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Article: New records of rove beetles from the Province of Quebec, and additional provincial records in Canada (Coleoptera, Staphylinidae).

Bédard, Nicolas / Brunke, Adam / Bloin, Pierrick / Leclerc, Ludovic

2024 Volume 1196, Page(s) 303–329

Abstract: We newly report 25 provincial records of rove beetles (Coleoptera: Staphylinidae) from the province of Quebec from the following subfamilies: Steninae (1), Euaesthetinae (1), Omaliinae (2), Oxyporinae (1), Paederinae (1), Proteininae (1), Pselaphinae (2), ...

Abstract	We newly report 25 provincial records of rove beetles (Coleoptera: Staphylinidae) from the province of Quebec from the following subfamilies: Steninae (1), Euaesthetinae (1), Omaliinae (2), Oxyporinae (1), Paederinae (1), Proteininae (1), Pselaphinae (2), Scaphidiinae (2), Scydmaeninae (2), Staphylininae (11) and Tachyporinae (1). Among these, two species are also reported for the first time from Ontario, two from Nova Scotia, and five are new Canadian records. We also report the first supporting data for
Language	English
Publishing date	2024-04-01
Publishing country	Bulgaria
Document type	Journal Article
ZDB-ID	2445640-8
ISSN	1313-2970 ; 1313-2989
ISSN (online)	1313-2970
ISSN	1313-2989
DOI	10.3897/zookeys.1196.118698
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Article ; Online: Optimizing management for early-stage esophageal adenocarcinoma: longitudinal results from a multidisciplinary program.

Jogiat, Uzair M / Wilson, Hillary / Bédard, Alexandre / Blakely, Pam / Dang, Jerry / Sun, Warren / Karmali, Shahzeer / Bédard, Eric L R / Wong, Clarence

Surgical endoscopy

2023 Volume 37, Issue 10, Page(s) 7933–7939

Abstract: ... months in the endoscopic resection group (log-rank p = 0.93). The median RFS for the surgery group was ... 109.4 months compared to 63.3 months in the endoscopic resection group (log-rank p = 0.0127 ... p = 0.032), but equivalent OS (HR 1.03, 95% CI 0.46-2.32; p = 0.941), compared to patients ...

Abstract	Background: The management of early-stage esophageal cancer is nuanced. A multidisciplinary approach may optimize management through selection of candidates for surgical or endoscopic therapies. The objective of this research was to examine long-term outcomes of patients with early-stage esophageal cancer who undergo treatment with endoscopic resection or surgery. Methods: Data on patient demographics, co-morbidities, pathology results, OS and RFS were obtained for both the endoscopic resection group and esophagectomy group. Univariate analysis of OS and RFS were conducted using the Kaplan-Meier method with calculation of the log-rank test. Multivariate cox-proportional hazards models were created for OS and RFS using a hypothesis-driven approach. A multivariate logistic regression model was created to identify predictors of esophagectomy among patients undergoing initial endoscopic resection. Results: A total of 111 patients were included. The median OS for the surgery group was 67.0 months compared to 74.0 months in the endoscopic resection group (log-rank p = 0.93). The median RFS for the surgery group was 109.4 months compared to 63.3 months in the endoscopic resection group (log-rank p = 0.0127). On multivariable analysis, patients undergoing endoscopic resection had significantly worse RFS (HR 2.55, 95% CI 1.09-6.00; p = 0.032), but equivalent OS (HR 1.03, 95% CI 0.46-2.32; p = 0.941), compared to patients undergoing esophagectomy. High-grade disease (OR 5.43, 95% CI 1.13-26.10; p = 0.035) and submucosal involvement (OR 7.75, 95% CI 1.90-31.40; p = 0.004) were identified as significant predictors of proceeding to esophagectomy. Conclusions: Through a multidisciplinary approach, patients with early-stage esophageal cancer achieve excellent RFS and OS. Submucosal involvement and high-grade disease place patients at increased risk for local disease recurrence; these patients may undergo endoscopic resection safely if treated with a multidisciplinary approach incorporating endoscopic surveillance and surgical consultation. Further risk-stratification models may enable better patient selection and optimization of long-term outcomes.
MeSH term(s)	Humans ; Esophageal Neoplasms/pathology ; Adenocarcinoma/pathology ; Esophagoscopy/adverse effects ; Endoscopic Mucosal Resection/adverse effects ; Esophagectomy/methods ; Retrospective Studies ; Neoplasm Staging ; Treatment Outcome
Language	English
Publishing date	2023-07-11
Publishing country	Germany
Document type	Journal Article
ZDB-ID	639039-0
ISSN	1432-2218 ; 0930-2794
ISSN (online)	1432-2218
ISSN	0930-2794
DOI	10.1007/s00464-023-10250-3
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Article ; Online: CD38 genetic variation is associated with increased personal distress to an emotional stimulus.

