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Article ; Online: Recent Advances in the Development of Biosensors for Malaria Diagnosis.

Krampa, Francis D / Aniweh, Yaw / Kanyong, Prosper / Awandare, Gordon A

2020 Volume 20, Issue 3

Abstract: The impact of malaria on global health has continually prompted the need to develop more effective diagnostic strategies that could overcome deficiencies in accurate and early detection. In this review, we examine the various biosensor-based methods for ... ...

Abstract	The impact of malaria on global health has continually prompted the need to develop more effective diagnostic strategies that could overcome deficiencies in accurate and early detection. In this review, we examine the various biosensor-based methods for malaria diagnostic biomarkers, namely;
MeSH term(s)	Antigens, Protozoan/immunology ; Antigens, Protozoan/isolation & purification ; Biosensing Techniques ; Diagnostic Tests, Routine/methods ; Fructose-Bisphosphate Aldolase/immunology ; Fructose-Bisphosphate Aldolase/isolation & purification ; Glutamate Dehydrogenase/immunology ; Glutamate Dehydrogenase/isolation & purification ; Hemeproteins/immunology ; Hemeproteins/isolation & purification ; Humans ; L-Lactate Dehydrogenase/immunology ; L-Lactate Dehydrogenase/isolation & purification ; Malaria, Falciparum/diagnosis ; Malaria, Falciparum/genetics ; Malaria, Falciparum/parasitology ; Plasmodium falciparum/immunology ; Plasmodium falciparum/pathogenicity ; Protozoan Proteins/immunology ; Protozoan Proteins/isolation & purification
Chemical Substances	Antigens, Protozoan ; HRP-2 antigen, Plasmodium falciparum ; Hemeproteins ; Protozoan Proteins ; hemozoin (39404-00-7) ; L-Lactate Dehydrogenase (EC 1.1.1.27) ; Glutamate Dehydrogenase (EC 1.4.1.2) ; Fructose-Bisphosphate Aldolase (EC 4.1.2.13)
Language	English
Publishing date	2020-02-01
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s20030799
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Graphene nanoplatelet-based sensor for the detection of dopamine and N-acetyl-p-aminophenol in urine

Francis D. Krampa / Yaw Aniweh / Prosper Kanyong / Gordon A. Awandare

Arabian Journal of Chemistry, Vol 13, Iss 1, Pp 3218-

2020 Volume 3225

Abstract: This paper reports the development and application of a disposable sensor for the individual and simultaneous voltammetric determination of dopamine (DA) and N-acetyl-p-aminophenol (APAP). The sensor was fabricated by drop-coating graphene nanoplatelets ( ...

Abstract	This paper reports the development and application of a disposable sensor for the individual and simultaneous voltammetric determination of dopamine (DA) and N-acetyl-p-aminophenol (APAP). The sensor was fabricated by drop-coating graphene nanoplatelets (GNPs)-Nafion (Naf) nanocomposite onto the working area of a screen-printed electrode (SPE). The sensor, designated as GNPs-Naf/SPE, was characterized by scanning electron microscopy (SEM), Raman spectroscopy, electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV). Differential pulse voltammetry (DPV) was used to simultaneously analyze DA and APAP in their binary mixtures. It showed excellent selectivity and sensitivity toward both compounds with limit of detection of 0.13 µM and 0.25 µM (S/N = 3) for DA and APAP, respectively. The performance of the sensor was evaluated by analyzing the compounds in human urine samples, and the recoveries were found to be well over 97.0%. Keywords: Dual sensor, Nanocomposites, Graphene, Modified electrodes, Simultaneous electrochemical analysis
Keywords	Chemistry ; QD1-999
Subject code	620
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Polydopamine-functionalized graphene nanoplatelet smart conducting electrode for bio-sensing applications

Prosper Kanyong / Francis D. Krampa / Yaw Aniweh / Gordon A. Awandare

Arabian Journal of Chemistry, Vol 13, Iss 1, Pp 1669-

2020 Volume 1677

Abstract: The development of a novel polydopamine (PDA)-functionalized graphene nanoplatelets (GNPs)-based disposable sensor is described. The sensor was fabricated by drop-coating PDA@GNPs in polyethylene glycol (PEG) and poly(3,4-ethylenedioxythiophene (PEDOT): ... ...

