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Article ; Online: A Novel Framework for Epileptic Seizure Detection Using Electroencephalogram Signals Based on the Bat Feature Selection Algorithm.

Pouryosef, Mahrad / Abedini-Nassab, Roozbeh / Akrami, Seyed Mohammad Reza

2024 Volume 541, Page(s) 35–49

Abstract: The precise electroencephalogram (EEG) signal classification with the highest possible accuracy is a key goal in the brain-computer interface (BCI). Considering the complexity and nonstationary nature of the EEG signals, there is an urgent need for ... ...

Abstract	The precise electroencephalogram (EEG) signal classification with the highest possible accuracy is a key goal in the brain-computer interface (BCI). Considering the complexity and nonstationary nature of the EEG signals, there is an urgent need for effective feature extraction and data mining techniques. Here, we introduce a novel pipeline based on Bat and genetic algorithms for feature construction and dimension reduction of EEG signals. After wavelet extraction and segmentation, the Bat algorithm identifies the most relevant features. We use these features and a genetic algorithm combined with a neural network method to automatically classify the segments of the epilepsy EEG signals. We also use available classification methods based on k-Nearest Neighbors or naïve Bayes for comparison purposes. The code distinguishes individual signals within various combinations of data obtained from healthy volunteers with open or closed eyes and patients suffering from epilepsy disorders during seizure-free periods or seizure activities. Compared to the previously introduced methods, our proposed framework demonstrates a superior balance of high accuracy and short runtime. The minimum achieved accuracies for balanced and unbalanced classes are 100% and 75.9%, respectively. This approach has the potential for direct applications in clinics, enabling accurate and rapid analysis of the epilepsy EEG signals obtained from patients.
MeSH term(s)	Humans ; Bayes Theorem ; Signal Processing, Computer-Assisted ; Epilepsy/diagnosis ; Seizures/diagnosis ; Algorithms ; Electroencephalography/methods
Language	English
Publishing date	2024-01-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	196739-3
ISSN	1873-7544 ; 0306-4522
ISSN (online)	1873-7544
ISSN	0306-4522
DOI	10.1016/j.neuroscience.2024.01.014
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Article: Controlled Transport of Magnetic Particles and Cells Using C-Shaped Magnetic Thin Films in Microfluidic Chips.

Abedini-Nassab, Roozbeh / Emamgholizadeh, Ali

Micromachines

2022 Volume 13, Issue 12

Abstract: Single-cell analysis is an emerging discipline that has shown a transformative impact in cell biology in the last decade. Progress in this field requires systems capable of accurately moving the cells and particles in a controlled manner. Here, we ... ...

Abstract	Single-cell analysis is an emerging discipline that has shown a transformative impact in cell biology in the last decade. Progress in this field requires systems capable of accurately moving the cells and particles in a controlled manner. Here, we present a microfluidic platform equipped with C-shaped magnetic thin films to precisely transport magnetic particles in a tri-axial rotating magnetic field. This innovative system, compared to the other rivals, offers numerous advantages. The magnetic particles repel each other to prevent undesired cluster formation. Many particles move synced with the external rotating magnetic field, which results in highly parallel controlled particle transport. We show that the particle transport in this system is analogous to electron transport and Ohm's law in electrical circuits. The proposed magnetic transport pattern is carefully studied using both simulations and experiments for various parameters, including the magnetic field characteristics, particle size, and gap size in the design. We demonstrate the appropriate transport of both magnetic beads and magnetized living cells. We also show a pilot mRNA-capturing experiment with barcode-carrying magnetic beads. The introduced chip offers fundamental potential applications in the fields of single-cell biology and bioengineering.
Language	English
Publishing date	2022-12-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2620864-7
ISSN	2072-666X
ISSN	2072-666X
DOI	10.3390/mi13122177
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Article ; Online: Single-Cell RNA Sequencing in Organ and Cell Transplantation.

Abedini-Nassab, Roozbeh / Taheri, Fatemeh / Emamgholizadeh, Ali / Naderi-Manesh, Hossein

Biosensors

2024 Volume 14, Issue 4

Abstract: Single-cell RNA sequencing is a high-throughput novel method that provides transcriptional profiling of individual cells within biological samples. This method typically uses microfluidics systems to uncover the complex intercellular communication ... ...

