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Article ; Online: C5aR

Kim, Sae-Hae / Shim, Eun-Hyeon / Kim, Doo-Jin / Jang, Yong-Suk

NPJ vaccines

2023 Volume 8, Issue 1, Page(s) 120

Abstract: The mucosal delivery route is considered ideal for immunization. However, induction of antigen-specific mucosal immunity is difficult due to the tolerogenic environment. Therefore, developing an immunogenic mucosal dendritic cell (DC)-targeting strategy ... ...

Abstract	The mucosal delivery route is considered ideal for immunization. However, induction of antigen-specific mucosal immunity is difficult due to the tolerogenic environment. Therefore, developing an immunogenic mucosal dendritic cell (DC)-targeting strategy is required. Herein, we investigated the characteristics and immunogenic potential of Peyer's patch (PP) DCs as an oral vaccination-targeting strategy. Single-cell RNA sequencing analysis of the PP DCs showed that complement C5a receptor- and lysozyme-expressing DCs exhibit increased expression of genes related to chemotaxis. Administration of the Co1 peptide, a C5aR ligand, increased CD8
Language	English
Publishing date	2023-08-14
Publishing country	England
Document type	Journal Article
ISSN	2059-0105
ISSN (online)	2059-0105
DOI	10.1038/s41541-023-00720-z
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Recent Insights into Cellular Crosstalk in Respiratory and Gastrointestinal Mucosal Immune Systems.

Kim, Sae-Hae / Jang, Yong-Suk

Immune network

2020 Volume 20, Issue 6, Page(s) e44

Abstract: The human body is continuously threatened by pathogens, and the immune system must maintain a balance between fighting infection and becoming over-activated. Mucosal surfaces cover several anatomically diverse organs throughout the body, such as the ... ...

Abstract	The human body is continuously threatened by pathogens, and the immune system must maintain a balance between fighting infection and becoming over-activated. Mucosal surfaces cover several anatomically diverse organs throughout the body, such as the respiratory and gastrointestinal tracts, and are directly exposed to the external environment. Various pathogens invade the body through mucosal surfaces, making the mucosa the frontline of immune defense. The immune systems of various mucosal tissues display distinctive features that reflect the tissues' anatomical and functional characteristics. This review discusses the cellular components that constitute the respiratory and gastrointestinal tracts; in particular, it highlights the complex interactions between epithelial and immune cells to induce Ag-specific immune responses in the lung and gut. This information on mucosal immunity may facilitate understanding of the defense mechanisms against infectious agents that invade mucosal surfaces, such as severe acute respiratory syndrome coronavirus 2, and provide insight into effective vaccine development.
Language	English
Publishing date	2020-11-13
Publishing country	Korea (South)
Document type	Journal Article ; Review
ZDB-ID	2536191-0
ISSN	2092-6685 ; 1598-2629
ISSN (online)	2092-6685
ISSN	1598-2629
DOI	10.4110/in.2020.20.e44
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Article ; Online: Complement C5a promotes antigen cross-presentation by Peyer's patch monocyte-derived dendritic cells and drives a protective CD8

Kim, Sae-Hae / Cho, Byeol-Hee / Kim, Kwang Soon / Jang, Yong-Suk

Cell reports

2021 Volume 35, Issue 2, Page(s) 108995

Abstract: The complement fragment C5a is closely associated with adaptive immune induction in the mucosa. However, the mechanisms that control ... ...

Abstract	The complement fragment C5a is closely associated with adaptive immune induction in the mucosa. However, the mechanisms that control CD8
MeSH term(s)	Adaptive Immunity ; Animals ; Antigen Presentation ; Complement C5a/genetics ; Complement C5a/immunology ; Complement C5a/pharmacology ; Cross-Priming ; Dendritic Cells/drug effects ; Dendritic Cells/immunology ; Dendritic Cells/microbiology ; Female ; Gene Expression Profiling ; Gene Expression Regulation ; Immunity, Mucosal ; Intestinal Mucosa/drug effects ; Intestinal Mucosa/immunology ; Intestinal Mucosa/microbiology ; Listeria monocytogenes/immunology ; Listeria monocytogenes/pathogenicity ; Macrophages/drug effects ; Macrophages/immunology ; Macrophages/microbiology ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Monocytes/drug effects ; Monocytes/immunology ; Monocytes/microbiology ; Muramidase/genetics ; Muramidase/immunology ; Peyer's Patches/drug effects ; Peyer's Patches/immunology ; Peyer's Patches/microbiology ; Reactive Oxygen Species/immunology ; Reactive Oxygen Species/metabolism ; Receptor, Anaphylatoxin C5a/genetics ; Receptor, Anaphylatoxin C5a/immunology ; Single-Cell Analysis ; T-Lymphocytes, Cytotoxic/drug effects ; T-Lymphocytes, Cytotoxic/immunology ; T-Lymphocytes, Cytotoxic/microbiology
Chemical Substances	Reactive Oxygen Species ; Receptor, Anaphylatoxin C5a ; Complement C5a (80295-54-1) ; Muramidase (EC 3.2.1.17)
Language	English
Publishing date	2021-04-13
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2649101-1
ISSN	2211-1247 ; 2211-1247
ISSN (online)	2211-1247
ISSN	2211-1247
DOI	10.1016/j.celrep.2021.108995
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Article: Yersinia enterocolitica