Abstract	The development of a novel polydopamine (PDA)-functionalized graphene nanoplatelets (GNPs)-based disposable sensor is described. The sensor was fabricated by drop-coating PDA@GNPs in polyethylene glycol (PEG) and poly(3,4-ethylenedioxythiophene (PEDOT):poly(styrenesulfonate) (PSS) aqueous suspension onto the working area of a screen-printed electrode (SPE). The final sensor, designated as PDA@GNPs/PPP/SPE, was characterized by scanning electron microscopy (SEM), Raman spectroscopy, Faradaic electrochemical impedance spectroscopy (FEIS) and cyclic voltammetry (CV). Mediated detection of hydrogen peroxide (H2O2) via the redox properties of PDA was achieved. It showed excellent selectivity and sensitivity towards H2O2 with a limit of detection and sensitivity of 0.55 µM (S/N = 3) and 3.0 µA mM−1 cm−2, respectively. Thereafter, glucose oxidase (GOx) was immobilized onto the electrode to develop GOx/PDA@GNPs/PPP/SPE sensor. The glucose biosensor exhibited a limit of detection of 0.25 μM (S/N = 3) and a sensitivity of 0.51 μA μM−1 cm−2; thus, proving its potential suitability for bio-sensing applications. Keywords: Polyethylene glycol, Screen-printed electrodes, Bio-sensing, Mediated sensors, Thin films, Dopamine, Organocatalysts
Keywords	Chemistry ; QD1-999
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Ultrasensitive electrochemical genosensors for species-specific diagnosis of malaria.

Ansah, Felix / Krampa, Francis / Donkor, Jacob K / Owusu-Appiah, Caleb / Ashitei, Sarah / Kornu, Victor E / Danku, Reinhard K / Chirawurah, Jersley D / Awandare, Gordon A / Aniweh, Yaw / Kanyong, Prosper

Electrochimica acta

2022 Volume 429, Page(s) 140988

Abstract: The absence of reliable species-specific diagnostic tools for malaria at point-of-care (POC) remains a major setback towards effective disease management. This is partly due to the limited sensitivity and specificity of the current malaria POC diagnostic ...

Abstract	The absence of reliable species-specific diagnostic tools for malaria at point-of-care (POC) remains a major setback towards effective disease management. This is partly due to the limited sensitivity and specificity of the current malaria POC diagnostic kits especially in cases of low-density parasitaemia and mixed species infections. In this study, we describe the first label-free DNA-based genosensors based on electrochemical impedance spectroscopy (EIS) for species-specific detection of
Language	English
Publishing date	2022-10-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	1483548-4
ISSN	0013-4686
ISSN	0013-4686
DOI	10.1016/j.electacta.2022.140988
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Article: Recent Progress in the Development of Diagnostic Tests for Malaria.

Krampa, Francis D / Aniweh, Yaw / Awandare, Gordon A / Kanyong, Prosper

Diagnostics (Basel, Switzerland)

2017 Volume 7, Issue 3

Abstract: The impact of malaria on global health has continually prompted the need to develop effective diagnostic strategies. In malaria endemic regions, routine diagnosis is hampered by technical and infrastructural challenges to laboratories. These laboratories ...

Abstract	The impact of malaria on global health has continually prompted the need to develop effective diagnostic strategies. In malaria endemic regions, routine diagnosis is hampered by technical and infrastructural challenges to laboratories. These laboratories lack standard facilities, expertise or diagnostic supplies; thus, therapy is administered based on clinical or self-diagnosis. There is the need for accurate diagnosis of malaria due to the continuous increase in the cost of medication, and the emergence and spread of drug resistant strains. However, the widely utilized Giemsa-stained microscopy and immunochromatographic tests for malaria are liable to several drawbacks, including inadequate sensitivity and false-positive outcomes. Alternative methods that offer improvements in performance are either expensive, have longer turnaround time or require a level of expertise that makes them unsuitable for point-of-care (POC) applications. These gaps necessitate exploration of more efficient detection techniques with the potential of POC applications, especially in resource-limited settings. This minireview discusses some of the recent trends and new approaches that are seeking to improve the clinical diagnosis of malaria.
Language	English
Publishing date	2017-09-19
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics7030054
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Article ; Online: A Disposable Amperometric Sensor Based on High-Performance PEDOT:PSS/Ionic Liquid Nanocomposite Thin Film-Modified Screen-Printed Electrode for the Analysis of Catechol in Natural Water Samples.

Krampa, Francis D / Aniweh, Yaw / Awandare, Gordon A / Kanyong, Prosper

Sensors (Basel, Switzerland)

2017 Volume 17, Issue 8

Abstract: A conducting polymer-based composite material of poly(3,4-ethylenedioxythiophene) (PEDOT): poly(4-styrenesulfonate) (PSS) doped with different percentages of a room temperature ionic liquid (IL), 1-ethyl-3-methylimidazolium tetrafluoroborate ([EMIM][BF₄]) ...

