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Article ; Online: Novel Strategies to Improve the Cardioprotective Effects of Cardioplegia.

Osorio-Llanes, Estefanie / Castellar-López, Jairo / Rosales-Rada, Wendy / Montoya, Yulieth / Bustamante, John / Zalaquett, Ricardo / Bravo-Sagua, Roberto / Riquelme, Jaime A / Sánchez, Gina / Chiong, Mario / Lavandero, Sergio / Mendoza-Torres, Evelyn

Current cardiology reviews

2024

Abstract: The use of cardioprotective strategies as adjuvants of cardioplegic solutions has become an ideal alternative for the improvement of post-surgery heart recovery. The choice of the optimal cardioplegia, as well as its distribution mechanism, remains ... ...

Abstract	The use of cardioprotective strategies as adjuvants of cardioplegic solutions has become an ideal alternative for the improvement of post-surgery heart recovery. The choice of the optimal cardioplegia, as well as its distribution mechanism, remains controversial in the field of cardiovascular surgery. There is still a need to search for new and better cardioprotective methods during cardioplegic procedures. New techniques for the management of cardiovascular complications during cardioplegia have evolved with new alternatives and additives, and each new strategy provides a tool to neutralize the damage after ischemia/reperfusion events. Researchers and clinicians have committed themselves to studying the effect of new strategies and adjuvant components with the potential to improve the cardioprotective effect of cardioplegic solutions in preventing myocardial ischemia/reperfusion-induced injury during cardiac surgery. The aim of this review is to explore the different types of cardioplegia, their protection mechanisms, and which strategies have been proposed to enhance the function of these solutions in hearts exposed to cardiovascular pathologies that require surgical alternatives for their corrective progression.
Language	English
Publishing date	2024-01-24
Publishing country	United Arab Emirates
Document type	Journal Article
ISSN	1875-6557
ISSN (online)	1875-6557
DOI	10.2174/011573403X263956231129064455
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The Role of METTL3 in the Progression of Cardiac Fibrosis.

Bolívar, Samir / Pérez-Cantillo, Marian / Monterroza-Torres, Jassiris / Vásquez-Trincado, César / Castellar-Lopez, Jairo / Mendoza-Torres, Evelyn

Current topics in medicinal chemistry

2023 Volume 23, Issue 26, Page(s) 2427–2435

Abstract: Cardiac fibrosis is known as the expansion of the cardiac interstitium through excessive deposition of extracellular matrix proteins; this process is performed by a multifunctional cell known as the cardiac fibroblast. After the myocardial injury, these ... ...

Abstract	Cardiac fibrosis is known as the expansion of the cardiac interstitium through excessive deposition of extracellular matrix proteins; this process is performed by a multifunctional cell known as the cardiac fibroblast. After the myocardial injury, these cells are activated as a repair program, increase, and switch to a contractile phenotype, which is evidenced by an increase in alpha- smooth muscle actin. Likewise, there is an increase in type I and III collagen, which are considered profibrotic biomarkers. It is believed that one of the proteins involved in cardiac remodeling is METTL3, which is the enzyme responsible for N6-methyladenosine (m6A) methylation, the most common and abundant epigenetic modification of eukaryotic mRNA. This review focuses on recent studies in which the possible role of METTL3 in the progression of fibrosis has been demonstrated, mainly in cardiac fibrogenesis.
MeSH term(s)	Humans ; Methylation ; Fibrosis ; Epigenesis, Genetic ; Collagen/metabolism ; Fibroblasts ; Methyltransferases/metabolism
Chemical Substances	Collagen (9007-34-5) ; METTL3 protein, human (EC 2.1.1.62) ; Methyltransferases (EC 2.1.1.-)
Language	English
Publishing date	2023-08-29
Publishing country	United Arab Emirates
Document type	Review ; Journal Article
ZDB-ID	2064823-6
ISSN	1873-4294 ; 1568-0266
ISSN (online)	1873-4294
ISSN	1568-0266
DOI	10.2174/1568026623666230825144949
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Article ; Online: Mechanisms of the Quorum Sensing Systems of Pseudomonas Aeruginosa: Host and Bacteria.