Procyshyn, Tanya L / Leclerc Bédard, Laury-Ann / Crespi, Bernard J / Bartz, Jennifer A

Scientific reports

2024 Volume 14, Issue 1, Page(s) 2571

Abstract: ... responses were higher for the CD38 rs3796863 AA/AC group vs. the CC group (p = 0.03, η ...

Abstract	Genetic variation in CD38-a putative oxytocin pathway gene-has been linked to higher oxytocin levels, empathy, and sensitive parenting, but also to more negative interpersonal outcomes (e.g., alienation from friends and family, poorer romantic relationship quality). To reconcile these seemingly contradictory findings, we drew upon the idea that CD38 variation may heighten social-emotional sensitivity and, consequently, make individuals prone to negative emotions in distressing interpersonal situations. To test this hypothesis, we performed a secondary analysis of a dataset including participants' (n = 171; 94 females) empathic concern ("sympathetic") and distress-related ("anxious") responses to an emotional video. Distress responses were higher for the CD38 rs3796863 AA/AC group vs. the CC group (p = 0.03, η
MeSH term(s)	Female ; Humans ; Oxytocin/genetics ; Receptors, Oxytocin/genetics ; Polymorphism, Single Nucleotide ; Emotions/physiology ; Empathy
Chemical Substances	Oxytocin (50-56-6) ; Receptors, Oxytocin
Language	English
Publishing date	2024-01-31
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-53081-5
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Article ; Online: Changes in Sarcopenia Status Predict Survival Among Patients with Resectable Esophageal Cancer.

Jogiat, Uzair M / Baracos, Vickie / Turner, Simon R / Eurich, Dean / Filafilo, Heather / Rouhi, Armin / Bédard, Alexandre / Bédard, Eric L R

Annals of surgical oncology

2023 Volume 30, Issue 12, Page(s) 7412–7421

Abstract: ... 1.59-4.40; p < 0.001] and DFS (HR 1.80, 95% CI 1.03-3.13; p = 0.038). The net change ... in skeletal muscle index was associated with OS (HR 0.93, 95% CI 0.90-0.97; p < 0.001) and DFS (HR 0.94, 95% CI 0.91 ... 0.98; p = 0.001).: Conclusions: Patients who develop sarcopenia as a consequence ...

