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Article ; Online: Strategies for gaseous neuromodulator release in chemical neuroscience: Experimental approaches and translational validation.

Ali, Rafat / Sen, Shantanu / Hameed, Rohil / Nazir, Aamir / Verma, Sandeep

Journal of controlled release : official journal of the Controlled Release Society

2023 Volume 365, Page(s) 132–160

Abstract: Gasotransmitters are a group of short-lived gaseous signaling molecules displaying diverse biological functions depending upon their localized concentration. Nitric oxide (NO), hydrogen sulfide ( ... ...

Abstract	Gasotransmitters are a group of short-lived gaseous signaling molecules displaying diverse biological functions depending upon their localized concentration. Nitric oxide (NO), hydrogen sulfide (H
MeSH term(s)	Humans ; Gasotransmitters ; Gases ; Hydrogen Sulfide ; Nitric Oxide ; Carbon Monoxide
Chemical Substances	Gasotransmitters ; Gases ; Hydrogen Sulfide (YY9FVM7NSN) ; Nitric Oxide (31C4KY9ESH) ; Carbon Monoxide (7U1EE4V452)
Language	English
Publishing date	2023-11-22
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	632533-6
ISSN	1873-4995 ; 0168-3659
ISSN (online)	1873-4995
ISSN	0168-3659
DOI	10.1016/j.jconrel.2023.11.014
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Article: Prevalence of Long COVID Syndrome and its Association With Blood Group: A Cross-Sectional Study.

Butt, Muhammad Abdurrahman / Abdullah, Muhammad Areeb / Waseem, Mustafa / Ahmed, Hamna / Aamir, Amna / Asif, Rafia / Durrani, Hameed M

Cureus

2024 Volume 16, Issue 2, Page(s) e53966

Abstract: Background: The coronavirus disease 2019 (COVID-19) virus pandemic rapidly spread across the globe since 2020. It was characterized by a number of acute signs and symptoms. There were, however, some new-onset signs and symptoms labelled as "Long COVID". ...

Abstract	Background: The coronavirus disease 2019 (COVID-19) virus pandemic rapidly spread across the globe since 2020. It was characterized by a number of acute signs and symptoms. There were, however, some new-onset signs and symptoms labelled as "Long COVID". This study was conducted to study its prevalence and associations with blood group. Methods: A retrospective analysis was conducted in Islamabad for patients diagnosed with COVID-19 in 2020-2021. Information was collected through an online and physical questionnaire regarding personal demographics, symptoms during and after COVID-19, and blood group. The data was analyzed using IBM SPSS Statistics for Windows, Version 25.0 (Released 2017; IBM Corp., Armonk, New York, United States). Results: The study identified 196 participants out of which 48.5% were male and 51% were female, with a median age of 30. Most participants (62.2%) belonged to the Punjabi ethnicity. The mean BMI was 25.56 kg/m Conclusion: There was no association found between long COVID and ABO blood groups. Females were more likely than males to experience long COVID. Long COVID was found to be more likely to develop in those with perceived severe acute infection, highlighting the need for further research regarding aggressive care from the onset of COVID-19 infection.
Language	English
Publishing date	2024-02-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.53966
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Article ; Online: Reverse Takotsubo Cardiomyopathy Following A Case Of Suspected Meningoencephalitis And Literature Review.

Shams, Pirbhat / Ahmed, Intisar / Khan, Aamir Hameed

Journal of Ayub Medical College, Abbottabad : JAMC

2022 Volume 33, Issue 4, Page(s) 695–697

Abstract: Reverse Takotsubo cardiomyopathy is a rare variant of stress cardiomyopathy. A 22-year-old male presented with altered mentation and fever. He was intubated due to low Glasgow Coma Scale. CT head plain showed diffuse cerebral oedema. Patient had raised ... ...

Abstract	Reverse Takotsubo cardiomyopathy is a rare variant of stress cardiomyopathy. A 22-year-old male presented with altered mentation and fever. He was intubated due to low Glasgow Coma Scale. CT head plain showed diffuse cerebral oedema. Patient had raised troponin-I and echocardiogram revealed reduced ejection fraction with hyperdynamic apical segments and akinetic basal to mid segments suggestive of reverse Takotsubo cardiomyopathy (rTCM). Association of rTCM with neuropsychiatric disorders such as intracranial/epidural haemorrhages and anorexia nervosa has been defined. However, it is rare to have rTCM with meningoencephalitis.
MeSH term(s)	Adult ; Echocardiography ; Humans ; Male ; Meningoencephalitis/diagnosis ; Takotsubo Cardiomyopathy/diagnosis ; Takotsubo Cardiomyopathy/etiology ; Young Adult
Language	English
Publishing date	2022-02-03
Publishing country	Pakistan
Document type	Case Reports ; Review
ZDB-ID	2192473-9
ISSN	1819-2718 ; 1025-9589
ISSN (online)	1819-2718
ISSN	1025-9589
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Article ; Online: A European update on transcatheter aortic valve implantation (TAVI) in the COVID era.