Abstract	Single-cell RNA sequencing is a high-throughput novel method that provides transcriptional profiling of individual cells within biological samples. This method typically uses microfluidics systems to uncover the complex intercellular communication networks and biological pathways buried within highly heterogeneous cell populations in tissues. One important application of this technology sits in the fields of organ and stem cell transplantation, where complications such as graft rejection and other post-transplantation life-threatening issues may occur. In this review, we first focus on research in which single-cell RNA sequencing is used to study the transcriptional profile of transplanted tissues. This technology enables the analysis of the donor and recipient cells and identifies cell types and states associated with transplant complications and pathologies. We also review the use of single-cell RNA sequencing in stem cell implantation. This method enables studying the heterogeneity of normal and pathological stem cells and the heterogeneity in cell populations. With their remarkably rapid pace, the single-cell RNA sequencing methodologies will potentially result in breakthroughs in clinical transplantation in the coming years.
MeSH term(s)	Humans ; Single-Cell Analysis ; Sequence Analysis, RNA ; Organ Transplantation ; Animals ; Cell Transplantation
Language	English
Publishing date	2024-04-11
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662125-3
ISSN	2079-6374 ; 2079-6374
ISSN (online)	2079-6374
ISSN	2079-6374
DOI	10.3390/bios14040189
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: High-throughput precise particle transport at single-particle resolution in a three-dimensional magnetic field for highly sensitive bio-detection.

Abedini-Nassab, Roozbeh / Shourabi, Reza

Scientific reports

2022 Volume 12, Issue 1, Page(s) 6380

Abstract: Precise manipulation of microparticles have fundamental applications in the fields of lab-on-a-chip and biomedical engineering. Here, for the first time, we propose a fully operational microfluidic chip equipped with thin magnetic films composed of ... ...

Abstract	Precise manipulation of microparticles have fundamental applications in the fields of lab-on-a-chip and biomedical engineering. Here, for the first time, we propose a fully operational microfluidic chip equipped with thin magnetic films composed of straight tracks and bends which precisely transports numerous single-particles in the size range of ~ 2.8-20 µm simultaneously, to certain points, synced with the general external three-axial magnetic field. The uniqueness of this design arises from the introduced vertical bias field that provides a repulsion force between the particles and prevents unwanted particle cluster formation, which is a challenge in devices operating in two-dimensional fields. Furthermore, the chip operates as an accurate sensor and detects low levels of proteins and DNA fragments, being captured by the ligand-functionalized magnetic beads, while lowering the background noise by excluding the unwanted bead pairs seen in the previous works. The image-processing detection method in this work allows detection at the single-pair resolution, increasing the sensitivity. The proposed device offers high-throughput particle transport and ultra-sensitive bio-detection in a highly parallel manner at single-particle resolution. It can also operate as a robust single-cell analysis platform for manipulating magnetized single-cells and assembling them in large arrays, with important applications in biology.
MeSH term(s)	Immunomagnetic Separation ; Lab-On-A-Chip Devices ; Magnetic Fields ; Magnetics ; Microfluidic Analytical Techniques ; Microfluidics
Language	English
Publishing date	2022-04-16
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-10122-1
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Synchronous control of magnetic particles and magnetized cells in a tri-axial magnetic field.

Abedini-Nassab, Roozbeh / Bahrami, Sajjad

Lab on a chip

2021 Volume 21, Issue 10, Page(s) 1998–2007

Abstract: Precise manipulation of single particles is one of the main goals in the lab-on-a-chip field. Here, we present a microfluidic platform with "T" and "I" shaped magnetic tracks on the substrate to transport magnetic particles and magnetized cells in a tri- ... ...

Abstract	Precise manipulation of single particles is one of the main goals in the lab-on-a-chip field. Here, we present a microfluidic platform with "T" and "I" shaped magnetic tracks on the substrate to transport magnetic particles and magnetized cells in a tri-axial time-varying magnetic field. The driving magnetic field is composed of a vertical field bias and an in-plane rotating field component, with the advantage of lowering the attraction tendency and cluster formation between the particles compared to the traditional magnetophoretic circuits. We demonstrate three fundamental achievements. First, all the particle movements are synced with the external rotating field to achieve precise control over individual particles. Second, single-particle and single living cell transport in a controlled fashion is achieved for a large number of them in parallel, without the need for a complicated control system to send signals to individual particles. We carefully study the proposed design and introduce proper operating parameters. Finally, in addition to moving the particles along straight tracks, transporting them using a ∼60° bend is demonstrated. The proposed chip has direct applications in the fields of lab-on-a-chip, single-cell biology, and drug screening, where precise control over single particles is needed.
MeSH term(s)	Lab-On-A-Chip Devices ; Magnetic Fields ; Magnetics ; Microfluidics
Language	English
Publishing date	2021-05-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2056646-3
ISSN	1473-0189 ; 1473-0197
ISSN (online)	1473-0189
ISSN	1473-0197
DOI	10.1039/d1lc00097g
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: High-throughput precise particle transport at single-particle resolution in a three-dimensional magnetic field for highly sensitive bio-detection

Roozbeh Abedini-Nassab / Reza Shourabi

Scientific Reports, Vol 12, Iss 1, Pp 1-

2022 Volume 15

Abstract: Abstract Precise manipulation of microparticles have fundamental applications in the fields of lab-on-a-chip and biomedical engineering. Here, for the first time, we propose a fully operational microfluidic chip equipped with thin magnetic films composed ...