Abstract	Background: Sarcopenia is a predictor of survival in patients with esophageal cancer. The objective of this research was to obtain insight into how changes in sarcopenia influence survival in resectable esophageal cancer. Patients and methods: A retrospective cohort of patients with esophageal cancer undergoing tri-modality therapy was selected. Body composition parameters from the staging, post-neoadjuvant, and 1-year surveillance computed tomography (CT) scans were calculated. Overall survival (OS) and disease-free survival (DFS) were evaluated using the Kaplan-Meier method and log-rank test, as well as multivariable Cox-proportional hazards models. Results: Of 141 patients, 118 had images at all three timepoints. The median DFS and OS were 33.2 [95% confidence interval (CI) 19.1-73.7] and 34.5 (95% CI 23.1-57.6) months, respectively. Sarcopenia classified by the staging CT was present in 20 (17.0%) patients. This changed to 45 (38.1%) patients by the post-neoadjuvant scan, and 44 (37.3%) by the surveillance scan. In multivariable analysis, sarcopenia at the post-neoadjuvant scan was significantly associated with OS [hazards ratio (HR) 2.65, 95% CI 1.59-4.40; p < 0.001] and DFS (HR 1.80, 95% CI 1.03-3.13; p = 0.038). The net change in skeletal muscle index was associated with OS (HR 0.93, 95% CI 0.90-0.97; p < 0.001) and DFS (HR 0.94, 95% CI 0.91-0.98; p = 0.001). Conclusions: Patients who develop sarcopenia as a consequence of skeletal muscle wasting during neoadjuvant therapy are at risk for worse DFS and OS. Patients who have a net loss of muscle over time may be at high risk for early disease recurrence.
MeSH term(s)	Humans ; Sarcopenia/complications ; Prognosis ; Retrospective Studies ; Neoplasm Recurrence, Local/pathology ; Esophageal Neoplasms/complications ; Esophageal Neoplasms/surgery ; Muscle, Skeletal/pathology
Language	English
Publishing date	2023-07-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	1200469-8
ISSN	1534-4681 ; 1068-9265
ISSN (online)	1534-4681
ISSN	1068-9265
DOI	10.1245/s10434-023-13840-6
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Article ; Online: The impact of Canadian-produced research on the global orthopedic literature: a bibliometric analysis.

Dartus, Julien / Devos, Patrick / Matache, Bogdan A / Bédard, Luc / Pelet, Stéphane / Belzile, Etienne L

Canadian journal of surgery. Journal canadien de chirurgie

2023 Volume 66, Issue 6, Page(s) E583–E595

Abstract: Background: Little is known about the quality and impact of Canadian-produced research relative to that of other developed nations. The purpose of this study was to determine the contribution of Canadian authors to the orthopedic literature globally and ...

Abstract	Background: Little is known about the quality and impact of Canadian-produced research relative to that of other developed nations. The purpose of this study was to determine the contribution of Canadian authors to the orthopedic literature globally and nationally as well as Canada's research productivity in orthopedics. We hypothesized that Canada ranks among the most impactful countries in terms of orthopedic research productivity. Methods: We performed a bibliometric analysis to identify articles published between 2001 and 2020 in the category of orthopedics. We identified Canada's global rank in terms of overall productivity and assessed the contributions of individual Canadian authors. We also examined the quality of publications as determined by category normalized citation impact (CNCI) and publication in the top quartile of journals (%Q1) in terms of impact factor. In addition, we calculated the percentage of Canadian publications that were in orthopedics. Results: We identified 10 821 orthopedic publications from 2001 to 2020. Canada placed sixth globally in terms of productivity in orthopedic research. The annual productivity of Canadian orthopedic researchers increased over the study period by a factor of 3.2. In terms of research quality, with a %Q1 of 36.5% and a CNCI of 1.22, Canada outperformed Asian countries and the United States; the latter country had a %Q1 of 35.3% and a CNCI of 1.14 over the study period. Conclusion: The body of Canadian orthopedic literature has grown consistently over the past 20 years. Despite the overall leadership of the United States and other developed nations such as China and Japan, Canada ranks among the most influential countries in terms of the quality and quantity of orthopedic research.
MeSH term(s)	Humans ; United States ; Canada ; Bibliometrics ; Orthopedics ; Orthopedic Procedures ; Japan
Language	English
Publishing date	2023-12-06
Publishing country	Canada
Document type	Journal Article
ZDB-ID	410651-9
ISSN	1488-2310 ; 0008-428X
ISSN (online)	1488-2310
ISSN	0008-428X
DOI	10.1503/cjs.007022
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Article: Reversible effect of L-dopa on tremor and catatonia induced by alpha-methyl-p-tyrosine.