Flores-Percino, Diana / Osorio-Llanes, Estefanie / Sepulveda, Yanireth / Castellar-López, Jairo / Belón Madera, Ricardo / Rosales, Wendy / Meléndez, Carlos Mario / Mendoza-Torres, Evelyn

Current medicinal chemistry

2023

Abstract: Quorum-sensing is a communication mechanism between bacteria with the ability to activate signaling pathways in the bacterium and in the host cells. Pseudomonas aeruginosa is a pathogen with high clinical relevance due to its vast virulence factors ... ...

Abstract	Quorum-sensing is a communication mechanism between bacteria with the ability to activate signaling pathways in the bacterium and in the host cells. Pseudomonas aeruginosa is a pathogen with high clinical relevance due to its vast virulence factors repertory and wide antibiotic resistance mechanisms. Due to this, it has become a pathogen of interest for developing new antimicrobial agents in recent years. P. aeruginosa has three major QS systems that regulate a wide gene range linked with virulence factors, metabolic regulation, and environment adaption. Consequently, inhibiting this communication mechanism would be a strategy to prevent the pathologic progression of the infections caused by this bacterium. In this review, we aim to overview the current studies about the signaling mechanisms of the QS system of P. aeruginosa and its effects on this bacterium and the host.
Language	English
Publishing date	2023-08-21
Publishing country	United Arab Emirates
Document type	Journal Article
ZDB-ID	1319315-6
ISSN	1875-533X ; 0929-8673
ISSN (online)	1875-533X
ISSN	0929-8673
DOI	10.2174/0929867331666230821110440
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Zs.A 4432: Show issues

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Article: Novel Insights into the Cardioprotective Effects of the Peptides of the Counter-Regulatory Renin-Angiotensin System.

Gamiño-Gutiérrez, Janette Alejandra / Terán-Hernández, Ivana María / Castellar-Lopez, Jairo / Villamizar-Villamizar, Wendy / Osorio-Llanes, Estefanie / Palacios-Cruz, Mariali / Rosales, Wendy / Chang, Aileen Y / Díaz-Ariza, Luis Antonio / Ospino, María Clara / Mendoza-Torres, Evelyn

Biomedicines

2024 Volume 12, Issue 2

Abstract: Currently, cardiovascular diseases are a major contributor to morbidity and mortality worldwide, having a significant negative impact on both the economy and public health. The renin-angiotensin system contributes to a high spectrum of cardiovascular ... ...

Abstract	Currently, cardiovascular diseases are a major contributor to morbidity and mortality worldwide, having a significant negative impact on both the economy and public health. The renin-angiotensin system contributes to a high spectrum of cardiovascular disorders and is essential for maintaining normal cardiovascular homeostasis. Overactivation of the classical renin-angiotensin system is one of the most important pathophysiological mechanisms in the progression of cardiovascular diseases. The counter-regulatory renin-angiotensin system is an alternate pathway which favors the synthesis of different peptides, including Angiotensin-(1-7), Angiotensin-(1-9), and Alamandine. These peptides, via the angiotensin type 2 receptor (AT2R), MasR, and MrgD, initiate multiple downstream signaling pathways that culminate in the activation of various cardioprotective mechanisms, such as decreased cardiac fibrosis, decreased myocardial hypertrophy, vasodilation, decreased blood pressure, natriuresis, and nitric oxide synthesis. These cardioprotective effects position them as therapeutic alternatives for reducing the progression of cardiovascular diseases. This review aims to show the latest findings on the cardioprotective effects of the main peptides of the counter-regulatory renin-angiotensin system.
Language	English
Publishing date	2024-01-23
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines12020255
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Article: Effects of Metformin on Ischemia/Reperfusion Injury: New Evidence and Mechanisms.

