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  1. Article ; Online: The Factors Associated With Confidence in Using the Internet to Access Health Information: Cross-sectional Data Analysis.

    Van Heel, Kasi Lou / Nelson, Anna / Handysides, Daniel / Shah, Huma

    JMIR formative research

    2023  Volume 7, Page(s) e39891

    Abstract: Background: Confidence in health information access is a measure of the perceived ability to obtain health information. One's beliefs or perceived ability to access health information is particularly important in understanding trends in health care ... ...

    Abstract Background: Confidence in health information access is a measure of the perceived ability to obtain health information. One's beliefs or perceived ability to access health information is particularly important in understanding trends in health care access. Previous literature has found that access to health information is lowest among society's most vulnerable population groups. These groups include older, less educated, and low-income populations. While health confidence has previously been used as a scale to measure health outcomes, additional research is needed describing the demographic factors associated with users' confidence in health information access. This may be a key component of health information seeking that affects beneficial health outcomes such as prevention and treatment.
    Objective: This study examines the demographic factors associated with the levels of confidence in using the internet to access health information for adults 18 years and older in the United States.
    Methods: Using a cross-sectional design, secondary data from the Health Information National Trends Survey (HINTS) 5, Cycle 3 (2019) were analyzed (N=5374). An ordinal regression stratified by internet use was used to determine the association between demographic characteristics and level of confidence in health information access.
    Results: When the internet is the primary source for health information, high school graduates (adjusted odds ratio [AOR] 0.58, 95% CI 0.37-0.89) compared to those with a college degree or more had significantly lower odds of being confident in obtaining health information. In addition, non-Hispanic Asian participants (AOR 0.44, 95% CI 0.24-0.82) compared to non-Hispanic White participants, male participants (AOR 0.72, 95% CI 0.54-0.97) compared to female participants, and those who made between US $20,000-$35,000 annually (AOR 0.55, 95% CI 0.31-0.98) compared to those who made US $75,000 or more annually had significantly lower odds of being confident in obtaining health information via the internet. Moreover, when the internet is the primary source for health information, those with health insurance had significantly higher odds of being confident in obtaining health information (AOR 2.91, 95% CI 1.58-5.34) compared to those who do not have health insurance. Lastly, a significant association was observed between confidence in health information access and primary health information source and frequency of visiting a health care provider.
    Conclusions: Confidence in accessing health information can differ by individual demographics. Accessing health-related information from the internet has become increasingly more common and can provide insight into health information-seeking behaviors. Further exploration of these factors can inform the science of health education by providing deeper insight into improving access to health information for vulnerable populations.
    Language English
    Publishing date 2023-04-11
    Publishing country Canada
    Document type Journal Article
    ISSN 2561-326X
    ISSN (online) 2561-326X
    DOI 10.2196/39891
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Interleukin 15: its role in intestinal inflammation.

    van Heel, D A

    Gut

    2006  Volume 55, Issue 4, Page(s) 444–445

    MeSH term(s) Celiac Disease/immunology ; Celiac Disease/therapy ; Humans ; Immunity, Cellular ; Immunotherapy/methods ; Inflammatory Bowel Diseases/immunology ; Inflammatory Bowel Diseases/therapy ; Interleukin-15/blood ; Interleukin-15/immunology ; Leukocytes/immunology
    Chemical Substances Interleukin-15
    Language English
    Publishing date 2006-04
    Publishing country England
    Document type Comment ; Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 80128-8
    ISSN 1468-3288 ; 0017-5749
    ISSN (online) 1468-3288
    ISSN 0017-5749
    DOI 10.1136/gut.2005.079335
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Genome-wide analyses identify 21 infertility loci and over 400 reproductive hormone loci across the allele frequency spectrum.