Bédard, P / Larochelle, L / Poirier, L J / Sourkes, T L

Canadian journal of physiology and pharmacology

1970 Volume 48, Issue 1, Page(s) 82–84

MeSH term(s)	Animals ; Catatonia/chemically induced ; Catatonia/drug therapy ; Dihydroxyphenylalanine/therapeutic use ; Haplorhini ; Humans ; Methyltyrosines ; Tremor/chemically induced ; Tremor/drug therapy
Chemical Substances	Methyltyrosines ; Dihydroxyphenylalanine (63-84-3)
Language	English
Publishing date	1970-01
Publishing country	Canada
Document type	Journal Article
ZDB-ID	127527-6
ISSN	1205-7541 ; 0008-4212
ISSN (online)	1205-7541
ISSN	0008-4212
DOI	10.1139/y70-013
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Article: Comparison of the burden of familial hypercholesterolemia between two cohorts of French Canadians hospitalized 25 years apart for coronary heart disease.

Lauzière, Alex / Brisson, Diane / Tremblay, Gérald / Bédard, Sophie / Khoury, Etienne / Gaudet, Daniel

Journal of clinical lipidology

2023 Volume 18, Issue 1, Page(s) e90–e96

Abstract: ... concentration <2.0 mmol/L in 2022 vs 0 % in 1998 (p <0.001).: Conclusions: Over 25 years, FH patients tend ... Cohort).: Results: At the time of admission, 24.6 % of CHD patients had LDL-C levels >5.0 mmol/L ... to 5.5 % in 2022 (p<0.001). FH patients hospitalized for a CHD event were older in 2022 than in 1998 (p ...

Abstract	Background: Familial hypercholesterolemia (FH) is associated with lifelong elevated plasma concentrations of low-density lipoprotein cholesterol (LDL-C) and high risk of premature coronary heart disease (CHD). Clinical recommendations and treatments have emerged to facilitate the management of FH patients. Their impact on the burden of FH is however not well documented. Objective: To compare the burden of FH between patients hospitalized for a CHD event 25 years apart in the French-Canadian founder population. Methods: Lipid profiles, cardiovascular risk factors, treatments and FH status of 2,029 patients consecutively hospitalized for an acute CHD event between 2017 and 2022 (2022 Cohort) were compared to those of 2,506 patients with angiographically-confirmed CHD who were admitted between 1995 and 1998 (1998 Cohort). Results: At the time of admission, 24.6 % of CHD patients had LDL-C levels >5.0 mmol/L in 1998 compared to 1.4 % in 2022, and FH was diagnosed in 9.6 % of patients in the 1998 cohort compared to 5.5 % in 2022 (p<0.001). FH patients hospitalized for a CHD event were older in 2022 than in 1998 (p <0.001). The prevalence of premature CHD requiring a hospitalization significantly decreased from 1998 to 2022 (64.3% vs. 44.1 %, p<0.001). At the moment of admission, 18.2 % of FH patients had LDL-C concentration <2.0 mmol/L in 2022 vs 0 % in 1998 (p <0.001). Conclusions: Over 25 years, FH patients tend to be older and contribute to a lower proportion of hospitalizations for CHD in the French-Canadian founder population. Despite significant improvement in diagnosis and treatment, FH management remains however sub-optimal.
MeSH term(s)	Humans ; Cholesterol, LDL ; Canada/epidemiology ; Hyperlipoproteinemia Type II/complications ; Hyperlipoproteinemia Type II/epidemiology ; Coronary Artery Disease/complications ; Risk Factors ; North American People
Chemical Substances	Cholesterol, LDL
Language	English
Publishing date	2023-10-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	2365061-8
ISSN	1876-4789 ; 1933-2874
ISSN (online)	1876-4789
ISSN	1933-2874
DOI	10.1016/j.jacl.2023.10.008
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Article ; Online: Endoscopic incisional therapy for benign anastomotic strictures after esophagectomy or gastrectomy: a systematic review and meta-analysis.