Kim, Sae-Hae / Jang, Yong-Suk

Immune network

2017 Volume 17, Issue 4, Page(s) 228–236

Abstract: In the intestinal mucosal surface, microfold cells (M cells) are the representative gateway for the uptake of luminal antigens. At the same time, M cells are the primary infection site for pathogens invading mucosal surface for their infection. Although ... ...

Abstract	In the intestinal mucosal surface, microfold cells (M cells) are the representative gateway for the uptake of luminal antigens. At the same time, M cells are the primary infection site for pathogens invading mucosal surface for their infection. Although it is well recognized that many mucosal pathogens exploit the M cells for their infection, the mechanism to infect M cells utilized by pathogens is not clearly understood yet. In this study, we found that M cells expressing complement 5a (C5a) receptor (C5aR) also express Toll-like receptor (TLR) 1/2 and TLR4. Infection of
Language	English
Publishing date	2017-08-10
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2536191-0
ISSN	2092-6685 ; 1598-2629
ISSN (online)	2092-6685
ISSN	1598-2629
DOI	10.4110/in.2017.17.4.228
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Article: The development of mucosal vaccines for both mucosal and systemic immune induction and the roles played by adjuvants.

Kim, Sae-Hae / Jang, Yong-Suk

Clinical and experimental vaccine research

2017 Volume 6, Issue 1, Page(s) 15–21

Abstract: Vaccination is the most successful immunological practice that improves the quality of human life and health. Vaccine materials include antigens of pathogens and adjuvants potentiating the effectiveness of vaccination. Vaccines are categorized using ... ...

Abstract	Vaccination is the most successful immunological practice that improves the quality of human life and health. Vaccine materials include antigens of pathogens and adjuvants potentiating the effectiveness of vaccination. Vaccines are categorized using various criteria, including the vaccination material used and the method of administration. Traditionally, vaccines have been injected via needles. However, given that most pathogens first infect mucosal surfaces, there is increasing interest in the establishment of protective mucosal immunity, achieved by vaccination via mucosal routes. This review summarizes recent developments in mucosal vaccines and their associated adjuvants.
Language	English
Publishing date	2017-01-25
Publishing country	Korea (South)
Document type	Journal Article ; Review
ZDB-ID	2684652-4
ISSN	2287-366X ; 2287-3651
ISSN (online)	2287-366X
ISSN	2287-3651
DOI	10.7774/cevr.2017.6.1.15
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Article ; Online: Complement C5a promotes antigen cross-presentation by Peyer’s patch monocyte-derived dendritic cells and drives a protective CD8+ T cell response

Sae-Hae Kim / Byeol-Hee Cho / Kwang Soon Kim / Yong-Suk Jang

Cell Reports, Vol 35, Iss 2, Pp 108995- (2021)

2021

Abstract: Summary: The complement fragment C5a is closely associated with adaptive immune induction in the mucosa. However, the mechanisms that control CD8+ T cell responses by C5a have not been extensively explored. This study reveals that C5/C5a in the Peyer’s ... ...