Abstract	A conducting polymer-based composite material of poly(3,4-ethylenedioxythiophene) (PEDOT): poly(4-styrenesulfonate) (PSS) doped with different percentages of a room temperature ionic liquid (IL), 1-ethyl-3-methylimidazolium tetrafluoroborate ([EMIM][BF₄]), was prepared and a very small amount of the composite (2.0 µL) was drop-coated on the working area of a screen-printed carbon electrode (SPCE). The SPCE, modified with PEDOT:PSS/IL composite thin-film, was characterized by cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), scanning electron microscopy (SEM), profilometry and sessile contact angle measurements. The prepared PEDOT:PSS/IL composite thin-film exhibited a nano-porous microstructure and was found to be highly stable and conductive with enhanced electrocatalytic properties towards catechol, a priority pollutant. The linear working range for catechol was found to be 0.1 µM-330.0 µM with a sensitivity of 18.2 mA·mM·cm
Language	English
Publishing date	2017-07-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s17081716
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Enzyme-based amperometric galactose biosensors: a review.

Kanyong, Prosper / Krampa, Francis D / Aniweh, Yaw / Awandare, Gordon A

Mikrochimica acta

2017 Volume 184, Issue 10, Page(s) 3663–3671

Abstract: This review (with 35 references) summarizes the various strategies used in biosensors for galactose, and their analytical performance. A brief comparison of the enzyme immobilization methods employed and the analytical performance characteristics of a ... ...

Abstract	This review (with 35 references) summarizes the various strategies used in biosensors for galactose, and their analytical performance. A brief comparison of the enzyme immobilization methods employed and the analytical performance characteristics of a range of galactose biosensors are first summarized in tabular form and then described in detail. Selected examples have been included to demonstrate the various applications of these biosensors to real samples. Following an introduction into the field that covers the significance of sensing galactose in various fields, the review covers biosensors based on the use of galactose oxidase, with a discussion of methods for their immobilization (via cross-linking, adsorption, covalent bonding and entrapment). This is followed by a short section on biosensors based on the use of galactose dehydrogenase. The conclusion section summarizes the state of the art and addresses current challenges. Graphical abstractFabrication of a disposable screen-printed (a) electrochemical galactose biosensor (b) for real sample analysis and a dummy biosensor
MeSH term(s)	Biosensing Techniques/methods ; Electrochemical Techniques/methods ; Enzymes, Immobilized/chemistry ; Galactose/blood ; Galactose/chemistry ; Galactose Dehydrogenases/chemistry ; Galactose Oxidase/chemistry ; Humans
Chemical Substances	Enzymes, Immobilized ; Galactose Dehydrogenases (EC 1.1.1.-) ; galactose dehydrogenase (EC 1.1.1.48) ; Galactose Oxidase (EC 1.1.3.9) ; Galactose (X2RN3Q8DNE)
Language	English
Publishing date	2017-08-25
Publishing country	Austria
Document type	Journal Article ; Review
ZDB-ID	89-9
ISSN	1436-5073 ; 0026-3672
ISSN (online)	1436-5073
ISSN	0026-3672
DOI	10.1007/s00604-017-2465-z
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Article ; Online: Recent Progress in the Development of Diagnostic Tests for Malaria

Francis D. Krampa / Yaw Aniweh / Gordon A. Awandare / Prosper Kanyong

Diagnostics, Vol 7, Iss 3, p

2017 Volume 54

Abstract	The impact of malaria on global health has continually prompted the need to develop effective diagnostic strategies. In malaria endemic regions, routine diagnosis is hampered by technical and infrastructural challenges to laboratories. These laboratories lack standard facilities, expertise or diagnostic supplies; thus, therapy is administered based on clinical or self-diagnosis. There is the need for accurate diagnosis of malaria due to the continuous increase in the cost of medication, and the emergence and spread of drug resistant strains. However, the widely utilized Giemsa-stained microscopy and immunochromatographic tests for malaria are liable to several drawbacks, including inadequate sensitivity and false-positive outcomes. Alternative methods that offer improvements in performance are either expensive, have longer turnaround time or require a level of expertise that makes them unsuitable for point-of-care (POC) applications. These gaps necessitate exploration of more efficient detection techniques with the potential of POC applications, especially in resource-limited settings. This minireview discusses some of the recent trends and new approaches that are seeking to improve the clinical diagnosis of malaria.
Keywords	rapid diagnostic tests (RDT) ; biosensing ; lateral flow assays ; Plasmodium spp ; multiplex biomarker detection ; histidine-rich protein 2 (HRP2) ; lactate dehydrogenase (LDH) ; aldolase ; point-of-care tests (POCT) ; disposal medical devices ; infectious diseases ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2017-09-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Investigating the Influence of Temperature on the Kaolinite-Base Synthesis of Zeolite and Urease Immobilization for the Potential Fabrication of Electrochemical Urea Biosensors.

