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  1. Book ; Online: Market Access. Nuovi paradigmi manageriali e strumenti operativi per le imprese del Life Science (perché niente è più come prima)

    Galliverti, Giuseppe / Saraceni, Nicola / Lega, Federico

    (Ahead)

    2023  

    Series title Ahead
    Keywords Business & management ; Market Access ; Healthcare ; Life Science ; Access ; Pharma ; Drugs ; Medical devices ; Pharmaceutical ; Stakeholder engagement
    Language Italian
    Size 1 electronic resource (164 pages)
    Publisher Milano University Press
    Publishing place Milano
    Document type Book ; Online
    Note Italian
    HBZ-ID HT030377203
    ISBN 9791255100225
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Parameter estimation from ICC curves.

    Lega, Joceline

    Journal of biological dynamics

    2021  Volume 15, Issue 1, Page(s) 195–212

    Abstract: Incidence vs. Cumulative Cases (ICC) curves are introduced and shown to provide a simple framework for parameter identification in the case of the most elementary epidemiological model, consisting of susceptible, infected, and removed compartments. This ... ...

    Abstract Incidence vs. Cumulative Cases (ICC) curves are introduced and shown to provide a simple framework for parameter identification in the case of the most elementary epidemiological model, consisting of susceptible, infected, and removed compartments. This novel methodology is used to estimate the basic reproduction ratio of recent outbreaks, including those associated with the ongoing COVID-19 pandemic.
    MeSH term(s) Basic Reproduction Number/statistics & numerical data ; COVID-19/epidemiology ; COVID-19/transmission ; China/epidemiology ; Computer Simulation ; Disease Susceptibility ; Gastroenteritis/epidemiology ; Humans ; Incidence ; Mathematical Concepts ; Models, Biological ; Models, Statistical ; Nonlinear Dynamics ; Pandemics/statistics & numerical data ; Poisson Distribution ; SARS-CoV-2 ; Signal-To-Noise Ratio ; Spain/epidemiology
    Language English
    Publishing date 2021-04-07
    Publishing country England
    Document type Journal Article
    ISSN 1751-3766
    ISSN (online) 1751-3766
    DOI 10.1080/17513758.2021.1912419
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Recent Insight into SARS-CoV2 Immunopathology and Rationale for Potential Treatment and Preventive Strategies in COVID-19.

    Lega, Sara / Naviglio, Samuele / Volpi, Stefano / Tommasini, Alberto

    Vaccines

    2020  Volume 8, Issue 2

    Abstract: As the outbreak of the new coronavirus (SARS-CoV-2) infection is spreading globally, great effort ... This review summarizes the current state of knowledge on the interaction between SARS-CoV-2 and the host ...

    Abstract As the outbreak of the new coronavirus (SARS-CoV-2) infection is spreading globally, great effort is being made to understand the disease pathogenesis and host factors that predispose to disease progression in an attempt to find a window of opportunity for intervention. In addition to the direct cytopathic effect of the virus, the host hyper-inflammatory response has emerged as a key factor in determining disease severity and mortality. Accumulating clinical observations raised hypotheses to explain why some patients develop more severe disease while others only manifest mild or no symptoms. So far, Covid-19 management remains mainly supportive. However, many researches are underway to clarify the role of antiviral and immunomodulating drugs in changing morbidity and mortality in patients who become severely ill. This review summarizes the current state of knowledge on the interaction between SARS-CoV-2 and the host immune system and discusses recent findings on proposed pharmacologic treatments.
    Keywords covid19
    Language English
    Publishing date 2020-05-14
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines8020224
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book ; Online: Recent Insight into SARS-CoV2 Immunopathology and Rationale for Potential Treatment and Preventive Strategies in COVID-19

    Sara Lega / Samuele Naviglio / Stefano Volpi / Alberto Tommasini

    Vaccines ; Volume 8 ; Issue 2

    2020  

    Abstract: As the outbreak of the new coronavirus (SARS-CoV-2) infection is spreading globally, great effort ... This review summarizes the current state of knowledge on the interaction between SARS-CoV-2 and the host ...

    Abstract As the outbreak of the new coronavirus (SARS-CoV-2) infection is spreading globally, great effort is being made to understand the disease pathogenesis and host factors that predispose to disease progression in an attempt to find a window of opportunity for intervention. In addition to the direct cytopathic effect of the virus, the host hyper-inflammatory response has emerged as a key factor in determining disease severity and mortality. Accumulating clinical observations raised hypotheses to explain why some patients develop more severe disease while others only manifest mild or no symptoms. So far, Covid-19 management remains mainly supportive. However, many researches are underway to clarify the role of antiviral and immunomodulating drugs in changing morbidity and mortality in patients who become severely ill. This review summarizes the current state of knowledge on the interaction between SARS-CoV-2 and the host immune system and discusses recent findings on proposed pharmacologic treatments.
    Keywords coronavirus ; Covid-19 ; SARS-CoV-2 ; immune response ; T cell repertoire ; cytokine storm ; antiviral immunity ; covid19
    Subject code 610
    Language English
    Publishing date 2020-05-14
    Publisher Multidisciplinary Digital Publishing Institute
    Publishing country ch
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Recent Insight into SARS-CoV2 Immunopathology and Rationale for Potential Treatment and Preventive Strategies in COVID-19