Abstract	Abstract Precise manipulation of microparticles have fundamental applications in the fields of lab-on-a-chip and biomedical engineering. Here, for the first time, we propose a fully operational microfluidic chip equipped with thin magnetic films composed of straight tracks and bends which precisely transports numerous single-particles in the size range of ~ 2.8–20 µm simultaneously, to certain points, synced with the general external three-axial magnetic field. The uniqueness of this design arises from the introduced vertical bias field that provides a repulsion force between the particles and prevents unwanted particle cluster formation, which is a challenge in devices operating in two-dimensional fields. Furthermore, the chip operates as an accurate sensor and detects low levels of proteins and DNA fragments, being captured by the ligand-functionalized magnetic beads, while lowering the background noise by excluding the unwanted bead pairs seen in the previous works. The image-processing detection method in this work allows detection at the single-pair resolution, increasing the sensitivity. The proposed device offers high-throughput particle transport and ultra-sensitive bio-detection in a highly parallel manner at single-particle resolution. It can also operate as a robust single-cell analysis platform for manipulating magnetized single-cells and assembling them in large arrays, with important applications in biology.
Keywords	Medicine ; R ; Science ; Q
Subject code	620
Language	English
Publishing date	2022-04-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Magnetophoretic circuits: A review of device designs and implementation for precise single-cell manipulation.

Abedini-Nassab, Roozbeh / Sadeghidelouei, Negar / Shields Iv, C Wyatt

Analytica chimica acta

2023 Volume 1272, Page(s) 341425

Abstract: Lab-on-a-chip tools have played a pivotal role in advancing modern biology and medicine. A key goal in this field is to precisely transport single particles and cells to specific locations on a chip for quantitative analysis. To address this large and ... ...

Abstract	Lab-on-a-chip tools have played a pivotal role in advancing modern biology and medicine. A key goal in this field is to precisely transport single particles and cells to specific locations on a chip for quantitative analysis. To address this large and growing need, magnetophoretic circuits have been developed in the last decade to manipulate a large number of single bioparticles in a parallel and highly controlled manner. Inspired by electrical circuits, magnetophoretic circuits are composed of passive and active circuit elements to offer commensurate levels of control and automation for transporting individual bioparticles. These specifications make them unique compared to other technologies in addressing crucial bioanalytical applications and answering fundamental questions buried in highly heterogeneous cell populations. In this comprehensive review, we describe key theoretical considerations for manufacturing and simulating magnetophoretic circuits. We provide a detailed tutorial for operating magnetophoretic devices containing different circuit elements (e.g., conductors, diodes, capacitors, and transistors). Finally, we provide a critical comparison of the utility of these devices to other microchip-based platforms for cellular manipulation, and discuss how they may address unmet needs in single-cell biology and medicine.
MeSH term(s)	Lab-On-A-Chip Devices ; Automation ; Electricity ; Equipment Design
Language	English
Publishing date	2023-05-31
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	1483436-4
ISSN	1873-4324 ; 0003-2670
ISSN (online)	1873-4324
ISSN	0003-2670
DOI	10.1016/j.aca.2023.341425
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Magnetophoretic capacitors for storing single particles and magnetized cells in microfluidic devices.

Abedini-Nassab, Roozbeh / Aldaghi, Zahra / Dan, Yaping

Biomicrofluidics

2022 Volume 16, Issue 4, Page(s) 44110

Abstract: Precise positioning of magnetic particles and magnetized cells in lab-on-a-chip systems has attracted broad attention. Recently, drawing inspiration from electrical circuits, we have demonstrated a magnetic particle transport platform composed of ... ...