Abstract	Summary: The complement fragment C5a is closely associated with adaptive immune induction in the mucosa. However, the mechanisms that control CD8+ T cell responses by C5a have not been extensively explored. This study reveals that C5/C5a in the Peyer’s patch (PP) subepithelial dome increases upon oral Listeria infection. We hypothesize that C5aR+ PP cells play an important role in the induction of antigen-specific T cell immunity. Using single-cell RNA sequencing, we identify C5aR- and lysozyme-expressing dendritic cells (C5aR+ LysoDCs) in PP and examine their role in CD8+ T cell immune induction. Stimulation of C5aR+ LysoDCs by C5a increases reactive oxygen species levels, leading to efficient antigen cross-presentation, which elicits an antigen-specific CD8+ T cell response. In C5-deficient mice, oral co-administration of C5a and Listeria enhances Listeria-specific cytotoxic T cell levels. Collectively, these findings suggest a role of the complement system in intestinal T cell immunity.
Keywords	C5a receptor ; CD8+ T cell ; complement C5a ; cross-presentation ; dendritic cells ; Peyer’s patch ; Biology (General) ; QH301-705.5
Subject code	570
Language	English
Publishing date	2021-04-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: N-terminal Domain of the Spike Protein of Porcine Epidemic Diarrhea Virus as a New Candidate Molecule for a Mucosal Vaccine.

Kim, Sae-Hae / Cho, Byeol-Hee / Lee, Kyung-Yeol / Jang, Yong-Suk

Immune network

2018 Volume 18, Issue 3, Page(s) e21

Abstract: Porcine epidemic diarrhea virus (PEDV) is a contagious coronavirus infecting pigs that leads to significant economic losses in the swine industry. Given that PEDV infection occurs in gut epithelial cells mainly via the fecal-oral route, induction of PEDV- ...

Abstract	Porcine epidemic diarrhea virus (PEDV) is a contagious coronavirus infecting pigs that leads to significant economic losses in the swine industry. Given that PEDV infection occurs in gut epithelial cells mainly via the fecal-oral route, induction of PEDV-specific immune responses in the mucosal compartment is required for protective immunity against viral infection. However, an effective mucosal vaccine against the currently prevalent PEDV strain is not available. In this study, we demonstrated that the N-terminal domain (NTD) of the spike (S) protein of PEDV represents a new vaccine candidate molecule to be applied via the mucosal route. We first established an
Keywords	covid19
Language	English
Publishing date	2018-06-15
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2536191-0
ISSN	2092-6685 ; 1598-2629
ISSN (online)	2092-6685
ISSN	1598-2629
DOI	10.4110/in.2018.18.e21
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Article ; Online: C5a receptor targeting of partial non-structural protein 3 of dengue virus promotes antigen-specific IFN-γ-producing T-cell responses in a mucosal dengue vaccine model.

Kim, Sae-Hae / Kim, Yu Na / Kim, Ju / Jang, Yong-Suk

Cellular immunology

2018 Volume 325, Page(s) 41–47

Abstract: Mucosal vaccination is an ideal strategy to induce protective immunity in both mucosal and parenteral areas. Successful induction of an antigen-specific immune response via mucosal administration essentially requires the effective delivery of antigen ... ...

Abstract	Mucosal vaccination is an ideal strategy to induce protective immunity in both mucosal and parenteral areas. Successful induction of an antigen-specific immune response via mucosal administration essentially requires the effective delivery of antigen into a mucosal immune inductive site, which depends on antigen delivery into M cells. We previously reported that M cells specifically express C5aR, and antigen targeting to C5aR by using specific ligands, including Co1 peptide, promotes the antigen-specific immune response in both mucosal and systemic immune compartments. In this study, we found that application of the Co1 peptide to dengue virus antigen containing CD8 T cell epitopes effectively induced an antigen-specific IFN-γ-producing CD8
MeSH term(s)	Animals ; Antigens ; Antigens, Viral/immunology ; CD8-Positive T-Lymphocytes/immunology ; Dengue Vaccines/metabolism ; Dengue Virus/metabolism ; Disease Models, Animal ; Immunity, Mucosal/immunology ; Mice ; Mice, Inbred BALB C ; Mucous Membrane/immunology ; Receptor, Anaphylatoxin C5a/metabolism ; Vaccination ; Viral Nonstructural Proteins/immunology ; Viral Nonstructural Proteins/metabolism
Chemical Substances	Antigens ; Antigens, Viral ; Dengue Vaccines ; Receptor, Anaphylatoxin C5a ; Viral Nonstructural Proteins
Language	English
Publishing date	2018-02-15
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80094-6
ISSN	1090-2163 ; 0008-8749
ISSN (online)	1090-2163
ISSN	0008-8749
DOI	10.1016/j.cellimm.2018.01.016
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Zs.A 417: Show issues

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Article ; Online: Antigen targeting to M cells for enhancing the efficacy of mucosal vaccines.

Kim, Sae-Hae / Jang, Yong-Suk

Experimental & molecular medicine

2014 Volume 46, Page(s) e85

Abstract: Vaccination is one of the most successful applications of immunology and for a long time has depended on parenteral administration protocols. However, recent studies have pointed to the promise of mucosal vaccination because of its ease, economy and ... ...