Osorio-Llanes, Estefanie / Villamizar-Villamizar, Wendy / Ospino Guerra, María Clara / Díaz-Ariza, Luis Antonio / Castiblanco-Arroyave, Sara Camila / Medrano, Luz / Mengual, Daniela / Belón, Ricardo / Castellar-López, Jairo / Sepúlveda, Yanireth / Vásquez-Trincado, César / Chang, Aileen Y / Bolívar, Samir / Mendoza-Torres, Evelyn

Pharmaceuticals (Basel, Switzerland)

2023 Volume 16, Issue 8

Abstract: The search for new drugs with the potential to ensure therapeutic success in the treatment of cardiovascular diseases has become an essential pathway to follow for health organizations and committees around the world. In June 2021, the World Health ... ...

Abstract	The search for new drugs with the potential to ensure therapeutic success in the treatment of cardiovascular diseases has become an essential pathway to follow for health organizations and committees around the world. In June 2021, the World Health Organization listed cardiovascular diseases as one of the main causes of death worldwide, representing 32% of them. The most common is coronary artery disease, which causes the death of cardiomyocytes, the cells responsible for cardiac contractility, through ischemia and subsequent reperfusion, which leads to heart failure in the medium and short term. Metformin is one of the most-used drugs for the control of diabetes, which has shown effects beyond the control of hyperglycemia. Some of these effects are mediated by the regulation of cellular energy metabolism, inhibiting apoptosis, reduction of cell death through regulation of autophagy and reduction of mitochondrial dysfunction with further reduction of oxidative stress. This suggests that metformin may attenuate left ventricular dysfunction induced by myocardial ischemia; preclinical and clinical trials have shown promising results, particularly in the setting of acute myocardial infarction. This is a review of the molecular and pharmacological mechanisms of the cardioprotective effects of metformin during myocardial ischemia-reperfusion injury.
Language	English
Publishing date	2023-08-09
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2193542-7
ISSN	1424-8247
ISSN	1424-8247
DOI	10.3390/ph16081121
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Article ; Online: Potential of Angiotensin-(1-7) in COVID-19 Treatment.

Luna, Patricia / Fernanda Pérez, María / Castellar-Lopez, Jairo / Chang, Aileen / Montoya, Yuliet / Bustamante, John / Rosales-Rada, Wendy / Mendoza-Torres, Evelyn

Current protein & peptide science

2022 Volume 24, Issue 1, Page(s) 89–97

Abstract: The new coronavirus currently named SARS-CoV-2 was announced by the World Health Organization as the virus causing the COVID-19 pandemic. The pathogenesis of SARS-CoV-2 initiates upon contact of a structural spike protein with the angiotensin II- ... ...

Abstract	The new coronavirus currently named SARS-CoV-2 was announced by the World Health Organization as the virus causing the COVID-19 pandemic. The pathogenesis of SARS-CoV-2 initiates upon contact of a structural spike protein with the angiotensin II-converting enzyme receptor, leading to the induction of inflammatory mechanisms and progression to severe disease in some cases. Currently, studies have emerged linking COVID-19 with angiotensin-(1-7), demonstrating the potential of angiotensin-(1-7)/Mas Receptor axis induction to control disease severity due to its antiinflammatory, vasodilator, antioxidant, antiproliferative, anticoagulant, antiangiogenic and fibrosis inhibitory effects. The renin angiotensin-system peptide Angiotensin-(1-7) shows a high therapeutic potential for COVID-19 mainly because of its ability to counteract the adverse effects caused in various organs due to angiotensin II-converting enzyme blockade. In light of these factors, the use of convalescent plasma conjugated therapy and Ang (1-7) agonists for the treatment of COVID-19 patients could be recommended. The differential expression of ACE2 and the varied response to SARSCoV- 2 are thought to be connected. According to several investigations, ACE2 antibodies and pharmacological inhibitors might be used to prevent viral entry. Given its capacity to eliminate the virus while ensuring lung and cardiovascular protection by regulating the inflammatory response, angiotensin-( 1-7) is expected to be a safe choice. However, more clinical evidence is required to clarify the therapeutic usage of this peptide. The aim of this review article is to present an update of scientific data and clinical trials on the therapeutic potential of angiotensin-(1-7) in patients with COVID-19.
MeSH term(s)	Humans ; COVID-19 ; SARS-CoV-2/metabolism ; Angiotensin II/therapeutic use ; Angiotensin II/metabolism ; Angiotensin II/pharmacology ; Angiotensin-Converting Enzyme 2/metabolism ; Angiotensin-Converting Enzyme 2/pharmacology ; Pandemics ; COVID-19 Drug Treatment ; Angiotensin-Converting Enzyme Inhibitors/therapeutic use ; COVID-19 Serotherapy ; Peptidyl-Dipeptidase A/metabolism ; Renin-Angiotensin System
Chemical Substances	angiotensin I (1-7) (IJ3FUK8MOF) ; Angiotensin II (11128-99-7) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23) ; Angiotensin-Converting Enzyme Inhibitors ; Peptidyl-Dipeptidase A (EC 3.4.15.1)
Language	English
Publishing date	2022-12-01
Publishing country	United Arab Emirates
Document type	Review ; Journal Article
ZDB-ID	2045662-1
ISSN	1875-5550 ; 1389-2037
ISSN (online)	1875-5550
ISSN	1389-2037
DOI	10.2174/1389203724666221130140416
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Zs.A 5884: Show issues