Antony, Ishan / Mehari Abraha, Hyab / Hameed, Aamir / Conway, Claire

Journal of anatomy

2022 Volume 242, Issue 1, Page(s) 50–63

Abstract: Minimally invasive approaches for aortic valve replacement are now at the forefront of pathological aortic valve treatment. New trials show comparability of these devices to existing therapies, not only in high-risk surgical cohorts but also in low-risk ... ...

Abstract	Minimally invasive approaches for aortic valve replacement are now at the forefront of pathological aortic valve treatment. New trials show comparability of these devices to existing therapies, not only in high-risk surgical cohorts but also in low-risk and intermediate-risk cohorts. This review provides vital clinical and anatomical background to aortic valvular disease treatment guidelines, while also providing an update on transcatheter aortic valve implantation (TAVI) devices in Europe, their interventional trials and associated complications.
MeSH term(s)	Humans ; Aortic Valve/surgery ; Aortic Valve Stenosis/surgery ; COVID-19 ; Transcatheter Aortic Valve Replacement ; Treatment Outcome
Language	English
Publishing date	2022-09-24
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2955-5
ISSN	1469-7580 ; 0021-8782
ISSN (online)	1469-7580
ISSN	0021-8782
DOI	10.1111/joa.13740
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Article ; Online: Interesting presentation of a broad complex tachycardia during the head up tilt table test.

Khan, Muhammad Taha / Hameed, Aamir / Saeed, Yawer

BMJ case reports

2021 Volume 14, Issue 10

Abstract: Broad complex tachycardia (BCT) during head up tilt test (HUTT) is infrequent. Electrophysiology Study (EPS) plays an important part in further differentiation of BCT. We present a case of BCT during HUTT in a patient presenting with presyncope which ... ...

Abstract	Broad complex tachycardia (BCT) during head up tilt test (HUTT) is infrequent. Electrophysiology Study (EPS) plays an important part in further differentiation of BCT. We present a case of BCT during HUTT in a patient presenting with presyncope which later on EPS with 3D mapping was diagnosed as ventricular tachycardia. This case highlights the unusual occurrence of BCT during HUTT, the differential diagnosis of BCT and the utility of EPS to reliably identify the type and origin of BCT.
MeSH term(s)	Arrhythmias, Cardiac ; Electrocardiography ; Humans ; Syncope/diagnosis ; Syncope/etiology ; Tachycardia, Ventricular/diagnosis ; Tilt-Table Test
Language	English
Publishing date	2021-10-04
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	1757-790X
ISSN (online)	1757-790X
DOI	10.1136/bcr-2021-245083
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Article ; Online: Functional implications of NHR-210 enrichment in C. elegans cephalic sheath glia: insights into metabolic and mitochondrial disruptions in Parkinson's disease models.

Hameed, Rohil / Naseer, Anam / Saxena, Ankit / Akbar, Mahmood / Toppo, Pranoy / Sarkar, Arunabh / Shukla, Sanjeev K / Nazir, Aamir

Cellular and molecular life sciences : CMLS

2024 Volume 81, Issue 1, Page(s) 202

Abstract: Glial cells constitute nearly half of the mammalian nervous system's cellular composition. The glia in C. elegans perform majority of tasks comparable to those conducted by their mammalian equivalents. The cephalic sheath (CEPsh) glia, which are known to ...