    Sara Lega / Samuele Naviglio / Stefano Volpi / Alberto Tommasini

    Vaccines, Vol 8, Iss 224, p

    2020  Volume 224

    Abstract: As the outbreak of the new coronavirus (SARS-CoV-2) infection is spreading globally, great effort ... This review summarizes the current state of knowledge on the interaction between SARS-CoV-2 and the host ...

    Abstract As the outbreak of the new coronavirus (SARS-CoV-2) infection is spreading globally, great effort is being made to understand the disease pathogenesis and host factors that predispose to disease progression in an attempt to find a window of opportunity for intervention. In addition to the direct cytopathic effect of the virus, the host hyper-inflammatory response has emerged as a key factor in determining disease severity and mortality. Accumulating clinical observations raised hypotheses to explain why some patients develop more severe disease while others only manifest mild or no symptoms. So far, Covid-19 management remains mainly supportive. However, many researches are underway to clarify the role of antiviral and immunomodulating drugs in changing morbidity and mortality in patients who become severely ill. This review summarizes the current state of knowledge on the interaction between SARS-CoV-2 and the host immune system and discusses recent findings on proposed pharmacologic treatments.
    Keywords coronavirus ; Covid-19 ; SARS-CoV-2 ; immune response ; T cell repertoire ; cytokine storm ; Medicine ; R ; covid19
    Subject code 610
    Language English
    Publishing date 2020-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  6. Article ; Online: Expression profiles of the lncRNA antisense GAS5-AS1 in colon biopsies from pediatric inflammatory bowel disease patients and its role in regulating sense transcript GAS5.

    Curci, Debora / Franzin, Martina / Zudeh, Giulia / Bramuzzo, Matteo / Lega, Sara / Decorti, Giuliana / Stocco, Gabriele / Lucafò, Marianna

    European journal of pediatrics

    2024  Volume 183, Issue 4, Page(s) 1657–1665

    Abstract: The long non-coding RNA (lncRNA) growth arrest-specific transcript 5 (GAS5) level was demonstrated as involved in pediatric inflammatory bowel disease (IBD) pathogenesis. Since its antisense transcript GAS5-AS1 has never been investigated in IBD, this ... ...

    Abstract The long non-coding RNA (lncRNA) growth arrest-specific transcript 5 (GAS5) level was demonstrated as involved in pediatric inflammatory bowel disease (IBD) pathogenesis. Since its antisense transcript GAS5-AS1 has never been investigated in IBD, this study aims to detect whether GAS5-AS1 and GAS5 levels are related to IBD clinical parameters and investigate their correlation in vitro. Twenty-six IBD pediatric patients were enrolled; paired inflamed and non-inflamed intestinal biopsies were collected. We evaluated GAS5 and GAS5-AS1 levels by real-time PCR. The role of GAS5 and GAS5-AS1 was assessed in vitro by transient silencing in THP1-derived macrophages. GAS5-AS1 and GAS5 levels were associated with patients' clinical parameters; GAS5-AS1 expression was downregulated in inflamed tissues and inversely correlated with disease activity. A positive correlation between GAS5-AS1 and GAS5 levels was observed in non-inflamed biopsies. On THP1-derived macrophages, a reduced amount of both GAS5-AS1 and GAS5 was observed; accordingly, matrix metalloproteinase (MMP) 9 was increased. After GAS5-AS1 silencing, a downregulation of GAS5 was found, whereas no effect was detected on GAS5-AS1 after GAS5 silencing.    Conclusion: This study provided for the first time new insights into the potential role of GAS5-AS1 in IBD. GAS5-AS1 modulates GAS5 levels in vitro and may serve as a potential IBD diagnostic biomarker. What is Known: • GAS5 is involved in regulating intestinal MMP-2 and MMP-9 in pediatric patients with IBD; • GAS5-AS1 has never been investigated in the context of IBD; • GAS5-AS1 regulates the expression of GAS5, increasing its stability in tissues and in vitro cell models of cancer. What is New: • GAS5-AS1 correlated with GAS5 and IBD clinical parameters; • GAS5-AS1 can modulate GAS5 levels in macrophages; • GAS5-AS1 may serve as potential IBD diagnostic biomarker.
    MeSH term(s) Humans ; Child ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; Inflammatory Bowel Diseases/diagnosis ; Inflammatory Bowel Diseases/genetics ; Biopsy ; Biomarkers ; Colon/metabolism
    Chemical Substances RNA, Long Noncoding ; Biomarkers
    Language English
    Publishing date 2024-01-10
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 194196-3
    ISSN 1432-1076 ; 0340-6199 ; 0943-9676
    ISSN (online) 1432-1076
    ISSN 0340-6199 ; 0943-9676
    DOI 10.1007/s00431-023-05403-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Uncommon urticaria.