Location:
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bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Recent Insights into COVID-19 in Children and Clinical Recommendations.

Castellar-López, Jairo / Villamizar-Villamizar, Wendy / Amaranto-Pallares, Aldo / Rosales-Rada, Wendy / De Los Angeles Vélez Verbel, Maria / Chang, Aileen / Jiménez, Franklin Torres / Mendoza-Torres, Evelyn

Current pediatric reviews

2021 Volume 18, Issue 2, Page(s) 121–137

Abstract: Pediatric coronavirus disease 2019 (COVID-19) and multisystem inflammatory syndrome in children (MIS-C) have been recognized in multiple countries globally. In this review, we provide recent insights into SARS-CoV-2 infection in children from ... ...

Abstract	Pediatric coronavirus disease 2019 (COVID-19) and multisystem inflammatory syndrome in children (MIS-C) have been recognized in multiple countries globally. In this review, we provide recent insights into SARS-CoV-2 infection in children from epidemiological, clinical, and laboratory perspectives, including reports on the disease course and therapy. We highlight key features of SARS-CoV-2 infection in children, the relationship between MIS-C and Kawasaki disease, and summarize treatment guidelines for COVID-19 in children from institutional protocols from Colombia, case reports, recommendations based on expert consensus, and official statements from organizations such as the World Health Organization (WHO), United States Center for Disease Control (CDC), Colombian Association of Infectious Diseases, and the Colombian Society of Pediatrics. Finally, we discuss gaps in research with suggestions for future research on the pathogenesis underlying pediatric COVID-19.
MeSH term(s)	COVID-19/complications ; Child ; Humans ; Mucocutaneous Lymph Node Syndrome/diagnosis ; Mucocutaneous Lymph Node Syndrome/epidemiology ; Mucocutaneous Lymph Node Syndrome/therapy ; SARS-CoV-2 ; Systemic Inflammatory Response Syndrome/diagnosis ; Systemic Inflammatory Response Syndrome/therapy ; United States
Language	English
Publishing date	2021-12-06
Publishing country	United Arab Emirates
Document type	Journal Article ; Review
ISSN	1875-6336
ISSN (online)	1875-6336
DOI	10.2174/1573396317666211206124347
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Cytokine and T cell responses in post-chikungunya viral arthritis: A cross-sectional study.