Abstract	Glial cells constitute nearly half of the mammalian nervous system's cellular composition. The glia in C. elegans perform majority of tasks comparable to those conducted by their mammalian equivalents. The cephalic sheath (CEPsh) glia, which are known to be the counterparts of mammalian astrocytes, are enriched with two nuclear hormone receptors (NHRs)-NHR-210 and NHR-231. This unique enrichment makes the CEPsh glia and these NHRs intriguing subjects of study concerning neuronal health. We endeavored to assess the role of these NHRs in neurodegenerative diseases and related functional processes, using transgenic C. elegans expressing human alpha-synuclein. We employed RNAi-mediated silencing, followed by behavioural, functional, and metabolic profiling in relation to suppression of NHR-210 and 231. Our findings revealed that depleting nhr-210 changes dopamine-associated behaviour and mitochondrial function in human alpha synuclein-expressing strains NL5901 and UA44, through a putative target, pgp-9, a transmembrane transporter. Considering the alteration in mitochondrial function and the involvement of a transmembrane transporter, we performed metabolomics study via HR-MAS NMR spectroscopy. Remarkably, substantial modifications in ATP, betaine, lactate, and glycine levels were seen upon the absence of nhr-210. We also detected considerable changes in metabolic pathways such as phenylalanine, tyrosine, and tryptophan biosynthesis metabolism; glycine, serine, and threonine metabolism; as well as glyoxalate and dicarboxylate metabolism. In conclusion, the deficiency of the nuclear hormone receptor nhr-210 in alpha-synuclein expressing strain of C. elegans, results in altered mitochondrial function, coupled with alterations in vital metabolite levels. These findings underline the functional and physiological importance of nhr-210 enrichment in CEPsh glia.
MeSH term(s)	Animals ; Caenorhabditis elegans/metabolism ; Caenorhabditis elegans/genetics ; Mitochondria/metabolism ; Neuroglia/metabolism ; Parkinson Disease/metabolism ; Parkinson Disease/pathology ; Parkinson Disease/genetics ; Humans ; alpha-Synuclein/metabolism ; alpha-Synuclein/genetics ; Disease Models, Animal ; Caenorhabditis elegans Proteins/metabolism ; Caenorhabditis elegans Proteins/genetics ; Animals, Genetically Modified ; Receptors, Cytoplasmic and Nuclear/metabolism ; Receptors, Cytoplasmic and Nuclear/genetics ; Dopamine/metabolism ; Metabolomics ; RNA Interference
Chemical Substances	alpha-Synuclein ; Caenorhabditis elegans Proteins ; Receptors, Cytoplasmic and Nuclear ; Dopamine (VTD58H1Z2X)
Language	English
Publishing date	2024-05-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1358415-7
ISSN	1420-9071 ; 1420-682X
ISSN (online)	1420-9071
ISSN	1420-682X
DOI	10.1007/s00018-024-05179-2
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Article ; Online: Multiple checkpoints of protein clearance machinery are modulated by a common microRNA, miR-4813-3p, through its putative target genes: Studies employing transgenic C. elegans model.

Sarkar, Arunabh / Shamsuzzama / Kumar, Lalit / Hameed, Rohil / Nazir, Aamir

Biochimica et biophysica acta. Molecular cell research

2022 Volume 1869, Issue 12, Page(s) 119342

Abstract: In order to maintain cellular homeostasis and a healthy state, aberrant and aggregated proteins are to be recognized and rapidly cleared from cells. Parkinson's disease, known to be associated with multiple factors; presents with impaired clearance of ... ...

Abstract	In order to maintain cellular homeostasis and a healthy state, aberrant and aggregated proteins are to be recognized and rapidly cleared from cells. Parkinson's disease, known to be associated with multiple factors; presents with impaired clearance of aggregated alpha synuclein as a key factor. We endeavored to study microRNA molecules with potential role on regulating multiple checkpoints of protein quality control within cells. Carrying out global miRNA profiling in a transgenic C. elegans model that expresses human alpha synuclein, we identified novel miRNA, miR-4813-3p, as a significantly downregulated molecule. Further studying its putative downstream target genes, we were able to mechanistically characterize six genes gbf-1, vha-5, cup-5, cpd-2, acs-1 and C27A12.7, which relate to endpoints associated with alpha synuclein expression, oxidative stress, locomotory behavior, autophagy and apoptotic pathways. Our study reveals the novel role of miR-4813-3p and provides potential functional characterization of its putative target genes, in regulating the various pathways associated with PQC network. miR-4813-3p modulates ER<sup>UPR</sup>, MT<sup>UPR</sup>, autophagosome-lysosomal-pathway and the ubiquitin-proteasomal-system, making this molecule an interesting target for further studies towards therapeutically addressing multifactorial aspect of Parkinson's disease.
MeSH term(s)	Animals ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans/metabolism ; Caenorhabditis elegans Proteins/genetics ; Disease Models, Animal ; Humans ; Membrane Proteins ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Parkinson Disease/genetics ; Parkinson Disease/metabolism ; Ubiquitins ; alpha-Synuclein/genetics ; alpha-Synuclein/metabolism
Chemical Substances	CUP-5 protein, C elegans ; Caenorhabditis elegans Proteins ; Membrane Proteins ; MicroRNAs ; Ubiquitins ; alpha-Synuclein
Language	English
Publishing date	2022-08-20
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	60-7
ISSN	1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
ISSN (online)	1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650
ISSN	0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
DOI	10.1016/j.bbamcr.2022.119342
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Article ; Online: Home-based cardiac rehabilitation

Rubina Barolia / Laila Ladak / Adnan Yaqoob / Asif Hanif / Aamir Hameed Khan / Wajeeha Sahar

BMJ Open, Vol 13, Iss

development, implementation and outcome evaluation in patients with coronary artery diseases in Lahore, Pakistan – a mixed-methods study protocol

2023 Volume 6

Abstract: Introduction Cardiac rehabilitation (CR) is an important strategy to bring cardiac patients back to a normal life after a cardiac event. The benefits of CR as part of secondary prevention are widely known among people who have undergone myocardial ... ...