    Venkatesh, Samvida S / Wittemans, Laura B L / Palmer, Duncan S / Baya, Nikolas A / Ferreira, Teresa / Hill, Barney / Lassen, Frederik Heymann / Parker, Melody J / Reibe, Saskia / Elhakeem, Ahmed / Banasik, Karina / Bruun, Mie T / Erikstrup, Christian / Jensen, Bitten A / Juul, Anders / Mikkelsen, Christina / Nielsen, Henriette S / Ostrowski, Sisse R / Pedersen, Ole B /
    Rohde, Palle D / Sorensen, Erik / Ullum, Henrik / Westergaard, David / Haraldsson, Asgeir / Holm, Hilma / Jonsdottir, Ingileif / Olafsson, Isleifur / Steingrimsdottir, Thora / Steinthorsdottir, Valgerdur / Thorleifsson, Gudmar / Figueredo, Jessica / Karjalainen, Minna K / Pasanen, Anu / Jacobs, Benjamin M / Hubers, Nikki / Lippincott, Margaret / Fraser, Abigail / Lawlor, Deborah A / Timpson, Nicholas J / Nyegaard, Mette / Stefansson, Kari / Magi, Reedik / Laivuori, Hannele / van Heel, David A / Boomsma, Dorret I / Balasubramanian, Ravikumar / Seminara, Stephanie B / Chan, Yee-Ming / Laisk, Triin / Lindgren, Cecilia M

    medRxiv : the preprint server for health sciences

    2024  

    Abstract: Genome-wide association studies (GWASs) may help inform treatments for infertility, whose causes remain unknown in many cases. Here we present GWAS meta-analyses across six cohorts for male and female infertility in up to 41,200 cases and 687,005 ... ...

    Abstract Genome-wide association studies (GWASs) may help inform treatments for infertility, whose causes remain unknown in many cases. Here we present GWAS meta-analyses across six cohorts for male and female infertility in up to 41,200 cases and 687,005 controls. We identified 21 genetic risk loci for infertility (
    Language English
    Publishing date 2024-03-20
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.03.19.24304530
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Genome-wide association study of thyroid-stimulating hormone highlights new genes, pathways and associations with thyroid disease.

    Williams, Alexander T / Chen, Jing / Coley, Kayesha / Batini, Chiara / Izquierdo, Abril / Packer, Richard / Abner, Erik / Kanoni, Stavroula / Shepherd, David J / Free, Robert C / Hollox, Edward J / Brunskill, Nigel J / Ntalla, Ioanna / Reeve, Nicola / Brightling, Christopher E / Venn, Laura / Adams, Emma / Bee, Catherine / Wallace, Susan E /
    Pareek, Manish / Hansell, Anna L / Esko, Tõnu / Stow, Daniel / Jacobs, Benjamin M / van Heel, David A / Hennah, William / Rao, Balasubramanya S / Dudbridge, Frank / Wain, Louise V / Shrine, Nick / Tobin, Martin D / John, Catherine

    Nature communications

    2023  Volume 14, Issue 1, Page(s) 6713

    Abstract: Thyroid hormones play a critical role in regulation of multiple physiological functions and thyroid dysfunction is associated with substantial morbidity. Here, we use electronic health records to undertake a genome-wide association study of thyroid- ... ...

    Abstract Thyroid hormones play a critical role in regulation of multiple physiological functions and thyroid dysfunction is associated with substantial morbidity. Here, we use electronic health records to undertake a genome-wide association study of thyroid-stimulating hormone (TSH) levels, with a total sample size of 247,107. We identify 158 novel genetic associations, more than doubling the number of known associations with TSH, and implicate 112 putative causal genes, of which 76 are not previously implicated. A polygenic score for TSH is associated with TSH levels in African, South Asian, East Asian, Middle Eastern and admixed American ancestries, and associated with hypothyroidism and other thyroid disease in South Asians. In Europeans, the TSH polygenic score is associated with thyroid disease, including thyroid cancer and age-of-onset of hypothyroidism and hyperthyroidism. We develop pathway-specific genetic risk scores for TSH levels and use these in phenome-wide association studies to identify potential consequences of pathway perturbation. Together, these findings demonstrate the potential utility of genetic associations to inform future therapeutics and risk prediction for thyroid diseases.
    MeSH term(s) Humans ; Thyrotropin/genetics ; Genome-Wide Association Study ; Thyroid Diseases/genetics ; Hypothyroidism/genetics ; Hyperthyroidism/genetics ; Thyroxine
    Chemical Substances Thyrotropin (9002-71-5) ; Thyroxine (Q51BO43MG4)
    Language English
    Publishing date 2023-10-23
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-42284-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: CYP2C19

    Magavern, Emma F / Jacobs, Benjamin / Warren, Helen / Finocchiaro, Gherardo / Finer, Sarah / van Heel, David A / Smedley, Damian / Caulfield, Mark J

    JACC. Advances

    2024  Volume 2, Issue 7, Page(s) None

    Abstract: Background: Cytochrome P450 family 2 subfamily C member 19 (CYP2C19) is a hepatic enzyme involved in the metabolism of clopidogrel from a prodrug to its active metabolite. Prior studies of genetic polymorphisms in : Objectives: The objective of this ... ...