Jimoh, Zaharadeen / Jogiat, Uzair / Hajjar, Alex / Verhoeff, Kevin / Turner, Simon / Wong, Clarence / Kung, Janice Y / Bédard, Eric L R

Surgical endoscopy

2024

Abstract: ... revealed reduced odds of overall stricture recurrence (OR 0.35, 95% CI 0.13-0.92, p = 0.03; I: Conclusion ...

Abstract	Background: Studies have evaluated the efficacy of endoscopic incisional therapy (EIT) for benign anastomotic strictures. We performed a systematic review and meta-analysis to evaluate stricture recurrence after EIT following esophagectomy or gastrectomy. Methods: A systematic search of databases was performed up to April 2nd, 2023, after selection of key search terms with the research team. Inclusion criteria included human participants undergoing EIT for a benign anastomotic stricture after esophagectomy or gastrectomy, age ≥ 18, and n ≥ 5. Our primary outcome was the incidence of stricture recurrence among patients treated with EIT compared to dilation. Our secondary outcome was the stricture-free duration after EIT and rate of adverse events. Meta-analysis was performed with RevMan 5.4.1 using a Mantel-Haenszel random-effects model. Publication bias was evaluated with funnel plots and the Egger test. Results: A total of 2550 unique preliminary studies underwent screening of abstracts and titles. This led to 33 studies which underwent full-text review and five studies met the inclusion criteria. Meta-analysis revealed reduced odds of overall stricture recurrence (OR 0.35, 95% CI 0.13-0.92, p = 0.03; I Conclusion: Current data suggest EIT is associated with reduced odds of stricture recurrence among naïve anastomotic strictures. Large, prospective studies are needed to characterize the safety profile of EIT, address publication bias, and to explore multimodal therapies for refractory strictures.
Language	English
Publishing date	2024-04-22
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	639039-0
ISSN	1432-2218 ; 0930-2794
ISSN (online)	1432-2218
ISSN	0930-2794
DOI	10.1007/s00464-024-10817-8
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Article ; Online: Oral care reduces incidence of pneumonia after esophagectomy: systematic review and meta-analysis.

Jogiat, Uzair / Kirkland, Megan / Verhoeff, Kevin / Bédard, Eric L R / Kung, Janice Y / Turner, Simon R

Langenbeck's archives of surgery

2023 Volume 408, Issue 1, Page(s) 209

Abstract: ... compared to those without an oral care intervention (OR 0.57, 95% CI 0.43-0.74, p < 0.0001; I: Conclusion ...

Abstract	Purpose: Post-operative pneumonia after esophagectomy is a major contributor to morbidity and mortality. Prior studies have demonstrated a link between the presence of pathologic oral flora and the development of aspiration pneumonia. The objective of this systematic review and meta-analysis was to evaluate the effect of pre-operative oral care on the incidence of post-operative pneumonia after esophagectomy. Methods: A systematic search of the literature was performed on September 2, 2022. Screening of titles and abstracts, full-text articles, and evaluation of methodological quality was performed by two authors. Case reports, conference proceedings, and animal studies were excluded. A meta-analysis of peri-operative oral care on the odds of post-operative pneumonia after esophagectomy was performed using Revman 5.4.1 with a Mantel-Haenszel, random-effects model. Results: A total of 736 records underwent title and abstract screening, leading to 28 full-text studies evaluated for eligibility. A total of nine studies met the inclusion criteria and underwent meta-analysis. Meta-analysis revealed a significant reduction in post-operative pneumonia among patients undergoing pre-operative oral care intervention compared to those without an oral care intervention (OR 0.57, 95% CI 0.43-0.74, p < 0.0001; I Conclusion: Pre-operative oral care interventions have significant potential in the reduction of post-operative pneumonia after esophagectomy. North American prospective studies, as well as studies on the cost-benefit analysis, are required.
MeSH term(s)	Animals ; Incidence ; Esophagectomy/adverse effects ; Prospective Studies ; Pneumonia/epidemiology ; Pneumonia/etiology ; Pneumonia/prevention & control ; Cost-Benefit Analysis
Language	English
Publishing date	2023-05-24
Publishing country	Germany
Document type	Meta-Analysis ; Systematic Review ; Journal Article
ZDB-ID	1423681-3
ISSN	1435-2451 ; 1435-2443
ISSN (online)	1435-2451
ISSN	1435-2443
DOI	10.1007/s00423-023-02936-y
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Article ; Online: Granisetron, a selective 5-HT3 antagonist, reduces L-3,4-dihydroxyphenylalanine-induced abnormal involuntary movements in the 6-hydroxydopamine-lesioned rat.