Abstract	Introduction Cardiac rehabilitation (CR) is an important strategy to bring cardiac patients back to a normal life after a cardiac event. The benefits of CR as part of secondary prevention are widely known among people who have undergone myocardial infarction or revascularisation. As evidenced by several systematic reviews and meta-analyses, home-based CR (HBCR) has similar or greater effects on health-related quality of life, health outcomes, physical activity, anxiety and unplanned visits to the emergency department as compared with centre-based CR. The purpose of this study is to develop a contextual HBCR intervention and evaluate its effects on quality of life, health behaviours, bio-physiological parameters and emergency hospital visits of patients with coronary artery diseases in Lahore, Pakistan.Methods and analysis This study will employ a mixed-method exploratory sequential research design. The researchers will invite 15–20 cardiac patients and 12–15 healthcare providers for semi-structured interviews in the qualitative phase of the study. Once the intervention is developed and validated through the qualitative phase, the outcomes will be evaluated through a single-blinded randomised control trial in the quantitative phase. A total of 118 patients with acute coronary syndrome will be recruited through a screening checklist and randomly allocated into the control and intervention groups (59 patients in each group). The inductive coding approach will be used for the thematic analysis of qualitative data, whereas the quantitative data will be analysed through descriptive and inferential statistics using SPSS to see the difference within the groups, between groups and between three intervals.Ethics and dissemination The Ethical Review Committee of Aga Khan University and Mayo Hospital Lahore under the registration number 2023-8282-24191 and No/75749MH have approved this study protocol, respectively. The results of this study will be disseminated to participating patients (in the Urdu language), healthcare ...
Keywords	Medicine ; R
Subject code	360
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	BMJ Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Multiple Actions of H

Ali, Rafat / Hameed, Rohil / Chauhan, Divya / Sen, Shantanu / Wahajuddin, Muhammad / Nazir, Aamir / Verma, Sandeep

ACS chemical neuroscience

2022 Volume 13, Issue 23, Page(s) 3378–3388

Abstract: Alzheimer's disease (AD) is a debilitating progressive neurodegenerative disorder characterized by the loss of cognitive function. A major challenge in treating this ailment fully is its multifactorial nature, as it is associated with effects like ... ...

Abstract	Alzheimer's disease (AD) is a debilitating progressive neurodegenerative disorder characterized by the loss of cognitive function. A major challenge in treating this ailment fully is its multifactorial nature, as it is associated with effects like deposition of Aβ plaques, oxidative distress, inflammation of neuronal cells, and low levels of the neurotransmitter acetylcholine (ACh). In the present work, we demonstrate the design, synthesis, and biological activity of peptide conjugates by coupling a H
MeSH term(s)	Humans ; Animals ; Amyloid beta-Peptides ; Caenorhabditis elegans
Chemical Substances	Amyloid beta-Peptides
Language	English
Publishing date	2022-11-09
Publishing country	United States
Document type	Journal Article
ISSN	1948-7193
ISSN (online)	1948-7193
DOI	10.1021/acschemneuro.2c00402
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Article ; Online: Sex disparity in left ventricular hypertrophy in South Asians with hypertension: influence of central obesity and high blood pressure.

Feng, Liang / Khan, Aamir Hameed / Jehan, Imtiaz / Samad, Zainab / Jafar, Tazeen H

Journal of human hypertension

2023 Volume 37, Issue 4, Page(s) 327–329

Abstract: Women have been reported to be at greater risk of left ventricular hypertrophy (LVH) than men in South Asia, but whether the sex disparity is affected by central obesity and blood pressure has not been well studied. We examined prospectively the ... ...

Abstract	Women have been reported to be at greater risk of left ventricular hypertrophy (LVH) than men in South Asia, but whether the sex disparity is affected by central obesity and blood pressure has not been well studied. We examined prospectively the interaction of sex with waist circumference and systolic blood pressure at baseline on LVH measured after a median of 8-year follow-up among 539 individuals with hypertension in Karachi, Pakistan, and found that the risk of LVH for women vs men increased with higher baseline waist circumference and systolic blood pressure. Our results underscore the urgency for public health programs to prevent obesity and control hypertension in women in South Asia.
MeSH term(s)	Male ; Humans ; Female ; Hypertrophy, Left Ventricular/epidemiology ; Hypertrophy, Left Ventricular/etiology ; Obesity, Abdominal/complications ; Obesity, Abdominal/epidemiology ; South Asian People ; Hypertension/epidemiology ; Obesity/complications ; Obesity/epidemiology ; Blood Pressure/physiology ; Risk Factors
Language	English
Publishing date	2023-02-18
Publishing country	England
Document type	Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	639472-3
ISSN	1476-5527 ; 0950-9240
ISSN (online)	1476-5527
ISSN	0950-9240
DOI	10.1038/s41371-023-00814-0
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