    Abstract Background: Cytochrome P450 family 2 subfamily C member 19 (CYP2C19) is a hepatic enzyme involved in the metabolism of clopidogrel from a prodrug to its active metabolite. Prior studies of genetic polymorphisms in
    Objectives: The objective of this study was to assess prevalence of common
    Methods: The Genes & Health cohort of British Bangladeshi and Pakistani ancestry participants were studied.
    Results: Genes & Health cohort participants (N = 44,396) have a high prevalence (57%) of intermediate or poor CYP2C19 metabolizers, with at least 1 loss-of-function
    Conclusions: A pharmacogenomic-driven approach to clopidogrel prescribing has the potential to impact significantly on clinical management and outcomes in individuals of Bangladeshi and Pakistani ancestry.
    Language English
    Publishing date 2024-03-13
    Publishing country United States
    Document type Journal Article
    ISSN 2772-963X
    ISSN (online) 2772-963X
    DOI 10.1016/j.jacadv.2023.100573
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: CYP2C19 loss-of-function alleles are not associated with higher prevalence of gastrointestinal bleeds in those who have been prescribed antidepressants: Analysis in a British-South Asian cohort.

    Magavern, Emma F / van Heel, David A / Smedley, Damian / Caulfield, Mark J

    British journal of clinical pharmacology

    2023  Volume 89, Issue 11, Page(s) 3432–3438

    Abstract: Aims: CYP2C19 is a hepatic enzyme involved in the metabolism of antidepressants associated with increased gastrointestinal bleed (GIB) risk. The aim of our study was to explore a possible association between loss-of-function CYP2C19 genotypes and GIB in ...

    Abstract Aims: CYP2C19 is a hepatic enzyme involved in the metabolism of antidepressants associated with increased gastrointestinal bleed (GIB) risk. The aim of our study was to explore a possible association between loss-of-function CYP2C19 genotypes and GIB in South Asian ancestry participants prescribed antidepressants.
    Methods: Genes & Health participants with a record in Barts Health NHS Trust (N 22 753) were studied using a cross-sectional approach. CYP2C19 diplotypes were assessed and metabolizer type inferred from consortia guidance. Fisher's exact test was used to compare the prevalence of GIB in different metabolizer categories. Multivariable regression was used to test for association between antidepressant prescriptions and GIB, and between CYP2C19 metabolizer state and GIB in the subcohort prescribed antidepressants.
    Results: Antidepressants were frequently prescribed (47%, N = 10 612). A total of 864 participants (4%) had a GIB; 534 (62%) had been prescribed a CYP2C19 metabolized antidepressant. There was an independent association between antidepressant prescriptions and GIB events (odds ratio 1.8, confidence interval 1.5-2.0, P < 0.0001). There was no relationship between CYP2C19 inferred poor (P 0.56) or intermediate (P 0.53) metabolizer status and GIB in those prescribed an antidepressant in unadjusted analysis. A multivariable logistic regression model did not show an independent association between poor (P 0.54) or intermediate (P 0.62) CYP2C19 metabolizers and GIB in the subcohort prescribed antidepressants.
    Conclusions: CYP2C19 dependent antidepressants are associated with increased GIB prevalence. GIB appeared independent from CYP2C19 metabolizer genotype in individuals who had been prescribed antidepressants. Precision dosing based on CYP2C19 genetic information alone is unlikely to reduce GIB prevalence.
    MeSH term(s) Humans ; Alleles ; Antidepressive Agents/adverse effects ; Antidepressive Agents/metabolism ; Aryl Hydrocarbon Hydroxylases/genetics ; Aryl Hydrocarbon Hydroxylases/metabolism ; Cytochrome P-450 CYP2C19/genetics ; Genotype ; Prevalence ; Loss of Function Mutation ; Gastrointestinal Hemorrhage/chemically induced ; Gastrointestinal Hemorrhage/ethnology ; Gastrointestinal Hemorrhage/genetics ; South Asian People/genetics ; Asia, Southern/ethnology ; United Kingdom
    Chemical Substances Antidepressive Agents ; Aryl Hydrocarbon Hydroxylases (EC 1.14.14.1) ; CYP2C19 protein, human (EC 1.14.14.1) ; Cytochrome P-450 CYP2C19 (EC 1.14.14.1)
    Language English
    Publishing date 2023-08-06
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 188974-6
    ISSN 1365-2125 ; 0306-5251 ; 0264-3774
    ISSN (online) 1365-2125
    ISSN 0306-5251 ; 0264-3774
    DOI 10.1111/bcp.15762
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: SLCO1B1*5 is protective against non-senile cataracts in cohort prescribed statins: analysis in a British-South Asian cohort.