Kwan, Cynthia / Frouni, Imane / Bédard, Dominique / Hamadjida, Adjia / Huot, Philippe

Behavioural pharmacology

2021 Volume 32, Issue 1, Page(s) 43–53

Abstract: Administration of L-3,4-dihydroxyphenylalanine (L-DOPA) provides Parkinson's disease patients ... with effective symptomatic relief. However, long-term L-DOPA therapy is often marred by complications ... 0.01, 0.1 and 1 mg/kg) or vehicle was acutely administered in combination with L-DOPA and ...

Abstract	Administration of L-3,4-dihydroxyphenylalanine (L-DOPA) provides Parkinson's disease patients with effective symptomatic relief. However, long-term L-DOPA therapy is often marred by complications such as dyskinesia. We have previously demonstrated that serotonin type 3 (5-HT3) receptor blockade with the clinically available and highly selective antagonist ondansetron alleviates dyskinesia in the 6-hydroxydopamine (6-OHDA)-lesioned rat. Here, we sought to explore the antidyskinetic efficacy of granisetron, another clinically available 5-HT3 receptor antagonist. Rats were rendered hemi-parkinsonian by 6-OHDA injection in the medial forebrain bundle. Following induction of stable abnormal involuntary movements (AIMs), granisetron (0.0001, 0.001, 0.01, 0.1 and 1 mg/kg) or vehicle was acutely administered in combination with L-DOPA and the severity of AIMs, both duration and amplitude, was determined. We also assessed the effect of granisetron on L-DOPA antiparkinsonian action by performing the cylinder test. Adding granisetron (0.0001, 0.001, 0.01, 0.1 and 1 mg/kg) to L-DOPA resulted in a significant reduction of AIMs duration and amplitude, with certain parameters being reduced by as much as 38 and 45% (P < 0.05 and P < 0.001, respectively). The antidyskinetic effect of granisetron was not accompanied by a reduction of L-DOPA antiparkinsonian action. These results suggest that 5-HT3 blockade may reduce L-DOPA-induced dyskinesia without impairing the therapeutic efficacy of L-DOPA. However, a U-shaped dose-response curve obtained with certain parameters may limit the therapeutic potential of this strategy and require further investigation.
MeSH term(s)	Animals ; Antiparkinson Agents/pharmacology ; Antiparkinson Agents/toxicity ; Dose-Response Relationship, Drug ; Dyskinesia, Drug-Induced/drug therapy ; Dyskinesia, Drug-Induced/etiology ; Female ; Granisetron/administration & dosage ; Granisetron/pharmacology ; Levodopa/pharmacology ; Levodopa/toxicity ; Oxidopamine/toxicity ; Parkinsonian Disorders/drug therapy ; Rats ; Rats, Sprague-Dawley ; Serotonin 5-HT3 Receptor Antagonists/administration & dosage ; Serotonin 5-HT3 Receptor Antagonists/pharmacology
Chemical Substances	Antiparkinson Agents ; Serotonin 5-HT3 Receptor Antagonists ; Levodopa (46627O600J) ; Oxidopamine (8HW4YBZ748) ; Granisetron (WZG3J2MCOL)
Language	English
Publishing date	2021-01-05
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1027374-8
ISSN	1473-5849 ; 0955-8810
ISSN (online)	1473-5849
ISSN	0955-8810
DOI	10.1097/FBP.0000000000000601
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