Abstract	Vaccination is one of the most successful applications of immunology and for a long time has depended on parenteral administration protocols. However, recent studies have pointed to the promise of mucosal vaccination because of its ease, economy and efficiency in inducing an immune response not only systemically, but also in the mucosal compartment where many pathogenic infections are initiated. However, successful mucosal vaccination requires the help of an adjuvant for the efficient delivery of vaccine material into the mucosa and the breaking of the tolerogenic environment, especially in oral mucosal immunization. Given that M cells are the main gateway to take up luminal antigens and initiate antigen-specific immune responses, understanding the role and characteristics of M cells is crucial for the development of successful mucosal vaccines. Especially, particular interest has been focused on the regulation of the tolerogenic mucosal microenvironment and the introduction of the luminal antigen into the lymphoid organ by exploiting the molecules of M cells. Here, we review the characteristics of M cells and the immune regulatory factors in mucosa that can be exploited for mucosal vaccine delivery and mucosal immune regulation.
MeSH term(s)	Administration, Oral ; Animals ; Antigens, Bacterial/immunology ; Antigens, Viral/immunology ; Bacterial Vaccines/administration & dosage ; Bacterial Vaccines/immunology ; Humans ; Immunity, Mucosal ; Intestinal Mucosa/cytology ; Intestinal Mucosa/immunology ; Peyer's Patches/cytology ; Peyer's Patches/immunology ; Viral Vaccines/administration & dosage ; Viral Vaccines/immunology
Chemical Substances	Antigens, Bacterial ; Antigens, Viral ; Bacterial Vaccines ; Viral Vaccines
Language	English
Publishing date	2014-03-14
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1328915-9
ISSN	2092-6413 ; 1226-3613 ; 0378-8512
ISSN (online)	2092-6413
ISSN	1226-3613 ; 0378-8512
DOI	10.1038/emm.2013.165
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Zs.A 4775: Show issues

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Article ; Online: Cutting Edge: LL-37-Mediated Formyl Peptide Receptor-2 Signaling in Follicular Dendritic Cells Contributes to B Cell Activation in Peyer's Patch Germinal Centers.

Kim, Sae-Hae / Kim, Yu Na / Jang, Yong-Suk

Journal of immunology (Baltimore, Md. : 1950)

2016 Volume 198, Issue 2, Page(s) 629–633

Abstract: Peyer's patches (PPs) are the major mucosal immune-inductive site, and germinal centers (GCs) in PPs determine the quality of the Abs produced. PP GCs are continuously induced by the gut microbiota, and their maintenance contributes to the induction of ... ...

Abstract	Peyer's patches (PPs) are the major mucosal immune-inductive site, and germinal centers (GCs) in PPs determine the quality of the Abs produced. PP GCs are continuously induced by the gut microbiota, and their maintenance contributes to the induction of strong IgA responses to Ags. In this study, we investigated the role of formyl peptide receptor (FPR)-mediated signaling in the maintenance of PP GCs, because FPRs recognize the microbiota and initiate an innate immune response by chemotaxis. We found that follicular dendritic cells (FDCs), a key organizer of B cell follicles and GCs in mucosal immunity, express Fpr2. Additionally, Fpr2-mediated signaling in PP FDCs promoted Cxcl13 and B cell activating factor expression, as well as B cell proliferation and activation. Therefore, we suggest that Fpr2-mediated signaling in FDCs plays a key role in GC maintenance in PPs and results in an Ag-specific IgA response in the gut mucosal immune compartment.
MeSH term(s)	Animals ; Antimicrobial Cationic Peptides/immunology ; B-Lymphocytes/immunology ; Dendritic Cells, Follicular/immunology ; Flow Cytometry ; Fluorescent Antibody Technique ; Germinal Center/immunology ; Immunity, Mucosal/immunology ; Lymphocyte Activation/immunology ; Mice ; Mice, Inbred BALB C ; Peyer's Patches/immunology ; Real-Time Polymerase Chain Reaction ; Receptors, Formyl Peptide/immunology ; Signal Transduction/immunology
Chemical Substances	Antimicrobial Cationic Peptides ; Receptors, Formyl Peptide ; formyl peptide receptor 2, mouse ; ropocamptide (3DD771JO2H)
Language	English
Publishing date	2016-12-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	3056-9
ISSN	1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
ISSN (online)	1550-6606
ISSN	0022-1767 ; 1048-3233 ; 1047-7381
DOI	10.4049/jimmunol.1600886
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