μΜ and 1.2 μΜ observed against the challenging former triple-negative breast cancer cell line and the latter one, respectively. The chemical structures of all new compounds were fully characterized by multinuclear nuclear magnetic resonance (NMR) spectroscopy and high accuracy mass measurements.
    Keywords biological assessment ; breast neoplasms ; cell lines ; ethanol ; neoplasm cells ; nuclear magnetic resonance spectroscopy ; solvents ; Isoselenocyanates ; Selenoureas ; Piperazine ; Pyrimidine ; MDA-MB-231 ; MCF-7
    Language English
    Dates of publication 2022-09
    Publishing place Elsevier Ltd
    Document type Article ; Online
    Note Use and reproduction
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2022.e10709
    Database NAL-Catalogue (AGRICOLA)

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  10. Article: Recent Advances in the Synthesis and Biological Activity of 8-Hydroxyquinolines

    Saadeh, Haythem A. / Sweidan, Kamal A. / Mubarak, Mohammad S.

    Molecules

    Abstract: Compounds containing the 8-hydroxyquinoline (8-HQ) 1 nucleus exhibit a wide range of biological activities, including antimicrobial, anticancer, and antifungal effects The chemistry and biology of this group have attracted the attention of chemists, ... ...

    Abstract Compounds containing the 8-hydroxyquinoline (8-HQ) 1 nucleus exhibit a wide range of biological activities, including antimicrobial, anticancer, and antifungal effects The chemistry and biology of this group have attracted the attention of chemists, medicinal chemists, and professionals in health sciences A number of prescribed drugs incorporate this group, and numerous 8-HQ- based molecules can be used to develop potent lead compounds with good efficacy and low toxicity This review focusses on the recent advances in the synthesis of 8-HQ derivatives with different pharmacological properties, including anticancer, antiviral, and antibacterial activities For this purpose, recent relevant references were searched in different known databases and search engines, such as MEDLINE (PubMed), Google Scholar, Science Direct, Scopus, Cochrane, Scientific Information Database (SID), SciFinder, and Institute for Scientific Information (ISI) Web of Knowledge This review article provides a literature overview of the various synthetic strategies and biological activities of 8-HQ derivatives and covers the recent related literature Taken together, compounds containing the 8-HQ moiety have huge therapeutic value and can act as potential building blocks for various pharmacologically active scaffolds In addition, several described compounds in this review could act leads for the development of drugs against numerous diseases including cancer
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #790351
    Database COVID19

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