    Magavern, Emma F / van Heel, David A / Smedley, Damian / Caulfield, Mark J

    The pharmacogenomics journal

    2023  Volume 23, Issue 5, Page(s) 134–139

    Abstract: Background: Reported association between statin use and cataract risk is controversial. The SLCO1B1 gene encodes a transport protein responsible for statin clearance. The aim of this study was to investigate a possible association between the SLCO1B1*5 ... ...

    Abstract Background: Reported association between statin use and cataract risk is controversial. The SLCO1B1 gene encodes a transport protein responsible for statin clearance. The aim of this study was to investigate a possible association between the SLCO1B1*5 reduced function variant and cataract risk in statin users of South Asian ethnicity.
    Methods: The Genes & Health cohort consists of British-Bangladeshi and British-Pakistani participants from East London, Manchester and Bradford, UK. SLCO1B1*5 genotype was assessed with the Illumina GSAMD-24v3-0-EA chip. Medication data from primary care health record linkage was used to compare those who had regularly used statins compared to those who had not. Multivariable logistic regression was used to test for association between statin use and cataracts, adjusting for population characteristics and potential confounders in 36,513 participants. Multivariable logistic regression was used to test association between SLCO1B1*5 heterozygotes or homozygotes and cataracts, in subgroups having been regularly prescribed statins versus not.
    Results: Statins were prescribed to 35% (12,704) of participants (average age 41 years old, 45% male). Non-senile cataract was diagnosed in 5% (1686) of participants. An apparent association between statins and non-senile cataract (12% in statin users and 0.8% in non-statin users) was negated by inclusion of confounders. In those prescribed a statin, presence of the SLCO1B1*5 genotype was independently associated with a decreased risk of non-senile cataract (OR 0.7 (CI 0.5-0.9, p 0.007)).
    Conclusions: Our findings suggest that there is no independent association between statin use and non-senile cataract risk after adjusting for confounders. Among statin users, the SLCO1B1*5 genotype is associated with a 30% risk reduction of non-senile cataracts. Stratification of on-drug cohorts by validated pharmacogenomic variants is a useful tool to support or repudiate adverse drug events in observational cohorts.
    MeSH term(s) Humans ; Male ; Adult ; Female ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/adverse effects ; Genotype ; Cataract/chemically induced ; Cataract/epidemiology ; Cataract/genetics ; Liver-Specific Organic Anion Transporter 1/genetics
    Chemical Substances Hydroxymethylglutaryl-CoA Reductase Inhibitors ; SLCO1B1 protein, human ; Liver-Specific Organic Anion Transporter 1
    Language English
    Publishing date 2023-05-23
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2106831-8
    ISSN 1473-1150 ; 1470-269X
    ISSN (online) 1473-1150
    ISSN 1470-269X
    DOI 10.1038/s41397-023-00307-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Myriapod haemocyanin: the first three-dimensional reconstruction of

    Riciluca, K C T / Borges, A C / Mello, J F R / de Oliveira, U C / Serdan, D C / Florez-Ariza, A / Chaparro, E / Nishiyama, M Y / Cassago, A / Junqueira-de-Azevedo, I L M / van Heel, M / Silva, P I / Portugal, R V

    Open biology

    2020  Volume 10, Issue 4, Page(s) 190258

    Abstract: Haemocyanins (Hcs) are copper-containing, respiratory proteins that occur in the haemolymph of many arthropod species. Here, we report the presence of Hcs in the chilopode Myriapoda, demonstrating that these proteins are more widespread among the ... ...