Abstract	Precise positioning of magnetic particles and magnetized cells in lab-on-a-chip systems has attracted broad attention. Recently, drawing inspiration from electrical circuits, we have demonstrated a magnetic particle transport platform composed of patterned magnetic thin films in a microfluidic environment, which accurately moves the particles and single cells to specific spots, called capacitors. However, we have made no prior attempts to optimize the capacitor geometry. Here, we carefully analyze various design parameters and their effect on capacitor operation. We run simulations based on finite element methods and stochastic numerical analysis using our semi-analytical model. We then perform the required experiments to study the loading efficiency of capacitors with different geometries for magnetic particles of multiple sizes. Our experimental results agree well with the design criteria we developed based on our simulation results. We also show the capability of designed capacitors in storing the magnetically labeled cells and illustrate using them in a pilot drug screening application. These results are directly applicable to the design of robust platforms capable of transporting and assembling a large number of single particles and single cells in arrays, which are useful in the emerging field of single-cell analysis.
Language	English
Publishing date	2022-08-16
Publishing country	United States
Document type	Journal Article
ISSN	1932-1058
ISSN	1932-1058
DOI	10.1063/5.0101907
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A novel magnetophoretic-based device for magnetometry and separation of single magnetic particles and magnetized cells.

Abedini-Nassab, Roozbeh / Ding, Xianting / Xie, Haiyang

Lab on a chip

2022 Volume 22, Issue 4, Page(s) 738–746

Abstract: The use of magnetic micro- and nanoparticles in medicine and biology is expanding. One important example is the transport of magnetic microparticles and magnetized cells in lab-on-a-chip systems. The magnetic susceptibility of the particles is a key ... ...

Abstract	The use of magnetic micro- and nanoparticles in medicine and biology is expanding. One important example is the transport of magnetic microparticles and magnetized cells in lab-on-a-chip systems. The magnetic susceptibility of the particles is a key factor in determining their response to the externally applied magnetic field. Typically, to measure this parameter, their magnetophoretic mobility is studied. However, the particle tracking system for accurately determining the traveled distance in a certain time may be too complicated. Here, we introduce a lithographically fabricated chip composed of an array of thin magnetic micro-disks for evaluating the magnetic susceptibility of numerous individual magnetic particles simultaneously. The proposed novel magnetometer works based on the phase change in the trajectory of microparticles circulating around the disks in a rotating in-plane magnetic field. We explain that the easily detectable transition between the "phase-locked" and the "phase-slipping" regimes and the frequency at which it happens are appropriate parameters for measuring the magnetic susceptibility of the magnetic particles at the single-particle level. We show that this high-throughput (
MeSH term(s)	Immunomagnetic Separation ; Magnetic Fields ; Magnetics ; Magnetometry ; Nanoparticles
Language	English
Publishing date	2022-02-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2056646-3
ISSN	1473-0189 ; 1473-0197
ISSN (online)	1473-0189
ISSN	1473-0197
DOI	10.1039/d1lc01104a
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Recent Patents and Advances on Nanotechnologies against Coronavirus.

Abedini-Nassab, Roozbeh / Mahdaviyan, Naeemeh

Recent patents on nanotechnology

2020 Volume 15, Issue 4, Page(s) 322–330

Abstract: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is one of the seven known coronaviruses infecting humans; HKU1, 229E, NL63, OC43, Acute Respiratory Syndrome Coronavirus (SARS-CoV), Middle East Respiratory Syndrome Coronavirus (MERS-CoV), and ...

Abstract	Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is one of the seven known coronaviruses infecting humans; HKU1, 229E, NL63, OC43, Acute Respiratory Syndrome Coronavirus (SARS-CoV), Middle East Respiratory Syndrome Coronavirus (MERS-CoV), and SARS-CoV-2, the last three of which can cause severe symptoms in patients. COVID-19, previously known as 2019 novel coronavirus, caused by SARS-CoV-2, was first reported in Wuhan, China, in late 2019, and quickly resulted in a major epidemic across the world. Although the origin of SARS-CoV-2 is not clear yet, genome sequencing results suggest that this is the third reported spillover of an animal coronavirus to humans, from 2002. The development of detection, therapeutic, and prevention strategies for COVID-19 is a fundamental task towards curing infected people and competing with the pandemic. Because of their similarities, scientists believe that treatment/ detection methods similar to what were used against the illnesses caused by SARS-CoV or MERS-CoV may be effective for curing/detecting COVID-19. Here, we review the recent nanotechnology techniques used for treating and testing SARS-CoV, MERS-CoV, and SARS-CoV-2, and potential therapeutic options for curing COVID-19. This patent summarizes the recent findings of advances on Nanotechnologies against Coronavirus.
MeSH term(s)	Animals ; COVID-19 ; Humans ; Nanotechnology ; Pandemics ; Patents as Topic ; SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-11-24
Publishing country	United Arab Emirates
Document type	Journal Article ; Review
ISSN	2212-4020
ISSN (online)	2212-4020
DOI	10.2174/1872210514666201110125536
Database	MEDical Literature Analysis and Retrieval System OnLINE

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