    Migliarino, Vanessa / Badina, Laura / Berti, Irene / Lega, Sara / Barbi, Egidio

    Archives of disease in childhood. Education and practice edition

    2021  Volume 107, Issue 6, Page(s) 426–429

    MeSH term(s) Humans ; Urticaria/diagnosis ; Urticaria/drug therapy ; Urticaria/etiology ; Dermatology
    Language English
    Publishing date 2021-06-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2148818-6
    ISSN 1743-0593 ; 1743-0585
    ISSN (online) 1743-0593
    ISSN 1743-0585
    DOI 10.1136/archdischild-2021-321828
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Recent insight into SARS-COV2 immunopathology and rationale for potential treatment and preventive strategies in COVID-19

    Lega, Sara / Naviglio, Samuele / Volpi, Stefano / Tommasini, Alberto

    Vaccines

    Abstract: As the outbreak of the new coronavirus (SARS-CoV-2) infection is spreading globally, great effort ... This review summarizes the current state of knowledge on the interaction between SARS-CoV-2 and the host ...

    Abstract As the outbreak of the new coronavirus (SARS-CoV-2) infection is spreading globally, great effort is being made to understand the disease pathogenesis and host factors that predispose to disease progression in an attempt to find a window of opportunity for intervention. In addition to the direct cytopathic effect of the virus, the host hyper-inflammatory response has emerged as a key factor in determining disease severity and mortality. Accumulating clinical observations raised hypotheses to explain why some patients develop more severe disease while others only manifest mild or no symptoms. So far, Covid-19 management remains mainly supportive. However, many researches are underway to clarify the role of antiviral and immunomodulating drugs in changing morbidity and mortality in patients who become severely ill. This review summarizes the current state of knowledge on the interaction between SARS-CoV-2 and the host immune system and discusses recent findings on proposed pharmacologic treatments.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #260121
    Database COVID19

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  9. Article ; Online: What Are the Targets of Inflammatory Bowel Disease Management.

    Lega, Sara / Dubinsky, Marla C

    Inflammatory bowel diseases

    2018  Volume 24, Issue 8, Page(s) 1670–1675

    Abstract: With recent evidence suggesting that keeping the inflammatory process under tight control prevents long-term disability, the aim of treatments in inflammatory bowel disease (IBD) has shifted from symptom control toward the resolution of bowel ... ...

    Abstract With recent evidence suggesting that keeping the inflammatory process under tight control prevents long-term disability, the aim of treatments in inflammatory bowel disease (IBD) has shifted from symptom control toward the resolution of bowel inflammation. Mucosal healing is currently recognized as the principal treatment target to be used in a "treat to target" paradigm, whereas histologic healing and normalization of biomarkers are being evaluated as potential future targets. Although symptom relief is no longer a sufficient target, patient experience with the disease is of unquestionable importance and should be assessed in the form of patient-reported outcomes, to be used as a co-primary target with an objective measure of disease activity. IBD in is a heterogeneous disease; thus besides defining common treatment targets, every effort should be made to deliver a personalized treatment plan based on the risk factors for disease progression and individual drug metabolism to improve treatment success.
    MeSH term(s) Biomarkers/analysis ; Disease Progression ; Humans ; Inflammatory Bowel Diseases/therapy ; Intestinal Mucosa/metabolism ; Patient Reported Outcome Measures ; Remission Induction ; Wound Healing
    Chemical Substances Biomarkers
    Language English
    Publishing date 2018-04-16
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1340971-2
    ISSN 1536-4844 ; 1078-0998
    ISSN (online) 1536-4844
    ISSN 1078-0998
    DOI 10.1093/ibd/izy064
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Lateral Displacement of the Inner Canthi in a Child of Deaf Parents.

    Carrato, Valentina / Lega, Sara / Ventura, Alessandro

    JAMA pediatrics

    2018  Volume 172, Issue 3, Page(s) 294–295

    MeSH term(s) Child, Preschool ; Deafness/genetics ; Diagnosis, Differential ; Female ; Humans ; Male ; Parents ; Waardenburg Syndrome/diagnosis ; Waardenburg Syndrome/genetics
    Language English
    Publishing date 2018-01-29
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2701223-2
    ISSN 2168-6211 ; 2168-6203
    ISSN (online) 2168-6211
    ISSN 2168-6203
    DOI 10.1001/jamapediatrics.2017.4372
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