    Abstract Haemocyanins (Hcs) are copper-containing, respiratory proteins that occur in the haemolymph of many arthropod species. Here, we report the presence of Hcs in the chilopode Myriapoda, demonstrating that these proteins are more widespread among the Arthropoda than previously thought. The analysis of transcriptome of
    MeSH term(s) Animals ; Arthropod Proteins/chemistry ; Arthropod Proteins/genetics ; Arthropod Proteins/metabolism ; Catechol Oxidase/chemistry ; Catechol Oxidase/metabolism ; Chilopoda/genetics ; Chilopoda/metabolism ; Chromatography, Gel ; Enzyme Precursors/chemistry ; Enzyme Precursors/metabolism ; Gene Expression Regulation ; Hemocyanins/chemistry ; Hemocyanins/genetics ; Hemocyanins/metabolism ; Hemolymph/metabolism ; Models, Molecular ; Molecular Weight ; Phylogeny ; Protein Conformation ; Protein Multimerization ; Sequence Analysis, DNA/methods
    Chemical Substances Arthropod Proteins ; Enzyme Precursors ; Hemocyanins (9013-72-3) ; pro-phenoloxidase (EC 1.10.3.-) ; Catechol Oxidase (EC 1.10.3.1)
    Language English
    Publishing date 2020-04-01
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2630944-0
    ISSN 2046-2441 ; 2046-2441
    ISSN (online) 2046-2441
    ISSN 2046-2441
    DOI 10.1098/rsob.190258
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Triage of colonoscopies: open access endoscopy versus outpatient consultation with a gastroenterologist.

    Wichers, C D / van Heel, N C M / Ter Borg, F / van Herwaarden, M A

    Endoscopy international open

    2014  Volume 2, Issue 3, Page(s) E187–90

    Abstract: Background and study aims: In many Dutch hospitals, open access referral for colonoscopy is authorized by a gastroenterologist after screening a standard referral letter (SRL) without face-to-face contact with the patient. We investigated the added ... ...

    Abstract Background and study aims: In many Dutch hospitals, open access referral for colonoscopy is authorized by a gastroenterologist after screening a standard referral letter (SRL) without face-to-face contact with the patient. We investigated the added value of a 7.5 min outpatient consultation with a gastroenterologist (OC), regarding the patient indications, priority for colonoscopy, and the frequency of correct information about patient medications and comorbidities on SRLs.
    Patients and methods: In a prospective, blinded, single-center study, gastroenterologists assessed SRLs for the accuracy and priority of the colonoscopy request (SRL). These data were compared to results from the OC, and primary outcomes were the number of patients who were not recommended for colonoscopy and priority scheduling of colonoscopy for suspicion of cancer.
    Results: Patients were analyzed using both SRL and OC and, of 255 patients, 224 of them underwent colonoscopy. Colonoscopy was not recommended for 6.3 % and 11.4 % of patients using the SRL and OC, respectively (P = 0.02). Using the SRL, gastroenterologists did not recommend colonoscopy for seven patients, but the same patients were recommended for colonoscopy when OC was available. This was explained because the indications on the SRL did not match the information obtained from OC. Compared to OC , more colonoscopies were prioritized when the SRL was used to make decisions. Cancer was detected in 7/112 (SRL ) versus 7/65 (OC ) of priority-scheduled patients. SRLs did not report the use of coumarins and insulin in 1.6 % of patients or the prevalence of serious comorbid conditions in 52 % of patients.
    Conclusions: A 7.5 min outpatient consultation with a gastroenterologist improved the identification of indications for colonoscopy, decreased priority scheduling of patients, and increased the number of patients diagnosed with cancer in the prioritized group. SRLs frequently omitted patients' medications and comorbidities.
    Language English
    Publishing date 2014-09-17
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2761052-4
    ISSN 2196-9736 ; 2364-3722
    ISSN (online) 2196-9736
    ISSN 2364-3722
    DOI 10.1055/s-0034-1377325
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Recent advances in coeliac disease.

    van Heel, D A / West, J

    Gut

    2006  Volume 55, Issue 7, Page(s) 1037–1046

    MeSH term(s) Celiac Disease/diagnosis ; Celiac Disease/diet therapy ; Celiac Disease/epidemiology ; Diagnostic Errors ; Fertility ; Humans ; Incidence ; Prevalence ; Risk
    Language English
    Publishing date 2006-07
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 80128-8
    ISSN 1468-3288 ; 0017-5749
    ISSN (online) 1468-3288
    ISSN 0017-5749
    DOI 10.1136/gut.2005.075119
    Database MEDical Literature Analysis and Retrieval System OnLINE

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