Chang, Aileen Y / Tritsch, Sarah R / Herrera Gomez, Carlos Andres / Encinales, Liliana / Cadena Bonfanti, Andres / Rosales, Wendy / Mendoza-Torres, Evelyn / Simmens, Samuel / Amdur, Richard L / Mores, Christopher N / Fierbaugh, Paige / Perez Hernandez, Carlos Alberto / Avendaño, Geraldine / Silvera, Paula Bruges / Crespo, Yerlenis Galvis / Jimenez, Alberto David Cabana / Martinez Zapata, Jennifer Carolina / Jimenez, Dennys / Osorio-Llanes, Estefanie /

Castellar-Lopez, Jairo / Suchowiecki, Karol / Martins, Karen / Gregory, Melissa / Zuluaga, Ivan / Proctor, Abigale / Hernández, Alfonso Sucerquia / Sierra-Carrero, Leandro / Colpas, Maria Villanueva / Hernandez, Juan Carlos Perez / Quast, Andres Alberto Figueroa / De Barros, Joaquin Andres Calderon / Mejía, José Forero / Ruiz, Johan Penagos / Boyle, David / Firestein, Gary S / Simon, Gary L

PloS one

2024 Volume 19, Issue 3, Page(s) e0299521

Abstract: Objective: To define the relationship between chronic chikungunya post-viral arthritis disease severity, cytokine response and T cell subsets in order to identify potential targets for therapy.: Methods: Participants with chikungunya arthritis were ... ...

Abstract	Objective: To define the relationship between chronic chikungunya post-viral arthritis disease severity, cytokine response and T cell subsets in order to identify potential targets for therapy. Methods: Participants with chikungunya arthritis were recruited from Colombia from 2019-2021. Arthritis disease severity was quantified using the Disease Activity Score-28 and an Arthritis-Flare Questionnaire adapted for chikungunya arthritis. Plasma cytokine concentrations (interleukin (IL)-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12p70, IL-13, interferon-γ and tumor necrosis factor (TNF)) were measured using a Meso Scale Diagnostics assay. Peripheral blood T cell subsets were measured using flow cytometry. Results: Among participants with chikungunya arthritis (N = 158), IL-2 levels and frequency of regulatory T cells (Tregs) were low. Increased arthritis disease activity was associated with higher levels of inflammatory cytokines (IL-6, TNF and CRP) and immunoregulatory cytokine IL-10 (p<0.05). Increased arthritis flare activity was associated with higher Treg frequencies (p<0.05) without affecting T effector (Teff) frequencies, Treg/Teff ratios and Treg subsets. Finally, elevated levels of IL-2 were correlated with increased Treg frequency, percent Tregs out of CD4+ T cells, and Treg subsets expressing immunosuppressive markers, while also correlating with an increased percent Teff out of live lymphocytes (p<0.05). Conclusion: Chikungunya arthritis is characterized by increased inflammatory cytokines and deficient IL-2 and Treg responses. Greater levels of IL-2 were associated with improved Treg numbers and immunosuppressive markers. Future research may consider targeting these pathways for therapy.
MeSH term(s)	Humans ; Cytokines/metabolism ; Interleukin-10/metabolism ; Cross-Sectional Studies ; Interleukin-2/metabolism ; Interleukin-6/metabolism ; Chikungunya Fever/complications ; T-Lymphocytes, Regulatory/metabolism ; CD4-Positive T-Lymphocytes/metabolism ; Tumor Necrosis Factor-alpha/metabolism ; Arthritis, Infectious ; Immunosuppressive Agents
Chemical Substances	Cytokines ; Interleukin-10 (130068-27-8) ; Interleukin-2 ; Interleukin-6 ; Tumor Necrosis Factor-alpha ; Immunosuppressive Agents
Language	English
Publishing date	2024-03-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0299521
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Article ; Online: Novel Strategies to Improve the Cardioprotective Effects of Cardioplegia.

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Article ; Online: The Role of METTL3 in the Progression of Cardiac Fibrosis.

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Article ; Online: Mechanisms of the Quorum Sensing Systems of Pseudomonas Aeruginosa: Host and Bacteria.

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Article: Novel Insights into the Cardioprotective Effects of the Peptides of the Counter-Regulatory Renin-Angiotensin System.

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Article: Effects of Metformin on Ischemia/Reperfusion Injury: New Evidence and Mechanisms.

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Article ; Online: Potential of Angiotensin-(1-7) in COVID-19 Treatment.

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Article ; Online: Recent Insights into COVID-19 in Children and Clinical Recommendations.

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Article ; Online: Cytokine and T cell responses in post-chikungunya viral arthritis: A cross-sectional study.

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