Anderson, David Ebo / Balapangu, Srinivasan / Fleischer, Heidimarie N A / Viade, Ruth A / Krampa, Francis D / Kanyong, Prosper / Awandare, Gordon A / Tiburu, Elvis K

Sensors (Basel, Switzerland)

2017 Volume 17, Issue 8

Abstract: Temperature-dependent zeolite synthesis has revealed a unique surface morphology, surface area and pore size which influence the immobilization of urease on gold electrode supports for biosensor fabrication. XRD characterization has identified zeolite X ( ...

Abstract	Temperature-dependent zeolite synthesis has revealed a unique surface morphology, surface area and pore size which influence the immobilization of urease on gold electrode supports for biosensor fabrication. XRD characterization has identified zeolite X (Na) at all crystallization temperatures tested. However, N₂ adsorption and desorption results showed a pore size and pore volume of zeolite X (Na) 60 °C, zeolite X (Na) 70 °C and zeolite X (Na) 90 °C to range from 1.92 nm to 2.45 nm and 0.012 cm³/g to 0.061 cm³/g, respectively, with no significant differences. The specific surface area of zeolite X (Na) at 60, 70 and 90 °C was 64 m²/g, 67 m²/g and 113 m²/g, respectively. The pore size, specific surface area and pore volumes of zeolite X (Na) 80 °C and zeolite X (Na) 100 °C were dramatically increased to 4.21 nm, 295 m²/g, 0.762 cm³/g and 4.92 nm, 389 m²/g, 0.837 cm³/g, in that order. The analytical performance of adsorbed urease on zeolite X (Na) surface was also investigated using cyclic voltammetry measurements, and the results showed distinct cathodic and anodic peaks by zeolite X (Na) 80 °C and zeolite X (Na) 100 °C. These zeolites' molar conductance was measured as a function of urea concentration and gave an average polynomial regression fit of 0.948. The findings in this study suggest that certain physicochemical properties, such as crystallization temperature and pH, are critical parameters for improving the morphological properties of zeolites synthesized from natural sources for various biomedical applications.
Language	English
Publishing date	2017--08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s17081831
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Article: Unrecognized human immunodeficiency virus infection and risk factors among elderly medical patients at the Korle Bu teaching hospital, Accra, Ghana.

Adjei, Andrew A / Agyemang, Seth / Krampa, Francis D / Abdul-Rahman, Mubarak / Ofei, Francis / Lartey, Margaret / Adiku, Theophilus K / Gyasi, Richard K / Tettey, Yao

Tropical diseases, travel medicine and vaccines

2016 Volume 2, Page(s) 18

Abstract: Background: The human immunodeficiency virus (HIV) infection usually infects persons in the reproductive age group (15-49 years), but elderly people are also susceptible. Many people in sub-Saharan Africa including Ghana believe that elderly people are ... ...

Abstract	Background: The human immunodeficiency virus (HIV) infection usually infects persons in the reproductive age group (15-49 years), but elderly people are also susceptible. Many people in sub-Saharan Africa including Ghana believe that elderly people are not at risk for HIV. Despite numerous reports of the high prevalence of HIV infection among the elderly worldwide, there are no from Ghana. This work determined the sero-prevalence of HIV infection and risk factors for its transmission among 1,100 hospitalized elderly people at the Korle Bu Teaching Hospital (KBTH), Accra, Ghana. Methods: Subjects voluntarily completed a risk-factor questionnaire and provided a blood specimen for HIV testing. Results: Of the study participants, 440 were male (mean age: 64 ± 10.55 years), and 660 were female (mean age: 63 ± 9.51 years). The overall HIV-1 sero-prevalence among the subjects was 4.18 % ( Conclusion: The results suggest high prevalence of HIV-1 among hospitalized elderly people at KBTH, recommending the need to include the elderly in HIV/AIDS testing, prevention, and control programmes. Trial registration: Trial registration number: MS-Et/M.9 - p4.10/2012-2013. Registered: 10th April, 2013.
Language	English
Publishing date	2016-09-02
Publishing country	England
Document type	Journal Article
ZDB-ID	2835327-4
ISSN	2055-0936
ISSN	2055-0936
DOI	10.1186/s40794-016-0034-9
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